Apoptosis and survival NGF signaling pathway

Pathway network for the Apoptosis and survival NGF signaling pathway SuperPath

Sources:

GeneGo (Thomson Reuters)
WikiPathways
PubChem
Reactome

Pathways in the Apoptosis and survival NGF signaling pathway SuperPath

#	Name	Source	Genes
1	Apoptosis and survival NGF signaling pathway	GeneGo (Thomson Reuters)	AGAP2 AKT1 AKT2 AKT3 BAD CASP3 CASP9 DFFA DFFB EPB41L1 GAB1 GRB2 HRAS NGF NPM1 NTRK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 SHC1 SOS1 SOS2 (see all 26) (see less)
2	Development HGF signaling pathway	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 CDH1 CRK CRKL CTNNB1 DOCK2 EGR1 ELK1 FAS FOS GAB1 GRB2 GSK3B HGF HGFAC HRAS JUN MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K1 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MET PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLAU PLCG1 PTGS2 RAC1 RAF1 RAP1A RAPGEF1 SDC1 SHC1 SNAI1 SOS1 SOS2 STAT3 TCF7L2 (see all 51) (see less)
3	Development Neurotrophin family signaling	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 BAX BDNF BRAF CRKL ELK1 GAB1 GAB2 GRB2 HRAS JUN MAGED1 MAP2K1 MAP2K2 MAP3K1 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 NGF NGFR NTF3 NTF4 NTRK1 NTRK2 NTRK3 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTPN11 RAC1 RAF1 RAP1A RAPGEF1 SH2B1 SHC1 SORT1 SOS1 SOS2 TP53 XIAP (see all 47) (see less)
4	Apoptosis and survival Role of CDK5 in neuronal death and survival	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 APAF1 BAD BAX BCL2 CASP3 CASP9 CDK1 CDK5 CDK5R1 CYCS EGR1 ERBB2 ERBB3 HRAS JUN MAP2K1 MAPK1 MAPK10 MAPK3 NGF NGFR NRG1 NTRK1 PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PRKCD RAF1 SHC1 SOS1 SOS2 TP53 (see all 38) (see less)
5	Hepatocyte growth factor receptor signaling	WikiPathways	CRK CRKL DOCK1 ELK1 FOS GAB1 GRB2 HGF HRAS ITGA1 ITGB1 JUN MAP2K1 MAP2K2 MAP4K1 MAPK1 MAPK3 MAPK8 MET PAK1 PIK3CA PTEN PTK2 PTK2B PTPN11 PXN RAF1 RAP1A RAP1B RAPGEF1 RASA1 SOS1 SRC STAT3 (see all 34) (see less)
6	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 BAD BAX BCL2 BCL2L1 CACNA1C CREB1 CYCS ESR1 MAP2K1 MAP2K2 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 NOS3 PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PRKCA PRKCE RAF1 RPS6KA1 SRC (see all 32) (see less)
7	Trk receptor signaling mediated by PI3K and PLC-gamma	PubChem	AGAP2 AKT1 BAD CAMK2A CAMK4 CCND1 CREB1 EGR1 EPB41L1 FOXO3 GAB1 GRB2 GSK3B NGF NTRK1 PDPK1 PIK3CA PIK3R1 PLCG1 PRKCD SFN SHC1 SOS1 SRC STAT5A TRPC3 TRPV1 (see all 27) (see less)
8	MET activates PTPN11	Reactome	GAB1 GRB2 HGF MET PTPN11
9	PLC-gamma1 signalling	Reactome	NGF NTRK1 PLCG1
10	MET activates STAT3	Reactome	HGF MET STAT3
11	TRKA activation by NGF	Reactome	NGF NTRK1
12	Drug-mediated inhibition of MET activation	Reactome	HGF MET
13	NFG and proNGF binds to p75NTR	Reactome	NGF

