Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway

No Pathway Network information available for Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway

Pathways in the Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway SuperPath

#	Name	Source	Genes
1	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway	WikiPathways	ACE2 CCL2 CHUK CXCL8 GCLC GCLM GSTA2 GUCY1A1 GUCY1A2 GUCY1B1 GUCY1B2 HMOX1 IKBKB IKBKG IL12A IL1B IL6 IRF3 KEAP1 LOC124905021 MMP1 MMP3 NFE2L2 NFKB1 NFKBIA NOX1 NQO1 PRKG2 RELA RXRA SLC7A11 TNF (see all 32) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	KEAP1	Kelch Like ECH Associated Protein 1	Protein Coding	1
2	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
3	TNF	Tumor Necrosis Factor	Protein Coding	1
4	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
5	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
6	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
7	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	1
8	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
9	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
10	NFE2L2	NFE2 Like BZIP Transcription Factor 2	Protein Coding	1
11	MMP3	Matrix Metallopeptidase 3	Protein Coding	1
12	MMP1	Matrix Metallopeptidase 1	Protein Coding	1
13	IRF3	Interferon Regulatory Factor 3	Protein Coding	1
14	IL12A	Interleukin 12A	Protein Coding	1
15	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
16	IL6	Interleukin 6	Protein Coding	1
17	IL1B	Interleukin 1 Beta	Protein Coding	1
18	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
19	HMOX1	Heme Oxygenase 1	Protein Coding	1
20	GUCY1A1	Guanylate Cyclase 1 Soluble Subunit Alpha 1	Protein Coding	1
21	GUCY1A2	Guanylate Cyclase 1 Soluble Subunit Alpha 2	Protein Coding	1
22	GSTA2	Glutathione S-Transferase Alpha 2	Protein Coding	1
23	GCLM	Glutamate-Cysteine Ligase Modifier Subunit	Protein Coding	1
24	GCLC	Glutamate-Cysteine Ligase Catalytic Subunit	Protein Coding	1
25	NOX1	NADPH Oxidase 1	Protein Coding	1
26	SLC7A11	Solute Carrier Family 7 Member 11	Protein Coding	1
27	NQO1	NAD(P)H Quinone Dehydrogenase 1	Protein Coding	1
28	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
29	LOC124905021	Uncharacterized LOC124905021	RNA Gene	1
30	PRKG2	Protein Kinase CGMP-Dependent 2	Protein Coding	1
31	GUCY1B1	Guanylate Cyclase 1 Soluble Subunit Beta 1	Protein Coding	1
32	GUCY1B2	Guanylate Cyclase 1 Soluble Subunit Beta 2 (Pseudogene)	Pseudogene	1

Disorders associated with Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	5.27
2	Myocardial infarction	Enrichment	GCLC, GCLM, GUCY1A1	4.75
3	Malaria	Enrichment	IKBKG, TNF	2.88
4	Incontinentia pigmenti	Enrichment	IKBKG	2.63
5	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.63
6	Fetal encasement syndrome	Enrichment	CHUK	2.63
7	Anemia, congenital, nonspherocytic hemolytic, 7	Enrichment	GCLC	2.63
8	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	2.63
9	Immunodeficiency 15b	Enrichment	IKBKB	2.63
10	Spondylometaphyseal dysplasia, pagnamenta type	Enrichment	PRKG2	2.63
11	Immunodeficiency 15a	Enrichment	IKBKB	2.63
12	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.63
13	Immunodeficiency, developmental delay, and hypohomocysteinemia	Enrichment	NFE2L2	2.63
14	Coronary heart disease 6	Enrichment	MMP3	2.63
15	Moyamoya disease 6 with or without achalasia	Enrichment	GUCY1A1	2.63
16	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.63
17	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.63
18	Moyamoya disease with early-onset achalasia	Enrichment	GUCY1A1	2.63
19	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.63
20	Cystic fibrosis	Enrichment	GCLC, HMOX1	2.59
21	Immunodeficiency 33	Enrichment	IKBKG	2.33
22	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.33
23	Goiter, multinodular 1, with or without sertoli-leydig cell tumors	Enrichment	KEAP1	2.33
24	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.33
25	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.33
26	Immunodeficiency 127	Enrichment	TNF	2.33
27	Rela fusion-positive ependymoma	Enrichment	RELA	2.33
28	Recessive dystrophic epidermolysis bullosa	Enrichment	MMP1	2.33
29	Acromesomelic dysplasia 4	Enrichment	PRKG2	2.33
30	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.33
31	Common variable immunodeficiency 12	Enrichment	NFKB1	2.33
32	Psoriatic arthritis	Enrichment	TNF	2.15
33	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.15
34	Migraine without aura	Enrichment	TNF	2.15
35	Kaposi sarcoma	Enrichment	IL6	2.03
36	Cerebral malaria	Enrichment	TNF	2.03
37	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	2.03
38	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.93
39	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.93
40	Vascular dementia	Enrichment	TNF	1.93
41	Moyamoya disease 1	Enrichment	GUCY1A1	1.85
42	Type 1 diabetes mellitus	Enrichment	IL6	1.85
43	Common variable immunodeficiency	Enrichment	NFKB1	1.79
44	Inflammatory bowel disease 1	Enrichment	IL6	1.68
45	Coronary heart disease 5	Enrichment	IKBKG	1.68
46	Primary biliary cholangitis	Enrichment	IL12A	1.68
47	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.63
48	Asthma	Enrichment	TNF	1.59
49	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	1.52
50	Alzheimer's disease	Enrichment	TNF	1.52
51	Gliosarcoma	Enrichment	NFKBIA	1.43
52	Giant cell glioblastoma	Enrichment	NFKBIA	1.40
53	Human immunodeficiency virus type 1	Enrichment	CCL2	1.38
54	Arteriovenous malformations of the brain	Enrichment	IL6	1.36
55	Behcet syndrome	Enrichment	IL12A	1.36
56	Multisystem inflammatory syndrome in children	Enrichment	IRF3	1.30
57	Lung cancer	Enrichment	NFE2L2	1.14
58	Severe combined immunodeficiency	Enrichment	IKBKB	1.12
59	Systemic lupus erythematosus	Enrichment	TNF	1.05
60	Type 2 diabetes mellitus	Enrichment	IL6	1.02
61	Gastric cancer	Enrichment	IL1B	1.01
62	Myeloma, multiple	Enrichment	RXRA	0.91
63	Colorectal cancer	Enrichment	NFE2L2	0.73

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway

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Pathways in the Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway SuperPath

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Associated Disorders for Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway

Disorders associated with Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway SuperPath

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