Amyotrophic lateral sclerosis (ALS)

No Pathway Network information available for Amyotrophic lateral sclerosis (ALS)

Pathways in the Amyotrophic lateral sclerosis (ALS) SuperPath

#	Name	Source	Genes
1	Amyotrophic lateral sclerosis (ALS)	WikiPathways	ALS2 APAF1 BAD BAX BCL2 BCL2L1 BID CASP1 CASP12 CASP3 CASP9 CAT CCS CST3 DAXX GPX1 MAP2K2 MAP2K6 MAP3K5 MAPK14 NEFH NEFL NEFM NOS1 PPP3CA PPP3CB PPP3CC PRPH RAB5A RAC1 SLC1A2 SOD1 TNF TNFRSF1A TOMM40 TP53 (see all 36) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLC1A2	Solute Carrier Family 1 Member 2	Protein Coding	1
2	CST3	Cystatin C	Protein Coding	1
3	TOMM40	Translocase Of Outer Mitochondrial Membrane 40	Protein Coding	1
4	CCS	Copper Chaperone For Superoxide Dismutase	Protein Coding	1
5	CAT	Catalase	Protein Coding	1
6	CASP9	Caspase 9	Protein Coding	1
7	CASP3	Caspase 3	Protein Coding	1
8	CASP1	Caspase 1	Protein Coding	1
9	TP53	Tumor Protein P53	Protein Coding	1
10	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
11	TNF	Tumor Necrosis Factor	Protein Coding	1
12	SOD1	Superoxide Dismutase 1	Protein Coding	1
13	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
14	BCL2L1	BCL2 Like 1	Protein Coding	1
15	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
16	RAC1	Rac Family Small GTPase 1	Protein Coding	1
17	RAB5A	RAB5A, Member RAS Oncogene Family	Protein Coding	1
18	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
19	ALS2	Alsin Rho Guanine Nucleotide Exchange Factor ALS2	Protein Coding	1
20	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
21	PRPH	Peripherin	Protein Coding	1
22	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
23	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
24	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	1
25	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	1
26	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
27	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
28	NEFL	Neurofilament Light Chain	Protein Coding	1
29	NEFH	Neurofilament Heavy Chain	Protein Coding	1
30	NEFM	Neurofilament Medium Chain	Protein Coding	1
31	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
32	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
33	GPX1	Glutathione Peroxidase 1	Protein Coding	1
34	DAXX	Death Domain Associated Protein	Protein Coding	1
35	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
36	CASP12	Caspase 12 (Gene/Pseudogene)	Protein Coding	1

