Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics

No Pathway Network information available for Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics

Pathways in the Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics	PharmGKB	ABCC8 AKT1 CACNA1A CACNA1C CACNA1D GCK HNF1A HNF1B HNF4A INS INSR IRS1 IRS2 ISL1 KCNJ11 MAFA NEUROD1 PDX1 PIK3C2A PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 SLC2A2 (see all 28) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLC2A2	Solute Carrier Family 2 Member 2	Protein Coding	1
2	CACNA1A	Calcium Voltage-Gated Channel Subunit Alpha1 A	Protein Coding	1
3	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	1
4	CACNA1D	Calcium Voltage-Gated Channel Subunit Alpha1 D	Protein Coding	1
5	ABCC8	ATP Binding Cassette Subfamily C Member 8	Protein Coding	1
6	HNF1A	HNF1 Homeobox A	Protein Coding	1
7	INS	Insulin	Protein Coding	1
8	INSR	Insulin Receptor	Protein Coding	1
9	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
10	ISL1	ISL LIM Homeobox 1	Protein Coding	1
11	KCNJ11	Potassium Inwardly Rectifying Channel Subfamily J Member 11	Protein Coding	1
12	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
13	NEUROD1	Neuronal Differentiation 1	Protein Coding	1
14	IRS2	Insulin Receptor Substrate 2	Protein Coding	1
15	HNF4A	Hepatocyte Nuclear Factor 4 Alpha	Protein Coding	1
16	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
17	GCK	Glucokinase	Protein Coding	1
18	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	1
19	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
20	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
21	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
22	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
23	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
24	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
25	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
26	MAFA	MAF BZIP Transcription Factor A	Protein Coding	1
27	HNF1B	HNF1 Homeobox B	Protein Coding	1
28	PDX1	Pancreatic And Duodenal Homeobox 1	Protein Coding	1

