Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

No Pathway Network information available for Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

Pathways in the Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway SuperPath

#	Name	Source	Genes
1	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway	GeneGo (Thomson Reuters)	BCL2 BCL2A1 BCL2L1 CD40 CD40LG CHUK IKBKB IKBKG IRAK1 IRAK2 MAP3K14 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NGF NGFR PRKCZ REL RELA RELB RIPK1 SQSTM1 TNF TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF17 TNFRSF1A TNFRSF1B TNFRSF4 TNFSF11 TNFSF12 TNFSF13 TNFSF13B TNFSF4 TRADD TRAF2 TRAF3 TRAF5 TRAF6 (see all 42) (see less)
2	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway	GeneGo (Thomson Reuters)	BIRC2 BIRC3 BIRC5 CHUK IKBKB IKBKG MAP3K14 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE REL RELA RELB RIPK1 TNF TNFRSF13B TNFRSF17 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF8 TNFSF13 TNFSF15 TNFSF8 TRADD TRAF2 TRAF3 TRAF5 XIAP (see all 31) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TNFRSF17	TNF Receptor Superfamily Member 17	Protein Coding	2
2	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
3	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
4	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
5	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	2
6	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
7	NFKBIB	NFKB Inhibitor Beta	Protein Coding	2
8	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	2
9	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	2
10	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
11	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	2
12	TNF	Tumor Necrosis Factor	Protein Coding	2
13	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	2
14	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	2
15	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	2
16	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	2
17	TRAF5	TNF Receptor Associated Factor 5	Protein Coding	2
18	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
19	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	2
20	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	2
21	TNFSF13	TNF Superfamily Member 13	Protein Coding	2
22	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	2
23	TNFRSF13B	TNF Receptor Superfamily Member 13B	Protein Coding	2
24	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
25	BCL2A1	BCL2 Related Protein A1	Protein Coding	1
26	BCL2L1	BCL2 Like 1	Protein Coding	1
27	CD40	CD40 Molecule	Protein Coding	1
28	CD40LG	CD40 Ligand	Protein Coding	1
29	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	1
30	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	1
31	NGF	Nerve Growth Factor	Protein Coding	1
32	NGFR	Nerve Growth Factor Receptor	Protein Coding	1
33	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
34	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
35	TNFSF4	TNF Superfamily Member 4	Protein Coding	1
36	TNFRSF4	TNF Receptor Superfamily Member 4	Protein Coding	1
37	TNFSF11	TNF Superfamily Member 11	Protein Coding	1
38	TNFSF12	TNF Superfamily Member 12	Protein Coding	1
39	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	1
40	SQSTM1	Sequestosome 1	Protein Coding	1
41	TNFSF13B	TNF Superfamily Member 13b	Protein Coding	1
42	TNFRSF12A	TNF Receptor Superfamily Member 12A	Protein Coding	1
43	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	1
44	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	1
45	XIAP	X-Linked Inhibitor Of Apoptosis	Protein Coding	1
46	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
47	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	1
48	TNFSF8	TNF Superfamily Member 8	Protein Coding	1
49	TNFRSF25	TNF Receptor Superfamily Member 25	Protein Coding	1
50	TNFSF15	TNF Superfamily Member 15	Protein Coding	1

