Apoptosis and survival TNFR1 signaling pathway

Pathway network for the Apoptosis and survival TNFR1 signaling pathway SuperPath

Sources:

GeneGo (Thomson Reuters)
WikiPathways
QIAGEN
PubChem

Pathways in the Apoptosis and survival TNFR1 signaling pathway SuperPath

#	Name	Source	Genes
1	Apoptosis and survival TNFR1 signaling pathway	GeneGo (Thomson Reuters)	APAF1 BABAM2 BAG4 BAX BCL2 BID BIRC2 BIRC3 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CFLAR CHUK CRADD CYCS DIABLO ERAP1 FADD HTRA2 IKBKB IKBKG JUN MAP2K4 MAP2K7 MAP3K1 MAP4K2 MAPK10 MAPK8 MAPK9 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE REL RELA RELB RIPK1 TNF TNFRSF1A TRADD TRAF2 XIAP (see all 48) (see less)
2	Apoptosis	WikiPathways	AKT1 APAF1 BAD BAK1 BAX BBC3 BCL2 BCL2L1 BCL2L11 BCL2L2 BID BIRC2 BIRC3 BIRC5 BNIP3L BOK CASP1 CASP10 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP9 CDKN2A CFLAR CHUK CRADD CYCS DFFA DFFB DIABLO FADD FAS FASLG GZMB HELLS HRK IGF1 IGF1R IGF2 IKBKB IKBKG IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 JUN LTA MAP2K4 MAP3K1 MAPK10 MCL1 MDM2 MIR29A MIR29B1 MIR29B2 MYC NFKB1 NFKBIA NFKBIB NFKBIE PIK3R1 PMAIP1 PRF1 RELA RIPK1 SCAF11 TNF TNFRSF10B TNFRSF1A TNFRSF1B TNFRSF21 TNFRSF25 TNFSF10 TP53 TP63 TP73 TRADD TRAF1 TRAF2 TRAF3 XIAP (see all 87) (see less)
3	Apoptosis through Death Receptors	QIAGEN	ACTA1 ACTA2 ACTB ACTG1 ACTG2 APAF1 ARHGDIB BAX BCL2 BID BIRC2 BIRC3 CASP10 CASP2 CASP3 CASP7 CASP8 CASP9 CFLAR CHUK CRADD CYCS DAPK1 DAXX DFFA DFFB DIABLO FADD FAS FASLG GAS2 HTRA2 IKBKB IKBKE IKBKG MAP2K4 MAP2K7 MAP3K14 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK10 MAPK8 MAPK9 NFKB1 NFKBIA NFKBIB NFKBIE NGF NGFR PARP1 RIPK1 SPTAN1 SPTBN1 TNF TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF1A TNFRSF21 TNFRSF25 TNFRSF6B TNFSF10 TNFSF12 TP53 TRADD TRAF2 (see all 69) (see less)
4	TNF Signaling	QIAGEN	APAF1 ATF1 ATF2 ATF3 ATF4 ATF5 ATF6 ATF7 BAG4 BID BIRC2 BIRC3 CASP1 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CHUK CRADD CYCS ELK1 FADD FOS IKBKB IKBKE IKBKG JUN LTA MADD MAP2K4 MAP3K14 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK6 MAPK7 MAPK8 NFKB1 NFKBIA NFKBIB NFKBIE RIPK1 TANK TNF TNFRSF1A TNFRSF1B TRADD TRAF2 TRAF3 (see all 59) (see less)
5	Apoptotic Pathways Triggered By HIV1	QIAGEN	APAF1 BAK1 BAX BCL2 BCL2L1 BID BIRC2 BIRC3 CASP3 CASP6 CASP7 CASP9 CCR5 CD4 CHUK CXCR4 CYCS DAXX DFFA DIABLO FADD FAS FASLG HTRA2 IKBKB IKBKE IKBKG MAP2K7 MAP3K14 MAP3K5 MAPK10 MAPK8 MAPK9 NFKB1 NFKBIA PTPN1 PTPN2 PTPN3 PTPRA PTPRB PTPRC RIPK1 TNF TNFRSF1A TNFRSF1B TP53 TRADD TRAF1 TRAF2 (see all 49) (see less)
6	Ceramide signaling pathway	PubChem	AIFM1 AKT1 ASAH1 BAD BAG4 BAX BCL2 BID BIRC3 CASP8 CHUK CRADD CTSD CYCS EGF EIF2AK2 FADD KSR1 MADD MAP2K1 MAP2K2 MAP2K4 MAP3K1 MAP4K4 MAPK1 MAPK3 MAPK8 MYC NFKB1 NFKBIA PAWR PDGFA PRKCD PRKCZ PRKRA RAF1 RELA RIPK1 SMPD1 SMPD3 SPHK2 TNF TNFRSF1A TRADD TRAF2 (see all 45) (see less)
7	TNFR1 Pathway	QIAGEN	APAF1 BAG4 BID BIRC2 BIRC3 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CDC42 CHUK CRADD CYCS FADD FOS IKBKB IKBKE IKBKG JUN MADD MAP2K4 MAP3K14 MAP3K7 MAP4K2 MAPK8 NFKB1 NFKBIA NFKBIB NFKBIE PAK1 PAK2 RIPK1 TANK TNF TNFAIP3 TNFRSF1A TRADD TRAF2 (see all 40) (see less)
8	TRAIL Pathway	QIAGEN	APAF1 BID CASP3 CASP8 CASP9 CBL CFLAR CHUK CYCS DAP3 DIABLO FADD IKBKB IKBKE IKBKG NFKB1 NFKBIA NFKBIB NFKBIE PARP1 TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF11A TNFRSF11B TNFSF10 TNFSF11 TRAF1 TRAF2 TRAF3 TRAF4 TRAF6 XIAP (see all 34) (see less)
9	HIV-1 Nef: Negative effector of Fas and TNF-alpha	PubChem	APAF1 BAG4 BCL2 BID BIRC3 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CD247 CFLAR CHUK CRADD CYCS DAXX FADD FAS FASLG MAP2K7 MAP3K14 MAP3K5 MAPK8 NFKB1 NFKBIA RELA RIPK1 TNF TNFRSF1A TRADD TRAF1 TRAF2 (see all 33) (see less)
10	TWEAK Pathway	QIAGEN	APAF1 BAG4 BID BIRC2 BIRC3 CASP3 CASP6 CASP7 CASP8 CASP9 CHUK CYCS FADD IKBKB IKBKE IKBKG MAP3K14 NFKB1 NFKBIA NFKBIB NFKBIE RIPK1 TNFRSF12A TNFRSF25 TNFSF12 TRADD TRAF1 TRAF2 TRAF3 (see all 29) (see less)
11	DR3 Signaling	QIAGEN	APAF1 BAG4 BID BIRC2 BIRC3 CASP3 CASP6 CASP7 CASP8 CASP9 CHUK CYCS FADD IKBKB IKBKE IKBKG MAP3K14 NFKB1 NFKBIA NFKBIB NFKBIE RIPK1 TNFRSF25 TNFSF12 TNFSF15 TRADD TRAF2 (see all 27) (see less)
12	GITR Pathway	QIAGEN	CASP1 CASP10 CASP2 CASP3 CASP4 CASP5 CASP6 CASP7 CASP8 CASP9 CHUK IKBKB IKBKE IKBKG MAP3K14 NFKB1 NFKBIA NFKBIB NFKBIE SIVA1 TNFRSF18 TNFSF18 TRAF1 TRAF2 TRAF3 (see all 25) (see less)
13	Apoptosis modulation by HSP70	WikiPathways	AIFM1 APAF1 BID CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CYCS FADD FAS FASLG HSPA1A MAP3K1 MAPK10 NFKB1 RIPK1 TNFRSF1A (see all 19) (see less)

Gene overlap in member pathways for Apoptosis and survival TNFR1 signaling pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	13
2	BID	BH3 Interacting Domain Death Agonist	Protein Coding	12
3	CASP3	Caspase 3	Protein Coding	12
4	CASP8	Caspase 8	Protein Coding	12
5	CASP9	Caspase 9	Protein Coding	12
6	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	12
7	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	12
8	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	12
9	FADD	Fas Associated Via Death Domain	Protein Coding	12
10	CYCS	Cytochrome C, Somatic	Protein Coding	12
11	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	11
12	CASP7	Caspase 7	Protein Coding	11
13	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	11
14	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	10
15	CASP6	Caspase 6	Protein Coding	10
16	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	10
17	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	10
18	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	10
19	NFKBIB	NFKB Inhibitor Beta	Protein Coding	9
20	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	9
21	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	9
22	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	8
23	CASP2	Caspase 2	Protein Coding	8
24	TNF	Tumor Necrosis Factor	Protein Coding	8
25	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	8
26	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	8
27	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	7
28	CRADD	CARD And Death Domain Containing Adaptor Protein	Protein Coding	7
29	BAG4	BAG Cochaperone 4	Protein Coding	7
30	BCL2	BCL2 Apoptosis Regulator	Protein Coding	6
31	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	6
32	TRAF1	TNF Receptor Associated Factor 1	Protein Coding	6
33	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	5
34	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	5
35	CFLAR	CASP8 And FADD Like Apoptosis Regulator	Protein Coding	5
36	DIABLO	Diablo IAP-Binding Mitochondrial Protein	Protein Coding	5
37	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	5
38	FASLG	Fas Ligand	Protein Coding	5
39	FAS	Fas Cell Surface Death Receptor	Protein Coding	5
40	CASP10	Caspase 10	Protein Coding	4
41	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	4
42	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	4
43	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	4
44	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	4
45	TNFRSF25	TNF Receptor Superfamily Member 25	Protein Coding	4
46	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	4
47	XIAP	X-Linked Inhibitor Of Apoptosis	Protein Coding	3
48	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	3
49	HTRA2	HtrA Serine Peptidase 2	Protein Coding	3
50	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	3
51	TNFSF10	TNF Superfamily Member 10	Protein Coding	3
52	CASP1	Caspase 1	Protein Coding	3
53	TP53	Tumor Protein P53	Protein Coding	3
54	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	3
55	DFFA	DNA Fragmentation Factor Subunit Alpha	Protein Coding	3
56	DAXX	Death Domain Associated Protein	Protein Coding	3
57	TNFSF12	TNF Superfamily Member 12	Protein Coding	3
58	MADD	MAP Kinase Activating Death Domain	Protein Coding	3
59	MAP4K2	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2	Protein Coding	2
60	CASP4	Caspase 4	Protein Coding	2
61	BCL2L1	BCL2 Like 1	Protein Coding	2
62	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	2
63	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	2
64	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	2
65	LTA	Lymphotoxin Alpha	Protein Coding	2
66	TNFRSF21	TNF Receptor Superfamily Member 21	Protein Coding	2
67	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
68	DFFB	DNA Fragmentation Factor Subunit Beta	Protein Coding	2
69	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	2
70	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	2
71	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	2
72	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	2
73	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	2
74	TNFRSF10C	TNF Receptor Superfamily Member 10c	Protein Coding	2
75	TNFRSF10D	TNF Receptor Superfamily Member 10d	Protein Coding	2
76	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
77	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	2
78	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
79	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
80	TANK	TRAF Family Member Associated NFKB Activator	Protein Coding	2
81	AIFM1	Apoptosis Inducing Factor Mitochondria Associated 1	Protein Coding	2
82	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
83	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
84	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
85	BABAM2	BRISC And BRCA1 A Complex Member 2	Protein Coding	1
86	CASP8AP2	Caspase 8 Associated Protein 2	Protein Coding	1
87	ERAP1	Endoplasmic Reticulum Aminopeptidase 1	Protein Coding	1
88	TP63	Tumor Protein P63	Protein Coding	1
89	TP73	Tumor Protein P73	Protein Coding	1
90	PRF1	Perforin 1	Protein Coding	1
91	PMAIP1	Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Protein Coding	1
92	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
93	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
94	MCL1	MCL1 Apoptosis Regulator, BCL2 Family Member	Protein Coding	1
95	MIR29B2	MicroRNA 29b-2	RNA Gene	1
96	MIR29A	MicroRNA 29a	RNA Gene	1
