Apoptosis

Pathway network for the Apoptosis SuperPath

Sources:

Reactome

Pathways in the Apoptosis SuperPath

#	Name	Source	Genes
1	Apoptosis	Reactome	ACIN1 ADRM1 AKT1 AKT2 AKT3 APC ARHGAP10 BAD BBC3 BCAP31 BCL2 BCL2L1 BCL2L11 BIRC2 BMF BMX C1QBP CASP8 CASP9 CD14 CDKN2A CLSPN CTNNB1 DAPK1 DAPK2 DAPK3 DNM1L DSG3 DYNLL1 DYNLL2 E2F1 FADD FNTA GSDMD GSDME HMGB1 KPNA1 KPNB1 LMNA LMNB1 LY96 MAGED1 MAPK1 MAPK3 MAPK8 OMA1 OPA1 PAK2 PMAIP1 PPP3CC PPP3R1 PRKCD PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTK2 RIPK1 ROCK1 RPS27A SATB1 SEM1 SEPTIN4 SFN SPTAN1 STAT3 STK24 STK26 TFDP1 TFDP2 TICAM1 TICAM2 TJP1 TJP2 TLR4 TMED7-TICAM2 TP53 TRAF2 UACA UBA52 UBB UBC UNC5A UNC5B VIM YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 117) (see less)
2	Programmed Cell Death	Reactome	ACIN1 ADRM1 AKT1 AKT2 AKT3 APC ARHGAP10 BAD BBC3 BCAP31 BCL2 BCL2L1 BCL2L11 BIRC2 BIRC3 BMF BMX C1QBP CASP1 CASP4 CASP5 CASP8 CASP9 CD14 CDC37 CDKN2A CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 CLSPN CTNNB1 DAPK1 DAPK2 DAPK3 DNM1L DSG3 DYNLL1 DYNLL2 E2F1 ELANE FADD FNTA GSDMD GSDME HMGB1 HSP90AA1 IL18 IL1A IL1B IRF1 IRF2 ITCH KPNA1 KPNB1 LMNA LMNB1 LY96 MAGED1 MAPK1 MAPK3 MAPK8 OMA1 OPA1 PAK2 PELI1 PMAIP1 PPP3CC PPP3R1 PRKCD PRKN PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTK2 RIPK1 RIPK3 RNF103-CHMP3 ROCK1 RPS27A SATB1 SEM1 SEPTIN4 SFN SPTAN1 STAT3 STK24 STK26 STUB1 TFDP1 TFDP2 TICAM1 TICAM2 TJP1 TJP2 TLR4 TMED7-TICAM2 TP53 TRAF2 UACA UBA52 UBB UBC UBE2L3 UNC5A UNC5B VIM YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 144) (see less)
3	Caspase activation via extrinsic apoptotic signalling pathway	Reactome	CASP8 CASP9 CD14 DAPK1 DAPK2 DAPK3 FADD LY96 MAGED1 RIPK1 TICAM1 TICAM2 TLR4 TMED7-TICAM2 TRAF2 UNC5A UNC5B (see all 17) (see less)
4	Caspase activation via Death Receptors in the presence of ligand	Reactome	CASP8 CD14 FADD LY96 RIPK1 TICAM1 TICAM2 TLR4 TMED7-TICAM2 TRAF2 (see all 10) (see less)
5	Caspase activation via Dependence Receptors in the absence of ligand	Reactome	CASP9 DAPK1 DAPK2 DAPK3 MAGED1 UNC5A UNC5B (see all 7) (see less)