Disorders associated with Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Common variable immunodeficiency	Enrichment	CD40LG, NFKB1, NFKB2, TNFRSF13B	8.56
2	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	5.30
3	Immunodeficiency, common variable, 1	Enrichment	NFKB2, TNFRSF13B	4.52
4	Paget disease of bone 2, early-onset	Enrichment	SQSTM1, TNFRSF11A	4.25
5	Paget's disease of bone 2	Enrichment	SQSTM1, TNFRSF11A	4.25
6	Systemic lupus erythematosus	Enrichment	IRAK1, TNF, TNFSF4	3.63
7	Malaria	Enrichment	IKBKG, TNF	2.91
8	Autoinflammatory disease	Enrichment	TNFRSF1A, XIAP	2.87
9	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.64
10	Immune deficiency, familial variable	Enrichment	TNFRSF13B	2.64
11	Incontinentia pigmenti	Enrichment	IKBKG	2.64
12	Lymphoproliferative syndrome, x-linked, 2	Enrichment	XIAP	2.64
13	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.64
14	Fetal encasement syndrome	Enrichment	CHUK	2.64
15	Immunodeficiency 15b	Enrichment	IKBKB	2.64
16	Immunodeficiency 15a	Enrichment	IKBKB	2.64
17	Immunodeficiency 92	Enrichment	REL	2.64
18	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.64
19	Immunodeficiency 132a	Enrichment	TRAF3	2.64
20	Immunodeficiency 132b	Enrichment	TRAF3	2.64
21	Immunoglobulin a deficiency 2	Enrichment	TNFRSF13B	2.64
22	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.64
23	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.64
24	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.64
25	Immunodeficiency 53	Enrichment	RELB	2.64
26	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.64
27	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.64
28	Immunodeficiency 112	Enrichment	MAP3K14	2.64
29	Common variable immunodeficiency phenotype due to homozygous taci deficiency	Enrichment	TNFRSF13B	2.64
30	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.64
31	Nik deficiency	Enrichment	MAP3K14	2.64
32	Paget disease of bone 3	Enrichment	SQSTM1	2.51
33	Osteopetrosis, autosomal recessive 7	Enrichment	TNFRSF11A	2.51
34	Immunodeficiency 16	Enrichment	TNFRSF4	2.51
35	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	2.51
36	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	2.51
37	Immunodeficiency with hyper-igm, type 1	Enrichment	CD40LG	2.51
38	Immunodeficiency with hyper-igm, type 3	Enrichment	CD40	2.51
39	Cd40 ligand deficiency	Enrichment	CD40LG	2.51
40	Common variable immunodeficiency phenotype due to tweak deficiency	Enrichment	TNFSF12	2.51
41	Immunodeficiency, common variable, 2	Enrichment	TNFRSF13B	2.34
42	Immunodeficiency 33	Enrichment	IKBKG	2.34
43	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.34
44	Immunodeficiency with hyper-igm, type 2	Enrichment	TNFRSF13B	2.34
45	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.34
46	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.34
47	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.34
48	Immunodeficiency 127	Enrichment	TNF	2.34
49	Rela fusion-positive ependymoma	Enrichment	RELA	2.34
50	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.34
51	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.34
52	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.34
53	Common variable immunodeficiency 12	Enrichment	NFKB1	2.34
54	Familial expansile osteolysis	Enrichment	TNFRSF11A	2.21
55	Paget disease of bone 5, juvenile-onset	Enrichment	TNFRSF11A	2.21
56	Welander distal myopathy	Enrichment	SQSTM1	2.21
57	Osteopetrosis, autosomal recessive 2	Enrichment	TNFSF11	2.21
58	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	2.21
59	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.21
60	Paget's disease of bone	Enrichment	SQSTM1	2.21
61	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	2.21
62	Mycosis fungoides	Enrichment	TNFRSF1B	2.16
63	Psoriatic arthritis	Enrichment	TNF	2.16
64	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.16
65	Migraine without aura	Enrichment	TNF	2.16
66	Saczary syndrome	Enrichment	TNFRSF1B	2.16
67	Lymphoproliferative syndrome 2	Enrichment	XIAP	2.04
68	Cerebral malaria	Enrichment	TNF	2.04
69	Dysosteosclerosis	Enrichment	TNFRSF11A	2.03
70	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.03
71	Adult-onset myasthenia gravis	Enrichment	TNFRSF11A	2.03
72	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	1.94
73	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.94
74	Vascular dementia	Enrichment	TNF	1.94
75	Herpes simplex virus encephalitis	Enrichment	TRAF3	1.94
76	Autosomal recessive osteopetrosis	Enrichment	TNFSF11	1.91
77	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	1.91
78	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.87
79	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.87
80	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.81
81	Follicular lymphoma	Enrichment	BCL2	1.81
82	Charge syndrome	Enrichment	TNFRSF1A	1.69
83	Coronary heart disease 5	Enrichment	IKBKG	1.69
84	Primary biliary cholangitis	Enrichment	TNFSF15	1.69
85	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF	1.67
86	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.65
87	Narcolepsy 1	Enrichment	TNFSF4	1.61
88	Immune deficiency disease	Enrichment	RIPK1	1.60
89	Asthma	Enrichment	TNF	1.60
90	Behavioral variant of frontotemporal dementia	Enrichment	SQSTM1	1.56
91	Alzheimer's disease	Enrichment	TNF	1.53
92	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1	1.52
93	Multiple sclerosis	Enrichment	TNFRSF1A	1.50
94	Gliosarcoma	Enrichment	NFKBIA	1.44
95	Giant cell glioblastoma	Enrichment	NFKBIA	1.42
96	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.40
97	Behcet syndrome	Enrichment	TNFRSF1A	1.37
98	Multisystem inflammatory syndrome in children	Enrichment	TRAF3	1.31
99	Myocardial infarction	Enrichment	TNFSF4	1.18
100	Severe combined immunodeficiency	Enrichment	IKBKB	1.14
101	Peripheral nervous system disease	Enrichment	NGF	1.02
102	Neuropathy	Enrichment	NGF	1.02
103	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	0.93
104	Myeloma, multiple	Enrichment	TRAF5	0.92
105	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SQSTM1	0.78

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

Pathway Network for Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

Member Pathways for Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

Pathways in the Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway SuperPath

Associated Genes for Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

Associated Disorders for Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

Disorders associated with Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway SuperPath

STRING Interaction Network for Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

Sources for Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway