Antiarrhythmic Pathway, Pharmacodynamics

No Pathway Network information available for Antiarrhythmic Pathway, Pharmacodynamics

Pathways in the Antiarrhythmic Pathway, Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Antiarrhythmic Pathway, Pharmacodynamics	PharmGKB	ABCC8 ABCC9 ADRA1D ADRA2A ADRB1 ADRB2 ANK2 ATP1A1 ATP2A1 ATP2A2 CACNA1C CACNA1D CACNA1G CACNA1H CACNB2 CASQ1 CASQ2 CHRM2 DSP FKBP1B GJA1 GJA5 GJD3 HCN2 HCN4 JUP KCNA5 KCNAB2 KCND3 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 KCNH2 KCNIP2 KCNJ11 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ8 KCNK1 KCNK3 KCNQ1 LMNA PLN RYR2 SCN1B SCN2B SCN3B SCN4B SCN5A SLC8A2 SLC8A3 (see all 55) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RYR2	Ryanodine Receptor 2	Protein Coding	1
2	SCN1B	Sodium Voltage-Gated Channel Beta Subunit 1	Protein Coding	1
3	SCN2B	Sodium Voltage-Gated Channel Beta Subunit 2	Protein Coding	1
4	SCN4B	Sodium Voltage-Gated Channel Beta Subunit 4	Protein Coding	1
5	SCN5A	Sodium Voltage-Gated Channel Alpha Subunit 5	Protein Coding	1
6	HCN2	Hyperpolarization Activated Cyclic Nucleotide Gated Potassium And Sodium Channel 2	Protein Coding	1
7	DSP	Desmoplakin	Protein Coding	1
8	CACNB2	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2	Protein Coding	1
9	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	1
10	CACNA1D	Calcium Voltage-Gated Channel Subunit Alpha1 D	Protein Coding	1
11	ABCC8	ATP Binding Cassette Subfamily C Member 8	Protein Coding	1
12	SLC8A2	Solute Carrier Family 8 Member A2	Protein Coding	1
13	SLC8A3	Solute Carrier Family 8 Member A3	Protein Coding	1
14	KCNIP2	Potassium Voltage-Gated Channel Interacting Protein 2	Protein Coding	1
15	CASQ1	Calsequestrin 1	Protein Coding	1
16	CASQ2	Calsequestrin 2	Protein Coding	1
17	JUP	Junction Plakoglobin	Protein Coding	1
18	KCND3	Potassium Voltage-Gated Channel Subfamily D Member 3	Protein Coding	1
19	KCNE1	Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 1	Protein Coding	1
20	KCNH2	Potassium Voltage-Gated Channel Subfamily H Member 2	Protein Coding	1
21	KCNJ2	Potassium Inwardly Rectifying Channel Subfamily J Member 2	Protein Coding	1
22	KCNJ3	Potassium Inwardly Rectifying Channel Subfamily J Member 3	Protein Coding	1
23	KCNJ4	Potassium Inwardly Rectifying Channel Subfamily J Member 4	Protein Coding	1
24	KCNJ5	Potassium Inwardly Rectifying Channel Subfamily J Member 5	Protein Coding	1
25	KCNJ8	Potassium Inwardly Rectifying Channel Subfamily J Member 8	Protein Coding	1
26	KCNJ11	Potassium Inwardly Rectifying Channel Subfamily J Member 11	Protein Coding	1
27	KCNK1	Potassium Two Pore Domain Channel Subfamily K Member 1	Protein Coding	1
28	KCNK3	Potassium Two Pore Domain Channel Subfamily K Member 3	Protein Coding	1
29	KCNQ1	Potassium Voltage-Gated Channel Subfamily Q Member 1	Protein Coding	1
30	KCNE3	Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 3	Protein Coding	1
31	HCN4	Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4	Protein Coding	1
32	CACNA1H	Calcium Voltage-Gated Channel Subunit Alpha1 H	Protein Coding	1
