Antimigraine Preparations Pathway, Pharmacodynamics
Pathways in the Antimigraine Preparations Pathway, Pharmacodynamics SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Antimigraine Preparations Pathway, Pharmacodynamics | PharmGKB |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | VIP | Vasoactive Intestinal Peptide | Protein Coding | 1 |
| 2 | VIPR1 | Vasoactive Intestinal Peptide Receptor 1 | Protein Coding | 1 |
| 3 | VIPR2 | Vasoactive Intestinal Peptide Receptor 2 | Protein Coding | 1 |
| 4 | TRPV1 | Transient Receptor Potential Cation Channel Subfamily V Member 1 | Protein Coding | 1 |
| 5 | CALCA | Calcitonin Related Polypeptide Alpha | Protein Coding | 1 |
| 6 | SNAP25 | Synaptosome Associated Protein 25 | Protein Coding | 1 |
| 7 | CALCRL | Calcitonin Receptor Like Receptor | Protein Coding | 1 |
| 8 | RAMP1 | Receptor Activity Modifying Protein 1 | Protein Coding | 1 |
| 9 | HTR1B | 5-Hydroxytryptamine Receptor 1B | Protein Coding | 1 |
| 10 | HTR1D | 5-Hydroxytryptamine Receptor 1D | Protein Coding | 1 |
| 11 | HTR1F | 5-Hydroxytryptamine Receptor 1F | Protein Coding | 1 |
| 12 | TRPA1 | Transient Receptor Potential Cation Channel Subfamily A Member 1 | Protein Coding | 1 |
| 13 | ADCYAP1R1 | ADCYAP Receptor Type I | Protein Coding | 1 |
| 14 | ADCYAP1 | Adenylate Cyclase Activating Polypeptide 1 | Protein Coding | 1 |
Disorders associated with Antimigraine Preparations Pathway, Pharmacodynamics SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Developmental and epileptic encephalopathy 117 | Enrichment | SNAP25 | 2.99 |
| 2 | Epilepsy with generalized tonic-clonic seizures | Enrichment | SNAP25 | 2.99 |
| 3 | Schizophrenia 16 | Enrichment | VIPR2 | 2.99 |
| 4 | Cramp-fasciculation syndrome | Enrichment | TRPA1 | 2.99 |
| 5 | Lymphatic malformation 8 | Enrichment | CALCRL | 2.69 |
| 6 | Episodic pain syndrome, familial, 1 | Enrichment | TRPA1 | 2.51 |
| 7 | Developmental and epileptic encephalopathy 2 | Enrichment | SNAP25 | 2.38 |
| 8 | Focal epilepsy | Enrichment | SNAP25 | 2.14 |
| 9 | Presynaptic congenital myasthenic syndromes | Enrichment | SNAP25 | 1.95 |
| 10 | Stereotypic movement disorder | Enrichment | SNAP25 | 1.87 |
| 11 | Non-immune hydrops fetalis | Enrichment | CALCRL | 1.50 |
| 12 | Developmental and epileptic encephalopathy | Enrichment | SNAP25 | 1.44 |
| 13 | Optic atrophy plus syndrome | Enrichment | SNAP25 | 1.35 |
| 14 | Microcephaly | Enrichment | SNAP25 | 0.92 |