Gene overlap in member pathways for Apoptosis and survival NGF signaling pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NGF	Nerve Growth Factor	Protein Coding	7
2	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	7
3	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	6
4	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	6
5	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	6
6	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	6
7	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	6
8	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	6
9	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	5
10	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	5
11	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	5
12	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	5
13	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	5
14	SHC1	SHC Adaptor Protein 1	Protein Coding	5
15	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	5
16	HGF	Hepatocyte Growth Factor	Protein Coding	5
17	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	5
18	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	5
19	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	5
20	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	5
21	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	5
22	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	4
23	PLCG1	Phospholipase C Gamma 1	Protein Coding	4
24	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	4
25	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	4
26	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	4
27	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	4
28	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	4
29	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	4
30	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	3
31	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	3
32	EGR1	Early Growth Response 1	Protein Coding	3
33	ELK1	ETS Transcription Factor ELK1	Protein Coding	3
34	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	3
35	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	3
36	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	3
37	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	3
38	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	3
39	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	3
40	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	3
41	CASP3	Caspase 3	Protein Coding	2
42	CASP9	Caspase 9	Protein Coding	2
43	EPB41L1	Erythrocyte Membrane Protein Band 4.1 Like 1	Protein Coding	2
44	AGAP2	ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 2	Protein Coding	2
45	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	2
46	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
47	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	2
48	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	2
49	RAC1	Rac Family Small GTPase 1	Protein Coding	2
50	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	2
51	NGFR	Nerve Growth Factor Receptor	Protein Coding	2
52	TP53	Tumor Protein P53	Protein Coding	2
53	BCL2	BCL2 Apoptosis Regulator	Protein Coding	2
54	PRKCD	Protein Kinase C Delta	Protein Coding	2
55	CYCS	Cytochrome C, Somatic	Protein Coding	2
56	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
57	DFFA	DNA Fragmentation Factor Subunit Alpha	Protein Coding	1
58	DFFB	DNA Fragmentation Factor Subunit Beta	Protein Coding	1
59	NPM1	Nucleophosmin 1	Protein Coding	1
60	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
61	CDH1	Cadherin 1	Protein Coding	1
62	CTNNB1	Catenin Beta 1	Protein Coding	1
63	DOCK2	Dedicator Of Cytokinesis 2	Protein Coding	1
64	HGFAC	HGF Activator	Protein Coding	1
65	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
66	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
67	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
68	SDC1	Syndecan 1	Protein Coding	1
69	SNAI1	Snail Family Transcriptional Repressor 1	Protein Coding	1
70	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
71	XIAP	X-Linked Inhibitor Of Apoptosis	Protein Coding	1
72	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	1
73	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
74	NTF3	Neurotrophin 3	Protein Coding	1
75	NTF4	Neurotrophin 4	Protein Coding	1
76	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	1
77	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	Protein Coding	1
78	SORT1	Sortilin 1	Protein Coding	1
79	MAGED1	MAGE Family Member D1	Protein Coding	1
80	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1
81	SH2B1	SH2B Adaptor Protein 1	Protein Coding	1
82	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
83	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1
84	CDK5	Cyclin Dependent Kinase 5	Protein Coding	1
85	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	1
86	ERBB3	Erb-B2 Receptor Tyrosine Kinase 3	Protein Coding	1
87	NRG1	Neuregulin 1	Protein Coding	1
88	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	1
89	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	1
90	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
91	PXN	Paxillin	Protein Coding	1
92	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
93	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
94	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
95	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
96	ITGA1	Integrin Subunit Alpha 1	Protein Coding	1
97	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
98	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	1
99	MAP4K1	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1	Protein Coding	1
100	BCL2L1	BCL2 Like 1	Protein Coding	1
101	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	1
102	ESR1	Estrogen Receptor 1	Protein Coding	1
103	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
104	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
105	PRKCA	Protein Kinase C Alpha	Protein Coding	1
106	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
107	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
108	TRPC3	Transient Receptor Potential Cation Channel Subfamily C Member 3	Protein Coding	1
109	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
110	CCND1	Cyclin D1	Protein Coding	1
111	FOXO3	Forkhead Box O3	Protein Coding	1
112	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	1
113	SFN	Stratifin	Protein Coding	1
114	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	1
115	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1