Disorders associated with Amyotrophic lateral sclerosis (ALS) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Amyotrophic lateral sclerosis 1	Enrichment	NEFH, PRPH, SOD1	5.69
2	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ALS2, NEFH, PRPH, SOD1	4.80
3	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.58
4	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.58
5	Amyotrophic lateral sclerosis 2, juvenile	Enrichment	ALS2	2.58
6	Macular degeneration, age-related, 11	Enrichment	CST3	2.58
7	Spastic paralysis, infantile-onset ascending	Enrichment	ALS2	2.58
8	Charcot-marie-tooth disease, demyelinating, type 1f	Enrichment	NEFL	2.58
9	Developmental and epileptic encephalopathy 41	Enrichment	SLC1A2	2.58
10	Charcot-marie-tooth disease, axonal, type 2cc	Enrichment	NEFH	2.58
11	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.58
12	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.58
13	Charcot-marie-tooth disease, dominant intermediate g	Enrichment	NEFL	2.58
14	Bone marrow failure syndrome 5	Enrichment	TP53	2.58
15	Papilloma of choroid plexus	Enrichment	TP53	2.58
16	Basal cell carcinoma 7	Enrichment	TP53	2.58
17	Anaplastic thyroid carcinoma	Enrichment	TP53	2.58
18	Acatalasemia	Enrichment	CAT	2.58
19	Glutathione peroxidase deficiency	Enrichment	GPX1	2.58
20	Charcot-marie-tooth disease type 1f	Enrichment	NEFL	2.58
21	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.58
22	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.58
23	Ductal carcinoma in situ	Enrichment	TP53	2.58
24	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.58
25	Als2-related disorder	Enrichment	ALS2	2.58
26	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.58
27	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.58
28	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.58
29	Leukodystrophy, adult-onset, autosomal dominant, without amyloid angiopathy	Enrichment	CST3	2.58
30	Charcot-marie-tooth disease type 2b5	Enrichment	NEFL	2.58
31	Choroid plexus cancer	Enrichment	TP53	2.58
32	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.58
33	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.58
34	Infantile-onset ascending hereditary spastic paralysis	Enrichment	ALS2	2.58
35	Cerebral amyloid angiopathy, cst3-related	Enrichment	CST3	2.28
36	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.28
37	Cervical cancer	Enrichment	TP53	2.28
38	Hereditary motor and sensory neuropathy, type iic	Enrichment	NEFH	2.28
39	Primary lateral sclerosis, juvenile	Enrichment	ALS2	2.28
40	Lymphoma, hodgkin, classic	Enrichment	TP53	2.28
41	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.28
42	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.28
43	Immunodeficiency 127	Enrichment	TNF	2.28
44	Congenital fibrosarcoma	Enrichment	TP53	2.28
45	Li-fraumeni syndrome 1	Enrichment	TP53	2.28
46	Sarcoma	Enrichment	TP53	2.28
47	Spastic tetraplegia and axial hypotonia, progressive	Enrichment	SOD1	2.28
48	Cervix carcinoma	Enrichment	TP53	2.28
49	Hodgkin's lymphoma	Enrichment	TP53	2.28
50	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.28
51	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.28
52	Tafro syndrome	Enrichment	MAP2K2	2.28
53	Osteogenic sarcoma	Enrichment	TP53	2.10
54	Psoriatic arthritis	Enrichment	TNF	2.10
55	Nasopharyngeal carcinoma	Enrichment	TP53	2.10
56	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.10
57	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.10
58	Anaplastic astrocytoma	Enrichment	TP53	2.10
59	Squamous cell carcinoma	Enrichment	TP53	2.10
60	T-cell acute lymphoblastic leukemia	Enrichment	BAX	2.10
61	Adenocarcinoma	Enrichment	TP53	2.10
62	Migraine without aura	Enrichment	TNF	2.10
63	Bone osteosarcoma	Enrichment	TP53	2.10
64	Tyrosinemia	Enrichment	ALS2	2.10
65	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA, SLC1A2	2.02
66	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K2	1.98
67	Small cell cancer of the lung	Enrichment	TP53	1.98
68	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.98
69	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.98
