Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins

No Pathway Network information available for Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins

Pathways in the Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins SuperPath

#	Name	Source	Genes
1	Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins	GeneGo (Thomson Reuters)	AIFM1 APAF1 BAD BAK1 BAX BBC3 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L11 BCL2L2 BID BIK BMF CASP8 CASP9 CYCS DIABLO FAS HRK IGF1R MCL1 MOAP1 MT-RNR2 PMAIP1 RAF1 SLC25A4 SLC25A5 SLC25A6 TNFRSF1A VDAC1 VDAC2 (see all 33) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLC25A4	Solute Carrier Family 25 Member 4	Protein Coding	1
2	SLC25A5	Solute Carrier Family 25 Member 5	Protein Coding	1
3	SLC25A6	Solute Carrier Family 25 Member 6	Protein Coding	1
4	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
5	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
6	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
7	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	1
8	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
9	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
10	BCL2A1	BCL2 Related Protein A1	Protein Coding	1
11	BCL2L1	BCL2 Like 1	Protein Coding	1
12	BCL2L2	BCL2 Like 2	Protein Coding	1
13	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
14	BIK	BCL2 Interacting Killer	Protein Coding	1
15	CASP8	Caspase 8	Protein Coding	1
16	CASP9	Caspase 9	Protein Coding	1
17	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
18	MCL1	MCL1 Apoptosis Regulator, BCL2 Family Member	Protein Coding	1
19	MT-RNR2	Mitochondrially Encoded 16S RRNA	RNA Gene	1
20	PMAIP1	Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Protein Coding	1
21	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
22	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
23	VDAC1	Voltage Dependent Anion Channel 1	Protein Coding	1
24	VDAC2	Voltage Dependent Anion Channel 2	Protein Coding	1
25	HRK	Harakiri, BCL2 Interacting Protein	Protein Coding	1
26	AIFM1	Apoptosis Inducing Factor Mitochondria Associated 1	Protein Coding	1
27	BCL2L10	BCL2 Like 10	Protein Coding	1
28	BCL2L11	BCL2 Like 11	Protein Coding	1
29	BBC3	BCL2 Binding Component 3	Protein Coding	1
30	CYCS	Cytochrome C, Somatic	Protein Coding	1
31	DIABLO	Diablo IAP-Binding Mitochondrial Protein	Protein Coding	1
32	MOAP1	Modulator Of Apoptosis 1	Protein Coding	1
33	BMF	Bcl2 Modifying Factor	Protein Coding	1

Disorders associated with Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Behcet syndrome	Enrichment	FAS, TNFRSF1A	3.02
2	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.61
3	Noonan syndrome 5	Enrichment	RAF1	2.61
4	Caspase 8 deficiency	Enrichment	CASP8	2.61
5	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 2	Enrichment	SLC25A4	2.61
6	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.61
7	Mitochondrial dna depletion syndrome 12b , autosomal recessive	Enrichment	SLC25A4	2.61
8	Mitochondrial dna depletion syndrome 12a , autosomal dominant	Enrichment	SLC25A4	2.61
9	Thrombocytopenia 4	Enrichment	CYCS	2.61
10	Leopard syndrome 2	Enrichment	RAF1	2.61
11	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.61
12	Mitochondrial metabolism disease	Enrichment	SLC25A4	2.61
13	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.61
14	Trigonitis	Enrichment	RAF1	2.61
15	Lung cancer	Enrichment	CASP8, FAS	2.57
16	Spondyloepimetaphyseal dysplasia, x-linked, with hypomyelinating leukodystrophy	Enrichment	AIFM1	2.31
17	Charcot-marie-tooth disease, x-linked recessive, 4, with or without cerebellar ataxia	Enrichment	AIFM1	2.31
18	Combined oxidative phosphorylation deficiency 6	Enrichment	AIFM1	2.31
19	Deafness, autosomal dominant 64	Enrichment	DIABLO	2.31
20	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.31
21	Charcot-marie-tooth disease x-linked recessive 4	Enrichment	AIFM1	2.31
22	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.31
23	Sengers syndrome	Enrichment	SLC25A4	2.14
24	Deafness, x-linked 5, with peripheral neuropathy	Enrichment	AIFM1	2.14
25	X-linked deafness 5	Enrichment	AIFM1	2.14
26	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.14
27	T-cell acute lymphoblastic leukemia	Enrichment	BAX	2.14
28	Combined oxidative phosphorylation deficiency	Enrichment	AIFM1	2.14
29	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	2.14
30	Vogt-koyanagi-harada disease	Enrichment	FAS	2.14
31	Autoimmune lymphoproliferative syndrome	Enrichment	FAS	2.01
32	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.01
33	Insulin-like growth factor i	Enrichment	IGF1R	1.92
34	Follicular lymphoma	Enrichment	BCL2	1.92
35	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.92
36	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1	Enrichment	SLC25A4	1.84
37	Noonan syndrome 3	Enrichment	RAF1	1.77
38	Pilomyxoid astrocytoma	Enrichment	RAF1	1.77
39	Mitochondrial disease	Enrichment	MT-RNR2, SLC25A4	1.72
40	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.71
41	Charge syndrome	Enrichment	TNFRSF1A	1.66
42	Adult hepatocellular carcinoma	Enrichment	CASP8	1.66
43	Mitochondrial myopathy	Enrichment	SLC25A4	1.58
44	Nk-cell enteropathy	Enrichment	IGF1R	1.51
45	Multiple sclerosis	Enrichment	TNFRSF1A	1.47
46	Myopia	Enrichment	SLC25A4	1.44
47	Noonan syndrome and noonan-related syndrome	Enrichment	RAF1	1.44
48	Leukodystrophy	Enrichment	AIFM1	1.32
49	Hepatocellular carcinoma	Enrichment	CASP8	1.28
50	Noonan syndrome 1	Enrichment	RAF1	1.26
51	Ear malformation	Enrichment	AIFM1	1.25
52	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.25
53	Autoinflammatory disease	Enrichment	TNFRSF1A	1.25
54	Rasopathy	Enrichment	RAF1	1.21
55	Auditory neuropathy	Enrichment	AIFM1	1.21
56	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.11
57	Left ventricular noncompaction	Enrichment	RAF1	1.09
58	Leber hereditary optic neuropathy, modifier of	Enrichment	MT-RNR2	1.06
59	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	Enrichment	MT-RNR2	1.05
60	Hypertrophic cardiomyopathy	Enrichment	SLC25A4	1.00
61	Sensorineural hearing loss	Enrichment	AIFM1	0.96
62	Thrombocytopenia	Enrichment	CYCS	0.96
63	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	DIABLO	0.92
64	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.92
65	Leigh syndrome, nuclear	Enrichment	MT-RNR2	0.81
66	Breast cancer	Enrichment	CASP8	0.78
67	Leigh disease	Enrichment	MT-RNR2	0.77
68	Dilated cardiomyopathy	Enrichment	RAF1	0.75
69	Colorectal cancer	Enrichment	BAX	0.72
70	Leber plus disease	Enrichment	MT-RNR2	0.68
71	Microcephaly	Enrichment	IGF1R	0.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins

Pathway Network for Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins

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Pathways in the Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins SuperPath

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Associated Disorders for Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins

Disorders associated with Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins SuperPath

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