Antigen Presentation: Folding, assembly and peptide loading of class I MHC

No Pathway Network information available for Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Pathways in the Antigen Presentation: Folding, assembly and peptide loading of class I MHC SuperPath

#	Name	Source	Genes
1	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Reactome	ATG14 B2M BCAP31 BECN1 CALR CANX ERAP1 ERAP2 HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G HSPA5 PDIA3 PIK3C3 PIK3R4 SAR1B SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A TAP1 TAP2 TAPBP (see all 29) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BCAP31	B Cell Receptor Associated Protein 31	Protein Coding	1
2	SEC24B	SEC24 Homolog B, COPII Component	Protein Coding	1
3	SEC23A	SEC23 Homolog A, COPII Component	Protein Coding	1
4	SEC24A	SEC24 Homolog A, COPII Component	Protein Coding	1
5	ATG14	Autophagy Related 14	Protein Coding	1
6	SEC31A	SEC31 Homolog A, COPII Component	Protein Coding	1
7	PDIA3	Protein Disulfide Isomerase Family A Member 3	Protein Coding	1
8	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
9	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	1
10	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	1
11	HLA-C	Major Histocompatibility Complex, Class I, C	Protein Coding	1
12	HLA-E	Major Histocompatibility Complex, Class I, E	Protein Coding	1
13	HLA-F	Major Histocompatibility Complex, Class I, F	Protein Coding	1
14	HLA-G	Major Histocompatibility Complex, Class I, G	Protein Coding	1
15	HSPA5	Heat Shock Protein Family A (Hsp70) Member 5	Protein Coding	1
16	SAR1B	Secretion Associated Ras Related GTPase 1B	Protein Coding	1
17	ERAP1	Endoplasmic Reticulum Aminopeptidase 1	Protein Coding	1
18	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	1
19	B2M	Beta-2-Microglobulin	Protein Coding	1
20	SEC13	SEC13 Homolog, Nuclear Pore And COPII Component	Protein Coding	1
21	ERAP2	Endoplasmic Reticulum Aminopeptidase 2	Protein Coding	1
22	TAP1	Transporter 1, ATP Binding Cassette Subfamily B Member	Protein Coding	1
23	TAP2	Transporter 2, ATP Binding Cassette Subfamily B Member	Protein Coding	1
24	TAPBP	TAP Binding Protein	Protein Coding	1
25	CALR	Calreticulin	Protein Coding	1
26	CANX	Calnexin	Protein Coding	1
27	BECN1	Beclin 1	Protein Coding	1
28	SEC24C	SEC24 Homolog C, COPII Component	Protein Coding	1
29	SEC24D	SEC24 Homolog D, COPII Component	Protein Coding	1

Disorders associated with Antigen Presentation: Folding, assembly and peptide loading of class I MHC SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Immunodeficiency by defective expression of mhc class i	Enrichment	B2M, TAP1, TAP2, TAPBP	10.55
2	Severe cutaneous adverse reaction	Enrichment	HLA-A, HLA-B	5.36
3	Mhc class i deficiency 1	Enrichment	TAP1, TAP2	4.58
4	Mhc class i deficiency	Enrichment	TAP1, TAP2	4.58
5	Behcet syndrome	Enrichment	ERAP1, HLA-B	3.13
6	Spondyloarthropathy 1	Enrichment	HLA-B	2.67
7	Psoriasis 1	Enrichment	HLA-C	2.67
8	Craniolenticulosutural dysplasia	Enrichment	SEC23A	2.67
9	Immunodeficiency 43	Enrichment	B2M	2.67
10	Cole-carpenter syndrome 2	Enrichment	SEC24D	2.67
11	Halperin-birk syndrome	Enrichment	SEC31A	2.67
12	Mhc class i deficiency 3	Enrichment	TAPBP	2.67
13	Deafness, dystonia, and cerebral hypomyelination	Enrichment	BCAP31	2.67
14	Dialysis-related amyloidosis	Enrichment	B2M	2.67
15	Ankylosing spondylitis 1	Enrichment	HLA-B	2.67
16	Birdshot chorioretinopathy	Enrichment	HLA-A	2.67
17	Reactive arthritis	Enrichment	HLA-B	2.67
18	Amyloidosis, hereditary systemic 6	Enrichment	B2M	2.67
19	Pulmonary arterial hypertension associated with connective tissue disease	Enrichment	HLA-B	2.67
20	Chylomicron retention disease	Enrichment	SAR1B	2.37
21	Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads	Enrichment	ERAP1	2.37
22	Stevens-johnson syndrome	Enrichment	HLA-B	2.37
23	Cadds	Enrichment	BCAP31	2.37
24	Thrombocythemia 1	Enrichment	CALR	2.19
25	Takayasu arteritis	Enrichment	HLA-B	2.19
26	Cole-carpenter syndrome	Enrichment	SEC24D	2.19
27	Temporal arteritis	Enrichment	HLA-B	2.07
28	Budd-chiari syndrome	Enrichment	CALR	2.07
29	Amyloidosis, hereditary systemic 2	Enrichment	B2M	1.97
30	Osteogenesis imperfecta, type i	Enrichment	SEC24D	1.89
31	Myelofibrosis	Enrichment	CALR	1.83
32	Essential thrombocythemia	Enrichment	CALR	1.83
33	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	HLA-C	1.83
34	Lymphoma, non-hodgkin, familial	Enrichment	B2M	1.77
35	Mhc class ii deficiency 1	Enrichment	TAP2	1.63
36	Asthma	Enrichment	HLA-G	1.63
37	Digeorge syndrome	Enrichment	SEC24C	1.60
38	Human immunodeficiency virus type 1	Enrichment	HLA-C	1.42
39	Severe covid-19	Enrichment	HLA-A	1.22
40	Developmental and epileptic encephalopathy	Enrichment	SEC24C	1.13

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Pathway Network for Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Member Pathways for Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Pathways in the Antigen Presentation: Folding, assembly and peptide loading of class I MHC SuperPath

Associated Genes for Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Associated Disorders for Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Disorders associated with Antigen Presentation: Folding, assembly and peptide loading of class I MHC SuperPath

STRING Interaction Network for Antigen Presentation: Folding, assembly and peptide loading of class I MHC

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