Disorders associated with Apoptosis and survival NGF signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1, SOS2	16.00
2	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1	11.21
3	Noonan syndrome 1	Enrichment	BRAF, HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1, SOS2	10.67
4	Noonan syndrome 3	Enrichment	HRAS, PTPN11, RAF1, SOS1	8.93
5	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA, RASA1	8.38
6	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA, RASA1	8.17
7	Bladder cancer	Enrichment	ERBB2, ERBB3, HRAS, PIK3CA, TP53	7.83
8	Lung non-small cell carcinoma	Enrichment	ERBB2, HRAS, MAP2K1, PIK3CA	7.77
9	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	7.60
10	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS, PIK3CA, TP53	7.21
11	Colorectal cancer	Enrichment	AKT1, BAX, ERBB2, PIK3CA, PIK3R1, TP53	6.86
12	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, MAP2K1, MAP2K2	6.81
13	Cardiofaciocutaneous syndrome	Enrichment	BRAF, MAP2K1, MAP2K2	6.81
14	Noonan syndrome with multiple lentigines	Enrichment	BRAF, PTPN11, RAF1	6.81
15	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF, NTRK1	6.64
16	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA, TP53	6.39
17	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA, RASA1	6.30
18	Gallbladder cancer	Enrichment	BRAF, PIK3CA, TP53	5.87
19	Pilomyxoid astrocytoma	Enrichment	BRAF, NTRK2, RAF1	5.87
20	Breast cancer	Enrichment	AKT1, JUN, PIK3CA, SHC1, TP53	5.71
21	Ovarian cancer	Enrichment	AKT1, CDH1, CTNNB1, MAP3K1, MET, PIK3CA	5.70
22	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, RAF1	5.67
23	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, NTRK1, NTRK3	5.55
24	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.98
25	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.98
26	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.98
27	Pulmonic stenosis	Enrichment	BRAF, SOS1	4.93
28	Childhood hepatocellular carcinoma	Enrichment	CTNNB1, MET	4.86
29	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	4.67
30	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1	4.45
31	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	4.45
32	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL, MAPK1	4.44
33	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF, MET	4.37
34	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	4.22
35	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF, TP53	4.15
36	Hepatocellular carcinoma	Enrichment	CTNNB1, MET, PIK3CA	4.13
37	Nevus, epidermal	Enrichment	HRAS, PIK3CA	4.13
38	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	4.04
39	Cowden syndrome 1	Enrichment	PIK3CA, PTEN	4.04
40	Lymphoma	Enrichment	PTPN11, TP53	3.93
41	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.90
42	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, PTEN	3.90
43	Follicular thyroid carcinoma	Enrichment	HRAS, PTEN	3.90
44	Deafness, autosomal recessive 39	Enrichment	HGF	3.83
45	Osteofibrous dysplasia	Enrichment	MET	3.83
46	Deafness, autosomal recessive 97	Enrichment	MET	3.83
47	Autism 9	Enrichment	MET	3.83
48	Arthrogryposis, distal, type 11	Enrichment	MET	3.83
49	Hereditary breast carcinoma	Enrichment	AKT1, ESR1, PIK3CA	3.83
50	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.80
51	Glioma susceptibility 1	Enrichment	ERBB2, TP53	3.67
52	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	3.66
53	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	3.66
54	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	3.66
55	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	3.66
56	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	3.66
57	Lung cancer	Enrichment	FAS, MET, PIK3CA	3.64
58	Meningioma	Enrichment	AKT1, PIK3CA	3.64
59	Gastric cancer	Enrichment	ERBB2, PIK3CA, TP53	3.64