97	IRF7	Interferon Regulatory Factor 7	Protein Coding	1
98	IRF6	Interferon Regulatory Factor 6	Protein Coding	1
99	IRF5	Interferon Regulatory Factor 5	Protein Coding	1
100	IRF4	Interferon Regulatory Factor 4	Protein Coding	1
101	IRF3	Interferon Regulatory Factor 3	Protein Coding	1
102	IRF2	Interferon Regulatory Factor 2	Protein Coding	1
103	IRF1	Interferon Regulatory Factor 1	Protein Coding	1
104	IGF2	Insulin Like Growth Factor 2	Protein Coding	1
105	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
106	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
107	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
108	HELLS	Helicase, Lymphoid Specific	Protein Coding	1
109	GZMB	Granzyme B	Protein Coding	1
110	BBC3	BCL2 Binding Component 3	Protein Coding	1
111	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
112	BCL2L11	BCL2 Like 11	Protein Coding	1
113	SCAF11	SR-Related CTD Associated Factor 11	Protein Coding	1
114	HRK	Harakiri, BCL2 Interacting Protein	Protein Coding	1
115	BOK	BCL2 Family Apoptosis Regulator BOK	Protein Coding	1
116	BNIP3L	BCL2 Interacting Protein 3 Like	Protein Coding	1
117	BCL2L2	BCL2 Like 2	Protein Coding	1
118	MIR29B1	MicroRNA 29b-1	RNA Gene	1
119	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
120	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
121	ACTB	Actin Beta	Protein Coding	1
122	ACTG1	Actin Gamma 1	Protein Coding	1
123	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
124	ARHGDIB	Rho GDP Dissociation Inhibitor Beta	Protein Coding	1
125	DAPK1	Death Associated Protein Kinase 1	Protein Coding	1
126	GAS2	Growth Arrest Specific 2	Protein Coding	1
127	NGF	Nerve Growth Factor	Protein Coding	1
128	NGFR	Nerve Growth Factor Receptor	Protein Coding	1
129	SPTAN1	Spectrin Alpha, Non-Erythrocytic 1	Protein Coding	1
130	SPTBN1	Spectrin Beta, Non-Erythrocytic 1	Protein Coding	1
131	TNFRSF6B	TNF Receptor Superfamily Member 6b	Protein Coding	1
132	ATF1	Activating Transcription Factor 1	Protein Coding	1
133	ATF2	Activating Transcription Factor 2	Protein Coding	1
134	ATF3	Activating Transcription Factor 3	Protein Coding	1
135	ATF4	Activating Transcription Factor 4	Protein Coding	1
136	ATF5	Activating Transcription Factor 5	Protein Coding	1
137	ATF6	Activating Transcription Factor 6	Protein Coding	1
138	ATF7	Activating Transcription Factor 7	Protein Coding	1
139	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
140	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
141	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
142	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
143	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
144	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
145	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
146	CCR5	C-C Motif Chemokine Receptor 5	Protein Coding	1
147	CD4	CD4 Molecule	Protein Coding	1
148	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	1
149	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	1
150	PTPN2	Protein Tyrosine Phosphatase Non-Receptor Type 2	Protein Coding	1
151	PTPN3	Protein Tyrosine Phosphatase Non-Receptor Type 3	Protein Coding	1
152	PTPRA	Protein Tyrosine Phosphatase Receptor Type A	Protein Coding	1
153	PTPRB	Protein Tyrosine Phosphatase Receptor Type B	Protein Coding	1
154	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	1
155	SMPD3	Sphingomyelin Phosphodiesterase 3	Protein Coding	1
156	MAP4K4	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4	Protein Coding	1
157	PAWR	Pro-Apoptotic WT1 Regulator	Protein Coding	1
158	ASAH1	N-Acylsphingosine Amidohydrolase 1	Protein Coding	1
159	SMPD1	Sphingomyelin Phosphodiesterase 1	Protein Coding	1
160	PDGFA	Platelet Derived Growth Factor Subunit A	Protein Coding	1
161	PRKRA	Protein Activator Of Interferon Induced Protein Kinase EIF2AK2	Protein Coding	1
162	KSR1	Kinase Suppressor Of Ras 1	Protein Coding	1
163	CTSD	Cathepsin D	Protein Coding	1
164	EGF	Epidermal Growth Factor	Protein Coding	1
165	PRKCD	Protein Kinase C Delta	Protein Coding	1
166	SPHK2	Sphingosine Kinase 2	Protein Coding	1
167	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
168	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
169	EIF2AK2	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2	Protein Coding	1
170	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
171	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
172	CDC42	Cell Division Cycle 42	Protein Coding	1
173	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
174	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
175	TNFAIP3	TNF Alpha Induced Protein 3	Protein Coding	1
176	CBL	Cbl Proto-Oncogene	Protein Coding	1
177	DAP3	Death Associated Protein 3	Protein Coding	1
178	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	1
179	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	1
180	TNFSF11	TNF Superfamily Member 11	Protein Coding	1
181	TRAF4	TNF Receptor Associated Factor 4	Protein Coding	1
182	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
183	CD247	CD247 Molecule	Protein Coding	1
