Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2

No Pathway Network information available for Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2

Pathways in the Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 SuperPath

#	Name	Source	Genes
1	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2	GeneGo (Thomson Reuters)	BAX BCL2 CYCS ESR1 ESR2 FOS GUCY1A1 GUCY1A2 GUCY1B1 GUCY1B2 JUN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP3K5 MAPK1 MAPK14 MAPK3 MAPK8 MYC NFKB1 NOS1 PRKG1 RAF1 RELA SOD2 TXN (see all 28) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
2	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
3	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
4	ESR1	Estrogen Receptor 1	Protein Coding	1
5	ESR2	Estrogen Receptor 2	Protein Coding	1
6	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
7	GUCY1B2	Guanylate Cyclase 1 Soluble Subunit Beta 2 (Pseudogene)	Pseudogene	1
8	GUCY1A2	Guanylate Cyclase 1 Soluble Subunit Alpha 2	Protein Coding	1
9	GUCY1A1	Guanylate Cyclase 1 Soluble Subunit Alpha 1	Protein Coding	1
10	GUCY1B1	Guanylate Cyclase 1 Soluble Subunit Beta 1	Protein Coding	1
11	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
12	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
13	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
14	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
15	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
16	PRKG1	Protein Kinase CGMP-Dependent 1	Protein Coding	1
17	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
18	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
19	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
20	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
21	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
22	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
23	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
24	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
25	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
26	SOD2	Superoxide Dismutase 2	Protein Coding	1
27	TXN	Thioredoxin	Protein Coding	1
28	CYCS	Cytochrome C, Somatic	Protein Coding	1

Disorders associated with Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, MAP2K2, RAF1	5.45
2	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, MYC	4.91
3	Noonan syndrome 1	Enrichment	MAP2K1, MAP2K2, RAF1	4.87
4	Rasopathy	Enrichment	MAP2K1, MAP2K2, RAF1	4.70
5	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	4.61
6	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	4.61
7	Myocardial infarction	Enrichment	ESR1, GUCY1A1	3.03
8	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.69
9	Noonan syndrome 5	Enrichment	RAF1	2.69
10	Melorheostosis, isolated	Enrichment	MAP2K1	2.69
11	Microvascular complications of diabetes 6	Enrichment	SOD2	2.69
12	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.69
13	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.69
14	Aortic aneurysm, familial thoracic 8	Enrichment	PRKG1	2.69
15	Noonan syndrome 13	Enrichment	MAPK1	2.69
16	Thrombocytopenia 4	Enrichment	CYCS	2.69
17	Ovarian dysgenesis 8	Enrichment	ESR2	2.69
18	Melorheostosis	Enrichment	MAP2K1	2.69
19	Leopard syndrome 2	Enrichment	RAF1	2.69
20	Moyamoya disease 6 with or without achalasia	Enrichment	GUCY1A1	2.69
21	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.69
22	Moyamoya disease with early-onset achalasia	Enrichment	GUCY1A1	2.69
23	Trigonitis	Enrichment	RAF1	2.69
24	Burkitt lymphoma	Enrichment	MYC	2.38
25	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.38
26	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.38
27	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.38
28	Rela fusion-positive ependymoma	Enrichment	RELA	2.38
29	Common variable immunodeficiency 12	Enrichment	NFKB1	2.38
30	Tafro syndrome	Enrichment	MAP2K2	2.38
31	Thyroid carcinoma, familial medullary	Enrichment	ESR2	2.21
32	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.21
33	Estrogen resistance	Enrichment	ESR1	2.21
34	T-cell acute lymphoblastic leukemia	Enrichment	BAX	2.21
35	Migraine without aura	Enrichment	ESR1	2.21
36	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	2.08
37	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.08
38	Congenital generalized lipodystrophy	Enrichment	FOS	2.08
39	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	2.08
40	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.08
41	Idiopathic achalasia	Enrichment	NOS1	2.08
42	Follicular lymphoma	Enrichment	BCL2	1.99
43	Histiocytoid hemangioma	Enrichment	FOS	1.99
44	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.99
45	Breast cancer	Enrichment	ESR1, JUN	1.98
46	Moyamoya disease 1	Enrichment	GUCY1A1	1.91
47	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.84
48	Noonan syndrome 3	Enrichment	RAF1	1.84
49	Pilomyxoid astrocytoma	Enrichment	RAF1	1.84
50	Common variable immunodeficiency	Enrichment	NFKB1	1.84
51	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.79
52	Arteriovenous malformation	Enrichment	MAP2K1	1.73
53	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.69
54	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.69
55	Migraine with or without aura 1	Enrichment	ESR1	1.65
56	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.65
57	Specific learning disability	Enrichment	MAPK1	1.65
58	Heart, malformation of	Enrichment	MAPK1	1.44
59	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.33
60	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.31
61	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.18
62	Left ventricular noncompaction	Enrichment	RAF1	1.16
63	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	PRKG1	1.06
64	Hereditary breast carcinoma	Enrichment	ESR1	1.06
65	Thrombocytopenia	Enrichment	CYCS	1.02
66	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.98
67	Dilated cardiomyopathy	Enrichment	RAF1	0.82
68	Colorectal cancer	Enrichment	BAX	0.78
69	Autism spectrum disorder	Enrichment	MAP2K1	0.69
70	Microcephaly	Enrichment	MAPK1	0.65

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2

Pathway Network for Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2

Member Pathways for Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2

Pathways in the Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 SuperPath

Associated Genes for Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2

Associated Disorders for Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2

Disorders associated with Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 SuperPath

STRING Interaction Network for Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2

Sources for Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2