70	Cardiofaciocutaneous syndrome	Enrichment	MAP2K2	1.98
71	Lung sarcomatoid carcinoma	Enrichment	TP53	1.98
72	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.98
73	Idiopathic achalasia	Enrichment	NOS1	1.98
74	Cerebral malaria	Enrichment	TNF	1.98
75	Rhabdomyosarcoma 2	Enrichment	TP53	1.88
76	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	SOD1	1.88
77	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	NEFL	1.88
78	Follicular lymphoma	Enrichment	BCL2	1.88
79	Lymphoma	Enrichment	TP53	1.88
80	Vascular dementia	Enrichment	TNF	1.88
81	Acute megakaryocytic leukemia	Enrichment	TP53	1.88
82	Li-fraumeni syndrome	Enrichment	TP53	1.80
83	Adrenocortical carcinoma	Enrichment	TP53	1.80
84	Breast adenocarcinoma	Enrichment	TP53	1.80
85	Esophageal cancer	Enrichment	TP53	1.73
86	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.73
87	Essential thrombocythemia	Enrichment	TP53	1.73
88	Motor neuron disease	Enrichment	SOD1	1.73
89	Gallbladder cancer	Enrichment	TP53	1.73
90	Early-onset autosomal dominant alzheimer disease	Enrichment	TOMM40	1.73
91	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.73
92	Glioma susceptibility 1	Enrichment	TP53	1.68
93	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.68
94	Colorectal cancer	Enrichment	BAX, TP53	1.65
95	Charge syndrome	Enrichment	TNFRSF1A	1.63
96	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.63
97	Adult hepatocellular carcinoma	Enrichment	TP53	1.63
98	Primary hyperaldosteronism	Enrichment	TP53	1.63
99	Juvenile amyotrophic lateral sclerosis	Enrichment	ALS2	1.63
100	Leukemia, chronic lymphocytic	Enrichment	TP53	1.58
101	Familial colorectal cancer	Enrichment	TP53	1.58
102	Asthma	Enrichment	TNF	1.54
103	Myelodysplastic syndrome	Enrichment	TP53	1.54
104	Lip and oral cavity carcinoma	Enrichment	TP53	1.50
105	Alzheimer's disease	Enrichment	TNF	1.47
106	Multiple sclerosis	Enrichment	TNFRSF1A	1.44
107	Lung cancer susceptibility 3	Enrichment	TP53	1.44
108	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K2	1.41
109	Rhabdomyosarcoma	Enrichment	TP53	1.38
110	Gliosarcoma	Enrichment	TP53	1.38
111	Giant cell glioblastoma	Enrichment	TP53	1.35
112	Behcet syndrome	Enrichment	TNFRSF1A	1.31
113	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	NEFL	1.31
114	Diffuse large b-cell lymphoma	Enrichment	TP53	1.31
115	Hepatoblastoma	Enrichment	TP53	1.27
116	Hepatocellular carcinoma	Enrichment	TP53	1.25
117	Diamond-blackfan anemia 1	Enrichment	TP53	1.23
118	Noonan syndrome 1	Enrichment	MAP2K2	1.23
119	Malaria	Enrichment	TNF	1.23
120	Autoinflammatory disease	Enrichment	TNFRSF1A	1.21
121	Pancreatic cancer	Enrichment	TP53	1.19
122	Rasopathy	Enrichment	MAP2K2	1.18
123	Auditory neuropathy	Enrichment	NEFL	1.18
124	Bladder cancer	Enrichment	TP53	1.13
125	Prostate cancer	Enrichment	TP53	1.13
126	Peripheral nervous system disease	Enrichment	NEFL	1.09
127	Neuropathy	Enrichment	NEFL	1.09
128	Diamond-blackfan anemia	Enrichment	TP53	1.04
129	Systemic lupus erythematosus	Enrichment	TNF	1.01
130	Leukemia, acute myeloid	Enrichment	TP53	1.00
131	Charcot-marie-tooth disease	Enrichment	NEFL	0.99
132	Gastric cancer	Enrichment	TP53	0.97
133	Hereditary breast carcinoma	Enrichment	TP53	0.96
134	Sensorineural hearing loss	Enrichment	NEFL	0.92
135	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPP3CA	0.90
136	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.87
137	Myeloma, multiple	Enrichment	TP53	0.86
138	Breast cancer	Enrichment	TP53	0.74
139	Ovarian cancer	Enrichment	TP53	0.63
140	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Amyotrophic lateral sclerosis (ALS)

Pathway Network for Amyotrophic lateral sclerosis (ALS)

Member Pathways for Amyotrophic lateral sclerosis (ALS)

Pathways in the Amyotrophic lateral sclerosis (ALS) SuperPath

Associated Genes for Amyotrophic lateral sclerosis (ALS)

Associated Disorders for Amyotrophic lateral sclerosis (ALS)

Disorders associated with Amyotrophic lateral sclerosis (ALS) SuperPath

STRING Interaction Network for Amyotrophic lateral sclerosis (ALS)

Sources for Amyotrophic lateral sclerosis (ALS)