184	TNFRSF12A	TNF Receptor Superfamily Member 12A	Protein Coding	1
185	TNFSF15	TNF Superfamily Member 15	Protein Coding	1
186	CASP5	Caspase 5	Protein Coding	1
187	SIVA1	SIVA1 Apoptosis Inducing Factor	Protein Coding	1
188	TNFRSF18	TNF Receptor Superfamily Member 18	Protein Coding	1
189	TNFSF18	TNF Superfamily Member 18	Protein Coding	1
190	HSPA1A	Heat Shock Protein Family A (Hsp70) Member 1A	Protein Coding	1

Disorders associated with Apoptosis and survival TNFR1 signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2, CASP10, FAS, FASLG	9.20
2	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	5.49
3	Li-fraumeni syndrome	Enrichment	CDKN2A, MDM2, TP53	5.30
4	Paget disease of bone 5, juvenile-onset	Enrichment	TNFRSF11A, TNFRSF11B	5.21
5	Lung cancer	Enrichment	CASP8, FAS, FASLG	4.95
6	Lymphoma, non-hodgkin, familial	Enrichment	CASP10, PRF1, TP53	4.86
7	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, MAP2K2, RAF1	4.82
8	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.59
9	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, MYC	4.49
10	Nasopharyngeal carcinoma	Enrichment	NFKBIA, TP53	4.42
11	Psoriatic arthritis	Enrichment	LTA, TNF	4.25
12	Noonan syndrome 1	Enrichment	MAP2K1, MAP2K2, RAF1	4.24
13	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	4.19
14	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	4.19
15	Rasopathy	Enrichment	MAP2K1, MAP2K2, RAF1	4.08
16	Gastric cancer	Enrichment	CASP10, CDKN2A, IRF1, TP53	3.79
17	Colorectal cancer	Enrichment	AKT1, BAX, IGF2, PIK3R1, TP53	3.63
18	Small cell cancer of the lung	Enrichment	TP53, TP73	3.62
19	Cleft lip and alveolus	Enrichment	IRF6, TP63	3.62
20	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.59
21	Behcet syndrome	Enrichment	FAS, TNFRSF1A	3.50
22	Adult hepatocellular carcinoma	Enrichment	CASP8, EGF	3.42
23	Insulin-like growth factor i	Enrichment	IGF1, IGF1R	3.40
24	Cleft upper lip	Enrichment	IRF6, TP63	3.40
25	Autoinflammatory disease	Enrichment	PRF1, TNFRSF1A, XIAP	3.33
26	Squamous cell carcinoma, head and neck	Enrichment	TNFRSF10B, TP53	3.28
27	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	3.22
28	Breast adenocarcinoma	Enrichment	AKT1, TP53	3.22
29	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, TP53	3.08
30	Breast cancer	Enrichment	AKT1, CASP8, JUN, TP53	2.87
31	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.85
32	Caspase 8 deficiency	Enrichment	CASP8	2.85
33	46,xy sex reversal 6	Enrichment	MAP3K1	2.85
34	Thrombocytopenia 4	Enrichment	CYCS	2.85
35	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.85
36	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.85
37	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.85
38	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.85
39	Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly	Enrichment	CASP2	2.85
40	Gliosarcoma	Enrichment	NFKBIA, TP53	2.83
41	Giant cell glioblastoma	Enrichment	NFKBIA, TP53	2.77
42	Incontinentia pigmenti	Enrichment	IKBKG	2.73
43	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.73
44	Fetal encasement syndrome	Enrichment	CHUK	2.73
45	Immunodeficiency 15b	Enrichment	IKBKB	2.73
46	Immunodeficiency 15a	Enrichment	IKBKB	2.73
47	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.73
48	Immunodeficiency 132a	Enrichment	TRAF3	2.73
49	Immunodeficiency 132b	Enrichment	TRAF3	2.73
50	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	2.73
51	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.73
52	Immunodeficiency 112	Enrichment	MAP3K14	2.73
53	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.73
54	Nik deficiency	Enrichment	MAP3K14	2.73
55	Common variable immunodeficiency phenotype due to tweak deficiency	Enrichment	TNFSF12	2.70
56	Malaria	Enrichment	IKBKG, TNF	2.69
57	Lung cancer susceptibility 3	Enrichment	ACTA2, TP53	2.65
58	Immunodeficiency 25	Enrichment	CD247	2.61
59	Intellectual developmental disorder, autosomal recessive 34, with variant lissencephaly	Enrichment	CRADD	2.61
60	Lymphoproliferative syndrome, x-linked, 2	Enrichment	XIAP	2.60
61	Osteopetrosis, autosomal recessive 7	Enrichment	TNFRSF11A	2.60
62	Perrault syndrome 7	Enrichment	DAP3	2.60
63	Lip and oral cavity carcinoma	Enrichment	CDKN2A, TP53	2.59
64	Spondyloepimetaphyseal dysplasia, x-linked, with hypomyelinating leukodystrophy	Enrichment	AIFM1	2.55
65	Charcot-marie-tooth disease, x-linked recessive, 4, with or without cerebellar ataxia	Enrichment	AIFM1	2.55
66	Combined oxidative phosphorylation deficiency 6	Enrichment	AIFM1	2.55
67	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.55
68	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.55
69	Charcot-marie-tooth disease x-linked recessive 4	Enrichment	AIFM1	2.55
70	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.55
71	Common variable immunodeficiency 12	Enrichment	NFKB1	2.55
72	Oculootodental syndrome	Enrichment	FADD	2.55
73	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.53
74	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.53
75	Knobloch syndrome 2	Enrichment	PAK2	2.53
76	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.53
