Antigen processing-Cross presentation

Pathway network for the Antigen processing-Cross presentation SuperPath

Sources:

Reactome

Pathways in the Antigen processing-Cross presentation SuperPath

#	Name	Source	Genes
1	Antigen processing-Cross presentation	Reactome	ADRM1 B2M BTK CALR CD14 CD207 CD36 CHUK CTSL CTSS CTSV CYBA CYBB FCGR1A FGA FGB FGG HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G HMGB1 IKBKB IKBKG ITGAV ITGB5 LNPEP LY96 MRC1 MRC2 MYD88 NCF1 NCF2 NCF4 PDIA3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PSME1 PSME2 RPS27A S100A1 S100A8 S100A9 SEC22B SEC61A1 SEC61A2 SEC61B SEC61G SEM1 SNAP23 STX4 TAP1 TAP2 TAPBP TIRAP TLR1 TLR2 TLR4 TLR6 UBA52 UBB UBC VAMP3 VAMP8 (see all 97) (see less)
2	ER-Phagosome pathway	Reactome	ADRM1 B2M BTK CALR CD14 CD36 CHUK FGA FGB FGG HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G HMGB1 IKBKB IKBKG LY96 MYD88 PDIA3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PSME1 PSME2 RPS27A S100A1 S100A8 S100A9 SEC22B SEC61A1 SEC61A2 SEC61B SEC61G SEM1 SNAP23 STX4 TAP1 TAP2 TAPBP TIRAP TLR1 TLR2 TLR4 TLR6 UBA52 UBB UBC VAMP3 VAMP8 (see all 82) (see less)
3	Endosomal/Vacuolar pathway	Reactome	B2M CTSL CTSS CTSV HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G LNPEP (see all 11) (see less)
4	Cross-presentation of particulate exogenous antigens (phagosomes)	Reactome	CD36 CYBA CYBB ITGAV ITGB5 NCF1 NCF2 NCF4 (see all 8) (see less)

