APC-Cdc20 mediated degradation of Nek2A

Pathway network for the APC-Cdc20 mediated degradation of Nek2A SuperPath

Sources:

Reactome

Pathways in the APC-Cdc20 mediated degradation of Nek2A SuperPath

#	Name	Source	Genes
1	APC-Cdc20 mediated degradation of Nek2A	Reactome	ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CDC16 CDC20 CDC23 CDC26 CDC27 MAD2L1 NEK2 RPS27A UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S (see all 26) (see less)
2	Transcriptional Regulation by VENTX	Reactome	AGO1 AGO3 AGO4 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CCND1 CDC16 CDC23 CDC26 CDC27 CDKN2A CEBPB CSF1R CTNNB1 EHMT1 EHMT2 FZR1 IL6 LEF1 MOV10 NFKB1 RELA TCF7L2 TNRC6A TNRC6B TNRC6C TP53 UBE2C UBE2D1 UBE2E1 UBE2S VENTX (see all 39) (see less)
3	APC/C:Cdc20 mediated degradation of Cyclin B	Reactome	ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CCNB1 CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 RPS27A UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S (see all 24) (see less)
4	Inactivation of APC/C via direct inhibition of the APC/C complex	Reactome	ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CDC16 CDC20 CDC23 CDC26 CDC27 MAD2L1 UBE2C UBE2D1 UBE2E1 UBE2S (see all 21) (see less)
5	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	Reactome	ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CDC16 CDC20 CDC23 CDC26 CDC27 MAD2L1 UBE2C UBE2D1 UBE2E1 UBE2S (see all 21) (see less)

Gene overlap in member pathways for APC-Cdc20 mediated degradation of Nek2A SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ANAPC10	Anaphase Promoting Complex Subunit 10	Protein Coding	5
2	UBE2C	Ubiquitin Conjugating Enzyme E2 C	Protein Coding	5
3	ANAPC16	Anaphase Promoting Complex Subunit 16	Protein Coding	5
4	CDC26	Cell Division Cycle 26	Protein Coding	5
5	ANAPC15	Anaphase Promoting Complex Subunit 15	Protein Coding	5
6	UBE2S	Ubiquitin Conjugating Enzyme E2 S	Protein Coding	5
7	ANAPC2	Anaphase Promoting Complex Subunit 2	Protein Coding	5
8	ANAPC4	Anaphase Promoting Complex Subunit 4	Protein Coding	5
9	ANAPC5	Anaphase Promoting Complex Subunit 5	Protein Coding	5
10	ANAPC7	Anaphase Promoting Complex Subunit 7	Protein Coding	5
11	ANAPC11	Anaphase Promoting Complex Subunit 11	Protein Coding	5
12	ANAPC1	Anaphase Promoting Complex Subunit 1	Protein Coding	5
13	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	5
14	UBE2E1	Ubiquitin Conjugating Enzyme E2 E1	Protein Coding	5
15	CDC23	Cell Division Cycle 23	Protein Coding	5
16	CDC16	Cell Division Cycle 16	Protein Coding	5
17	CDC27	Cell Division Cycle 27	Protein Coding	5
18	CDC20	Cell Division Cycle 20	Protein Coding	4
19	MAD2L1	Mitotic Arrest Deficient 2 Like 1	Protein Coding	3
20	BUB1B	BUB1 Mitotic Checkpoint Serine/Threonine Kinase B	Protein Coding	3
21	BUB3	BUB3 Mitotic Checkpoint Protein	Protein Coding	3
22	RPS27A	Ribosomal Protein S27a	Protein Coding	2
23	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
24	UBB	Ubiquitin B	Protein Coding	2
25	UBC	Ubiquitin C	Protein Coding	2
26	NEK2	NIMA Related Kinase 2	Protein Coding	1
27	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
28	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
29	EHMT2	Euchromatic Histone Lysine Methyltransferase 2	Protein Coding	1
30	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	1
31	CTNNB1	Catenin Beta 1	Protein Coding	1
32	AGO3	Argonaute RISC Catalytic Component 3	Protein Coding	1
33	AGO4	Argonaute RISC Component 4	Protein Coding	1
34	TNRC6B	Trinucleotide Repeat Containing Adaptor 6B	Protein Coding	1
35	AGO1	Argonaute RISC Component 1	Protein Coding	1
36	VENTX	VENT Homeobox	Protein Coding	1
37	TNRC6A	Trinucleotide Repeat Containing Adaptor 6A	Protein Coding	1
38	IL6	Interleukin 6	Protein Coding	1
39	MOV10	Mov10 RNA Helicase	Protein Coding	1
40	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
41	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
42	FZR1	Fizzy And Cell Division Cycle 20 Related 1	Protein Coding	1
43	TNRC6C	Trinucleotide Repeat Containing Adaptor 6C	Protein Coding	1
44	CCND1	Cyclin D1	Protein Coding	1
45	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
46	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
47	TP53	Tumor Protein P53	Protein Coding	1
48	EHMT1	Euchromatic Histone Lysine Methyltransferase 1	Protein Coding	1
49	CCNB1	Cyclin B1	Protein Coding	1
50	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1