77	Deeah syndrome	Enrichment	MADD	2.53
78	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.53
79	Neurodevelopmental disorder with dysmorphic facies, impaired speech, and hypotonia	Enrichment	MADD	2.53
80	Familial behcet-like autoinflammatory syndrome	Enrichment	TNFAIP3	2.53
81	Nocarh syndrome	Enrichment	CDC42	2.53
82	Proteus syndrome	Enrichment	AKT1	2.48
83	Noonan syndrome 5	Enrichment	RAF1	2.48
84	Hypomagnesemia 4, renal	Enrichment	EGF	2.48
85	Melorheostosis, isolated	Enrichment	MAP2K1	2.48
86	Keloid formation	Enrichment	ASAH1	2.48
87	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.48
88	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.48
89	Ceroid lipofuscinosis, neuronal, 10	Enrichment	CTSD	2.48
90	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.48
91	Noonan syndrome 13	Enrichment	MAPK1	2.48
92	Leukoencephalopathy, developmental delay, and episodic neurologic regression syndrome	Enrichment	EIF2AK2	2.48
93	Melorheostosis	Enrichment	MAP2K1	2.48
94	Leopard syndrome 2	Enrichment	RAF1	2.48
95	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.48
96	Cowden syndrome 6	Enrichment	AKT1	2.48
97	Acid sphingomyelinase deficiency	Enrichment	SMPD1	2.48
98	Dystonia 33	Enrichment	EIF2AK2	2.48
99	Trigonitis	Enrichment	RAF1	2.48
100	Asah1-related disorders	Enrichment	ASAH1	2.48
101	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.48
102	Cleft lip/palate	Enrichment	IRF6, TP63	2.45
103	Parkinson disease 13, autosomal dominant	Enrichment	HTRA2	2.45
104	Immunodeficiency 92	Enrichment	REL	2.45
105	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.45
106	Immunodeficiency 53	Enrichment	RELB	2.45
107	Whim syndrome 1	Enrichment	CXCR4	2.44
108	Bone marrow failure syndrome 5	Enrichment	TP53	2.44
109	Okt4 epitope deficiency	Enrichment	CD4	2.44
110	Papilloma of choroid plexus	Enrichment	TP53	2.44
111	Basal cell carcinoma 7	Enrichment	TP53	2.44
112	Anaplastic thyroid carcinoma	Enrichment	TP53	2.44
113	Type 1 diabetes mellitus 22	Enrichment	CCR5	2.44
114	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.44
115	Ductal carcinoma in situ	Enrichment	TP53	2.44
116	Immunodeficiency 79	Enrichment	CD4	2.44
117	Cd45 deficiency	Enrichment	PTPRC	2.44
118	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.44
119	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.44
120	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.44
121	Choroid plexus cancer	Enrichment	TP53	2.44
122	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.44
123	Immunodeficiency 33	Enrichment	IKBKG	2.43
124	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.43
125	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.43
126	Neuromuscular disease	Enrichment	ACTA1, SPTAN1	2.43
127	Ovarian cancer	Enrichment	AKT1, CDKN2A, MAP3K1, TP53	2.40
128	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	2.38
129	Deafness, x-linked 5, with peripheral neuropathy	Enrichment	AIFM1	2.38
130	X-linked deafness 5	Enrichment	AIFM1	2.38
131	Combined oxidative phosphorylation deficiency	Enrichment	AIFM1	2.38
132	Vogt-koyanagi-harada disease	Enrichment	FAS	2.38
133	Leprosy 4	Enrichment	LTA	2.36
134	Achromatopsia 7	Enrichment	ATF6	2.36
135	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.36
136	Verrucous hemangioma	Enrichment	MAP3K3	2.36
137	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.31
138	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.31
139	Immunodeficiency 127	Enrichment	TNF	2.31
140	Rela fusion-positive ependymoma	Enrichment	RELA	2.31
141	Familial expansile osteolysis	Enrichment	TNFRSF11A	2.30
142	Ovarian germ cell cancer	Enrichment	CBL	2.30
143	Grange syndrome	Enrichment	DAP3	2.30
144	Osteopetrosis, autosomal recessive 2	Enrichment	TNFSF11	2.30
145	Deafness, autosomal dominant 64	Enrichment	DIABLO	2.30
146	Malignant germ cell tumor of ovary	Enrichment	CBL	2.30
147	Baraitser-winter syndrome 1	Enrichment	ACTB	2.29
148	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.29
149	Developmental and epileptic encephalopathy 5	Enrichment	SPTAN1	2.29
150	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.29
151	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.29
152	Deafness, autosomal recessive 125	Enrichment	GAS2	2.29
153	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.29
154	Developmental delay, impaired speech, and behavioral abnormalities	Enrichment	SPTBN1	2.29
155	Becker nevus syndrome	Enrichment	ACTB	2.29
156	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.29
157	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.29
158	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.29
159	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.29
160	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.29
161	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.29
162	Spastic paraplegia 91, autosomal dominant, with or without cerebellar ataxia	Enrichment	SPTAN1	2.29
163	Developmental delay with or without epilepsy	Enrichment	SPTAN1	2.29
164	Baraitser-winter syndrome	Enrichment	ACTB	2.29
165	Neuronopathy, distal hereditary motor, autosomal dominant 11	Enrichment	SPTAN1	2.29