60	Adult hepatocellular carcinoma	Enrichment	PIK3CA, TP53	3.57
61	Insensitivity to pain, congenital, with anhidrosis	Enrichment	NTRK1	3.53
62	Pain sensitivity quantitative trait locus 1	Enrichment	NTRK1	3.53
63	Papillary renal cell carcinoma	Enrichment	MET	3.53
64	Lymphoma, non-hodgkin, familial	Enrichment	BRAF, TP53	3.49
65	Specific learning disability	Enrichment	MAPK1, PTPN11	3.48
66	Metachondromatosis	Enrichment	PTPN11	3.43
67	Deafness, autosomal recessive 26	Enrichment	GAB1	3.43
68	Leopard syndrome 1	Enrichment	PTPN11	3.43
69	Malignant astrocytoma	Enrichment	PTPN11	3.43
70	Primary hyperaldosteronism	Enrichment	BRAF, TP53	3.38
71	Thyroid carcinoma, familial medullary	Enrichment	NTRK1	3.35
72	Renal cell carcinoma	Enrichment	MET	3.35
73	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	3.18
74	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	3.18
75	Hyper ige syndrome	Enrichment	STAT3	3.18
76	Lung cancer susceptibility 3	Enrichment	ERBB2, TP53	3.17
77	Rhabdomyosarcoma	Enrichment	HRAS, PTEN	3.15
78	Werner syndrome	Enrichment	PTPN11	3.13
79	Inherited cancer-predisposing syndrome	Enrichment	MET, PTPN11	3.04
80	Myeloma, multiple	Enrichment	BRAF, PIK3R2, TP53	3.02
81	Diffuse large b-cell lymphoma	Enrichment	PTEN, STAT3	2.99
82	Renal cell carcinoma, papillary, 1	Enrichment	MET	2.99
83	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	2.98
84	Tricuspid valve insufficiency	Enrichment	PTPN11	2.96
85	Arthrogryposis, distal, type 1a	Enrichment	MET	2.93
86	Endometrial cancer	Enrichment	PIK3CA, PTEN	2.91
87	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CACNA1C, RAF1	2.84
88	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.83
89	Permanent neonatal diabetes mellitus	Enrichment	STAT3	2.75
90	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.72
91	Macrodactyly	Enrichment	PIK3CA	2.72
92	Proteus syndrome	Enrichment	AKT1	2.72
93	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.72
94	Noonan syndrome 4	Enrichment	SOS1	2.72
95	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.72
96	Cowden syndrome 5	Enrichment	PIK3CA	2.72
97	Chromosome 20q11-q12 deletion syndrome	Enrichment	EPB41L1	2.72
98	Noonan syndrome 9	Enrichment	SOS2	2.72
99	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.72
100	Short syndrome	Enrichment	PIK3R1	2.72
101	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.72
102	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.72
103	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.72
104	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.72
105	Cowden syndrome 6	Enrichment	AKT1	2.72
106	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.72
107	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.72
108	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.72
109	Hypospadias	Enrichment	PIK3CA	2.72
110	Capillary hemangioma	Enrichment	AKT3	2.72
111	Acute myeloid leukemia with multilineage dysplasia	Enrichment	NPM1	2.72
112	Rare venous malformation	Enrichment	PIK3CA	2.72
113	Acute myeloid leukemia with npm1 somatic mutations	Enrichment	NPM1	2.72
114	Diaphragmatic eventration	Enrichment	PIK3CA	2.72
115	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.72
116	Rare combined vascular malformation	Enrichment	PIK3CA	2.72
117	Cavernous lymphangioma	Enrichment	PIK3CA	2.72
118	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.72
119	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.72
120	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.72
121	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.72
122	Macrodactyly of toe	Enrichment	PIK3CA	2.72
123	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.72
124	Spinocerebellar ataxia 41	Enrichment	TRPC3	2.70
125	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.70
126	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.70
