Apoptosis and survival FAS signaling cascades

Pathway network for the Apoptosis and survival FAS signaling cascades SuperPath

Sources:

GeneGo (Thomson Reuters)
PubChem
QIAGEN
WikiPathways

Pathways in the Apoptosis and survival FAS signaling cascades SuperPath

#	Name	Source	Genes
1	Apoptosis and survival FAS signaling cascades	GeneGo (Thomson Reuters)	APAF1 BABAM2 BAX BCL2 BCL2L11 BID BIRC2 BMF CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CFLAR CRADD CYCS DAXX DFFA DFFB DIABLO FADD FAS FASLG HSPB1 HTRA2 LMNA LMNB1 LMNB2 MAP2K4 MAP3K1 MAP3K5 MAPK10 MAPK8 MAPK9 NUMA1 PAK2 PARP1 RIPK1 SUMO1 TNFRSF6B XIAP (see all 44) (see less)
2	Caspase Cascade in Apoptosis	PubChem	ACTA1 AKT1 APAF1 APP ARHGDIB BAX BCL2 BCL2L1 BID BIRC3 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CFL2 CRADD CYCS DFFA DFFB DIABLO FADD FAS FASLG GAS2 GSN GZMB KRT18 LIMK1 MADD MAP3K1 NUMA1 PARP1 PIDD1 PRF1 PTK2 RIPK1 SATB1 SPTAN1 SREBF1 TFAP2A TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFSF10 TOP1 TRADD TRAF2 VIM XIAP (see all 53) (see less)
3	Fas Signaling	QIAGEN	APAF1 ARHGDIB BID BIRC2 BIRC3 BTK CASP1 CASP10 CASP2 CASP3 CASP7 CASP8 CASP8AP2 CASP9 CFLAR CHUK CRADD CYCS DAXX DFFA FADD FAS FASLG IKBKB IKBKE IKBKG JUN LMNA LMNB1 LMNB2 MAP2K1 MAP2K4 MAP3K14 MAP3K5 MAPK3 MAPK8 NFKB1 PAK1 PAK2 PARP1 PRKDC RAF1 RB1 RIPK2 SMPD1 SMPD2 SMPD3 SUMO1 TNFRSF6B TRAF1 TRAF2 UBE2I (see all 52) (see less)
4	Fas ligand pathway and stress induction of heat shock proteins	WikiPathways	ACTA1 ACTB ACTG1 APAF1 ARHGDIB BCL2 CASP10 CASP3 CASP6 CASP7 CASP8 CASP9 CFLAR CYCS DAXX DFFA DFFB FADD FAF1 FAS FASLG HSPB1 IL1A JUN LMNA LMNB1 LMNB2 MAP2K4 MAP3K1 MAP3K7 MAPK8 MAPKAPK2 MAPKAPK3 NFX1 PAK1 PAK2 PARP1 PRKDC RB1 RIPK2 SPTAN1 TNF (see all 42) (see less)
5	Apoptosis and survival Caspase cascade	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 APAF1 BAX BID CASP10 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP9 CRADD CYCS DFFA DFFB FADD FAS FASLG IGF1 IGF1R IRS1 LMNA LMNB1 LMNB2 NUMA1 PARP1 RIPK1 TNF TNFRSF1A TRADD XIAP (see all 34) (see less)

