Apoptosis-related network due to altered Notch3 in ovarian cancer

No Pathway Network information available for Apoptosis-related network due to altered Notch3 in ovarian cancer

Pathways in the Apoptosis-related network due to altered Notch3 in ovarian cancer SuperPath

#	Name	Source	Genes
1	Apoptosis-related network due to altered Notch3 in ovarian cancer	WikiPathways	ABL1 AKT1 ANXA5 APOE APP AXIN1 BEX3 BIRC5 CARD14 CASP7 CDKN1A CDKN1B CTNNA1 CUL1 CUL5 ERBB3 ERN1 ETS1 F2R GCLC HDAC1 HELLS HSPA5 HSPB1 HSPD1 IER3 IL7R JUND MAPK1 NET1 NFKB1 NQO1 NRG1 PAK2 PKN1 PTK2 PTK2B RIPK2 RNF7 RPS6KB1 SERBP1 SMAD7 SOCS3 SQSTM1 THBS1 TNF TNFRSF10B TNFRSF21 TRAF1 VAV3 VIM YBX3 (see all 52) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
2	SQSTM1	Sequestosome 1	Protein Coding	1
3	IER3	Immediate Early Response 3	Protein Coding	1
4	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	1
5	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	1
6	CUL1	Cullin 1	Protein Coding	1
7	CASP7	Caspase 7	Protein Coding	1
8	AXIN1	Axin 1	Protein Coding	1
9	CUL5	Cullin 5	Protein Coding	1
10	CARD14	Caspase Recruitment Domain Family Member 14	Protein Coding	1
11	VIM	Vimentin	Protein Coding	1
12	TRAF1	TNF Receptor Associated Factor 1	Protein Coding	1
13	TNF	Tumor Necrosis Factor	Protein Coding	1
14	THBS1	Thrombospondin 1	Protein Coding	1
15	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
16	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
17	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
18	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
19	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
20	SMAD7	SMAD Family Member 7	Protein Coding	1
21	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
22	IL7R	Interleukin 7 Receptor	Protein Coding	1
23	APP	Amyloid Beta Precursor Protein	Protein Coding	1
24	APOE	Apolipoprotein E	Protein Coding	1
25	HSPD1	Heat Shock Protein Family D (Hsp60) Member 1	Protein Coding	1
26	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
27	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
28	HSPA5	Heat Shock Protein Family A (Hsp70) Member 5	Protein Coding	1
29	NRG1	Neuregulin 1	Protein Coding	1
30	ANXA5	Annexin A5	Protein Coding	1
31	HELLS	Helicase, Lymphoid Specific	Protein Coding	1
32	HDAC1	Histone Deacetylase 1	Protein Coding	1
33	GCLC	Glutamate-Cysteine Ligase Catalytic Subunit	Protein Coding	1
34	TNFRSF21	TNF Receptor Superfamily Member 21	Protein Coding	1
35	SERBP1	SERPINE1 MRNA Binding Protein 1	Protein Coding	1
36	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
37	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
38	F2R	Coagulation Factor II Thrombin Receptor	Protein Coding	1
39	ETS1	ETS Proto-Oncogene 1, Transcription Factor	Protein Coding	1
40	ERN1	Endoplasmic Reticulum To Nucleus Signaling 1	Protein Coding	1
41	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
42	ERBB3	Erb-B2 Receptor Tyrosine Kinase 3	Protein Coding	1
43	NQO1	NAD(P)H Quinone Dehydrogenase 1	Protein Coding	1
44	CTNNA1	Catenin Alpha 1	Protein Coding	1
45	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
46	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
47	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
48	YBX3	Y-Box Binding Protein 3	Protein Coding	1
49	NET1	Neuroepithelial Cell Transforming 1	Protein Coding	1
50	PKN1	Protein Kinase N1	Protein Coding	1
51	RNF7	Ring Finger Protein 7	Protein Coding	1
52	BEX3	Brain Expressed X-Linked 3	Protein Coding	1

Disorders associated with Apoptosis-related network due to altered Notch3 in ovarian cancer SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Alzheimer's disease	Enrichment	APOE, APP, TNF	4.83
2	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	3.52
3	Alzheimer disease, familial, 1	Enrichment	APOE, APP	2.72
4	Erythroleukemia, familial	Enrichment	ERBB3	2.42
5	Proteus syndrome	Enrichment	AKT1	2.42
6	Pityriasis rubra pilaris	Enrichment	CARD14	2.42
7	Paget disease of bone 3	Enrichment	SQSTM1	2.42
8	Sea-blue histiocyte disease	Enrichment	APOE	2.42
9	Psoriasis 2	Enrichment	CARD14	2.42
10	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	2.42
11	Dermatitis, atopic, 4	Enrichment	SOCS3	2.42
12	Lipoprotein glomerulopathy	Enrichment	APOE	2.42
13	Lethal congenital contracture syndrome 2	Enrichment	ERBB3	2.42
14	Immunodeficiency-centromeric instability-facial anomalies syndrome 4	Enrichment	HELLS	2.42
15	Caudal duplication anomaly	Enrichment	AXIN1	2.42
16	Anemia, congenital, nonspherocytic hemolytic, 7	Enrichment	GCLC	2.42
17	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	2.42
18	Noonan syndrome 13	Enrichment	MAPK1	2.42
19	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	2.42
20	Knobloch syndrome 2	Enrichment	PAK2	2.42
21	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.42
22	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.42
23	Spastic paraplegia 13, autosomal dominant	Enrichment	HSPD1	2.42
24	Neuroendocrine tumor	Enrichment	CDKN1B	2.42
25	Cowden syndrome 6	Enrichment	AKT1	2.42
26	Colorectal cancer 3	Enrichment	SMAD7	2.42
27	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.42
28	T-b+ severe combined immunodeficiency due to il-7ralpha deficiency	Enrichment	IL7R	2.42
29	Premature aging	Enrichment	VIM	2.42
30	Bladder cancer	Enrichment	CDKN1A, ERBB3	2.26
31	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	2.12
32	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	ERBB3	2.12
33	Alzheimer disease 3	Enrichment	APOE	2.12
34	Leukodystrophy, hypomyelinating, 4	Enrichment	HSPD1	2.12
35	Welander distal myopathy	Enrichment	SQSTM1	2.12
36	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	2.12
37	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.12
38	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.12
39	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	2.12
40	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.12
41	Hyperlipoproteinemia, type iii	Enrichment	APOE	2.12
42	Immunodeficiency 127	Enrichment	TNF	2.12
43	Cataract 30	Enrichment	VIM	2.12
44	Immunodeficiency 104, severe combined	Enrichment	IL7R	2.12
45	Multiple sclerosis 3	Enrichment	IL7R	2.12
46	Paget's disease of bone	Enrichment	SQSTM1	2.12
47	Common variable immunodeficiency 12	Enrichment	NFKB1	2.12
48	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	2.12
49	Systemic lupus erythematosus	Enrichment	ETS1, TNF	2.01
50	Jacobsen syndrome	Enrichment	ETS1	1.94
51	Alzheimer disease 4	Enrichment	APOE	1.94
52	Psoriatic arthritis	Enrichment	TNF	1.94
53	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.94
54	Migraine without aura	Enrichment	TNF	1.94
55	Laryngeal squamous cell carcinoma	Enrichment	TNFRSF10B	1.94
56	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	1.94
57	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CTNNA1	1.82
58	Macular degeneration, age-related, 1	Enrichment	APOE	1.82
59	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	1.82
60	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	1.82
61	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.82
62	Pregnancy loss, recurrent 3	Enrichment	ANXA5	1.82
63	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.82
64	Knobloch syndrome	Enrichment	PAK2	1.82