33	CACNA1G	Calcium Voltage-Gated Channel Subunit Alpha1 G	Protein Coding	1
34	KCNAB2	Potassium Voltage-Gated Channel Subfamily A Regulatory Beta Subunit 2	Protein Coding	1
35	ATP1A1	ATPase Na+/K+ Transporting Subunit Alpha 1	Protein Coding	1
36	ATP2A1	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 1	Protein Coding	1
37	ATP2A2	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2	Protein Coding	1
38	KCNE5	Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 5	Protein Coding	1
39	KCNE4	Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 4	Protein Coding	1
40	FKBP1B	FKBP Prolyl Isomerase 1B	Protein Coding	1
41	LMNA	Lamin A/C	Protein Coding	1
42	PLN	Phospholamban	Protein Coding	1
43	ADRA1D	Adrenoceptor Alpha 1D	Protein Coding	1
44	ADRA2A	Adrenoceptor Alpha 2A	Protein Coding	1
45	ADRB1	Adrenoceptor Beta 1	Protein Coding	1
46	ADRB2	Adrenoceptor Beta 2	Protein Coding	1
47	ANK2	Ankyrin 2	Protein Coding	1
48	ABCC9	ATP Binding Cassette Subfamily C Member 9	Protein Coding	1
49	GJA1	Gap Junction Protein Alpha 1	Protein Coding	1
50	GJA5	Gap Junction Protein Alpha 5	Protein Coding	1
51	KCNE2	Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 2	Protein Coding	1
52	CHRM2	Cholinergic Receptor Muscarinic 2	Protein Coding	1
53	SCN3B	Sodium Voltage-Gated Channel Beta Subunit 3	Protein Coding	1
54	KCNA5	Potassium Voltage-Gated Channel Subfamily A Member 5	Protein Coding	1
55	GJD3	Gap Junction Protein Delta 3	Protein Coding	1

Disorders associated with Antiarrhythmic Pathway, Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Brugada syndrome	Enrichment	ABCC9, CACNA1C, CACNB2, HCN4, KCND3, KCNE3, KCNE5, KCNH2, KCNJ8, LMNA, SCN1B, SCN2B, SCN3B, SCN5A	16.00
2	Long qt syndrome	Enrichment	ANK2, CACNA1C, CASQ2, DSP, KCNE1, KCNH2, KCNJ5, KCNQ1, LMNA, RYR2, SCN5A	16.00
3	Cardiac conduction defect	Enrichment	CACNA1C, DSP, LMNA, PLN, RYR2, SCN1B, SCN5A	11.36
4	Long qt syndrome 1	Enrichment	ANK2, CACNA1C, DSP, KCNE1, KCNE2, KCNH2, KCNJ5, KCNQ1, SCN4B, SCN5A	11.15
5	Familial atrial fibrillation	Enrichment	ABCC9, GJA5, KCNA5, KCNE1, KCNE2, KCNJ2, KCNJ3, KCNJ5, KCNQ1, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A	10.57
6	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	DSP, JUP, LMNA, PLN, RYR2	8.75
7	Wolff-parkinson-white syndrome	Enrichment	ABCC9, CASQ2, JUP, KCNQ1, SCN5A	8.41
8	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	DSP, JUP, LMNA, RYR2, SCN5A	8.41
9	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	DSP, JUP, LMNA, RYR2	6.93
10	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	DSP, JUP, LMNA, RYR2	6.93
11	Congenital long qt syndrome	Enrichment	KCNE1, KCNH2, KCNQ1, SCN5A	6.93
12	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	CACNA1C, RYR2, SCN5A	6.60
13	Long qt syndrome 2	Enrichment	KCNH2, KCNQ1, SCN5A	6.60
14	Left ventricular noncompaction	Enrichment	DSP, HCN4, LMNA, RYR2, SCN5A	6.57
15	Sudden infant death syndrome	Enrichment	KCNJ8, KCNQ1, PLN, SCN5A	6.26