Disorders associated with Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Maturity-onset diabetes of the young	Enrichment	ABCC8, GCK, HNF1A, HNF1B, HNF4A, INS, KCNJ11, NEUROD1, PDX1	10.91
2	Type 2 diabetes mellitus	Enrichment	ABCC8, GCK, HNF1A, HNF1B, HNF4A, INSR, IRS1, IRS2, KCNJ11, NEUROD1, PDX1, SLC2A2	10.79
3	Permanent neonatal diabetes mellitus	Enrichment	ABCC8, GCK, INS, KCNJ11, PDX1	10.47
4	Diabetes mellitus	Enrichment	GCK, HNF1A, INS, KCNJ11	8.32
5	Maturity-onset diabetes of the young, type 3	Enrichment	GCK, HNF1A, HNF4A	7.50
6	Neonatal diabetes mellitus	Enrichment	ABCC8, INS, KCNJ11	7.50
7	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	ABCC8, GCK, KCNJ11	6.80
8	Nonsyndromic genetic hyperinsulinism	Enrichment	ABCC8, GCK, KCNJ11	6.80
9	Maturity-onset diabetes of the young, type 1	Enrichment	GCK, HNF4A	5.39
10	Diabetes mellitus, permanent neonatal, 1	Enrichment	GCK, KCNJ11	5.39
11	Hyperinsulinism	Enrichment	HNF4A, KCNJ11	5.39
12	Hyperinsulinism due to hnf1a deficiency	Enrichment	HNF1A, HNF4A	5.39
13	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.91
14	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.91
15	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1A, CACNA1C	4.91
16	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.91
17	Chromophobe renal cell carcinoma	Enrichment	HNF1A, HNF1B	4.91
18	Dend syndrome	Enrichment	ABCC8, KCNJ11	4.91
19	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	4.61
20	Transient neonatal diabetes mellitus	Enrichment	ABCC8, KCNJ11	4.39
21	Hypoglycemia	Enrichment	ABCC8, KCNJ11	4.39
22	Ovarian cancer	Enrichment	AKT1, HNF1A, HNF1B, PIK3CA	4.29
23	Type 1 diabetes mellitus	Enrichment	HNF1A, INS	4.21
24	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.21
25	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.83
26	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.74
27	Meningioma	Enrichment	AKT1, PIK3CA	3.57
28	Renal cell carcinoma, nonpapillary	Enrichment	HNF1A, HNF1B	3.37
29	Breast cancer	Enrichment	AKT1, HNF1A, PIK3CA	3.32
30	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1	3.13
31	Prostate cancer	Enrichment	HNF1B, PIK3CA	2.79
32	Long qt syndrome 1	Enrichment	CACNA1C, SLC2A2	2.76
33	Macrodactyly	Enrichment	PIK3CA	2.69
34	Proteus syndrome	Enrichment	AKT1	2.69
35	Insulinomatosis and diabetes mellitus	Enrichment	MAFA	2.69
36	Hepatic adenomas, familial	Enrichment	HNF1A	2.69
37	Pancreatic agenesis 1	Enrichment	PDX1	2.69
38	Donohue syndrome	Enrichment	INSR	2.69
39	Hyperinsulinemic hypoglycemia, familial, 2	Enrichment	KCNJ11	2.69
40	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.69
41	Maturity-onset diabetes of the young, type 4	Enrichment	PDX1	2.69
42	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.69
43	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.69
44	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.69
45	Maturity-onset diabetes of the young, type 6	Enrichment	NEUROD1	2.69
46	Maturity-onset diabetes of the young, type 2	Enrichment	GCK	2.69
47	Prostate cancer, hereditary, 11	Enrichment	HNF1B	2.69
48	Cowden syndrome 5	Enrichment	PIK3CA	2.69
49	Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young	Enrichment	HNF4A	2.69
50	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.69
51	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.69
52	Maturity-onset diabetes of the young, type 12	Enrichment	ABCC8	2.69
53	Short syndrome	Enrichment	PIK3R1	2.69
54	Oculoskeletodental syndrome	Enrichment	PIK3C2A	2.69
55	Diabetes mellitus, transient neonatal, 3	Enrichment	KCNJ11	2.69
56	Primary aldosteronism, seizures, and neurologic abnormalities	Enrichment	CACNA1D	2.69
57	Hyperinsulinemic hypoglycemia, familial, 3	Enrichment	GCK	2.69
58	Brugada syndrome 3	Enrichment	CACNA1C	2.69
59	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.69
60	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.69
61	Sinoatrial node dysfunction and deafness	Enrichment	CACNA1D	2.69
62	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.69
63	Cowden syndrome 6	Enrichment	AKT1	2.69
64	Diabetes mellitus, permanent neonatal, 2	Enrichment	KCNJ11	2.69
65	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.69
66	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.69
67	Maturity-onset diabetes of the young, type 13	Enrichment	KCNJ11	2.69
68	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.69
69	Type 1 diabetes mellitus 20	Enrichment	HNF1A	2.69
70	Autosomal dominant hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	2.69
71	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.69
72	Hypospadias	Enrichment	PIK3CA	2.69
73	Diazoxide-resistant focal hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	2.69
74	Gestational diabetes	Enrichment	GCK	2.69
75	Hyperinsulinism due to hnf4a deficiency	Enrichment	HNF4A	2.69
76	Rare venous malformation	Enrichment	PIK3CA	2.69
77	Diaphragmatic eventration	Enrichment	PIK3CA	2.69
78	Congestive heart failure	Enrichment	ABCC8	2.69
79	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.69
80	Sporadic hemiplegic migraine	Enrichment	CACNA1A	2.69
81	Atypical timothy syndrome	Enrichment	CACNA1C	2.69
82	Aldosterone-producing adenoma with seizures and neurological abnormalities	Enrichment	CACNA1D	2.69
83	Rare combined vascular malformation	Enrichment	PIK3CA	2.69
84	Cavernous lymphangioma	Enrichment	PIK3CA	2.69
85	Intermediate dend syndrome	Enrichment	KCNJ11	2.69
86	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.69
87	Oculocerebrodental syndrome	Enrichment	PIK3C2A	2.69
88	Timothy syndrome type 2	Enrichment	CACNA1C	2.69
89	Medullary sponge kidney	Enrichment	HNF1B	2.69
90	Renal dysplasia, bilateral	Enrichment	HNF1B	2.69
91	Unilateral multicystic dysplastic kidney	Enrichment	HNF1B	2.69
92	Diazoxide-resistant focal hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.69
93	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.69
94	Renal dysplasia, unilateral	Enrichment	HNF1B	2.69
95	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.69
96	Timothy syndrome type 1	Enrichment	CACNA1C	2.69
97	Autosomal recessive hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	2.69
98	Macrodactyly of toe	Enrichment	PIK3CA	2.69
99	Cacna1c-related disorders	Enrichment	CACNA1C	2.69
100	Benign paroxysmal torticollis of infancy	Enrichment	CACNA1A	2.69
101	Autosomal dominant hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.69
102	Autosomal recessive hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.69
103	Cerebral palsy	Enrichment	CACNA1A, CACNA1C	2.54
104	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.43
105	Tubulointerstitial kidney disease, autosomal dominant 1	Enrichment	HNF1B	2.38
106	Renal cysts and diabetes syndrome	Enrichment	HNF1B	2.38
107	Congenital anomalies of kidney and urinary tract 2	Enrichment	HNF1B	2.38
108	Pancreas, dorsal, agenesis of	Enrichment	PDX1	2.38
109	Fanconi-bickel syndrome	Enrichment	SLC2A2	2.38
110	Timothy syndrome	Enrichment	CACNA1C	2.38
111	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.38
112	Alternating hemiplegia of childhood 1	Enrichment	CACNA1A	2.38
113	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.38
114	Keratosis, seborrheic	Enrichment	PIK3CA	2.38
115	Bone marrow failure syndrome 2	Enrichment	GCK	2.38
116	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.38
117	Hypoglycemia, leucine-induced	Enrichment	ABCC8	2.38
118	Maturity-onset diabetes of the young, type 10	Enrichment	INS	2.38
119	Noonan syndrome 8	Enrichment	PIK3CA	2.38
120	Diabetes mellitus, transient neonatal, 2	Enrichment	ABCC8	2.38
121	Long qt syndrome 8	Enrichment	CACNA1C	2.38
122	Hyperproinsulinemia	Enrichment	INS	2.38
123	Hyperuricemic nephropathy, familial juvenile, 3	Enrichment	HNF1B	2.38
124	Bladder exstrophy	Enrichment	ISL1	2.38
125	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.38
126	Diabetes mellitus, permanent neonatal, 3	Enrichment	ABCC8	2.38
127	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	2.38
128	Immune system disease	Enrichment	PIK3CD	2.38
129	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	CACNA1D	2.38
130	Progressive bulbar palsy	Enrichment	CACNA1A	2.38
131	Type 1 diabetes mellitus 2	Enrichment	INS	2.21
132	Nijmegen breakage syndrome	Enrichment	GCK	2.21
133	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.21
134	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	HNF1B	2.21
135	Chromosome 17q12 deletion syndrome	Enrichment	HNF1B	2.21
136	Keratoderma-ichthyosis-deafness syndrome, autosomal recessive	Enrichment	HNF1A	2.21
137	Hyperinsulinemic hypoglycemia	Enrichment	ABCC8	2.21
138	Keratoacanthoma	Enrichment	PIK3CA	2.21
139	Hereditary episodic ataxia	Enrichment	CACNA1A	2.21
140	Migraine, familial hemiplegic, 1	Enrichment	CACNA1A	2.08
141	Spinocerebellar ataxia 6	Enrichment	CACNA1A	2.08