Gene overlap in member pathways for Apoptosis and survival FAS signaling cascades SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	5
2	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	5
3	FAS	Fas Cell Surface Death Receptor	Protein Coding	5
4	FASLG	Fas Ligand	Protein Coding	5
5	CASP3	Caspase 3	Protein Coding	5
6	CASP7	Caspase 7	Protein Coding	5
7	CASP8	Caspase 8	Protein Coding	5
8	CASP9	Caspase 9	Protein Coding	5
9	CASP10	Caspase 10	Protein Coding	5
10	DFFA	DNA Fragmentation Factor Subunit Alpha	Protein Coding	5
11	FADD	Fas Associated Via Death Domain	Protein Coding	5
12	CYCS	Cytochrome C, Somatic	Protein Coding	5
13	BID	BH3 Interacting Domain Death Agonist	Protein Coding	4
14	CASP2	Caspase 2	Protein Coding	4
15	CASP6	Caspase 6	Protein Coding	4
16	DFFB	DNA Fragmentation Factor Subunit Beta	Protein Coding	4
17	LMNA	Lamin A/C	Protein Coding	4
18	LMNB1	Lamin B1	Protein Coding	4
19	CRADD	CARD And Death Domain Containing Adaptor Protein	Protein Coding	4
20	LMNB2	Lamin B2	Protein Coding	4
21	XIAP	X-Linked Inhibitor Of Apoptosis	Protein Coding	3
22	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	3
23	BCL2	BCL2 Apoptosis Regulator	Protein Coding	3
24	DAXX	Death Domain Associated Protein	Protein Coding	3
25	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	3
26	NUMA1	Nuclear Mitotic Apparatus Protein 1	Protein Coding	3
27	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	3
28	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	3
29	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	3
30	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	3
31	CFLAR	CASP8 And FADD Like Apoptosis Regulator	Protein Coding	3
32	ARHGDIB	Rho GDP Dissociation Inhibitor Beta	Protein Coding	3
33	TNF	Tumor Necrosis Factor	Protein Coding	3
34	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	2
35	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	2
36	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	2
37	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	2
38	TNFRSF6B	TNF Receptor Superfamily Member 6b	Protein Coding	2
39	CASP8AP2	Caspase 8 Associated Protein 2	Protein Coding	2
40	DIABLO	Diablo IAP-Binding Mitochondrial Protein	Protein Coding	2
41	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	2
42	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	2
43	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	2
44	SPTAN1	Spectrin Alpha, Non-Erythrocytic 1	Protein Coding	2
45	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	2
46	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	2
47	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
48	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
49	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
50	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	2
51	RB1	RB Transcriptional Corepressor 1	Protein Coding	2
52	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	2
53	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
54	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
55	BABAM2	BRISC And BRCA1 A Complex Member 2	Protein Coding	1
56	BCL2L11	BCL2 Like 11	Protein Coding	1
57	HTRA2	HtrA Serine Peptidase 2	Protein Coding	1
58	BMF	Bcl2 Modifying Factor	Protein Coding	1
59	KRT18	Keratin 18	Protein Coding	1
60	CFL2	Cofilin 2	Protein Coding	1
61	MADD	MAP Kinase Activating Death Domain	Protein Coding	1
62	PRF1	Perforin 1	Protein Coding	1
63	PIDD1	P53-Induced Death Domain Protein 1	Protein Coding	1
64	TNFSF10	TNF Superfamily Member 10	Protein Coding	1
65	GAS2	Growth Arrest Specific 2	Protein Coding	1
66	SATB1	SATB Homeobox 1	Protein Coding	1
67	VIM	Vimentin	Protein Coding	1
68	GSN	Gelsolin	Protein Coding	1
69	GZMB	Granzyme B	Protein Coding	1
70	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	1
71	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	1
72	TFAP2A	Transcription Factor AP-2 Alpha	Protein Coding	1
73	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
74	LIMK1	LIM Domain Kinase 1	Protein Coding	1
75	APP	Amyloid Beta Precursor Protein	Protein Coding	1
76	TOP1	DNA Topoisomerase I	Protein Coding	1
77	BCL2L1	BCL2 Like 1	Protein Coding	1
78	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	1
79	BTK	Bruton Tyrosine Kinase	Protein Coding	1
80	CASP1	Caspase 1	Protein Coding	1
81	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
82	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
83	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	1
84	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
85	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
86	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
87	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
88	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
89	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
90	SMPD1	Sphingomyelin Phosphodiesterase 1	Protein Coding	1
91	SMPD2	Sphingomyelin Phosphodiesterase 2	Protein Coding	1
92	SMPD3	Sphingomyelin Phosphodiesterase 3	Protein Coding	1
93	TRAF1	TNF Receptor Associated Factor 1	Protein Coding	1
94	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	1
95	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	1
96	ACTG1	Actin Gamma 1	Protein Coding	1
97	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
98	ACTB	Actin Beta	Protein Coding	1
99	IL1A	Interleukin 1 Alpha	Protein Coding	1
100	FAF1	Fas Associated Factor 1	Protein Coding	1
101	NFX1	Nuclear Transcription Factor, X-Box Binding 1	Protein Coding	1
102	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
103	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
104	CASP4	Caspase 4	Protein Coding	1
105	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
106	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
107	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
108	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1