Disorders associated with APC-Cdc20 mediated degradation of Nek2A SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Adrenocortical carcinoma	Enrichment	CDKN2A, CTNNB1, TP53	6.36
2	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1B, BUB3	4.20
3	Bladder cancer	Enrichment	CDKN2A, CTNNB1, TP53	4.12
4	Li-fraumeni syndrome	Enrichment	CDKN2A, TP53	3.92
5	Gallbladder cancer	Enrichment	CTNNB1, TP53	3.78
6	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, TP53	3.78
7	Adult hepatocellular carcinoma	Enrichment	CTNNB1, TP53	3.54
8	Leukemia, chronic lymphocytic	Enrichment	CCND1, TP53	3.45
9	Lip and oral cavity carcinoma	Enrichment	CDKN2A, TP53	3.28
10	Premature chromatid separation trait	Enrichment	BUB1B	2.81
11	Oocyte/zygote/embryo maturation arrest 14	Enrichment	CDC20	2.81
12	Ferguson-bonni neurodevelopmental syndrome	Enrichment	ANAPC7	2.81
13	Rothmund-thomson syndrome, type 1	Enrichment	ANAPC1	2.81
14	Hepatoblastoma	Enrichment	CTNNB1, TP53	2.79
15	Hepatocellular carcinoma	Enrichment	CTNNB1, TP53	2.75
16	Retinitis pigmentosa 67	Enrichment	NEK2	2.72
17	Colorectal cancer	Enrichment	CCND1, CTNNB1, TP53	2.71
18	Pancreatic cancer	Enrichment	CDKN2A, TP53	2.63
19	Global developmental delay with speech and behavioral abnormalities	Enrichment	TNRC6B	2.54
20	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.54
21	Bone marrow failure syndrome 5	Enrichment	TP53	2.54
22	Papilloma of choroid plexus	Enrichment	TP53	2.54
23	Basal cell carcinoma 7	Enrichment	TP53	2.54
24	Anaplastic thyroid carcinoma	Enrichment	TP53	2.54
25	Developmental and epileptic encephalopathy 109	Enrichment	FZR1	2.54
26	Ductal carcinoma in situ	Enrichment	TP53	2.54
27	Epilepsy, familial adult myoclonic, 6	Enrichment	TNRC6A	2.54
28	Brain abnormalities, neurodegeneration, and dysosteosclerosis	Enrichment	CSF1R	2.54
29	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.54
30	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.54
31	Adenoid ameloblastoma	Enrichment	CTNNB1	2.54
32	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.54
33	Csf1r-related disorder	Enrichment	CSF1R	2.54
34	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.54
35	Choroid plexus cancer	Enrichment	TP53	2.54
36	Early-onset calcifying leukoencephalopathy-skeletal dysplasia	Enrichment	CSF1R	2.54
37	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.54
38	Microcystic stromal tumor	Enrichment	CTNNB1	2.54
39	Ovarian cancer	Enrichment	CDKN2A, CTNNB1, TP53	2.52
40	Submucosal cleft palate	Enrichment	UBB	2.45
41	Cleft hard palate	Enrichment	UBB	2.45
42	Uvula, bifid	Enrichment	UBB	2.28
43	Cleft soft palate	Enrichment	UBB	2.28
44	Complex neurodevelopmental disorder	Enrichment	AGO1, TCF7L2, TNRC6B	2.27
45	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.24
46	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.24
47	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.24
48	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.24
49	Cervical cancer	Enrichment	TP53	2.24
50	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.24
51	Lymphoma, hodgkin, classic	Enrichment	TP53	2.24
52	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.24
