Angiotensin II receptor type 1 pathway

No Pathway Network information available for Angiotensin II receptor type 1 pathway

Pathways in the Angiotensin II receptor type 1 pathway SuperPath

#	Name	Source	Genes
1	Angiotensin II receptor type 1 pathway	WikiPathways	ACE2 ACTA2 AGT AGTR1 CCN2 COL1A1 COL1A2 F12 HIF1A IL11 IL11RA IL6ST JUND MAP2K6 MAPK1 MAS1 NOX4 PDGFD PTPN11 RACK1 RAF1 RRAS SMAD3 SMAD4 SP1 TGFB1 TGFBR1 TGFBR2 (see all 28) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	1
2	AGT	Angiotensinogen	Protein Coding	1
3	PDGFD	Platelet Derived Growth Factor D	Protein Coding	1
4	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
5	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
6	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
7	SP1	Sp1 Transcription Factor	Protein Coding	1
8	RRAS	RAS Related	Protein Coding	1
9	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
10	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
11	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
12	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
13	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
14	NOX4	NADPH Oxidase 4	Protein Coding	1
15	MAS1	MAS1 Proto-Oncogene, G Protein-Coupled Receptor	Protein Coding	1
16	SMAD4	SMAD Family Member 4	Protein Coding	1
17	SMAD3	SMAD Family Member 3	Protein Coding	1
18	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
19	IL11RA	Interleukin 11 Receptor Subunit Alpha	Protein Coding	1
20	IL11	Interleukin 11	Protein Coding	1
21	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	1
22	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
23	F12	Coagulation Factor XII	Protein Coding	1
24	AGTR1	Angiotensin II Receptor Type 1	Protein Coding	1
25	CCN2	Cellular Communication Network Factor 2	Protein Coding	1
26	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	1
27	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	1
28	RACK1	Receptor For Activated C Kinase 1	Protein Coding	1