16	Heart conduction disease	Enrichment	CACNA1C, RYR2, SCN5A	6.20
17	Cardiac arrest	Enrichment	DSP, PLN, SCN5A	6.20
18	Congenital short qt syndrome	Enrichment	KCNH2, KCNJ2, KCNQ1	6.20
19	Dilated cardiomyopathy	Enrichment	DSP, JUP, KCNE1, LMNA, PLN, SCN5A	6.10
20	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	ANK2, CASQ2, RYR2	5.90
21	Familial isolated dilated cardiomyopathy	Enrichment	ABCC9, DSP, LMNA, PLN, SCN5A	5.65
22	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	ANK2, CASQ2, RYR2	5.46
23	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	DSP, LMNA, PLN	5.28
24	Atrial standstill 1	Enrichment	GJA5, SCN5A	4.79
25	Andersen cardiodysrhythmic periodic paralysis	Enrichment	KCNJ2, KCNJ5	4.79
26	Ventricular tachycardia, catecholaminergic polymorphic, 2	Enrichment	CASQ2, RYR2	4.79
27	Jervell-lange nielsen syndrome	Enrichment	KCNE1, KCNQ1	4.79
28	Cantu syndrome	Enrichment	ABCC9, KCNJ8	4.32
29	Epidermolysis bullosa, lethal acantholytic	Enrichment	DSP, JUP	4.32
30	Dend syndrome	Enrichment	ABCC8, KCNJ11	4.32
31	Jervell and lange-nielsen syndrome 1	Enrichment	KCNE1, KCNQ1	4.02
32	Atrial fibrillation	Enrichment	KCNQ1, SCN5A	4.02
33	Neonatal diabetes mellitus	Enrichment	ABCC8, KCNJ11	4.02
34	Hereditary progressive cardiac conduction defect	Enrichment	SCN1B, SCN5A	4.02
35	Sick sinus syndrome	Enrichment	LMNA, SCN5A	4.02
36	Paroxysmal familial ventricular fibrillation	Enrichment	RYR2, SCN5A	4.02
37	Familial sick sinus syndrome	Enrichment	HCN4, SCN5A	4.02
38	Transient neonatal diabetes mellitus	Enrichment	ABCC8, KCNJ11	3.80
39	Hypoglycemia	Enrichment	ABCC8, KCNJ11	3.80
40	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	ABCC8, KCNJ11	3.62
41	Nonsyndromic genetic hyperinsulinism	Enrichment	ABCC8, KCNJ11	3.62
42	Brugada syndrome 1	Enrichment	KCNH2, SCN5A	3.48
43	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CASQ2, RYR2	3.35
44	Myocarditis	Enrichment	DSP, LMNA	3.35
45	Permanent neonatal diabetes mellitus	Enrichment	ABCC8, KCNJ11	3.35
46	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	DSP, SCN5A	3.24
47	Cardiomyopathy, dilated, 1e	Enrichment	LMNA, SCN5A	2.68
48	Maturity-onset diabetes of the young	Enrichment	ABCC8, KCNJ11	2.53
49	Cardiomyopathy, dilated, 1a	Enrichment	DSP, LMNA	2.49
50	Palmoplantar keratoderma and congenital alopecia 1	Enrichment	GJA1	2.39
51	Sick sinus syndrome 2	Enrichment	HCN4	2.39
52	Hypoplastic left heart syndrome 1	Enrichment	GJA1	2.39
53	Hyperinsulinemic hypoglycemia, familial, 2	Enrichment	KCNJ11	2.39
54	Cardiac arrhythmia, ankyrin-b-related	Enrichment	ANK2	2.39
55	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	2.39
56	Atrial fibrillation, familial, 7	Enrichment	KCNA5	2.39
57	Long qt syndrome 13	Enrichment	KCNJ5	2.39
58	Brugada syndrome 4	Enrichment	CACNB2	2.39
59	Jervell and lange-nielsen syndrome 2	Enrichment	KCNE1	2.39
60	Short qt syndrome 3	Enrichment	KCNJ2	2.39
61	Resting heart rate, variation in	Enrichment	ADRB1	2.39
62	Brugada syndrome 5	Enrichment	SCN1B	2.39
63	Oculodentodigital dysplasia	Enrichment	GJA1	2.39