53	Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures	Enrichment	AGO1	2.24
54	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.24
55	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.24
56	Rela fusion-positive ependymoma	Enrichment	RELA	2.24
57	Split hand-foot malformation	Enrichment	LEF1	2.24
58	Kleefstra syndrome	Enrichment	EHMT1	2.24
59	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.24
60	Congenital fibrosarcoma	Enrichment	TP53	2.24
61	Li-fraumeni syndrome 1	Enrichment	TP53	2.24
62	Sarcoma	Enrichment	TP53	2.24
63	Cervix carcinoma	Enrichment	TP53	2.24
64	Hodgkin's lymphoma	Enrichment	TP53	2.24
65	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.24
66	Kleefstra syndrome due to a point mutation	Enrichment	EHMT1	2.24
67	Teratoma	Enrichment	CTNNB1	2.24
68	Common variable immunodeficiency 12	Enrichment	NFKB1	2.24
69	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.24
70	Type 2 diabetes mellitus	Enrichment	IL6, TCF7L2	2.19
71	Gastric cancer	Enrichment	CDKN2A, TP53	2.17
72	Deafness, autosomal recessive 63	Enrichment	ANAPC15	2.11
73	Mosaic variegated aneuploidy syndrome 1	Enrichment	BUB1B	2.11
74	Desmoid disease, hereditary	Enrichment	CTNNB1	2.07
75	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	CSF1R	2.07
76	Osteogenic sarcoma	Enrichment	TP53	2.07
77	Nasopharyngeal carcinoma	Enrichment	TP53	2.07
78	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.07
79	Anus, imperforate	Enrichment	CTNNB1	2.07
80	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.07
81	Desmoid tumor	Enrichment	CTNNB1	2.07
82	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.07
83	Anaplastic astrocytoma	Enrichment	TP53	2.07
84	Squamous cell carcinoma	Enrichment	TP53	2.07
85	Adenocarcinoma	Enrichment	TP53	2.07
86	Bone osteosarcoma	Enrichment	TP53	2.07
87	Myeloma, multiple	Enrichment	CCND1, TP53	1.95
88	Kaposi sarcoma	Enrichment	IL6	1.94
89	Small cell cancer of the lung	Enrichment	TP53	1.94
90	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.94
91	Pilomatrixoma	Enrichment	CTNNB1	1.94
92	Alazami syndrome	Enrichment	CTNNB1	1.94
93	Mantle cell lymphoma	Enrichment	CCND1	1.94
94	Lung sarcomatoid carcinoma	Enrichment	TP53	1.94
95	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.94
96	Craniopharyngioma	Enrichment	CTNNB1	1.94
97	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.94
98	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.84
99	Von hippel-lindau syndrome	Enrichment	CCND1	1.84
100	Rhabdomyosarcoma 2	Enrichment	TP53	1.84
101	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.84
102	Lymphoma	Enrichment	TP53	1.84
103	Acute megakaryocytic leukemia	Enrichment	TP53	1.84
104	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.77
105	Split-hand/foot malformation 1	Enrichment	LEF1	1.77
106	Type 1 diabetes mellitus	Enrichment	IL6	1.77
107	Kleefstra syndrome 1	Enrichment	EHMT1	1.77
108	Breast adenocarcinoma	Enrichment	TP53	1.77
109	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.77
110	Esophageal cancer	Enrichment	TP53	1.70
111	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.70
112	Essential thrombocythemia	Enrichment	TP53	1.70
113	Common variable immunodeficiency	Enrichment	NFKB1	1.70