Disorders associated with Apoptosis and survival FAS signaling cascades SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10, FAS, FASLG	7.24
2	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	5.03
3	Neuromuscular disease	Enrichment	ACTA1, LMNA, SPTAN1	4.66
4	Insulin-like growth factor i	Enrichment	IGF1, IGF1R	4.22
5	Lung cancer	Enrichment	CASP8, FAS, FASLG	4.17
6	Autoinflammatory disease	Enrichment	PRF1, TNFRSF1A, XIAP	3.97
7	Typical nemaline myopathy	Enrichment	ACTA1, CFL2	3.65
8	Lymphoma, non-hodgkin, familial	Enrichment	CASP10, PRF1	3.38
9	Behcet syndrome	Enrichment	FAS, TNFRSF1A	2.99
10	Alzheimer's disease	Enrichment	APP, TNF	2.94
11	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, RAF1	2.83
12	Malaria	Enrichment	MAPKAPK3, TNF	2.64
13	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.60
14	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, typical	Enrichment	LMNB1	2.60
15	Proteus syndrome	Enrichment	AKT1	2.60
16	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.60
17	Lymphoproliferative syndrome, x-linked, 2	Enrichment	XIAP	2.60
18	Caspase 8 deficiency	Enrichment	CASP8	2.60
19	Adult onset demyelinating leukodystrophy	Enrichment	LMNB1	2.60
20	Epilepsy, progressive myoclonic, 9	Enrichment	LMNB2	2.60
21	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.60
22	Thrombocytopenia 4	Enrichment	CYCS	2.60
23	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	2.60
24	Lipodystrophy, partial, acquired	Enrichment	LMNB2	2.60
25	Intellectual developmental disorder, autosomal recessive 34, with variant lissencephaly	Enrichment	CRADD	2.60
26	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.60
27	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.60
28	Cowden syndrome 6	Enrichment	AKT1	2.60
29	Microcephaly 26, primary, autosomal dominant	Enrichment	LMNB1	2.60
30	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.60
31	Atypical werner syndrome	Enrichment	LMNA	2.60
32	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.60
33	Microcephaly 27, primary, autosomal dominant	Enrichment	LMNB2	2.60
34	Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly	Enrichment	CASP2	2.60
35	Mandibuloacral dysplasia	Enrichment	LMNA	2.60
36	Atrioventricular block	Enrichment	LMNA	2.60
37	Capillary hemangioma	Enrichment	AKT3	2.60
38	Lmna-related cardiocutaneous progeria syndrome	Enrichment	LMNA	2.60
39	Autosomal semi-dominant severe lipodystrophic laminopathy	Enrichment	LMNA	2.60
40	Autosomal recessive axonal hereditary motor and sensory neuropathy	Enrichment	LMNA	2.60
41	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.60
42	Laminopathy	Enrichment	LMNA	2.60
43	Centronuclear myopathy	Enrichment	ACTA1, CFL2	2.52
44	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.51
45	Baraitser-winter syndrome 1	Enrichment	ACTB	2.51
46	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.51
47	Developmental and epileptic encephalopathy 5	Enrichment	SPTAN1	2.51
48	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.51
49	46,xy sex reversal 6	Enrichment	MAP3K1	2.51
50	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.51
51	Knobloch syndrome 2	Enrichment	PAK2	2.51
52	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.51
53	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.51
54	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.51
55	Becker nevus syndrome	Enrichment	ACTB	2.51
56	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.51
57	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.51
58	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	2.51
59	Macular dystrophy, patterned, 3	Enrichment	MAPKAPK3	2.51
60	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.51
61	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.51
62	Trilateral retinoblastoma	Enrichment	RB1	2.51
63	Spastic paraplegia 91, autosomal dominant, with or without cerebellar ataxia	Enrichment	SPTAN1	2.51
64	Developmental delay with or without epilepsy	Enrichment	SPTAN1	2.51
65	Baraitser-winter syndrome	Enrichment	ACTB	2.51