Gene overlap in member pathways for Apoptosis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TMED7-TICAM2	TMED7-TICAM2 Readthrough	Protein Coding	4
2	TICAM1	TIR Domain Containing Adaptor Molecule 1	Protein Coding	4
3	DAPK1	Death Associated Protein Kinase 1	Protein Coding	4
4	DAPK3	Death Associated Protein Kinase 3	Protein Coding	4
5	UNC5B	Unc-5 Netrin Receptor B	Protein Coding	4
6	DAPK2	Death Associated Protein Kinase 2	Protein Coding	4
7	LY96	Lymphocyte Antigen 96	Protein Coding	4
8	TICAM2	TIR Domain Containing Adaptor Molecule 2	Protein Coding	4
9	TLR4	Toll Like Receptor 4	Protein Coding	4
10	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	4
11	CASP8	Caspase 8	Protein Coding	4
12	CASP9	Caspase 9	Protein Coding	4
13	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	4
14	FADD	Fas Associated Via Death Domain	Protein Coding	4
15	UNC5A	Unc-5 Netrin Receptor A	Protein Coding	4
16	CD14	CD14 Molecule	Protein Coding	4
17	MAGED1	MAGE Family Member D1	Protein Coding	4
18	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
19	BCL2L11	BCL2 Like 11	Protein Coding	2
20	DNM1L	Dynamin 1 Like	Protein Coding	2
21	BCAP31	B Cell Receptor Associated Protein 31	Protein Coding	2
22	PSMD14	Proteasome 26S Subunit, Non-ATPase 14	Protein Coding	2
23	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	2
24	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	2
25	ADRM1	ADRM1 26S Proteasome Ubiquitin Receptor	Protein Coding	2
26	OMA1	OMA1 Zinc Metallopeptidase	Protein Coding	2
27	DYNLL2	Dynein Light Chain LC8-Type 2	Protein Coding	2
28	CTNNB1	Catenin Beta 1	Protein Coding	2
29	GSDME	Gasdermin E	Protein Coding	2
30	DSG3	Desmoglein 3	Protein Coding	2
31	E2F1	E2F Transcription Factor 1	Protein Coding	2
32	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
33	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
34	ACIN1	Apoptotic Chromatin Condensation Inducer 1	Protein Coding	2
35	FNTA	Farnesyltransferase, CAAX Box, Subunit Alpha	Protein Coding	2
36	BBC3	BCL2 Binding Component 3	Protein Coding	2
37	SFN	Stratifin	Protein Coding	2
38	HMGB1	High Mobility Group Box 1	Protein Coding	2
39	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	2
40	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	2
41	KPNA1	Karyopherin Subunit Alpha 1	Protein Coding	2
42	KPNB1	Karyopherin Subunit Beta 1	Protein Coding	2
43	LMNA	Lamin A/C	Protein Coding	2
44	LMNB1	Lamin B1	Protein Coding	2
45	OPA1	OPA1 Mitochondrial Dynamin Like GTPase	Protein Coding	2
46	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	2
47	STK26	Serine/Threonine Kinase 26	Protein Coding	2
48	PMAIP1	Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Protein Coding	2
49	SEPTIN4	Septin 4	Protein Coding	2
50	UACA	Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats	Protein Coding	2
51	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	2
52	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	2
53	PRKCD	Protein Kinase C Delta	Protein Coding	2
54	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
55	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
56	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
57	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	2
58	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	2
59	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	2
60	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	2
61	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	2
62	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	2
63	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	2
64	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	2
65	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	2
66	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	2
67	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	2
68	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	2
69	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	2
70	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	2
71	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	2
72	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	2
73	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	2
74	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	2
75	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	2
76	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	2
77	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	2
78	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	2
79	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	2
80	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	2
81	PSMD8	Proteasome 26S Subunit, Non-ATPase 8	Protein Coding	2
82	PSMD11	Proteasome 26S Subunit, Non-ATPase 11	Protein Coding	2
83	PSMD12	Proteasome 26S Subunit, Non-ATPase 12	Protein Coding	2
84	PSMD13	Proteasome 26S Subunit, Non-ATPase 13	Protein Coding	2
85	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	2
86	PTK2	Protein Tyrosine Kinase 2	Protein Coding	2
87	BCL2	BCL2 Apoptosis Regulator	Protein Coding	2
88	BCL2L1	BCL2 Like 1	Protein Coding	2
89	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	2
90	RPS27A	Ribosomal Protein S27a	Protein Coding	2
91	SATB1	SATB Homeobox 1	Protein Coding	2
92	CLSPN	Claspin	Protein Coding	2
93	BMX	BMX Non-Receptor Tyrosine Kinase	Protein Coding	2
94	SPTAN1	Spectrin Alpha, Non-Erythrocytic 1	Protein Coding	2
95	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
96	TFDP1	Transcription Factor Dp-1	Protein Coding	2
97	TFDP2	Transcription Factor Dp-2	Protein Coding	2
98	C1QBP	Complement C1q Binding Protein	Protein Coding	2
99	TJP1	Tight Junction Protein 1	Protein Coding	2
100	TP53	Tumor Protein P53	Protein Coding	2
101	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
102	UBB	Ubiquitin B	Protein Coding	2
103	UBC	Ubiquitin C	Protein Coding	2
104	VIM	Vimentin	Protein Coding	2
105	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	2
106	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	2
107	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	2
108	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	2
109	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	2
110	ARHGAP10	Rho GTPase Activating Protein 10	Protein Coding	2
111	SEM1	SEM1 26S Proteasome Subunit	Protein Coding	2
112	GSDMD	Gasdermin D	Protein Coding	2
113	STK24	Serine/Threonine Kinase 24	Protein Coding	2
114	DYNLL1	Dynein Light Chain LC8-Type 1	Protein Coding	2
115	BMF	Bcl2 Modifying Factor	Protein Coding	2
116	TJP2	Tight Junction Protein 2	Protein Coding	2
117	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	2
118	RNF103-CHMP3	RNF103-CHMP3 Readthrough	Protein Coding	1
119	STUB1	STIP1 Homology And U-Box Containing Protein 1	Protein Coding	1
120	RIPK3	Receptor Interacting Serine/Threonine Kinase 3	Protein Coding	1
121	CDC37	Cell Division Cycle 37, HSP90 Cochaperone	Protein Coding	1
122	CHMP4B	Charged Multivesicular Body Protein 4B	Protein Coding	1
123	ELANE	Elastase, Neutrophil Expressed	Protein Coding	1
124	CHMP2B	Charged Multivesicular Body Protein 2B	Protein Coding	1
125	CHMP2A	Charged Multivesicular Body Protein 2A	Protein Coding	1
126	CHMP4A	Charged Multivesicular Body Protein 4A	Protein Coding	1
127	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	1
128	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
129	IL1A	Interleukin 1 Alpha	Protein Coding	1
130	IL1B	Interleukin 1 Beta	Protein Coding	1
131	IL18	Interleukin 18	Protein Coding	1
132	IRF1	Interferon Regulatory Factor 1	Protein Coding	1
133	IRF2	Interferon Regulatory Factor 2	Protein Coding	1
134	PRKN	Parkin RBR E3 Ubiquitin Protein Ligase	Protein Coding	1
135	CHMP3	Charged Multivesicular Body Protein 3	Protein Coding	1
136	PELI1	Pellino E3 Ubiquitin Protein Ligase 1	Protein Coding	1
137	UBE2L3	Ubiquitin Conjugating Enzyme E2 L3	Protein Coding	1
138	CHMP6	Charged Multivesicular Body Protein 6	Protein Coding	1
139	CASP1	Caspase 1	Protein Coding	1
140	CASP4	Caspase 4	Protein Coding	1
141	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
142	CASP5	Caspase 5	Protein Coding	1
143	CHMP7	Charged Multivesicular Body Protein 7	Protein Coding	1
144	CHMP4C	Charged Multivesicular Body Protein 4C	Protein Coding	1