64	Long qt syndrome 10	Enrichment	SCN4B	2.39
65	Short qt syndrome 1	Enrichment	KCNH2	2.39
66	Long qt syndrome 5	Enrichment	KCNE1	2.39
67	Craniometaphyseal dysplasia, autosomal recessive	Enrichment	GJA1	2.39
68	Atrial fibrillation, familial, 14	Enrichment	SCN2B	2.39
69	Naxos disease	Enrichment	JUP	2.39
70	Epilepsy, idiopathic generalized 17	Enrichment	HCN2	2.39
71	Intellectual disability and myopathy syndrome	Enrichment	ABCC9	2.39
72	Epilepsy, idiopathic generalized 18	Enrichment	HCN4	2.39
73	Maturity-onset diabetes of the young, type 12	Enrichment	ABCC8	2.39
74	Long qt syndrome 4	Enrichment	ANK2	2.39
75	Atrial fibrillation, familial, 13	Enrichment	SCN1B	2.39
76	Familial febrile seizures 2	Enrichment	HCN2	2.39
77	Hyperaldosteronism, familial, type iii	Enrichment	KCNJ5	2.39
78	Oculodentodigital dysplasia, autosomal recessive	Enrichment	GJA1	2.39
79	Diabetes mellitus, transient neonatal, 3	Enrichment	KCNJ11	2.39
80	Primary aldosteronism, seizures, and neurologic abnormalities	Enrichment	CACNA1D	2.39
81	Brugada syndrome 3	Enrichment	CACNA1C	2.39
82	Epilepsy, childhood absence 6	Enrichment	CACNA1H	2.39
83	Brugada syndrome 6	Enrichment	KCNE3	2.39
84	Spinocerebellar ataxia 19	Enrichment	KCND3	2.39
85	Sinoatrial node dysfunction and deafness	Enrichment	CACNA1D	2.39
86	Myopathy, vacuolar, with casq1 aggregates	Enrichment	CASQ1	2.39
87	Diabetes mellitus, permanent neonatal, 2	Enrichment	KCNJ11	2.39
88	Pulmonary hypertension, primary, 4	Enrichment	KCNK3	2.39
89	Brugada syndrome 7	Enrichment	SCN3B	2.39
90	Maturity-onset diabetes of the young, type 13	Enrichment	KCNJ11	2.39
91	Spinocerebellar ataxia 42	Enrichment	CACNA1G	2.39
92	Atrial fibrillation, familial, 9	Enrichment	KCNJ2	2.39
93	Autosomal dominant hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	2.39
94	Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits	Enrichment	CACNA1G	2.39
95	Brugada syndrome 9	Enrichment	KCND3	2.39
96	Atypical werner syndrome	Enrichment	LMNA	2.39
97	Erythrokeratodermia variabilis et progressiva 3	Enrichment	GJA1	2.39
98	Hyperaldosteronism, familial, type iv	Enrichment	CACNA1H	2.39
99	Short sleep, familial natural, 2	Enrichment	ADRB1	2.39
100	Myopathy due to calsequestrin and serca1 protein overload	Enrichment	CASQ1	2.39
101	Mandibuloacral dysplasia	Enrichment	LMNA	2.39
102	Atrioventricular block	Enrichment	LMNA	2.39
103	Skin fragility-woolly hair-palmoplantar keratoderma syndrome	Enrichment	DSP	2.39
104	Lipodystrophy, familial partial, type 8	Enrichment	ADRA2A	2.39
105	Spinocerebellar ataxia type 19/22	Enrichment	KCND3	2.39
106	Diazoxide-resistant focal hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	2.39
107	Rhabdomyolysis 2	Enrichment	ATP2A2	2.39
108	Conn's syndrome	Enrichment	CACNA1H	2.39
109	Congestive heart failure	Enrichment	ABCC8	2.39
110	Atypical timothy syndrome	Enrichment	CACNA1C	2.39
111	Aldosterone-producing adenoma with seizures and neurological abnormalities	Enrichment	CACNA1D	2.39
112	Intermediate dend syndrome	Enrichment	KCNJ11	2.39