66	Neuronopathy, distal hereditary motor, autosomal dominant 11	Enrichment	SPTAN1	2.51
67	Zebra body myopathy	Enrichment	ACTA1	2.51
68	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.51
69	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.51
70	Actin-accumulation myopathy	Enrichment	ACTA1	2.51
71	Lung oat cell carcinoma	Enrichment	RB1	2.51
72	Parkinson disease 13, autosomal dominant	Enrichment	HTRA2	2.49
73	Orofacial cleft 10	Enrichment	SUMO1	2.49
74	Noonan syndrome 1	Enrichment	MAP2K1, RAF1	2.46
75	Cardiomyopathy, familial hypertrophic, 1	Enrichment	LMNA, RAF1	2.42
76	Incontinentia pigmenti	Enrichment	IKBKG	2.42
77	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.42
78	Noonan syndrome 5	Enrichment	RAF1	2.42
79	Melorheostosis, isolated	Enrichment	MAP2K1	2.42
80	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.42
81	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.42
82	Fetal encasement syndrome	Enrichment	CHUK	2.42
83	Immunodeficiency 15b	Enrichment	IKBKB	2.42
84	Immunodeficiency 15a	Enrichment	IKBKB	2.42
85	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.42
86	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.42
87	Melorheostosis	Enrichment	MAP2K1	2.42
88	Leopard syndrome 2	Enrichment	RAF1	2.42
89	Acid sphingomyelinase deficiency	Enrichment	SMPD1	2.42
90	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.42
91	Trigonitis	Enrichment	RAF1	2.42
92	Immunodeficiency 112	Enrichment	MAP3K14	2.42
93	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.42
94	Nik deficiency	Enrichment	MAP3K14	2.42
95	Hemophagocytic lymphohistiocytosis, familial, 2	Enrichment	PRF1	2.41
96	Amyloidosis, finnish type	Enrichment	GSN	2.41
97	Mucoepithelial dysplasia, hereditary	Enrichment	SREBF1	2.41
98	Developmental delay with dysmorphic facies and dental anomalies	Enrichment	SATB1	2.41
99	Deafness, autosomal recessive 125	Enrichment	GAS2	2.41
100	Deeah syndrome	Enrichment	MADD	2.41
101	Ifap syndrome 2	Enrichment	SREBF1	2.41
102	Nemaline myopathy 7	Enrichment	CFL2	2.41
103	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.41
104	Neurodevelopmental disorder with dysmorphic facies, impaired speech, and hypotonia	Enrichment	MADD	2.41
105	Den hoed-de boer-voisin syndrome	Enrichment	SATB1	2.41
106	Intellectual developmental disorder, autosomal recessive 75, with neuropsychiatric features and variant lissencephaly	Enrichment	PIDD1	2.41
107	Premature aging	Enrichment	VIM	2.41
108	Fatal post-viral neurodegenerative disorder	Enrichment	PRF1	2.41
109	Intellectual disability-acpilepsy-dental anomalies-facial dysmorphism syndrome	Enrichment	SATB1	2.41
110	Rasopathy	Enrichment	MAP2K1, RAF1	2.35
111	Type 2 diabetes mellitus	Enrichment	AKT2, IRS1	2.31
112	Mandibuloacral dysplasia with type a lipodystrophy	Enrichment	LMNA	2.30
113	Lipomatosis, multiple symmetric, with or without axonal peripheral neuropathy	Enrichment	LMNB2	2.30
114	Heart-hand syndrome, slovenian type	Enrichment	LMNA	2.30
115	Charcot-marie-tooth disease, axonal, type 2b1	Enrichment	LMNA	2.30
116	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	Enrichment	LMNA	2.30
117	Cardiomyopathy, dilated, 1d	Enrichment	LMNA	2.30
118	Restrictive dermopathy 2	Enrichment	LMNA	2.30
119	Emery-dreifuss muscular dystrophy 3, autosomal recessive	Enrichment	LMNA	2.30
120	Immunodeficiency 127	Enrichment	TNF	2.30
121	Senior-loken syndrome 7	Enrichment	AKT3	2.30
122	Lipodystrophy, familial partial, type 1	Enrichment	LMNA	2.30
123	Autosomal dominant primary microcephaly	Enrichment	LMNB1	2.30
124	Bardet-biedl syndrome 16	Enrichment	AKT3	2.30
125	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.30
126	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.30
127	Familial partial lipodystrophy	Enrichment	LMNA	2.30
128	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	2.30
129	Charcot-marie-tooth disease type 2b1	Enrichment	LMNA	2.30
130	Oculootodental syndrome	Enrichment	FADD	2.30
131	Intellectual developmental disorder, x-linked, syndromic, raymond type	Enrichment	SPTAN1	2.21