Disorders associated with Apoptosis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Adrenocortical carcinoma	Enrichment	CDKN2A, CTNNB1, TP53	4.91
2	Hepatocellular carcinoma	Enrichment	APC, CASP8, CTNNB1, TP53	4.47
3	Adult hepatocellular carcinoma	Enrichment	CASP8, CTNNB1, TP53	4.30
4	Gastric cancer	Enrichment	APC, CDKN2A, IL1B, IRF1, TP53	4.06
5	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	3.66
6	Desmoid tumor	Enrichment	APC, CTNNB1	3.66
7	Autosomal dominant optic atrophy, classic form	Enrichment	DNM1L, OPA1	3.66
8	Craniopharyngioma	Enrichment	APC, CTNNB1	3.36
9	Ovarian cancer	Enrichment	AKT1, APC, CDKN2A, CTNNB1, PRKN, TP53	3.15
10	Histiocytoid hemangioma	Enrichment	LMNA, VIM	3.14
11	Caspase 8 deficiency	Enrichment	CASP8	3.13
12	Encephalopathy, acute, infection-induced 6	Enrichment	TICAM1	3.13
13	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	3.13
14	Macular degeneration, age-related, 10	Enrichment	TLR4	3.13
15	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	3.13
16	Hepatoblastoma	Enrichment	APC, CTNNB1, TP53	3.13
17	Li-fraumeni syndrome	Enrichment	CDKN2A, TP53	2.97
18	Breast adenocarcinoma	Enrichment	AKT1, TP53	2.97
19	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.83
20	Oculootodental syndrome	Enrichment	FADD	2.83
21	Gallbladder cancer	Enrichment	CTNNB1, TP53	2.82
22	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, TP53	2.82
23	Bladder cancer	Enrichment	CDKN2A, CTNNB1, TP53	2.71
24	Polymicrogyria	Enrichment	AKT3, PSMC3	2.50
25	Herpes simplex virus encephalitis	Enrichment	TICAM1	2.43
26	Specific learning disability	Enrichment	MAPK1, YWHAG	2.41
27	Breast cancer	Enrichment	AKT1, APC, CASP8, TP53	2.40
28	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	2.35
29	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	2.35
30	Lip and oral cavity carcinoma	Enrichment	CDKN2A, TP53	2.34
31	Lung cancer	Enrichment	CASP8, IRF1, PRKN	2.33
32	Medulloblastoma	Enrichment	APC, CTNNB1	2.20
33	Hereditary breast carcinoma	Enrichment	AKT1, APC, TP53	2.19
34	Colorectal cancer	Enrichment	AKT1, APC, CTNNB1, TP53	2.17
35	Immune deficiency disease	Enrichment	RIPK1	2.09
36	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, typical	Enrichment	LMNB1	2.06
37	Proteus syndrome	Enrichment	AKT1	2.06
38	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.06
39	Deafness, autosomal dominant 51	Enrichment	TJP2	2.06
40	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	2.06
41	Optic atrophy 5	Enrichment	DNM1L	2.06
42	Developmental and epileptic encephalopathy 5	Enrichment	SPTAN1	2.06
43	Encephalopathy due to defective mitochondrial and peroxisomal fission 1	Enrichment	DNM1L	2.06
44	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.06
45	Noonan syndrome 13	Enrichment	MAPK1	2.06
46	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	2.06
47	Developmental delay with dysmorphic facies and dental anomalies	Enrichment	SATB1	2.06
48	Combined oxidative phosphorylation deficiency 33	Enrichment	C1QBP	2.06
49	Knobloch syndrome 2	Enrichment	PAK2	2.06
50	Bone marrow failure syndrome 5	Enrichment	TP53	2.06
51	Stankiewicz-isidor syndrome	Enrichment	PSMD12	2.06
52	Papilloma of choroid plexus	Enrichment	TP53	2.06
53	Basal cell carcinoma 7	Enrichment	TP53	2.06
54	Deafness, dystonia, and cerebral hypomyelination	Enrichment	BCAP31	2.06
55	Spermatogenic failure 99	Enrichment	SEPTIN4	2.06
56	Anaplastic thyroid carcinoma	Enrichment	TP53	2.06
57	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.06
58	Adult onset demyelinating leukodystrophy	Enrichment	LMNB1	2.06
59	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	2.06
60	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.06
61	Deafness, autosomal dominant 5	Enrichment	GSDME	2.06
62	Dominant hereditary optic atrophy	Enrichment	OPA1	2.06
63	Cowden syndrome 6	Enrichment	AKT1	2.06
64	Microcephaly 26, primary, autosomal dominant	Enrichment	LMNB1	2.06
65	Ductal carcinoma in situ	Enrichment	TP53	2.06
