Angiogenesis (WikiPathways)

No Pathway Network information available for Angiogenesis (WikiPathways)

Pathways in the Angiogenesis (WikiPathways) SuperPath

#	Name	Source	Genes
1	Angiogenesis	WikiPathways	AKT1 ARNT CREBBP FGF2 FGFR2 FLT1 HIF1A KDR MAPK1 MAPK14 MMP9 NOS3 PDGFB PIK3CA PLCG1 SMAD1 SRC TEK TIMP2 (see all 19) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TIMP2	TIMP Metallopeptidase Inhibitor 2	Protein Coding	1
2	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	1
3	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
4	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
5	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
6	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
7	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
8	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
9	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
10	SMAD1	SMAD Family Member 1	Protein Coding	1
11	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	Protein Coding	1
12	KDR	Kinase Insert Domain Receptor	Protein Coding	1
13	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
14	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	1
15	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
16	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
17	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
18	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
19	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1

Disorders associated with Angiogenesis (WikiPathways) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Meningioma	Enrichment	AKT1, PDGFB, PIK3CA	6.29
2	Colorectal cancer	Enrichment	AKT1, FGFR2, PIK3CA, SRC	5.25
3	Pre-eclampsia	Enrichment	FLT1, NOS3	4.73
4	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.56
5	Arteriovenous malformation	Enrichment	PIK3CA, TEK	4.18
6	Cowden syndrome	Enrichment	AKT1, PIK3CA	4.18
7	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA, TEK	4.08
8	Endometrial cancer	Enrichment	FGFR2, PIK3CA	3.42
9	Macrodactyly	Enrichment	PIK3CA	2.85
10	Proteus syndrome	Enrichment	AKT1	2.85
11	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.85
12	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.85
13	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.85
14	Apert syndrome	Enrichment	FGFR2	2.85
15	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.85
16	Cowden syndrome 5	Enrichment	PIK3CA	2.85
17	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.85
18	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.85
19	Noonan syndrome 13	Enrichment	MAPK1	2.85
20	Venous malformations, multiple cutaneous and mucosal	Enrichment	TEK	2.85
21	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.85
22	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.85
23	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.85
24	Cowden syndrome 6	Enrichment	AKT1	2.85
25	Thrombocytopenia 6	Enrichment	SRC	2.85
26	Glaucoma 3, primary congenital, e	Enrichment	TEK	2.85
27	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.85
28	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.85
29	Tufted angioma of skin	Enrichment	KDR	2.85
30	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.85
31	Hypospadias	Enrichment	PIK3CA	2.85
32	Bockenheimer syndrome	Enrichment	TEK	2.85
33	Rare venous malformation	Enrichment	PIK3CA	2.85
34	Diaphragmatic eventration	Enrichment	PIK3CA	2.85
35	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.85
36	Menke-hennekam syndrome	Enrichment	CREBBP	2.85
37	Rare combined vascular malformation	Enrichment	PIK3CA	2.85
38	Cavernous lymphangioma	Enrichment	PIK3CA	2.85
39	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.85
40	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.85
41	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.85
42	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.85
43	Macrodactyly of toe	Enrichment	PIK3CA	2.85
44	Gastric cancer	Enrichment	FGFR2, PIK3CA	2.79
45	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.77
46	Hypertelorism	Enrichment	FGFR2, PIK3CA	2.63
47	Blue rubber bleb nevus	Enrichment	TEK	2.55
48	Thumb deformity	Enrichment	CREBBP	2.55
49	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	2.55
50	Aural atresia, congenital	Enrichment	FGFR2	2.55
51	Keratosis, seborrheic	Enrichment	PIK3CA	2.55
52	Pfeiffer syndrome	Enrichment	FGFR2	2.55
53	Jackson-weiss syndrome	Enrichment	FGFR2	2.55
54	Angioma, tufted	Enrichment	KDR	2.55
55	Noonan syndrome 8	Enrichment	PIK3CA	2.55
56	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.55