65	Paget's disease of bone 2	Enrichment	SQSTM1	1.82
66	Cerebral malaria	Enrichment	TNF	1.82
67	Primary hyperparathyroidism	Enrichment	CDKN1B	1.82
68	Alzheimer disease 2	Enrichment	APOE	1.72
69	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.72
70	Knobloch syndrome 1	Enrichment	PAK2	1.72
71	Histiocytoid hemangioma	Enrichment	VIM	1.72
72	Vascular dementia	Enrichment	TNF	1.72
73	Mucopolysaccharidosis, type iiia	Enrichment	CARD14	1.64
74	Immunodeficiency-centromeric instability-facial anomalies syndrome	Enrichment	HELLS	1.64
75	Lipid metabolism disorder	Enrichment	APOE	1.64
76	Mucopolysaccharidosis iii	Enrichment	CARD14	1.64
77	Breast adenocarcinoma	Enrichment	AKT1	1.64
78	Squamous cell carcinoma, head and neck	Enrichment	TNFRSF10B	1.58
79	Leukemia, chronic myeloid	Enrichment	ABL1	1.58
80	Alzheimer's disease 1	Enrichment	APP	1.58
81	Common variable immunodeficiency	Enrichment	NFKB1	1.58
82	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	1.58
83	Moyamoya angiopathy	Enrichment	ABL1	1.58
84	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.58
85	Breast cancer	Enrichment	AKT1, IL7R	1.48
86	Adult hepatocellular carcinoma	Enrichment	AXIN1	1.47
87	Cowden syndrome	Enrichment	AKT1	1.47
88	Behavioral variant of frontotemporal dementia	Enrichment	SQSTM1	1.47
89	Cataract 30, multiple types	Enrichment	VIM	1.42
90	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1	1.42
91	Omenn syndrome	Enrichment	IL7R	1.42
92	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.42
93	Asthma	Enrichment	TNF	1.38
94	Specific learning disability	Enrichment	MAPK1	1.38
95	Colorectal cancer	Enrichment	AKT1, CTNNA1	1.36
96	Meningioma	Enrichment	AKT1	1.35
97	Lip and oral cavity carcinoma	Enrichment	ABL1	1.35
98	Heart disease	Enrichment	ABL1	1.28
99	Familial hypercholesterolemia	Enrichment	APOE	1.25
100	Ovarian cancer	Enrichment	AKT1, CDKN1B	1.24
101	Heart, malformation of	Enrichment	MAPK1	1.17
102	Leukodystrophy	Enrichment	HSPD1	1.13
103	Craniosynostosis	Enrichment	CTNNA1	1.13
104	Microcephaly	Enrichment	ABL1, MAPK1	1.09
105	Hepatocellular carcinoma	Enrichment	AXIN1	1.09
106	Myocardial infarction	Enrichment	GCLC	1.09
107	Malaria	Enrichment	TNF	1.07
108	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.07
109	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, CTNNA1	1.04
110	Hirschsprung disease 1	Enrichment	ERBB3	0.98
111	Cystic fibrosis	Enrichment	GCLC	0.94
112	Severe combined immunodeficiency	Enrichment	IL7R	0.92
113	Charcot-marie-tooth disease	Enrichment	HSPB1	0.84
114	Hereditary breast carcinoma	Enrichment	AKT1	0.81
115	Hereditary breast ovarian cancer syndrome	Enrichment	CTNNA1	0.72
116	Myeloma, multiple	Enrichment	IL7R	0.71
117	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SQSTM1	0.70
118	Primary ovarian insufficiency	Enrichment	THBS1	0.69
119	Hereditary retinal dystrophy	Enrichment	CTNNA1	0.17
120	Fundus dystrophy	Enrichment	CTNNA1	0.17

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Apoptosis-related network due to altered Notch3 in ovarian cancer

Pathway Network for Apoptosis-related network due to altered Notch3 in ovarian cancer

Member Pathways for Apoptosis-related network due to altered Notch3 in ovarian cancer

Pathways in the Apoptosis-related network due to altered Notch3 in ovarian cancer SuperPath

Associated Genes for Apoptosis-related network due to altered Notch3 in ovarian cancer

Associated Disorders for Apoptosis-related network due to altered Notch3 in ovarian cancer

Disorders associated with Apoptosis-related network due to altered Notch3 in ovarian cancer SuperPath

STRING Interaction Network for Apoptosis-related network due to altered Notch3 in ovarian cancer

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