66	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	2.06
67	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.06
68	Atypical werner syndrome	Enrichment	LMNA	2.06
69	Blistering, acantholytic, of oral and laryngeal mucosa	Enrichment	DSG3	2.06
70	Den hoed-de boer-voisin syndrome	Enrichment	SATB1	2.06
71	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.06
72	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.06
73	Adenoid ameloblastoma	Enrichment	CTNNB1	2.06
74	Spastic paraplegia 91, autosomal dominant, with or without cerebellar ataxia	Enrichment	SPTAN1	2.06
75	Developmental delay with or without epilepsy	Enrichment	SPTAN1	2.06
76	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.06
77	Mandibuloacral dysplasia	Enrichment	LMNA	2.06
78	Atrioventricular block	Enrichment	LMNA	2.06
79	Neuronopathy, distal hereditary motor, autosomal dominant 11	Enrichment	SPTAN1	2.06
80	Capillary hemangioma	Enrichment	AKT3	2.06
81	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.06
82	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.06
83	Choroid plexus cancer	Enrichment	TP53	2.06
84	Familial adenomatous polyposis	Enrichment	APC	2.06
85	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.06
86	Lmna-related cardiocutaneous progeria syndrome	Enrichment	LMNA	2.06
87	Gardner syndrome	Enrichment	APC	2.06
88	5q22 microdeletion syndrome	Enrichment	APC	2.06
89	Attenuated familial adenomatous polyposis	Enrichment	APC	2.06
90	Autosomal semi-dominant severe lipodystrophic laminopathy	Enrichment	LMNA	2.06
91	Premature aging	Enrichment	VIM	2.06
92	Intellectual disability-acpilepsy-dental anomalies-facial dysmorphism syndrome	Enrichment	SATB1	2.06
93	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.06
94	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.06
95	Encephalopathy due to mitochondrial and peroxisomal fission defect	Enrichment	DNM1L	2.06
96	Microcystic stromal tumor	Enrichment	CTNNB1	2.06
97	Autosomal recessive axonal hereditary motor and sensory neuropathy	Enrichment	LMNA	2.06
98	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.06
99	Laminopathy	Enrichment	LMNA	2.06
100	Lung cancer susceptibility 3	Enrichment	PRKN, TP53	2.03
101	Neuromuscular disease	Enrichment	LMNA, SPTAN1	1.99
102	Cataract 31, multiple types	Enrichment	CHMP4B	1.97
103	Leprosy 2	Enrichment	PRKN	1.97
104	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	1.97
105	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	1.97
106	Diffuse large b-cell lymphoma	Enrichment	STAT3, TP53	1.94
107	Behcet syndrome	Enrichment	TLR4	1.86
108	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	1.77
109	Optic atrophy 1	Enrichment	OPA1	1.77
110	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.77
111	Behr syndrome	Enrichment	OPA1	1.77
112	Mandibuloacral dysplasia with type a lipodystrophy	Enrichment	LMNA	1.77
113	Intellectual developmental disorder, x-linked, syndromic, raymond type	Enrichment	SPTAN1	1.77
114	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.77
115	Cervical cancer	Enrichment	TP53	1.77
116	Hyperaldosteronism, familial, type ii	Enrichment	SATB1	1.77
117	Heart-hand syndrome, slovenian type	Enrichment	LMNA	1.77
118	Charcot-marie-tooth disease, axonal, type 2b1	Enrichment	LMNA	1.77
119	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	1.77
120	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	Enrichment	LMNA	1.77
121	Mitochondrial dna depletion syndrome 14	Enrichment	OPA1	1.77
122	Cholestasis, progressive familial intrahepatic, 4	Enrichment	TJP2	1.77
123	Lymphoma, hodgkin, classic	Enrichment	TP53	1.77
124	Optic atrophy 8	Enrichment	OPA1	1.77
125	Cardiomyopathy, dilated, 1d	Enrichment	LMNA	1.77
126	Restrictive dermopathy 2	Enrichment	LMNA	1.77
127	Emery-dreifuss muscular dystrophy 3, autosomal recessive	Enrichment	LMNA	1.77
128	Birk-aharoni syndrome	Enrichment	PSMC1	1.77
129	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4	1.77
130	Intravascular large b-cell lymphoma	Enrichment	BCL2	1.77