Gene overlap in member pathways for Antigen processing-Cross presentation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	3
2	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	3
3	HLA-C	Major Histocompatibility Complex, Class I, C	Protein Coding	3
4	HLA-E	Major Histocompatibility Complex, Class I, E	Protein Coding	3
5	HLA-F	Major Histocompatibility Complex, Class I, F	Protein Coding	3
6	HLA-G	Major Histocompatibility Complex, Class I, G	Protein Coding	3
7	B2M	Beta-2-Microglobulin	Protein Coding	3
8	CD36	CD36 Molecule (CD36 Blood Group)	Protein Coding	3
9	PSMD14	Proteasome 26S Subunit, Non-ATPase 14	Protein Coding	2
10	TLR6	Toll Like Receptor 6	Protein Coding	2
11	SEC61B	SEC61 Translocon Subunit Beta	Protein Coding	2
12	ADRM1	ADRM1 26S Proteasome Ubiquitin Receptor	Protein Coding	2
13	TIRAP	TIR Domain Containing Adaptor Protein	Protein Coding	2
14	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
15	CTSL	Cathepsin L	Protein Coding	2
16	CTSV	Cathepsin V	Protein Coding	2
17	CTSS	Cathepsin S	Protein Coding	2
18	CYBA	Cytochrome B-245 Alpha Chain	Protein Coding	2
19	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	2
20	FGA	Fibrinogen Alpha Chain	Protein Coding	2
21	FGB	Fibrinogen Beta Chain	Protein Coding	2
22	FGG	Fibrinogen Gamma Chain	Protein Coding	2
23	SEC61G	SEC61 Translocon Subunit Gamma	Protein Coding	2
24	LY96	Lymphocyte Antigen 96	Protein Coding	2
25	PDIA3	Protein Disulfide Isomerase Family A Member 3	Protein Coding	2
26	SEC61A1	SEC61 Translocon Subunit Alpha 1	Protein Coding	2
27	HMGB1	High Mobility Group Box 1	Protein Coding	2
28	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
29	ITGAV	Integrin Subunit Alpha V	Protein Coding	2
30	ITGB5	Integrin Subunit Beta 5	Protein Coding	2
31	LNPEP	Leucyl And Cystinyl Aminopeptidase	Protein Coding	2
32	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	2
33	NCF2	Neutrophil Cytosolic Factor 2	Protein Coding	2
34	NCF4	Neutrophil Cytosolic Factor 4	Protein Coding	2
35	SEC61A2	SEC61 Translocon Subunit Alpha 2	Protein Coding	2
36	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	2
37	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	2
38	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	2
39	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	2
40	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	2
41	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	2
42	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	2
43	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	2
44	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	2
45	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	2
46	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	2
47	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	2
48	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	2
49	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	2
50	PSMB8	Proteasome 20S Subunit Beta 8	Protein Coding	2
51	PSMB9	Proteasome 20S Subunit Beta 9	Protein Coding	2
52	PSMB10	Proteasome 20S Subunit Beta 10	Protein Coding	2
53	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	2
54	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	2
55	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	2
56	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	2
57	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	2
58	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	2
59	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	2
60	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	2
61	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	2
62	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	2
63	PSMD8	Proteasome 26S Subunit, Non-ATPase 8	Protein Coding	2
64	PSMD11	Proteasome 26S Subunit, Non-ATPase 11	Protein Coding	2
65	PSMD12	Proteasome 26S Subunit, Non-ATPase 12	Protein Coding	2
66	PSMD13	Proteasome 26S Subunit, Non-ATPase 13	Protein Coding	2
67	PSME1	Proteasome Activator Subunit 1	Protein Coding	2
68	PSME2	Proteasome Activator Subunit 2	Protein Coding	2
69	RPS27A	Ribosomal Protein S27a	Protein Coding	2
70	S100A1	S100 Calcium Binding Protein A1	Protein Coding	2
71	S100A8	S100 Calcium Binding Protein A8	Protein Coding	2
72	S100A9	S100 Calcium Binding Protein A9	Protein Coding	2
73	NCF1	Neutrophil Cytosolic Factor 1	Protein Coding	2
74	STX4	Syntaxin 4	Protein Coding	2
75	TAP1	Transporter 1, ATP Binding Cassette Subfamily B Member	Protein Coding	2
76	TAP2	Transporter 2, ATP Binding Cassette Subfamily B Member	Protein Coding	2
77	TAPBP	TAP Binding Protein	Protein Coding	2
78	BTK	Bruton Tyrosine Kinase	Protein Coding	2
79	TLR1	Toll Like Receptor 1	Protein Coding	2
80	TLR2	Toll Like Receptor 2	Protein Coding	2
81	TLR4	Toll Like Receptor 4	Protein Coding	2
82	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
83	UBB	Ubiquitin B	Protein Coding	2
84	UBC	Ubiquitin C	Protein Coding	2
85	SEM1	SEM1 26S Proteasome Subunit	Protein Coding	2
86	CALR	Calreticulin	Protein Coding	2
87	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
88	VAMP8	Vesicle Associated Membrane Protein 8	Protein Coding	2
89	SNAP23	Synaptosome Associated Protein 23	Protein Coding	2
90	CD14	CD14 Molecule	Protein Coding	2
91	VAMP3	Vesicle Associated Membrane Protein 3	Protein Coding	2
92	SEC22B	SEC22 Homolog B, Vesicle Trafficking Protein	Protein Coding	2
93	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	2
94	FCGR1A	Fc Gamma Receptor Ia	Protein Coding	1
95	MRC1	Mannose Receptor C-Type 1	Protein Coding	1
96	CD207	CD207 Molecule	Protein Coding	1
97	MRC2	Mannose Receptor C-Type 2	Protein Coding	1