114	Glioma susceptibility 1	Enrichment	TP53	1.64
115	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.64
116	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.64
117	Inflammatory bowel disease 1	Enrichment	IL6	1.59
118	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	TNRC6B	1.59
119	Primary hyperaldosteronism	Enrichment	TP53	1.59
120	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.55
121	Polymicrogyria	Enrichment	EHMT1	1.55
122	Melanoma	Enrichment	CDKN2A	1.55
123	Familial colorectal cancer	Enrichment	TP53	1.55
124	Frontotemporal dementia 1	Enrichment	CSF1R	1.51
125	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.51
126	Myelodysplastic syndrome	Enrichment	TP53	1.51
127	Alzheimer's disease	Enrichment	CSF1R	1.43
128	Autism spectrum disorder	Enrichment	EHMT1, TNRC6B	1.41
129	Medulloblastoma	Enrichment	CTNNB1	1.40
130	Lung cancer susceptibility 3	Enrichment	TP53	1.40
131	Rhabdomyosarcoma	Enrichment	TP53	1.35
132	Gliosarcoma	Enrichment	TP53	1.35
133	Alzheimer disease, familial, 1	Enrichment	CSF1R	1.32
134	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	1.32
135	Polycystic liver disease	Enrichment	CTNNB1	1.32
136	Giant cell glioblastoma	Enrichment	TP53	1.32
137	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.32
138	Arteriovenous malformations of the brain	Enrichment	IL6	1.27
139	Diffuse large b-cell lymphoma	Enrichment	TP53	1.27
140	Inherited cancer-predisposing syndrome	Enrichment	CDKN2A, TP53	1.26
141	Diamond-blackfan anemia 1	Enrichment	TP53	1.19
142	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A	1.19
143	Prostate cancer	Enrichment	TP53	1.10
144	Diamond-blackfan anemia	Enrichment	TP53	1.01
145	Leukemia, acute myeloid	Enrichment	TP53	0.96
146	Hereditary breast carcinoma	Enrichment	TP53	0.92
147	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.83
148	Undetermined early-onset epileptic encephalopathy	Enrichment	FZR1	0.83
149	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CSF1R	0.81
150	Schizophrenia	Enrichment	EHMT1	0.81
151	Autism	Enrichment	TCF7L2	0.73
152	Breast cancer	Enrichment	TP53	0.71
153	Congenital nervous system abnormality	Enrichment	CTNNB1	0.58
154	Nervous system disease	Enrichment	CTNNB1	0.58
155	Microcephaly	Enrichment	CTNNB1	0.52
156	Retinitis pigmentosa	Enrichment	NEK2	0.47
157	Hereditary retinal dystrophy	Enrichment	NEK2	0.37
158	Fundus dystrophy	Enrichment	NEK2	0.37

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

APC-Cdc20 mediated degradation of Nek2A

Pathway Network for APC-Cdc20 mediated degradation of Nek2A

Pathway network for the APC-Cdc20 mediated degradation of Nek2A SuperPath

Member Pathways for APC-Cdc20 mediated degradation of Nek2A

Pathways in the APC-Cdc20 mediated degradation of Nek2A SuperPath

Gene overlap in member pathways for APC-Cdc20 mediated degradation of Nek2A SuperPath

Associated Genes for APC-Cdc20 mediated degradation of Nek2A

Associated Disorders for APC-Cdc20 mediated degradation of Nek2A

Disorders associated with APC-Cdc20 mediated degradation of Nek2A SuperPath

STRING Interaction Network for APC-Cdc20 mediated degradation of Nek2A

Sources for APC-Cdc20 mediated degradation of Nek2A