131	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.77
132	Senior-loken syndrome 7	Enrichment	AKT3	1.77
133	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	1.77
134	Cataract 30	Enrichment	VIM	1.77
135	Lipodystrophy, familial partial, type 1	Enrichment	LMNA	1.77
136	Congenital fibrosarcoma	Enrichment	TP53	1.77
137	Li-fraumeni syndrome 1	Enrichment	TP53	1.77
138	Sarcoma	Enrichment	TP53	1.77
139	Periampullary adenoma	Enrichment	APC	1.77
140	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	1.77
141	Cervix carcinoma	Enrichment	TP53	1.77
142	Hodgkin's lymphoma	Enrichment	TP53	1.77
143	Autosomal dominant primary microcephaly	Enrichment	LMNB1	1.77
144	Bardet-biedl syndrome 16	Enrichment	AKT3	1.77
145	17q24.2 microdeletion syndrome	Enrichment	PSMD12	1.77
146	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.77
147	Familial partial lipodystrophy	Enrichment	LMNA	1.77
148	Cadds	Enrichment	BCAP31	1.77
149	Teratoma	Enrichment	CTNNB1	1.77
150	Charcot-marie-tooth disease type 2b1	Enrichment	LMNA	1.77
151	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.77
152	Submucosal cleft palate	Enrichment	UBB	1.77
153	Cleft hard palate	Enrichment	UBB	1.77
154	Pancreatic cancer	Enrichment	CDKN2A, TP53	1.71
155	Cyclic neutropenia	Enrichment	ELANE	1.68
156	Neutropenia, severe congenital, x-linked	Enrichment	ELANE	1.68
157	Parkinson disease 12	Enrichment	PRKN	1.68
158	Spinocerebellar ataxia 48	Enrichment	STUB1	1.68
159	Immunodeficiency 117	Enrichment	IRF1	1.68
160	Microcephaly	Enrichment	CTNNB1, MAPK1, PSMC3, YWHAG	1.66
161	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.59
162	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4	1.59
163	Uvula, bifid	Enrichment	UBB	1.59
164	Restrictive dermopathy 1	Enrichment	LMNA	1.59
165	Osteogenic sarcoma	Enrichment	TP53	1.59
166	Cleft soft palate	Enrichment	UBB	1.59
167	Hypercholanemia, familial 1	Enrichment	TJP2	1.59
168	Nasopharyngeal carcinoma	Enrichment	TP53	1.59
169	Glaucoma, normal tension	Enrichment	OPA1	1.59
170	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.59
171	Lipodystrophy, familial partial, type 2	Enrichment	LMNA	1.59
172	Cenani-lenz syndactyly syndrome	Enrichment	APC	1.59
173	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.59
174	Muscular dystrophy, congenital, lmna-related	Enrichment	LMNA	1.59
175	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.59
176	Short-rib thoracic dysplasia 11 with or without polydactyly	Enrichment	SPTAN1	1.59
177	Anus, imperforate	Enrichment	CTNNB1	1.59
178	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.59
179	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.59
180	Hyper ige syndrome	Enrichment	STAT3	1.59
181	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	1.59
182	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4	1.59
183	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.59
184	Anaplastic astrocytoma	Enrichment	TP53	1.59
185	Squamous cell carcinoma	Enrichment	TP53	1.59
186	Adenocarcinoma	Enrichment	TP53	1.59
187	Bone osteosarcoma	Enrichment	TP53	1.59
188	Restrictive dermopathy	Enrichment	LMNA	1.59
189	Colon adenocarcinoma	Enrichment	APC	1.59
190	Thyroid hemiagenesis	Enrichment	PSMD3	1.59
191	Apc-associated polyposis conditions	Enrichment	APC	1.59
192	Neutropenia, severe congenital, 1, autosomal dominant	Enrichment	ELANE	1.50
193	Hutchinson-gilford progeria syndrome	Enrichment	LMNA	1.47
194	Small cell cancer of the lung	Enrichment	TP53	1.47
195	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	LMNA	1.47
196	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.47
197	Microtia-anotia	Enrichment	LMNA	1.47
198	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	1.47
199	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.47
200	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.47
201	Pilomatrixoma	Enrichment	CTNNB1	1.47
202	Alazami syndrome	Enrichment	CTNNB1	1.47
203	Emery-dreifuss muscular dystrophy	Enrichment	LMNA	1.47
204	Lung sarcomatoid carcinoma	Enrichment	TP53	1.47