Disorders associated with Antigen processing-Cross presentation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Chronic granulomatous disease	Enrichment	CYBA, CYBB, NCF1, NCF2, NCF4	10.26
2	Immunodeficiency by defective expression of mhc class i	Enrichment	B2M, TAP1, TAP2, TAPBP	8.90
3	Dysfibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	6.67
4	Familial dysfibrinogenemia	Enrichment	FGA, FGB, FGG	6.67
5	Familial hypofibrinogenemia	Enrichment	FGA, FGB, FGG	6.67
6	Severe cutaneous adverse reaction	Enrichment	HLA-A, HLA-B	6.22
7	Afibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	6.07
8	Granulomatous disease, chronic, autosomal recessive, 2	Enrichment	NCF1, NCF2	6.04
9	Granulomatous disease, chronic, x-linked	Enrichment	CYBB, NCF1	5.74
10	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4, PSMB9	4.44
11	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4, PSMB8	3.97
12	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4, PSMB8	3.97
13	Mhc class i deficiency 1	Enrichment	TAP1, TAP2	3.67
14	Mhc class i deficiency	Enrichment	TAP1, TAP2	3.67
15	Malaria	Enrichment	CD36, IKBKG, TIRAP	3.46
16	Amyloidosis, hereditary systemic 2	Enrichment	B2M, FGA	3.45
17	Granulomatous disease, chronic, autosomal recessive, 4	Enrichment	CYBA	3.23
18	Immunodeficiency 34	Enrichment	CYBB	3.23
19	Coronary heart disease 7	Enrichment	CD36	3.23
20	Platelet glycoprotein iv deficiency	Enrichment	CD36	3.23
21	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	3.23
22	Spondyloarthropathy 1	Enrichment	HLA-B	3.09
23	Psoriasis 1	Enrichment	HLA-C	3.09
24	Immunodeficiency 43	Enrichment	B2M	3.09
25	Dialysis-related amyloidosis	Enrichment	B2M	3.09
26	Ankylosing spondylitis 1	Enrichment	HLA-B	3.09
27	Birdshot chorioretinopathy	Enrichment	HLA-A	3.09
28	Reactive arthritis	Enrichment	HLA-B	3.09
29	Amyloidosis, hereditary systemic 6	Enrichment	B2M	3.09
30	Pulmonary arterial hypertension associated with connective tissue disease	Enrichment	HLA-B	3.09
31	Granulomatous disease, chronic, autosomal recessive, 1	Enrichment	NCF1	2.93
32	Granulomatous disease, chronic, autosomal recessive, 3	Enrichment	NCF4	2.93
33	Stevens-johnson syndrome	Enrichment	HLA-B	2.79
34	Autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	Enrichment	CYBA	2.75
35	Autoimmune polyendocrine syndrome type 1	Enrichment	CYBA	2.75
36	Blood platelet disease	Enrichment	CD36	2.63
37	Cerebral malaria	Enrichment	CD36	2.63
38	Takayasu arteritis	Enrichment	HLA-B	2.61
39	Temporal arteritis	Enrichment	HLA-B	2.49
40	Cardiomyopathy, familial hypertrophic, 4	Enrichment	NCF1	2.28
41	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	HLA-C	2.25
42	Behcet syndrome	Enrichment	HLA-B, TLR4	2.24
43	Diffuse large b-cell lymphoma	Enrichment	BTK, MYD88	2.24
44	Leprosy 3	Enrichment	TLR2	2.22
45	Incontinentia pigmenti	Enrichment	IKBKG	2.22
46	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.22
47	Immunodeficiency 68	Enrichment	MYD88	2.22
48	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	2.22
49	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.22
50	Bacteremia 1	Enrichment	TIRAP	2.22
51	Leprosy 5	Enrichment	TLR1	2.22
52	Fetal encasement syndrome	Enrichment	CHUK	2.22
53	Immunodeficiency 15b	Enrichment	IKBKB	2.22
54	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	2.22
55	Immunodeficiency 15a	Enrichment	IKBKB	2.22
56	Mhc class i deficiency 3	Enrichment	TAPBP	2.22
57	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.22
58	Stankiewicz-isidor syndrome	Enrichment	PSMD12	2.22
59	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.22
60	Tubulointerstitial kidney disease, autosomal dominant 5	Enrichment	SEC61A1	2.22
61	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	2.22
62	Deafness, autosomal recessive 123	Enrichment	STX4	2.22
63	Proteasome-associated autoinflammatory syndrome 6	Enrichment	PSMB9	2.22