132	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.21
133	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	2.21
134	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.21
135	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.21
136	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.21
137	Familial retinoblastoma	Enrichment	RB1	2.21
138	Deafness, autosomal dominant 64	Enrichment	DIABLO	2.19
139	Charcot-marie-tooth disease	Enrichment	HSPB1, LMNA	2.15
140	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	2.12
141	Restrictive dermopathy 1	Enrichment	LMNA	2.12
142	Psoriatic arthritis	Enrichment	TNF	2.12
143	Lipodystrophy, familial partial, type 2	Enrichment	LMNA	2.12
144	Muscular dystrophy, congenital, lmna-related	Enrichment	LMNA	2.12
145	T-cell acute lymphoblastic leukemia	Enrichment	BAX	2.12
146	Migraine without aura	Enrichment	TNF	2.12
147	Restrictive dermopathy	Enrichment	LMNA	2.12
148	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	2.12
149	Vogt-koyanagi-harada disease	Enrichment	FAS	2.12
150	Immunodeficiency 33	Enrichment	IKBKG	2.12
151	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	2.12
152	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.12
153	Agammaglobulinemia, x-linked	Enrichment	BTK	2.12
154	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.12
155	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.12
156	Common variable immunodeficiency 12	Enrichment	NFKB1	2.12
157	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	2.11
158	Hyperaldosteronism, familial, type ii	Enrichment	SATB1	2.11
159	Cataract 30	Enrichment	VIM	2.11
160	Esotropia	Enrichment	TFAP2A	2.11
161	Lens subluxation	Enrichment	TFAP2A	2.11
162	Left ventricular noncompaction	Enrichment	LMNA, RAF1	2.10
163	Retinoblastoma	Enrichment	RB1	2.03
164	Osteogenic sarcoma	Enrichment	RB1	2.03
165	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.03
166	Short-rib thoracic dysplasia 11 with or without polydactyly	Enrichment	SPTAN1	2.03
167	Hypotrichosis 8	Enrichment	RB1	2.03
168	Bacteremia 2	Enrichment	MAPKAPK3	2.03
169	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.03
170	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.03
171	Squamous cell carcinoma	Enrichment	RB1	2.03
172	Bone osteosarcoma	Enrichment	RB1	2.03
173	Hutchinson-gilford progeria syndrome	Enrichment	LMNA	2.00
174	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	LMNA	2.00
175	Microtia-anotia	Enrichment	LMNA	2.00
176	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.00
177	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.00
178	Lymphoproliferative syndrome 2	Enrichment	XIAP	2.00
179	Emery-dreifuss muscular dystrophy	Enrichment	LMNA	2.00
180	Sick sinus syndrome	Enrichment	LMNA	2.00
181	Cerebral malaria	Enrichment	TNF	2.00
182	Niemann-pick disease, type a	Enrichment	SMPD1	1.94
183	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.94
184	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.94
185	Niemann-pick disease, type b	Enrichment	SMPD1	1.94
186	Agammaglobulinemia 1	Enrichment	BTK	1.94
187	Ceroid lipofuscinosis, neuronal, 6a	Enrichment	SMPD1	1.94
188	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	SREBF1	1.93
189	Laryngeal squamous cell carcinoma	Enrichment	TNFRSF10B	1.93
190	Cryptogenic cirrhosis	Enrichment	KRT18	1.93
191	Small cell cancer of the lung	Enrichment	RB1	1.91
192	Nemaline myopathy 2	Enrichment	ACTA1	1.91
193	Aminoacylase 1 deficiency	Enrichment	ACTB	1.91
194	Lynch syndrome 4	Enrichment	RB1	1.91
195	Tuberculosis	Enrichment	MAPKAPK3	1.91
196	Charcot-marie-tooth hereditary neuropathy	Enrichment	SPTAN1	1.91
197	Knobloch syndrome	Enrichment	PAK2	1.91
198	Intermediate nemaline myopathy	Enrichment	ACTA1	1.91
199	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.91
200	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	LMNA	1.90
201	Histiocytoid hemangioma	Enrichment	LMNA	1.90
202	Vascular dementia	Enrichment	TNF	1.90
203	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.90