205	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.47
206	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	1.47
207	Charcot-marie-tooth hereditary neuropathy	Enrichment	SPTAN1	1.47
208	Knobloch syndrome	Enrichment	PAK2	1.47
209	Sick sinus syndrome	Enrichment	LMNA	1.47
210	Mitochondrial disease	Enrichment	C1QBP, DNM1L, OPA1	1.41
211	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	1.40
212	Complex hereditary spastic paraplegia	Enrichment	PRKN	1.38
213	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.37
214	3-methylglutaconic aciduria, type iii	Enrichment	OPA1	1.37
215	Rhabdomyosarcoma 2	Enrichment	TP53	1.37
216	Knobloch syndrome 1	Enrichment	PAK2	1.37
217	Familial adenomatous polyposis 1	Enrichment	APC	1.37
218	Follicular lymphoma	Enrichment	BCL2	1.37
219	Lymphoma	Enrichment	TP53	1.37
220	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	LMNA	1.37
221	Acute megakaryocytic leukemia	Enrichment	TP53	1.37
222	Hemimegalencephaly	Enrichment	AKT3	1.37
223	Endometrial stromal sarcoma	Enrichment	YWHAE	1.37
224	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.30
225	Branchiootorenal syndrome 1	Enrichment	TJP2	1.30
226	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	LMNA	1.30
227	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.30
228	Patent ductus arteriosus	Enrichment	PSMC3	1.30
229	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.30
230	Familial hypercholanemia	Enrichment	TJP2	1.30
231	Kidney clear cell sarcoma	Enrichment	YWHAE	1.30
232	Cataract 6, multiple types	Enrichment	CHMP4B	1.28
233	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	1.28
234	Parkinson disease 2, autosomal recessive juvenile	Enrichment	PRKN	1.28
235	Parkin type of early-onset parkinson disease	Enrichment	PRKN	1.28
236	Autosomal dominant severe congenital neutropenia	Enrichment	ELANE	1.28
237	Esophageal cancer	Enrichment	TP53	1.23
238	Bethlem myopathy 1a	Enrichment	LMNA	1.23
239	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.23
240	Branchiootorenal syndrome	Enrichment	TJP2	1.23
241	Essential thrombocythemia	Enrichment	TP53	1.23
242	Megacolon	Enrichment	AKT3	1.23
243	Focal epilepsy	Enrichment	SPTAN1	1.23
244	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	STUB1	1.21
245	Glioma susceptibility 1	Enrichment	TP53	1.17
246	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.17
247	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.17
248	Congenital muscular dystrophy	Enrichment	LMNA	1.17
249	Myocarditis	Enrichment	LMNA	1.17
250	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.17
251	Isolated split hand-split foot malformation	Enrichment	SEM1	1.17
252	Male infertility due to globozoospermia	Enrichment	SEPTIN4	1.17
253	Semantic dementia	Enrichment	CHMP2B	1.14
254	Neutropenia	Enrichment	ELANE	1.14
255	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	GSDME, TJP2	1.13
256	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	LMNA	1.12
257	Primary hyperaldosteronism	Enrichment	TP53	1.12
258	Colonic benign neoplasm	Enrichment	APC	1.12
259	Primary biliary cholangitis	Enrichment	TJP2	1.12
260	Cowden syndrome	Enrichment	AKT1	1.12
261	Autosomal dominant cerebellar ataxia	Enrichment	OPA1	1.12
262	Early-onset posterior polar cataract	Enrichment	CHMP4B	1.09
263	Cataract 30, multiple types	Enrichment	VIM	1.08
264	Leukemia, chronic lymphocytic	Enrichment	TP53	1.08
265	Melanoma	Enrichment	CDKN2A	1.08
266	Familial colorectal cancer	Enrichment	TP53	1.08
267	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.04
268	Myelodysplastic syndrome	Enrichment	TP53	1.04
269	Progressive non-fluent aphasia	Enrichment	CHMP2B	1.04
270	Behavioral variant of frontotemporal dementia	Enrichment	CHMP2B	1.04
271	Cardiac conduction defect	Enrichment	LMNA	1.01
272	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	LMNA	1.01
273	Meningioma	Enrichment	AKT1	1.01
274	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	LMNA	1.01
275	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	LMNA	1.01