57	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.55
58	Split hand-foot malformation	Enrichment	FGFR2	2.55
59	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.55
60	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.55
61	Metaphyseal anadysplasia	Enrichment	MMP9	2.55
62	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.55
63	Primary ovarian insufficiency	Enrichment	KDR, NOS3	2.52
64	Crouzon syndrome	Enrichment	FGFR2	2.38
65	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2	2.38
66	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.38
67	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	2.38
68	Tethered spinal cord syndrome	Enrichment	CREBBP	2.38
69	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.38
70	Enchondromatosis	Enrichment	HIF1A	2.38
71	Keratoacanthoma	Enrichment	PIK3CA	2.38
72	Breast cancer	Enrichment	AKT1, PIK3CA	2.31
73	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.25
74	Glaucoma 3, primary infantile, b	Enrichment	TEK	2.25
75	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.25
76	Saethre-chotzen syndrome	Enrichment	FGFR2	2.25
77	Cerebrovascular disease	Enrichment	PIK3CA	2.25
78	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.25
79	Glioma	Enrichment	FGFR2	2.25
80	Hemifacial hyperplasia	Enrichment	FGFR2	2.16
81	Capillary malformations, congenital	Enrichment	PIK3CA	2.16
82	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	2.16
83	Alzheimer disease 2	Enrichment	NOS3	2.16
84	Hemimegalencephaly	Enrichment	PIK3CA	2.16
85	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.08
86	Cowden syndrome 1	Enrichment	PIK3CA	2.08
87	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	2.08
88	Split-hand/foot malformation 1	Enrichment	FGFR2	2.08
89	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.08
90	Hemangioma, capillary infantile	Enrichment	KDR	2.08
91	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	2.08
92	Lung squamous cell carcinoma	Enrichment	PIK3CA	2.08
93	Hypertrichosis	Enrichment	CREBBP	2.08
94	Ovarian cancer	Enrichment	AKT1, PIK3CA	2.06
95	Nevus, epidermal	Enrichment	PIK3CA	2.01
96	Glaucoma 3, primary congenital, a	Enrichment	TEK	2.01
97	Myelofibrosis	Enrichment	SRC	2.01
98	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	2.01
99	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	2.01
100	Gallbladder cancer	Enrichment	PIK3CA	2.01
101	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB	1.95
102	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.90
103	Ventricular septal defect	Enrichment	TEK	1.90
104	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.86
105	Stroke, ischemic	Enrichment	NOS3	1.86
106	Meningioma, familial	Enrichment	PDGFB	1.82
107	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.82
108	Specific learning disability	Enrichment	MAPK1	1.82
109	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.78
110	Osteoporosis	Enrichment	SRC	1.71
111	Heart disease	Enrichment	CREBBP	1.71
112	Corpus callosum, agenesis of	Enrichment	CREBBP	1.68
113	Hydrocephalus	Enrichment	FGFR2	1.68
114	Lynch syndrome	Enrichment	PIK3CA	1.68
115	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.68
116	Rare genetic intellectual disability	Enrichment	CREBBP	1.68
117	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.68
118	Alzheimer disease, familial, 1	Enrichment	NOS3	1.63
119	Hypertension, essential	Enrichment	NOS3	1.63
120	Heart, malformation of	Enrichment	MAPK1	1.60
121	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.58
122	Craniosynostosis	Enrichment	FGFR2	1.56
123	Hepatocellular carcinoma	Enrichment	PIK3CA	1.52
124	Scoliosis	Enrichment	CREBBP	1.48
125	Tetralogy of fallot	Enrichment	KDR	1.45
126	Bladder cancer	Enrichment	PIK3CA	1.40
127	Prostate cancer	Enrichment	PIK3CA	1.40
128	Lung cancer	Enrichment	PIK3CA	1.36
129	Thrombocytopenia	Enrichment	SRC	1.19
130	Myeloma, multiple	Enrichment	CREBBP	1.12
131	Autism	Enrichment	CREBBP	1.02
132	Congenital nervous system abnormality	Enrichment	CREBBP	0.86
133	Nervous system disease	Enrichment	CREBBP	0.86
134	Microcephaly	Enrichment	MAPK1	0.80

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Angiogenesis (WikiPathways)

Pathway Network for Angiogenesis (WikiPathways)

Member Pathways for Angiogenesis (WikiPathways)

Pathways in the Angiogenesis (WikiPathways) SuperPath

Associated Genes for Angiogenesis (WikiPathways)

Associated Disorders for Angiogenesis (WikiPathways)

Disorders associated with Angiogenesis (WikiPathways) SuperPath

STRING Interaction Network for Angiogenesis (WikiPathways)

Sources for Angiogenesis (WikiPathways)