127	Thrombocytopenia 6	Enrichment	SRC	2.70
128	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.70
129	Patent ductus arteriosus	Enrichment	PTPN11	2.66
130	Renal cell carcinoma, nonpapillary	Enrichment	MET	2.66
131	Noonan syndrome 5	Enrichment	RAF1	2.63
132	Melorheostosis, isolated	Enrichment	MAP2K1	2.63
133	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.63
134	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.63
135	Noonan syndrome 13	Enrichment	MAPK1	2.63
136	Brugada syndrome 3	Enrichment	CACNA1C	2.63
137	Thrombocytopenia 4	Enrichment	CYCS	2.63
138	Melorheostosis	Enrichment	MAP2K1	2.63
139	Leopard syndrome 2	Enrichment	RAF1	2.63
140	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.63
141	Trigonitis	Enrichment	RAF1	2.63
142	Atypical timothy syndrome	Enrichment	CACNA1C	2.63
143	Timothy syndrome type 2	Enrichment	CACNA1C	2.63
144	Timothy syndrome type 1	Enrichment	CACNA1C	2.63
145	Cacna1c-related disorders	Enrichment	CACNA1C	2.63
146	Peripheral nervous system disease	Enrichment	NGF	2.63
147	Neuropathy	Enrichment	NGF	2.63
148	Prostate cancer	Enrichment	PIK3CA, PTEN	2.62
149	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.60
150	Vacterl association with hydrocephalus	Enrichment	PTEN	2.60
151	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.60
152	Papillary tumor of the pineal region	Enrichment	PTEN	2.60
153	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	2.60
154	Glioma susceptibility 2	Enrichment	PTEN	2.60
155	Gorham's disease	Enrichment	RASA1	2.60
156	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.60
157	Temporomandibular joint anomaly	Enrichment	DOCK1	2.60
158	Autism spectrum disorder	Enrichment	MAP2K1, PTEN, PTPN11	2.60
159	Non-immune hydrops fetalis	Enrichment	HRAS, PTPN11	2.57
160	Erythroleukemia, familial	Enrichment	ERBB3	2.55
161	Paget disease, extramammary	Enrichment	ERBB2	2.55
162	Lethal congenital contracture syndrome 2	Enrichment	ERBB3	2.55
163	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.55
164	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.55
165	Bone marrow failure syndrome 5	Enrichment	TP53	2.55
166	Papilloma of choroid plexus	Enrichment	TP53	2.55
167	Basal cell carcinoma 7	Enrichment	TP53	2.55
168	Anaplastic thyroid carcinoma	Enrichment	TP53	2.55
169	Ductal carcinoma in situ	Enrichment	TP53	2.55
170	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.55
171	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.55
172	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.55
173	Choroid plexus cancer	Enrichment	TP53	2.55
174	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.55
175	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.55
176	Acute promyelocytic leukemia	Enrichment	STAT3	2.54
177	Hirschsprung disease 1	Enrichment	ERBB2, ERBB3	2.53
178	Lymphoproliferative syndrome, x-linked, 2	Enrichment	XIAP	2.46
179	Noonan syndrome 7	Enrichment	BRAF	2.46
180	Leopard syndrome 3	Enrichment	BRAF	2.46
181	Low density lipoprotein cholesterol level quantitative trait locus 6	Enrichment	SORT1	2.46
182	46,xy sex reversal 6	Enrichment	MAP3K1	2.46
183	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	2.46
184	Lymphangioma	Enrichment	BRAF	2.46
185	Phace association	Enrichment	BRAF	2.46
186	Glaucoma 1, open angle, o	Enrichment	NTF4	2.46
187	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	2.46
188	Syringocystadenoma papilliferum	Enrichment	BRAF	2.46
189	Ganglioglioma	Enrichment	BRAF	2.46
190	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.46
191	Phace syndrome	Enrichment	BRAF	2.46
192	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.46
193	Classic hairy cell leukemia	Enrichment	BRAF	2.46
194	Severe early-onset obesity-insulin resistance syndrome due to sh2b1 deficiency	Enrichment	SH2B1	2.46
195	Immunodeficiency 40	Enrichment	DOCK2	2.42