166	Zebra body myopathy	Enrichment	ACTA1	2.29
167	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.29
168	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.29
169	Actin-accumulation myopathy	Enrichment	ACTA1	2.29
170	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.29
171	Actg2 visceral myopathy	Enrichment	ACTG2	2.29
172	Hepatocellular carcinoma	Enrichment	CASP8, TP53	2.26
173	Systemic lupus erythematosus	Enrichment	TNF, TNFAIP3	2.23
174	Autoinflammatory syndrome, familial, behcet-like 1	Enrichment	TNFAIP3	2.23
175	Immune system disease	Enrichment	CDC42	2.23
176	Severe combined immunodeficiency	Enrichment	IKBKB, PTPRC	2.20
177	Rapp-hodgkin syndrome	Enrichment	TP63	2.19
178	Ankyloblepharon-ectodermal defects-cleft lip/palate	Enrichment	TP63	2.19
179	Hemophagocytic lymphohistiocytosis, familial, 2	Enrichment	PRF1	2.19
180	Split-hand/foot malformation 4	Enrichment	TP63	2.19
181	Ankyloblepharon filiforme adnatum and cleft palate	Enrichment	TP63	2.19
182	Skin/hair/eye pigmentation, variation in, 8	Enrichment	IRF4	2.19
183	Orofacial cleft 6	Enrichment	IRF6	2.19
184	Popliteal pterygium syndrome	Enrichment	IRF6	2.19
185	Adult syndrome	Enrichment	TP63	2.19
186	Immunodeficiency 39 viral infections	Enrichment	IRF7	2.19
187	Immunodeficiency-centromeric instability-facial anomalies syndrome 4	Enrichment	HELLS	2.19
188	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	2.19
189	Accelerated tumor formation	Enrichment	MDM2	2.19
190	Ciliary dyskinesia, primary, 47, and lissencephaly	Enrichment	TP73	2.19
191	Immunodeficiency 131	Enrichment	IRF4	2.19
192	Lessel-kubisch syndrome	Enrichment	MDM2	2.19
193	Short syndrome	Enrichment	PIK3R1	2.19
194	Immunodeficiency 39	Enrichment	IRF7	2.19
195	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	Enrichment	TP63	2.19
196	Limb-mammary syndrome	Enrichment	TP63	2.19
197	Systemic lupus erythematosus 10	Enrichment	IRF5	2.19
198	Premature ovarian failure 21	Enrichment	TP63	2.19
199	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.19
200	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.19
201	Inflammatory bowel disease 14	Enrichment	IRF5	2.19
202	Orofacial cleft 8	Enrichment	TP63	2.19
203	Irf6-related disorders	Enrichment	IRF6	2.19
204	Autosomal dominant popliteal pterygium syndrome	Enrichment	IRF6	2.19
205	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.19
206	Tp63-related disorders	Enrichment	TP63	2.19
207	Whipple disease	Enrichment	IRF4	2.19
208	Fatal post-viral neurodegenerative disorder	Enrichment	PRF1	2.19
209	Burkitt lymphoma	Enrichment	MYC	2.18
210	Spinal muscular atrophy with progressive myoclonic epilepsy	Enrichment	ASAH1	2.18
211	Farber lipogranulomatosis	Enrichment	ASAH1	2.18
212	Dystonia 16	Enrichment	PRKRA	2.18
213	Tafro syndrome	Enrichment	MAP2K2	2.18
214	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	2.16
215	Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads	Enrichment	ERAP1	2.15
216	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.15
217	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.14
218	Cervical cancer	Enrichment	TP53	2.14
219	West nile virus	Enrichment	CCR5	2.14
220	Lymphoma, hodgkin, classic	Enrichment	TP53	2.14
221	Dystonia 30	Enrichment	PTPRA	2.14
222	Congenital fibrosarcoma	Enrichment	TP53	2.14
223	Li-fraumeni syndrome 1	Enrichment	TP53	2.14
224	Sarcoma	Enrichment	TP53	2.14
225	Immunodeficiency 104, severe combined	Enrichment	PTPRC	2.14
226	Cervix carcinoma	Enrichment	TP53	2.14
227	Hodgkin's lymphoma	Enrichment	TP53	2.14
228	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.14
229	Migraine without aura	Enrichment	TNF	2.14
230	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247	2.14
231	Dysosteosclerosis	Enrichment	TNFRSF11A	2.12
232	Laryngeal squamous cell carcinoma	Enrichment	TNFRSF10B	2.12
233	Adult-onset myasthenia gravis	Enrichment	TNFRSF11A	2.12
234	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	2.08
235	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	2.08
236	Multisystem inflammatory syndrome in children	Enrichment	IRF3, TRAF3	2.06
237	Scoliosis, isolated 1	Enrichment	MAPK7	2.06
238	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.05
239	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.04
240	Herpes simplex virus encephalitis	Enrichment	TRAF3	2.04
241	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A, MYC	2.03
242	Cerebral malaria	Enrichment	TNF	2.01
243	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	2.00
244	Niemann-pick disease, type a	Enrichment	SMPD1	2.00
245	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.00
246	Niemann-pick disease, type b	Enrichment	SMPD1	2.00
247	Anus, imperforate	Enrichment	MAP4K4	2.00
248	Ceroid lipofuscinosis, neuronal, 6a	Enrichment	SMPD1	2.00
249	Torsion dystonia 1	Enrichment	EIF2AK2	2.00
250	T-cell acute lymphoblastic leukemia	Enrichment	BAX	2.00
251	Paget disease of bone 2, early-onset	Enrichment	TNFRSF11A	2.00
252	Lymphoproliferative syndrome 2	Enrichment	XIAP	2.00
253	Chondrocalcinosis 2	Enrichment	TNFRSF11B	2.00