64	Macular degeneration, age-related, 10	Enrichment	TLR4	2.22
65	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.22
66	Neutropenia, severe congenital, 11, autosomal dominant	Enrichment	SEC61A1	2.22
67	Congenital fibrinogen deficiency	Enrichment	FGG	2.22
68	Waldenstram macroglobulinemia	Enrichment	MYD88	2.22
69	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.22
70	Lymphoma, non-hodgkin, familial	Enrichment	B2M	2.19
71	Birbeck granule deficiency	Enrichment	CD207	2.15
72	Asthma	Enrichment	HLA-G	2.05
73	Williams-beuren syndrome	Enrichment	NCF1	1.93
74	Immunodeficiency 33	Enrichment	IKBKG	1.92
75	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.92
76	Proteasome-associated autoinflammatory syndrome 5	Enrichment	PSMB10	1.92
77	Agammaglobulinemia, x-linked	Enrichment	BTK	1.92
78	Immunodeficiency, common variable, 15	Enrichment	SEC61A1	1.92
79	Immunodeficiency 121 with autoinflammation	Enrichment	PSMB10	1.92
80	Birk-aharoni syndrome	Enrichment	PSMC1	1.92
81	Leprosy 1	Enrichment	TLR6	1.92
82	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	1.92
83	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.92
84	17q24.2 microdeletion syndrome	Enrichment	PSMD12	1.92
85	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	MYD88	1.92
86	Submucosal cleft palate	Enrichment	UBB	1.92
87	Cleft hard palate	Enrichment	UBB	1.92
88	Human immunodeficiency virus type 1	Enrichment	HLA-C	1.84
89	Severe covid-19	Enrichment	ITGAV	1.77
90	Thrombocythemia 1	Enrichment	CALR	1.74
91	Uvula, bifid	Enrichment	UBB	1.74
92	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.74
93	Cleft soft palate	Enrichment	UBB	1.74
94	Agammaglobulinemia 1	Enrichment	BTK	1.74
95	Thyroid hemiagenesis	Enrichment	PSMD3	1.74
96	Budd-chiari syndrome	Enrichment	CALR	1.62
97	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.52
98	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.45
99	Patent ductus arteriosus	Enrichment	PSMC3	1.45
100	Thrombophilia due to thrombin defect	Enrichment	FGA	1.38
101	Myelofibrosis	Enrichment	CALR	1.38
102	Essential thrombocythemia	Enrichment	CALR	1.38
103	Spastic paraplegia 4, autosomal dominant	Enrichment	FGG	1.32
104	Isolated split hand-split foot malformation	Enrichment	SEM1	1.32
105	Rheumatoid arthritis	Enrichment	TLR1	1.27
106	Coronary heart disease 5	Enrichment	IKBKG	1.27
107	Omenn syndrome	Enrichment	PSMB10	1.23
108	Polymicrogyria	Enrichment	PSMC3	1.23
109	Mhc class ii deficiency 1	Enrichment	TAP2	1.19
110	Polycystic liver disease	Enrichment	SEC61A1	1.01
111	Autosomal dominant polycystic liver disease	Enrichment	SEC61A1	1.01
112	Patent foramen ovale	Enrichment	PSMC3	0.99
113	Myocardial infarction	Enrichment	PSMA6	0.90
114	Multisystem inflammatory syndrome in children	Enrichment	TLR6	0.90
115	Autoinflammatory disease	Enrichment	PSMB8	0.87
116	Severe combined immunodeficiency	Enrichment	IKBKB	0.74
117	Sensorineural hearing loss	Enrichment	STX4	0.60
118	Thrombocytopenia	Enrichment	FGG	0.60
119	Colorectal cancer	Enrichment	TLR2	0.39
120	Microcephaly	Enrichment	PSMC3	0.28
121	Complex neurodevelopmental disorder	Enrichment	PSMD12	0.28

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Antigen processing-Cross presentation

Pathway Network for Antigen processing-Cross presentation

Pathway network for the Antigen processing-Cross presentation SuperPath

Member Pathways for Antigen processing-Cross presentation

Pathways in the Antigen processing-Cross presentation SuperPath

Gene overlap in member pathways for Antigen processing-Cross presentation SuperPath

Associated Genes for Antigen processing-Cross presentation

Associated Disorders for Antigen processing-Cross presentation

Disorders associated with Antigen processing-Cross presentation SuperPath

STRING Interaction Network for Antigen processing-Cross presentation

Sources for Antigen processing-Cross presentation