204	Hemimegalencephaly	Enrichment	AKT3	1.90
205	3-methylglutaconic aciduria, type viii	Enrichment	HTRA2	1.89
206	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	LMNA	1.83
207	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.83
208	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.83
209	Breast adenocarcinoma	Enrichment	AKT1	1.83
210	Breast cancer	Enrichment	AKT1, CASP8	1.82
211	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	1.82
212	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	1.82
213	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.82
214	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.81
215	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.81
216	Knobloch syndrome 1	Enrichment	PAK2	1.81
217	Follicular lymphoma	Enrichment	BCL2	1.81
218	Coloboma of choroid and retina	Enrichment	ACTG1	1.81
219	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.81
220	Branchiooculofacial syndrome	Enrichment	TFAP2A	1.81
221	Bethlem myopathy 1a	Enrichment	LMNA	1.76
222	Megacolon	Enrichment	AKT3	1.76
223	Familial isolated dilated cardiomyopathy	Enrichment	LMNA, RAF1	1.76
224	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	1.72
225	Niemann-pick disease, type c1	Enrichment	SMPD1	1.72
226	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.72
227	Niemann-pick disease	Enrichment	SMPD1	1.72
228	Hemophagocytic lymphohistiocytosis, familial, 1	Enrichment	PRF1	1.71
229	Amblyopia	Enrichment	TFAP2A	1.71
230	Multiple acyl-coa dehydrogenase deficiency, severe neonatal type	Enrichment	MADD	1.71
231	Idiopathic aplastic anemia	Enrichment	PRF1	1.71
232	Congenital muscular dystrophy	Enrichment	LMNA	1.70
233	Myocarditis	Enrichment	LMNA	1.70
234	Colorectal cancer	Enrichment	AKT1, BAX	1.70
235	Focal epilepsy	Enrichment	SPTAN1	1.67
236	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.67
237	Charge syndrome	Enrichment	TNFRSF1A	1.65
238	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	LMNA	1.65
239	Adult hepatocellular carcinoma	Enrichment	CASP8	1.65
240	Cowden syndrome	Enrichment	AKT1	1.65
241	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	CRADD	1.65
242	Branchiootorenal syndrome 1	Enrichment	TFAP2A	1.63
243	Polymicrogyria	Enrichment	AKT3	1.61
244	Dilated cardiomyopathy	Enrichment	ACTA1, LMNA	1.60
245	Lennox-gastaut syndrome	Enrichment	MAPK10	1.59
246	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.58
247	Noonan syndrome 3	Enrichment	RAF1	1.58
248	Pilomyxoid astrocytoma	Enrichment	RAF1	1.58
249	Common variable immunodeficiency	Enrichment	NFKB1	1.58
250	Squamous cell carcinoma, head and neck	Enrichment	TNFRSF10B	1.57
251	Alzheimer's disease 1	Enrichment	APP	1.57
252	Branchiootorenal syndrome	Enrichment	TFAP2A	1.57
253	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	1.57
254	Immune deficiency disease	Enrichment	RIPK1	1.56
255	Asthma	Enrichment	TNF	1.56
256	Cardiac conduction defect	Enrichment	LMNA	1.53
257	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	LMNA	1.53
258	Meningioma	Enrichment	AKT1	1.53
259	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	LMNA	1.53
260	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	LMNA	1.53
261	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.52
262	Cat eye syndrome	Enrichment	ACTG1	1.52
263	Nemaline myopathy	Enrichment	ACTA1	1.52
264	Acute promyelocytic leukemia	Enrichment	NUMA1	1.49
265	Nk-cell enteropathy	Enrichment	IGF1R	1.49
266	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.47
267	Coronary heart disease 5	Enrichment	IKBKG	1.47
268	Arteriovenous malformation	Enrichment	MAP2K1	1.47
269	Multiple sclerosis	Enrichment	TNFRSF1A	1.46
270	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	LMNA	1.46
271	Lip and oral cavity carcinoma	Enrichment	RB1	1.44
272	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.42
273	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.42
274	Early-onset parkinson's disease	Enrichment	HTRA2	1.42
275	Cataract 30, multiple types	Enrichment	VIM	1.42