196	Adenoid ameloblastoma	Enrichment	CTNNB1	2.42
197	Breast lobular carcinoma	Enrichment	CDH1	2.42
198	Microcystic stromal tumor	Enrichment	CTNNB1	2.42
199	Fibromatosis, gingival, 1	Enrichment	SOS1	2.42
200	Costello syndrome	Enrichment	HRAS	2.42
201	Keratosis, seborrheic	Enrichment	PIK3CA	2.42
202	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.42
203	Noonan syndrome 8	Enrichment	PIK3CA	2.42
204	Senior-loken syndrome 7	Enrichment	AKT3	2.42
205	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.42
206	Immune system disease	Enrichment	PIK3CD	2.42
207	Bardet-biedl syndrome 16	Enrichment	AKT3	2.42
208	Acute myeloid leukemia without maturation	Enrichment	NPM1	2.42
209	Lymphomatoid papulosis	Enrichment	NPM1	2.42
210	Primary cutaneous anaplastic large cell lymphoma	Enrichment	NPM1	2.42
211	Wooly hair nevus	Enrichment	HRAS	2.42
212	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.40
213	Pectus excavatum	Enrichment	PTPN11	2.39
214	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, EPB41L1	2.36
215	Epicanthus	Enrichment	PTPN11	2.35
216	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.35
217	Congenital long qt syndrome	Enrichment	PTPN11	2.35
218	Timothy syndrome	Enrichment	CACNA1C	2.33
219	Long qt syndrome 8	Enrichment	CACNA1C	2.33
220	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.33
221	Tafro syndrome	Enrichment	MAP2K2	2.33
222	Vacterl with hydrocephalus	Enrichment	PTEN	2.30
223	Juvenile polyposis of infancy	Enrichment	PTEN	2.30
224	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.25
225	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	ERBB3	2.25
226	Cervical cancer	Enrichment	TP53	2.25
227	Lymphoma, hodgkin, classic	Enrichment	TP53	2.25
228	Congenital fibrosarcoma	Enrichment	TP53	2.25
229	Li-fraumeni syndrome 1	Enrichment	TP53	2.25
230	Sarcoma	Enrichment	TP53	2.25
231	Cervix carcinoma	Enrichment	TP53	2.25
232	Hodgkin's lymphoma	Enrichment	TP53	2.25
233	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.25
234	Thrombocytopenia	Enrichment	CYCS, SRC	2.25
235	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.24
236	Nuchal bleb, familial	Enrichment	SOS1	2.24
237	Large congenital melanocytic nevus	Enrichment	HRAS	2.24
238	Spermatocytoma	Enrichment	HRAS	2.24
239	Keratoacanthoma	Enrichment	PIK3CA	2.24
240	Melanoma of soft tissue	Enrichment	CREB1	2.22
241	Patent foramen ovale	Enrichment	PTPN11	2.18
242	Chromosome 16p11.2 deletion syndrome, 220-kb	Enrichment	SH2B1	2.16
243	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.16
244	Congenital mesoblastic nephroma	Enrichment	NTRK3	2.16
245	Chromosome 16p11.2 deletion syndrome, 593-kb	Enrichment	SH2B1	2.16
246	Fibrosarcoma	Enrichment	NTRK3	2.16
247	Estrogen resistance	Enrichment	ESR1	2.15
248	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1C	2.15
249	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.15
250	T-cell acute lymphoblastic leukemia	Enrichment	BAX	2.15
251	Migraine without aura	Enrichment	ESR1	2.15
252	Sensorineural hearing loss	Enrichment	HGF	2.15
253	Wieacker-wolff syndrome	Enrichment	RASA1	2.12
254	Laryngeal squamous cell carcinoma	Enrichment	PTEN	2.12
255	Blepharocheilodontic syndrome 1	Enrichment	CDH1	2.12
256	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.12
257	Quebec platelet disorder	Enrichment	PLAU	2.12
258	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.12
259	Teratoma	Enrichment	CTNNB1	2.12
260	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	2.12
261	Cerebrovascular disease	Enrichment	PIK3CA	2.12
262	Epidermolytic nevus	Enrichment	HRAS	2.12
263	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.12
264	Gingival fibromatosis	Enrichment	SOS1	2.12
265	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	2.12
266	Mantle cell lymphoma	Enrichment	CCND1	2.10
267	Osteogenic sarcoma	Enrichment	TP53	2.08