276	Inherited cancer-predisposing syndrome	Enrichment	APC, CDKN2A, TP53	0.98
277	Acute promyelocytic leukemia	Enrichment	STAT3	0.97
278	Lung non-small cell carcinoma	Enrichment	IRF1	0.96
279	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	LMNA	0.94
280	Early-onset parkinson's disease	Enrichment	PRKN	0.92
281	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	LMNA	0.89
282	Rhabdomyosarcoma	Enrichment	TP53	0.89
283	Gliosarcoma	Enrichment	TP53	0.89
284	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	0.86
285	Cardiomyopathy, dilated, 1e	Enrichment	LMNA	0.86
286	Polycystic liver disease	Enrichment	CTNNB1	0.86
287	Giant cell glioblastoma	Enrichment	TP53	0.86
288	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	0.86
289	Heart, malformation of	Enrichment	MAPK1	0.84
290	Patent foramen ovale	Enrichment	PSMC3	0.84
291	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	LMNA	0.82
292	Cardiomyopathy, dilated, 1a	Enrichment	LMNA	0.78
293	Centronuclear myopathy	Enrichment	OPA1	0.78
294	Myocardial infarction	Enrichment	PSMA6	0.76
295	Diamond-blackfan anemia 1	Enrichment	TP53	0.74
296	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A	0.74
297	Parkinson's disease	Enrichment	PRKN	0.74
298	Cardiomyopathy, familial hypertrophic, 1	Enrichment	LMNA	0.73
299	Muscular dystrophy	Enrichment	LMNA	0.73
300	Jeune thoracic dystrophy	Enrichment	SPTAN1	0.71
301	Brugada syndrome	Enrichment	LMNA	0.70
302	Auditory neuropathy	Enrichment	OPA1	0.70
303	Asphyxiating thoracic dystrophy	Enrichment	SPTAN1	0.67
304	Prostate cancer	Enrichment	TP53	0.65
305	Parkinson disease, late-onset	Enrichment	PRKN	0.65
306	Autoinflammatory disease	Enrichment	ELANE	0.65
307	Stargardt disease 1	Enrichment	OPA1	0.64
308	Long qt syndrome	Enrichment	LMNA	0.63
309	Peripheral nervous system disease	Enrichment	LMNA	0.62
310	Neuropathy	Enrichment	LMNA	0.62
311	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	SPTAN1	0.60
312	Left ventricular noncompaction	Enrichment	LMNA	0.58
313	Developmental and epileptic encephalopathy	Enrichment	SPTAN1	0.57
314	Diamond-blackfan anemia	Enrichment	TP53	0.57
315	Leukemia, acute myeloid	Enrichment	TP53	0.53
316	Charcot-marie-tooth disease	Enrichment	LMNA	0.52
317	Benign epilepsy with centrotemporal spikes	Enrichment	SPTAN1	0.52
318	Type 2 diabetes mellitus	Enrichment	AKT2	0.52
319	Hereditary spastic paraplegia	Enrichment	SPTAN1	0.52
320	Centralopathic epilepsy	Enrichment	SPTAN1	0.51
321	Optic atrophy plus syndrome	Enrichment	OPA1	0.50
322	West syndrome	Enrichment	SPTAN1	0.50
323	Systemic lupus erythematosus	Enrichment	UBE2L3	0.47
324	Body mass index quantitative trait locus 11	Enrichment	DNM1L	0.45
325	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	0.45
326	Spastic ataxia	Enrichment	SPTAN1	0.43
327	Familial isolated dilated cardiomyopathy	Enrichment	LMNA	0.43
328	Myeloma, multiple	Enrichment	TP53	0.41
329	Undetermined early-onset epileptic encephalopathy	Enrichment	YWHAG	0.41
330	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CHMP2B	0.34
331	Schizophrenia	Enrichment	PRKN	0.33
332	Rare genetic deafness	Enrichment	GSDME	0.30
333	Dilated cardiomyopathy	Enrichment	LMNA	0.30
334	Autism	Enrichment	PRKN	0.27
335	Congenital nervous system abnormality	Enrichment	CTNNB1	0.22
336	Nervous system disease	Enrichment	CTNNB1	0.22
337	Complex neurodevelopmental disorder	Enrichment	PSMD12	0.18
338	Autism spectrum disorder	Enrichment	PRKN	0.16
339	Hereditary retinal dystrophy	Enrichment	OPA1	0.04
340	Fundus dystrophy	Enrichment	OPA1	0.04

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Apoptosis

Pathway Network for Apoptosis

Pathway network for the Apoptosis SuperPath

Member Pathways for Apoptosis

Pathways in the Apoptosis SuperPath

Gene overlap in member pathways for Apoptosis SuperPath

Associated Genes for Apoptosis

Associated Disorders for Apoptosis

Disorders associated with Apoptosis SuperPath

STRING Interaction Network for Apoptosis

Sources for Apoptosis