276	Aplastic anemia	Enrichment	PRF1	1.42
277	Ovarian cancer	Enrichment	MAP3K1, RB1	1.41
278	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	LMNA	1.40
279	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.38
280	Cardiomyopathy, dilated, 1e	Enrichment	LMNA	1.38
281	Lung cancer susceptibility 3	Enrichment	RB1	1.37
282	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.37
283	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	1.34
284	Epicanthus	Enrichment	TFAP2A	1.34
285	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	LMNA	1.33
286	Cardiomyopathy, dilated, 1a	Enrichment	LMNA	1.29
287	Hepatocellular carcinoma	Enrichment	CASP8	1.27
288	Microcephaly	Enrichment	ACTB, ACTG1	1.26
289	Congenital myopathy	Enrichment	ACTA1	1.24
290	Muscular dystrophy	Enrichment	LMNA	1.23
291	Lissencephaly	Enrichment	ACTG1	1.20
292	Brugada syndrome	Enrichment	LMNA	1.20
293	Alzheimer disease, familial, 1	Enrichment	APP	1.19
294	Tooth agenesis	Enrichment	SUMO1	1.16
295	Severe covid-19	Enrichment	CASP10	1.15
296	Diffuse large b-cell lymphoma	Enrichment	BTK	1.15
297	Jeune thoracic dystrophy	Enrichment	SPTAN1	1.13
298	Long qt syndrome	Enrichment	LMNA	1.13
299	Williams-beuren syndrome	Enrichment	LIMK1	1.12
300	Peripheral nervous system disease	Enrichment	LMNA	1.11
301	Neuropathy	Enrichment	LMNA	1.11
302	Hydrops fetalis, nonimmune	Enrichment	ACTA1	1.11
303	Microphthalmia	Enrichment	TFAP2A	1.08
304	Asphyxiating thoracic dystrophy	Enrichment	SPTAN1	1.08
305	Bladder cancer	Enrichment	RB1	1.07
306	Non-immune hydrops fetalis	Enrichment	ACTA1	1.04
307	Systemic lupus erythematosus	Enrichment	TNF	1.03
308	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	SPTAN1	1.01
309	Cakut	Enrichment	ACTG1	1.00
310	Gastric cancer	Enrichment	CASP10	0.99
311	Hereditary breast carcinoma	Enrichment	AKT1	0.98
312	Developmental and epileptic encephalopathy	Enrichment	SPTAN1	0.98
313	Non-syndromic genetic deafness	Enrichment	ACTG1	0.98
314	Hirschsprung disease 1	Enrichment	SREBF1	0.97
315	Fetal akinesia deformation sequence 1	Enrichment	ACTA1	0.96
316	Thrombocytopenia	Enrichment	CYCS	0.94
317	Myopathy	Enrichment	ACTA1	0.93
318	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.92
319	Severe combined immunodeficiency	Enrichment	IKBKB	0.92
320	Benign epilepsy with centrotemporal spikes	Enrichment	SPTAN1	0.92
321	Distal arthrogryposis	Enrichment	ACTA1	0.91
322	Hereditary spastic paraplegia	Enrichment	SPTAN1	0.91
323	Nonsyndromic hearing loss	Enrichment	ACTG1	0.91
324	Centralopathic epilepsy	Enrichment	SPTAN1	0.90
325	West syndrome	Enrichment	SPTAN1	0.89
326	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	0.89
327	Autosomal recessive non-syndromic intellectual disability	Enrichment	CRADD	0.87
328	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.83
329	Spastic ataxia	Enrichment	SPTAN1	0.82
330	Hypertelorism	Enrichment	TFAP2A	0.73
331	Undetermined early-onset epileptic encephalopathy	Enrichment	LIMK1	0.71
332	Rare genetic deafness	Enrichment	ACTG1	0.66
333	Inherited cancer-predisposing syndrome	Enrichment	RB1	0.47
334	Autism spectrum disorder	Enrichment	MAP2K1	0.46
335	Complex neurodevelopmental disorder	Enrichment	MADD	0.41

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Apoptosis and survival FAS signaling cascades

Pathway Network for Apoptosis and survival FAS signaling cascades

Pathway network for the Apoptosis and survival FAS signaling cascades SuperPath

Member Pathways for Apoptosis and survival FAS signaling cascades

Pathways in the Apoptosis and survival FAS signaling cascades SuperPath

Gene overlap in member pathways for Apoptosis and survival FAS signaling cascades SuperPath

Associated Genes for Apoptosis and survival FAS signaling cascades

Associated Disorders for Apoptosis and survival FAS signaling cascades

Disorders associated with Apoptosis and survival FAS signaling cascades SuperPath

STRING Interaction Network for Apoptosis and survival FAS signaling cascades

Sources for Apoptosis and survival FAS signaling cascades