268	Nasopharyngeal carcinoma	Enrichment	TP53	2.08
269	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.08
270	Anaplastic astrocytoma	Enrichment	TP53	2.08
271	Squamous cell carcinoma	Enrichment	TP53	2.08
272	Adenocarcinoma	Enrichment	TP53	2.08
273	Bone osteosarcoma	Enrichment	TP53	2.08
274	Primary ovarian insufficiency	Enrichment	NTRK1	2.06
275	Scoliosis	Enrichment	PTPN11	2.05
276	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	2.03
277	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	CACNA1C	2.03
278	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	2.03
279	Acute myeloid leukemia with maturation	Enrichment	NPM1	2.02
280	Von hippel-lindau syndrome	Enrichment	CCND1	2.00
281	Strabismus	Enrichment	PTPN11	2.00
282	Congenital generalized lipodystrophy	Enrichment	FOS	2.00
283	Glioma	Enrichment	PTEN	2.00
284	Ataxia-telangiectasia	Enrichment	BRAF	1.98
285	Tethered spinal cord syndrome	Enrichment	BRAF	1.98
286	Type 2 diabetes mellitus	Enrichment	AKT2, TCF7L2	1.96
287	Long qt syndrome 1	Enrichment	PTPN11	1.96
288	Small cell cancer of the lung	Enrichment	TP53	1.95
289	Barrett esophagus	Enrichment	ERBB2	1.95
290	Lung sarcomatoid carcinoma	Enrichment	TP53	1.95
291	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.95
292	Desmoid disease, hereditary	Enrichment	CTNNB1	1.95
293	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.95
294	Anus, imperforate	Enrichment	CTNNB1	1.95
295	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.95
296	Desmoid tumor	Enrichment	CTNNB1	1.95
297	Vogt-koyanagi-harada disease	Enrichment	FAS	1.95
298	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.94
299	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.94
300	Alzheimer disease 2	Enrichment	NOS3	1.93
301	Pre-eclampsia	Enrichment	NOS3	1.93
302	Follicular lymphoma	Enrichment	BCL2	1.93
303	Heart conduction disease	Enrichment	CACNA1C	1.93
304	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.93
305	Macrocephaly/autism syndrome	Enrichment	PTEN	1.90
306	Hemangioma	Enrichment	PTEN	1.90
307	Histiocytoid hemangioma	Enrichment	FOS	1.90
308	Acute megakaryocytic leukemia	Enrichment	PTEN	1.90
309	Megacolon	Enrichment	AKT3	1.87
310	Overgrowth syndrome	Enrichment	PIK3R1	1.87
311	Lymphoproliferative syndrome 2	Enrichment	XIAP	1.86
312	Craniopharyngioma	Enrichment	BRAF	1.86
313	Newborn respiratory distress syndrome	Enrichment	BRAF	1.86
314	Myelofibrosis	Enrichment	SRC	1.86
315	Rhabdomyosarcoma 2	Enrichment	TP53	1.86
316	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.83
317	Hemangioma, capillary infantile	Enrichment	RASA1	1.83
318	Basal cell carcinoma 1	Enrichment	RASA1	1.83
319	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1	1.83
320	Autoimmune lymphoproliferative syndrome	Enrichment	FAS	1.83
321	Pilomatrixoma	Enrichment	CTNNB1	1.83
322	Alazami syndrome	Enrichment	CTNNB1	1.83
323	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.80
324	Li-fraumeni syndrome	Enrichment	TP53	1.78
325	Adrenocortical carcinoma	Enrichment	TP53	1.78
326	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.76
327	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.76
328	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.73
329	Lennox-gastaut syndrome	Enrichment	MAPK10	1.73
330	Polymicrogyria	Enrichment	AKT3	1.72
331	Esophageal cancer	Enrichment	TP53	1.71
332	Essential thrombocythemia	Enrichment	TP53	1.71
333	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.71
334	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.70
335	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.69
336	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	1.69
337	Wilms tumor 5	Enrichment	BRAF	1.69
338	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	CACNA1C	1.68
339	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.65