113	Lmna-related cardiocutaneous progeria syndrome	Enrichment	LMNA	2.39
114	Timothy syndrome type 2	Enrichment	CACNA1C	2.39
115	Autosomal semi-dominant severe lipodystrophic laminopathy	Enrichment	LMNA	2.39
116	Diazoxide-resistant focal hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.39
117	Timothy syndrome type 1	Enrichment	CACNA1C	2.39
118	Autosomal recessive hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	2.39
119	Cacna1c-related disorders	Enrichment	CACNA1C	2.39
120	Autosomal recessive axonal hereditary motor and sensory neuropathy	Enrichment	LMNA	2.39
121	Laminopathy	Enrichment	LMNA	2.39
122	Autosomal dominant hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.39
123	Autosomal recessive hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.39
124	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CACNA1C, LMNA	2.38
125	Progressive familial heart block, type ia	Enrichment	SCN5A	2.09
126	Acrokeratosis verruciformis	Enrichment	ATP2A2	2.09
127	Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome	Enrichment	RYR2	2.09
128	Mandibuloacral dysplasia with type a lipodystrophy	Enrichment	LMNA	2.09
129	Brody disease	Enrichment	ATP2A1	2.09
130	Timothy syndrome	Enrichment	CACNA1C	2.09
131	Arrhythmogenic right ventricular dysplasia, familial, 8	Enrichment	DSP	2.09
132	Cardiomyopathy, dilated, 1o	Enrichment	ABCC9	2.09
133	Sick sinus syndrome 1	Enrichment	SCN5A	2.09
134	Heart-hand syndrome, slovenian type	Enrichment	LMNA	2.09
135	Cardiomyopathy, dilated, 1p	Enrichment	PLN	2.09
136	Charcot-marie-tooth disease, axonal, type 2b1	Enrichment	LMNA	2.09
137	Diabetes mellitus, permanent neonatal, 1	Enrichment	KCNJ11	2.09
138	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	Enrichment	LMNA	2.09
139	Hallermann-streiff syndrome	Enrichment	GJA1	2.09
140	Hypoglycemia, leucine-induced	Enrichment	ABCC8	2.09
141	Atrial fibrillation, familial, 10	Enrichment	SCN5A	2.09
142	Long qt syndrome 6	Enrichment	KCNE2	2.09
143	Atrial fibrillation, familial, 11	Enrichment	GJA5	2.09
144	Atrial fibrillation, familial, 12	Enrichment	ABCC9	2.09
145	Diabetes mellitus, transient neonatal, 2	Enrichment	ABCC8	2.09
146	Syndactyly, type iii	Enrichment	GJA1	2.09
147	Syndactyly, type v	Enrichment	GJA1	2.09
148	Cardiomyopathy, familial hypertrophic, 18	Enrichment	PLN	2.09
149	Keratosis palmoplantaris striata ii	Enrichment	DSP	2.09
150	Atrial fibrillation, familial, 4	Enrichment	KCNE2	2.09
151	Long qt syndrome 3	Enrichment	SCN5A	2.09
152	Long qt syndrome 8	Enrichment	CACNA1C	2.09
153	Cardiomyopathy, dilated, 1d	Enrichment	LMNA	2.09
154	Sinoatrial node disease	Enrichment	SCN5A	2.09
155	Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis	Enrichment	DSP	2.09
156	Restrictive dermopathy 2	Enrichment	LMNA	2.09
157	Emery-dreifuss muscular dystrophy 3, autosomal recessive	Enrichment	LMNA	2.09
158	Charcot-marie-tooth disease, axonal, type 2dd	Enrichment	ATP1A1	2.09
159	Craniometaphyseal dysplasia	Enrichment	GJA1	2.09
160	Progressive familial heart block	Enrichment	DSP	2.09