Disorders associated with Angiotensin II receptor type 1 pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2, COL1A1, SMAD3, SMAD4, TGFBR1, TGFBR2	9.56
2	Ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2, SMAD3, TGFBR2	7.26
3	Classic ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2, TGFBR1	6.80
4	Loeys-dietz syndrome	Enrichment	SMAD3, TGFBR1, TGFBR2	6.18
5	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	5.39
6	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1, COL1A2	5.39
7	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1, COL1A2	5.39
8	Loeys-dietz syndrome 1	Enrichment	TGFBR1, TGFBR2	4.91
9	High bone mass osteogenesis imperfecta	Enrichment	COL1A1, COL1A2	4.91
10	Noonan syndrome 1	Enrichment	PTPN11, RAF1, RRAS	4.87
11	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1, COL1A2	4.61
12	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	4.61
13	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	4.61
14	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1, COL1A2	4.61
15	Connective tissue disease	Enrichment	ACTA2, SMAD3, TGFBR2	4.43
16	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1, COL1A2	4.21
17	Osteogenesis imperfecta, type i	Enrichment	COL1A1, COL1A2	4.21
18	Renal tubular dysgenesis	Enrichment	AGT, AGTR1	4.21
19	Osteogenesis imperfecta, type ii	Enrichment	COL1A1, COL1A2	4.07
20	Noonan syndrome 3	Enrichment	PTPN11, RAF1	4.07
21	Marfan syndrome	Enrichment	TGFBR1, TGFBR2	3.74
22	Primary bone dysplasia	Enrichment	COL1A1, COL1A2	3.74
23	Pectus excavatum	Enrichment	PTPN11, TGFBR1	3.65
24	Osteochondrodysplasia	Enrichment	COL1A1, COL1A2	3.65
25	Specific learning disability	Enrichment	MAPK1, PTPN11	3.65
26	Juvenile myelomonocytic leukemia	Enrichment	PTPN11, RRAS	3.57
27	Osteogenesis imperfecta, type iv	Enrichment	COL1A1, COL1A2	3.50
28	Osteoporosis	Enrichment	COL1A1, COL1A2	3.43
29	Osteogenesis imperfecta, type iii	Enrichment	COL1A1, COL1A2	3.37
30	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11, RAF1	3.37
31	Hypertension, essential	Enrichment	AGT, AGTR1	3.26
32	Brittle bone disorder	Enrichment	COL1A1, COL1A2	2.99
33	Rasopathy	Enrichment	PTPN11, RAF1	2.89
34	Metachondromatosis	Enrichment	PTPN11	2.69
35	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.69
36	Noonan syndrome 5	Enrichment	RAF1	2.69
37	Angioedema, hereditary, 3	Enrichment	F12	2.69
38	Leopard syndrome 1	Enrichment	PTPN11	2.69
39	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.69
40	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.69
41	Craniosynostosis and dental anomalies	Enrichment	IL11RA	2.69
42	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.69
43	Noonan syndrome 13	Enrichment	MAPK1	2.69
44	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.69
45	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.69
46	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.69
47	Leopard syndrome 2	Enrichment	RAF1	2.69
48	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.69
49	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.69
50	Trigonitis	Enrichment	RAF1	2.69
51	Asphyxia neonatorum	Enrichment	COL1A1	2.69
52	Heritable thoracic aortic disease	Enrichment	SMAD4	2.69
53	Urticaria	Enrichment	F12	2.69
54	F12-associated cold autoinflammatory syndrome	Enrichment	F12	2.69
55	Malignant astrocytoma	Enrichment	PTPN11	2.69
56	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.38
57	Myhre syndrome	Enrichment	SMAD4	2.38
58	Camurati-engelmann disease 1	Enrichment	TGFB1	2.38
59	Bruck syndrome 1	Enrichment	COL1A2	2.38
60	Kyphomelic dysplasia	Enrichment	CCN2	2.38
61	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	2.38
62	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	2.38
63	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.38
64	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.38
65	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	2.38
66	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	2.38
67	Factor xii deficiency	Enrichment	F12	2.38
68	Moyamoya disease 5	Enrichment	ACTA2	2.38
69	Albinism, oculocutaneous, type ia	Enrichment	NOX4	2.38
70	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.38
71	Spondyloepimetaphyseal dysplasia, li-shao-li type	Enrichment	CCN2	2.38
72	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.38
73	Werner syndrome	Enrichment	PTPN11	2.38
74	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.38
75	Camurati-engelmann disease	Enrichment	TGFB1	2.38
76	Stickler syndrome, type ii	Enrichment	COL1A1	2.38
77	Hereditary angioedema	Enrichment	F12	2.38
78	Angioedema	Enrichment	F12	2.38
79	Dentinogenesis imperfecta	Enrichment	COL1A2	2.38
80	Thrombocytopenia	Enrichment	PTPN11, SMAD4	2.36
81	Angioedema, hereditary, 1	Enrichment	F12	2.21
82	Juvenile polyposis syndrome	Enrichment	SMAD4	2.21
83	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	2.21
84	Caffey disease	Enrichment	COL1A1	2.21
85	Tricuspid valve insufficiency	Enrichment	PTPN11	2.21
86	Enchondromatosis	Enrichment	HIF1A	2.21
87	Stüve-wiedemann syndrome	Enrichment	IL6ST	2.21
88	Phenylketonuria	Enrichment	COL1A1	2.08
89	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	2.08
90	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.08
91	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.08
92	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.99
93	Lymphoma	Enrichment	PTPN11	1.99
94	Diffuse cutaneous systemic sclerosis	Enrichment	CCN2	1.99
95	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.99
96	Moyamoya disease 1	Enrichment	ACTA2	1.91
97	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.91
98	Keratoconus	Enrichment	COL1A1	1.91
99	Patent ductus arteriosus	Enrichment	PTPN11	1.91
100	Limited scleroderma	Enrichment	CCN2	1.91
101	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.91
102	Esophageal cancer	Enrichment	TGFBR2	1.84
103	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.84
104	Gallbladder cancer	Enrichment	SMAD4	1.84
105	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.84
106	Pilomyxoid astrocytoma	Enrichment	RAF1	1.84
107	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.79
108	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.73
109	Bilirubin metabolic disorder	Enrichment	F12	1.65
110	Epicanthus	Enrichment	PTPN11	1.61
111	Congenital long qt syndrome	Enrichment	PTPN11	1.61
112	Microcephaly	Enrichment	MAPK1, PTPN11	1.58
113	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.54
114	Lung cancer susceptibility 3	Enrichment	ACTA2	1.54
115	Inherited cancer-predisposing syndrome	Enrichment	PTPN11, SMAD4	1.52
116	Lynch syndrome	Enrichment	TGFBR2	1.52
117	Hypertension	Enrichment	F12	1.49
118	Heart, malformation of	Enrichment	MAPK1	1.44
119	Patent foramen ovale	Enrichment	PTPN11	1.44
120	Craniosynostosis	Enrichment	IL11RA	1.39
121	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.31
122	Scoliosis	Enrichment	PTPN11	1.31
123	Pancreatic cancer	Enrichment	SMAD4	1.30
124	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.28
125	Strabismus	Enrichment	PTPN11	1.27
126	Long qt syndrome 1	Enrichment	PTPN11	1.22
127	Non-immune hydrops fetalis	Enrichment	PTPN11	1.21
128	Lung cancer	Enrichment	ACTA2	1.19
129	Cystic fibrosis	Enrichment	TGFB1	1.19
130	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.18
131	Left ventricular noncompaction	Enrichment	RAF1	1.16
132	Gastric cancer	Enrichment	SMAD4	1.07
133	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.07
134	Hypertelorism	Enrichment	COL1A1	0.99
135	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.98
136	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.96
137	Dilated cardiomyopathy	Enrichment	RAF1	0.82
138	Colorectal cancer	Enrichment	SMAD4	0.78
139	Autism spectrum disorder	Enrichment	PTPN11	0.69

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Angiotensin II receptor type 1 pathway

Pathway Network for Angiotensin II receptor type 1 pathway

Member Pathways for Angiotensin II receptor type 1 pathway

Pathways in the Angiotensin II receptor type 1 pathway SuperPath

Associated Genes for Angiotensin II receptor type 1 pathway

Associated Disorders for Angiotensin II receptor type 1 pathway

Disorders associated with Angiotensin II receptor type 1 pathway SuperPath

STRING Interaction Network for Angiotensin II receptor type 1 pathway

Sources for Angiotensin II receptor type 1 pathway