340	Cleft lip with or without cleft palate	Enrichment	CDH1	1.65
341	Stroke, ischemic	Enrichment	NOS3	1.63
342	Aortic valve disease 1	Enrichment	SOS1	1.61
343	Nk-cell enteropathy	Enrichment	PIK3CB	1.61
344	Melanoma	Enrichment	PTEN	1.61
345	Migraine with or without aura 1	Enrichment	ESR1	1.59
346	Meningioma, familial	Enrichment	PTEN	1.56
347	Uterine corpus cancer	Enrichment	PTEN	1.56
348	Osteoporosis	Enrichment	SRC	1.56
349	Familial colorectal cancer	Enrichment	TP53	1.56
350	Cardiac conduction defect	Enrichment	CACNA1C	1.55
351	Lynch syndrome	Enrichment	PIK3CA	1.55
352	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.53
353	Myelodysplastic syndrome	Enrichment	TP53	1.52
354	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.51
355	Congenital central hypoventilation syndrome	Enrichment	BDNF	1.51
356	Ventricular septal defect	Enrichment	BRAF	1.51
357	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	1.50
358	Neural tube defects	Enrichment	ITGB1	1.49
359	Dyskeratosis congenita	Enrichment	NPM1	1.45
360	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.43
361	Microcephaly	Enrichment	MAPK1, PTPN11	1.42
362	Alzheimer disease, familial, 1	Enrichment	NOS3	1.40
363	Hypertension, essential	Enrichment	NOS3	1.40
364	Heart, malformation of	Enrichment	MAPK1	1.38
365	Gliosarcoma	Enrichment	TP53	1.36
366	Giant cell glioblastoma	Enrichment	TP53	1.33
367	Myocardial infarction	Enrichment	ESR1	1.30
368	Wilms tumor 1	Enrichment	BRAF	1.29
369	Medulloblastoma	Enrichment	CTNNB1	1.29
370	Cleft lip/palate	Enrichment	CDH1	1.29
371	Hepatoblastoma	Enrichment	TP53	1.24
372	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.24
373	Dandy-walker syndrome	Enrichment	BRAF	1.24
374	Brugada syndrome	Enrichment	CACNA1C	1.22
375	Polycystic liver disease	Enrichment	CTNNB1	1.21
376	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.21
377	Diamond-blackfan anemia 1	Enrichment	TP53	1.20
378	Arteriovenous malformations of the brain	Enrichment	BRAF	1.19
379	Pancreatic cancer	Enrichment	TP53	1.17
380	Behcet syndrome	Enrichment	FAS	1.16
381	Long qt syndrome	Enrichment	CACNA1C	1.15
382	Leukemia, acute myeloid	Enrichment	NPM1	1.13
383	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.12
384	Left ventricular noncompaction	Enrichment	RAF1	1.10
385	Autoinflammatory disease	Enrichment	XIAP	1.10
386	Cerebral palsy	Enrichment	CACNA1C	1.05
387	Hypertelorism	Enrichment	PIK3CA	1.02
388	Diamond-blackfan anemia	Enrichment	TP53	1.02
389	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.93
390	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	0.89
391	West syndrome	Enrichment	NTRK2	0.85
392	Body mass index quantitative trait locus 11	Enrichment	BDNF	0.80
393	Undetermined early-onset epileptic encephalopathy	Enrichment	NTRK2	0.75
394	Congenital nervous system abnormality	Enrichment	PTEN	0.63
395	Nervous system disease	Enrichment	PTEN	0.63
396	Autism	Enrichment	TCF7L2	0.62
397	Complex neurodevelopmental disorder	Enrichment	CACNA1C	0.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Apoptosis and survival NGF signaling pathway

Pathway Network for Apoptosis and survival NGF signaling pathway

Pathway network for the Apoptosis and survival NGF signaling pathway SuperPath

Member Pathways for Apoptosis and survival NGF signaling pathway

Pathways in the Apoptosis and survival NGF signaling pathway SuperPath

Gene overlap in member pathways for Apoptosis and survival NGF signaling pathway SuperPath

Associated Genes for Apoptosis and survival NGF signaling pathway

Associated Disorders for Apoptosis and survival NGF signaling pathway

Disorders associated with Apoptosis and survival NGF signaling pathway SuperPath

STRING Interaction Network for Apoptosis and survival NGF signaling pathway

Sources for Apoptosis and survival NGF signaling pathway