254	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL	2.00
255	Autosomal recessive osteopetrosis	Enrichment	TNFSF11	2.00
256	Paget's disease of bone 2	Enrichment	TNFRSF11A	2.00
257	Intellectual developmental disorder, x-linked, syndromic, raymond type	Enrichment	SPTAN1	1.99
258	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	1.99
259	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.99
260	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	1.99
261	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	1.99
262	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.99
263	Moyamoya disease 5	Enrichment	ACTA2	1.99
264	Intestinal obstruction	Enrichment	ACTG2	1.99
265	Mycosis fungoides	Enrichment	TNFRSF1B	1.97
266	Osteogenic sarcoma	Enrichment	TP53	1.97
267	Hepatitis c virus	Enrichment	CCR5	1.97
268	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.97
269	Anaplastic astrocytoma	Enrichment	TP53	1.97
270	Squamous cell carcinoma	Enrichment	TP53	1.97
271	Adenocarcinoma	Enrichment	TP53	1.97
272	Bone osteosarcoma	Enrichment	TP53	1.97
273	Saczary syndrome	Enrichment	TNFRSF1B	1.97
274	Pancreatic cancer	Enrichment	CDKN2A, TP53	1.96
275	Lennox-gastaut syndrome	Enrichment	MAPK10	1.95
276	Congenital generalized lipodystrophy	Enrichment	FOS	1.93
277	Knobloch syndrome	Enrichment	PAK2	1.93
278	Follicular lymphoma	Enrichment	BCL2	1.92
279	Vascular dementia	Enrichment	TNF	1.92
280	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.90
281	Myeloproliferative neoplasm	Enrichment	CBL	1.90
282	Aggressive systemic mastocytosis	Enrichment	CBL	1.90
283	Charge syndrome	Enrichment	TNFRSF1A	1.90
284	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	1.89
285	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1	Enrichment	TP63	1.89
286	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	1.89
287	Silver-russell syndrome 3	Enrichment	IGF2	1.89
288	Bladder exstrophy	Enrichment	TP63	1.89
289	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	1.89
290	Fissured tongue	Enrichment	TP63	1.89
291	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	1.89
292	Immunodeficiency 117	Enrichment	IRF1	1.89
293	Van der woude syndrome	Enrichment	IRF6	1.89
294	Silver-russell syndrome due to an imprinting defect of 11p15	Enrichment	IGF2	1.89
295	Silver-russell syndrome due to 11p15 microduplication	Enrichment	IGF2	1.89
296	Melanoma of soft tissue	Enrichment	ATF1	1.89
297	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.88
298	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.88
299	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.88
300	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.86
301	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.85
302	3-methylglutaconic aciduria, type viii	Enrichment	HTRA2	1.85
303	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.84
304	Cholangiocarcinoma	Enrichment	PTPN3	1.84
305	Lung sarcomatoid carcinoma	Enrichment	TP53	1.84
306	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.84
307	Knobloch syndrome 1	Enrichment	PAK2	1.83
308	Histiocytoid hemangioma	Enrichment	FOS	1.83
309	Multiple acyl-coa dehydrogenase deficiency, severe neonatal type	Enrichment	MADD	1.83
310	Bladder cancer	Enrichment	CDKN2A, TP53	1.83
311	Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophy	Enrichment	SPTBN1	1.82
312	Short-rib thoracic dysplasia 11 with or without polydactyly	Enrichment	SPTAN1	1.82
313	Immune deficiency disease	Enrichment	RIPK1	1.82
314	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.82
315	Coronary heart disease 5	Enrichment	IKBKG	1.78
316	Niemann-pick disease, type c1	Enrichment	SMPD1	1.78
317	Niemann-pick disease	Enrichment	SMPD1	1.78
318	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1, TP53	1.77
319	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	1.77
320	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	1.77
321	Primary biliary cholangitis	Enrichment	TNFSF15	1.75
322	Rhabdomyosarcoma 2	Enrichment	TP53	1.75
323	Lymphoma	Enrichment	TP53	1.75
324	Acute megakaryocytic leukemia	Enrichment	TP53	1.75
325	Van der woude syndrome 1	Enrichment	IRF6	1.72
326	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.72
327	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.72
328	Dedifferentiated liposarcoma	Enrichment	MDM2	1.72
329	Immunodeficiency 14	Enrichment	PIK3R1	1.72
330	Respiratory failure	Enrichment	TP73	1.72
331	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.72
332	Well-differentiated liposarcoma	Enrichment	MDM2	1.72
333	Beckwith-wiedemann syndrome due to imprinting defect of 11p15	Enrichment	IGF2	1.72
334	Multiple sclerosis	Enrichment	TNFRSF1A	1.71
335	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.71
336	Nemaline myopathy 2	Enrichment	ACTA1	1.69
337	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.69
338	Aminoacylase 1 deficiency	Enrichment	ACTB	1.69
339	Charcot-marie-tooth hereditary neuropathy	Enrichment	SPTAN1	1.69
340	Intermediate nemaline myopathy	Enrichment	ACTA1	1.69
341	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.69