161	Cardiovascular system disease	Enrichment	KCNQ1	2.09
162	Lipodystrophy, familial partial, type 1	Enrichment	LMNA	2.09
163	Cardiomyopathy, dilated, with woolly hair and keratoderma	Enrichment	DSP	2.09
164	Hypomagnesemia, seizures, and impaired intellectual development 2	Enrichment	ATP1A1	2.09
165	Diabetes mellitus, permanent neonatal, 3	Enrichment	ABCC8	2.09
166	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	CACNA1D	2.09
167	Familial partial lipodystrophy	Enrichment	LMNA	2.09
168	Hyperinsulinism	Enrichment	KCNJ11	2.09
169	Isolated atrial standstill	Enrichment	SCN5A	2.09
170	Charcot-marie-tooth disease type 2b1	Enrichment	LMNA	2.09
171	Darier-white disease	Enrichment	ATP2A2	1.92
172	Platelet disorder, familial, with associated myeloid malignancy	Enrichment	KCNE2	1.92
173	Restrictive dermopathy 1	Enrichment	LMNA	1.92
174	Atrial fibrillation, familial, 3	Enrichment	KCNQ1	1.92
175	Generalized epilepsy with febrile seizures plus, type 1	Enrichment	SCN1B	1.92
176	Short qt syndrome 2	Enrichment	KCNQ1	1.92
177	Lipodystrophy, familial partial, type 2	Enrichment	LMNA	1.92
178	Immune dysregulation with autoimmunity, immunodeficiency, and lymphoproliferation	Enrichment	KCNH2	1.92
179	Muscular dystrophy, congenital, lmna-related	Enrichment	LMNA	1.92
180	Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige	Enrichment	DSP	1.92
181	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1C	1.92
182	Woolly hair-skin fragility syndrome	Enrichment	DSP	1.92
183	Keratosis palmoplantaris striata	Enrichment	DSP	1.92
184	Intrinsic cardiomyopathy	Enrichment	PLN	1.92
185	Hyperinsulinemic hypoglycemia	Enrichment	ABCC8	1.92
186	Brugada syndrome 8	Enrichment	HCN4	1.92
187	Restrictive dermopathy	Enrichment	LMNA	1.92
188	Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with runx1	Enrichment	KCNE2	1.92
189	Type 2 diabetes mellitus	Enrichment	ABCC8, KCNJ11	1.90
190	Hutchinson-gilford progeria syndrome	Enrichment	LMNA	1.79
191	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	LMNA	1.79
192	Dermatitis, atopic	Enrichment	KCNJ11	1.79
193	Microtia-anotia	Enrichment	LMNA	1.79
194	Amme complex	Enrichment	KCNE5	1.79
195	Cardiomyopathy, familial hypertrophic, 26	Enrichment	KCNH2	1.79
196	Developmental and epileptic encephalopathy 52	Enrichment	SCN1B	1.79
197	Emery-dreifuss muscular dystrophy	Enrichment	LMNA	1.79
198	Pregnancy loss, recurrent 1	Enrichment	KCNQ1	1.79
199	Newborn respiratory distress syndrome	Enrichment	ABCC8	1.79
200	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	LMNA	1.70
201	Polyhydramnios	Enrichment	ABCC8	1.70
202	Histiocytoid hemangioma	Enrichment	LMNA	1.70
203	Cleft upper lip	Enrichment	GJA1	1.70
204	Hypokalemic periodic paralysis, type 1	Enrichment	KCNE3	1.62
205	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	LMNA	1.62
206	Kleefstra syndrome 1	Enrichment	ABCC9	1.62
207	Patent ductus arteriosus	Enrichment	ABCC9	1.62
208	Hypertrichosis	Enrichment	KCNJ11	1.62
209	Inherited arrhythmogenic cardiomyopathy	Enrichment	DSP	1.62
210	Childhood absence epilepsy	Enrichment	CACNA1H	1.62