142	Dermatitis, atopic	Enrichment	KCNJ11	2.08
143	Developmental and epileptic encephalopathy 2	Enrichment	CACNA1A	2.08
144	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	CACNA1C	2.08
145	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.08
146	Developmental and epileptic encephalopathy 42	Enrichment	CACNA1A	2.08
147	Developmental and epileptic encephalopathy 52	Enrichment	CACNA1A	2.08
148	Cerebrovascular disease	Enrichment	PIK3CA	2.08
149	Newborn respiratory distress syndrome	Enrichment	ABCC8	2.08
150	Episodic ataxia	Enrichment	CACNA1A	2.08
151	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.08
152	Familial or sporadic hemiplegic migraine	Enrichment	CACNA1A	2.08
153	Clear cell papillary renal cell carcinoma	Enrichment	HNF1A	2.08
154	Capillary malformations, congenital	Enrichment	PIK3CA	1.99
155	Episodic ataxia, type 2	Enrichment	CACNA1A	1.99
156	Heart conduction disease	Enrichment	CACNA1C	1.99
157	Polyhydramnios	Enrichment	ABCC8	1.99
158	Hemimegalencephaly	Enrichment	PIK3CA	1.99
159	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.91
160	Cowden syndrome 1	Enrichment	PIK3CA	1.91
161	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.91
162	Clear cell renal cell carcinoma	Enrichment	HNF1A	1.91
163	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.91
164	Hypertrichosis	Enrichment	KCNJ11	1.91
165	46,xy disorder of sex development	Enrichment	INSR	1.91
166	Nevus, epidermal	Enrichment	PIK3CA	1.84
167	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.84
168	Gallbladder cancer	Enrichment	PIK3CA	1.84
169	Overgrowth syndrome	Enrichment	PIK3R1	1.84
170	Gastroesophageal reflux	Enrichment	ABCC8	1.79
171	Lennox-gastaut syndrome	Enrichment	CACNA1A	1.79
172	Alternating hemiplegia of childhood	Enrichment	CACNA1A	1.79
173	Difference of sex development	Enrichment	CACNA1A	1.79
174	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	CACNA1C	1.73
175	Arteriovenous malformation	Enrichment	PIK3CA	1.73
176	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.73
177	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.69
178	Migraine with or without aura 1	Enrichment	CACNA1A	1.65
179	Atrial heart septal defect	Enrichment	ABCC8	1.65
180	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.65
181	Interatrial communication	Enrichment	ABCC8	1.65
182	Cardiac conduction defect	Enrichment	CACNA1C	1.61
183	Digeorge syndrome	Enrichment	HNF1A	1.61
184	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.61
185	Congenital long qt syndrome	Enrichment	SLC2A2	1.61
186	Nk-cell enteropathy	Enrichment	PIK3CB	1.58
187	Lynch syndrome	Enrichment	PIK3CA	1.52
188	Polycystic liver disease	Enrichment	HNF4A	1.46
189	Autosomal dominant polycystic liver disease	Enrichment	HNF4A	1.46
190	Endometrial cancer	Enrichment	PIK3CA	1.37
191	Hepatocellular carcinoma	Enrichment	PIK3CA	1.35
192	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CACNA1C	1.31
193	Brugada syndrome	Enrichment	CACNA1C	1.28
194	Auditory neuropathy	Enrichment	CACNA1A	1.28
195	Strabismus	Enrichment	CACNA1A	1.27
196	Bladder cancer	Enrichment	PIK3CA	1.23
197	Long qt syndrome	Enrichment	CACNA1C	1.21
198	Lung cancer	Enrichment	PIK3CA	1.19
199	Cakut	Enrichment	HNF1B	1.17
200	Gastric cancer	Enrichment	PIK3CA	1.07
201	Hypertelorism	Enrichment	PIK3CA	0.99
202	Myeloma, multiple	Enrichment	PIK3R2	0.96
203	Undetermined early-onset epileptic encephalopathy	Enrichment	CACNA1A	0.96
204	Congenital nervous system abnormality	Enrichment	CACNA1A	0.70
205	Nervous system disease	Enrichment	CACNA1A	0.70
206	Complex neurodevelopmental disorder	Enrichment	CACNA1C	0.64
207	Hereditary retinal dystrophy	Enrichment	NEUROD1	0.34
208	Fundus dystrophy	Enrichment	NEUROD1	0.34

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics

Pathway Network for Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics

Member Pathways for Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics

Pathways in the Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics SuperPath

Associated Genes for Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics

Associated Disorders for Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics

Disorders associated with Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics SuperPath

STRING Interaction Network for Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics

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