211	Bethlem myopathy 1a	Enrichment	LMNA	1.55
212	Silver-russell syndrome 1	Enrichment	KCNQ1	1.55
213	Third-degree atrioventricular block	Enrichment	KCNA5	1.55
214	Gastroesophageal reflux	Enrichment	ABCC8	1.50
215	Erythrokeratodermia variabilis et progressiva 1	Enrichment	GJA1	1.50
216	Myopathy, tubular aggregate, 1	Enrichment	CASQ1	1.50
217	Fanconi anemia, complementation group c	Enrichment	ABCC9	1.50
218	Congenital muscular dystrophy	Enrichment	LMNA	1.50
219	Hypoplastic left heart syndrome	Enrichment	GJA1	1.50
220	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	CACNA1C	1.44
221	Primary hyperaldosteronism	Enrichment	CACNA1H	1.44
222	Dravet syndrome	Enrichment	SCN1B	1.40
223	Rare genetic deafness	Enrichment	KCNE1, KCNQ1	1.39
224	Epilepsy, idiopathic generalized	Enrichment	CACNA1H	1.36
225	Atrial heart septal defect	Enrichment	ABCC8	1.36
226	Diabetes mellitus	Enrichment	KCNJ11	1.36
227	Heritable pulmonary arterial hypertension	Enrichment	KCNK3	1.36
228	Interatrial communication	Enrichment	ABCC8	1.36
229	Epicanthus	Enrichment	ABCC9	1.32
230	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	LMNA	1.32
231	Aortic valve disease 1	Enrichment	DSP	1.29
232	Pulmonary hypertension, primary, 1	Enrichment	KCNK3	1.29
233	Chromosome 1p36 deletion syndrome	Enrichment	KCNAB2	1.29
234	Generalized epilepsy with febrile seizures plus	Enrichment	SCN1B	1.26
235	Interstitial lung disease 2	Enrichment	DSP	1.18
236	Beckwith-wiedemann syndrome	Enrichment	KCNQ1	1.15
237	Neuromuscular disease	Enrichment	LMNA	1.15
238	Early infantile developmental and epileptic encephalopathy	Enrichment	SCN1B	1.15
239	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	LMNA	1.13
240	Cardiomyopathy, dilated, 1g	Enrichment	DSP	1.07
241	Complex neurodevelopmental disorder	Enrichment	ANK2, CACNA1C	1.05
242	Ear malformation	Enrichment	KCNQ1	1.03
243	Muscular dystrophy	Enrichment	LMNA	1.03
244	Tetralogy of fallot	Enrichment	GJA5	1.00
245	Peripheral nervous system disease	Enrichment	LMNA	0.91
246	Neuropathy	Enrichment	LMNA	0.91
247	Familial hypertrophic cardiomyopathy	Enrichment	KCNH2	0.90
248	Fetal akinesia deformation sequence 1	Enrichment	SCN5A	0.85
249	Cerebral palsy	Enrichment	CACNA1C	0.83
250	Charcot-marie-tooth disease	Enrichment	LMNA	0.81
251	Benign epilepsy with centrotemporal spikes	Enrichment	SCN1B	0.81
252	Distal arthrogryposis	Enrichment	SCN5A	0.80
253	Centralopathic epilepsy	Enrichment	SCN1B	0.79
254	Hypertrophic cardiomyopathy	Enrichment	PLN	0.79
255	Sensorineural hearing loss	Enrichment	KCNE1	0.75
256	Body mass index quantitative trait locus 11	Enrichment	KCNH2	0.73
257	Spastic ataxia	Enrichment	CACNA1G	0.71
258	Undetermined early-onset epileptic encephalopathy	Enrichment	SCN1B	0.69
259	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	GJA1	0.52
260	Autism spectrum disorder	Enrichment	ANK2	0.44

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Antiarrhythmic Pathway, Pharmacodynamics

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