342	Multiple endocrine neoplasia, type i	Enrichment	MAP4K2	1.69
343	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	CRADD	1.66
344	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.64
345	Noonan syndrome 3	Enrichment	RAF1	1.64
346	Pilomyxoid astrocytoma	Enrichment	RAF1	1.64
347	Esophageal cancer	Enrichment	TP53	1.60
348	Essential thrombocythemia	Enrichment	TP53	1.60
349	Gallbladder cancer	Enrichment	TP53	1.60
350	Visceral myopathy 1	Enrichment	ACTG2	1.60
351	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.60
352	Pervasive developmental disorder	Enrichment	SPTBN1	1.60
353	Coloboma of choroid and retina	Enrichment	ACTG1	1.60
354	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.60
355	Rare pervasive developmental disorder	Enrichment	SPTBN1	1.60
356	Silver-russell syndrome due to a point mutation	Enrichment	IGF2	1.59
357	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.58
358	Renal hypodysplasia/aplasia 1	Enrichment	MAP4K4	1.58
359	Asthma	Enrichment	TNF	1.58
360	Leukodystrophy	Enrichment	AIFM1	1.56
361	Glioma susceptibility 1	Enrichment	TP53	1.54
362	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1, DIABLO	1.54
363	Arteriovenous malformation	Enrichment	MAP2K1	1.53
364	Cowden syndrome	Enrichment	AKT1	1.53
365	Juvenile myelomonocytic leukemia	Enrichment	CBL	1.53
366	Moyamoya disease 1	Enrichment	ACTA2	1.52
367	Intestinal pseudo-obstruction	Enrichment	ACTG2	1.52
368	Typical nemaline myopathy	Enrichment	ACTA1	1.52
369	Alzheimer's disease	Enrichment	TNF	1.51
370	Hemophagocytic lymphohistiocytosis, familial, 1	Enrichment	PRF1	1.50
371	Diffuse cutaneous systemic sclerosis	Enrichment	IRF5	1.50
372	Idiopathic aplastic anemia	Enrichment	PRF1	1.50
373	Primary hyperaldosteronism	Enrichment	TP53	1.49
374	Hereditary breast carcinoma	Enrichment	AKT1, TP53	1.49
375	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.49
376	Ear malformation	Enrichment	AIFM1	1.48
377	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF	1.45
378	Focal epilepsy	Enrichment	SPTAN1	1.45
379	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.45
380	Leukemia, chronic lymphocytic	Enrichment	TP53	1.45
381	Familial colorectal cancer	Enrichment	TP53	1.45
382	Auditory neuropathy	Enrichment	AIFM1	1.45
383	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.44
384	Specific learning disability	Enrichment	MAPK1	1.44
385	Hemihyperplasia, isolated	Enrichment	IGF2	1.42
386	Immunodeficiency-centromeric instability-facial anomalies syndrome	Enrichment	HELLS	1.42
387	Limited scleroderma	Enrichment	IRF5	1.42
388	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.42
389	Myelodysplastic syndrome	Enrichment	TP53	1.41
390	Meningioma	Enrichment	AKT1	1.41
391	Perrault syndrome 1	Enrichment	DAP3	1.40
392	Rhabdomyosarcoma	Enrichment	CBL	1.40
393	Early-onset parkinson's disease	Enrichment	HTRA2	1.38
394	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.37
395	Achromatopsia	Enrichment	ATF6	1.37
396	Silver-russell syndrome 1	Enrichment	IGF2	1.36
397	Overgrowth syndrome	Enrichment	PIK3R1	1.36
398	Neuronal ceroid lipofuscinosis	Enrichment	CTSD	1.31
399	Cat eye syndrome	Enrichment	ACTG1	1.30
400	Nemaline myopathy	Enrichment	ACTA1	1.30
401	Isolated split hand-split foot malformation	Enrichment	TP63	1.30
402	Severe covid-19	Enrichment	CASP10	1.28
403	Rheumatoid arthritis	Enrichment	IRF5	1.25
404	Heart, malformation of	Enrichment	MAPK1	1.24
405	Arteriovenous malformations of the brain	Enrichment	MAP4K4	1.21
406	Aplastic anemia	Enrichment	PRF1	1.21
407	Melanoma	Enrichment	CDKN2A	1.21
408	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.21
409	Human immunodeficiency virus type 1	Enrichment	CCR5	1.20
410	Sensorineural hearing loss	Enrichment	AIFM1	1.19
411	Thrombocytopenia	Enrichment	CYCS	1.19
412	Diffuse large b-cell lymphoma	Enrichment	TP53	1.18
413	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.17
414	Hepatoblastoma	Enrichment	TP53	1.14
415	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	1.13
416	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.12
417	Diamond-blackfan anemia 1	Enrichment	TP53	1.10
418	Premature menopause	Enrichment	TP63	1.10
419	Nk-cell enteropathy	Enrichment	IGF1R	1.10
420	Myocardial infarction	Enrichment	LTA	1.04
421	Wilms tumor 1	Enrichment	IGF2	1.04
422	Male infertility with spermatogenesis disorder	Enrichment	TP63	1.04
423	Congenital myopathy	Enrichment	ACTA1	1.03
424	Prostate cancer	Enrichment	TP53	1.00
425	Lissencephaly	Enrichment	ACTG1	0.99
426	Centronuclear myopathy	Enrichment	ACTA1	0.99
427	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	0.98
428	Cleft palate, isolated	Enrichment	IRF6	0.98
429	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.98
430	Beckwith-wiedemann syndrome	Enrichment	IGF2	0.96
431	Left ventricular noncompaction	Enrichment	RAF1	0.96
432	Fetal akinesia deformation sequence 1	Enrichment	ASAH1	0.94
433	Jeune thoracic dystrophy	Enrichment	SPTAN1	0.92
434	Diamond-blackfan anemia	Enrichment	TP53	0.91
435	Hydrops fetalis, nonimmune	Enrichment	ACTA1	0.91
436	Benign epilepsy with centrotemporal spikes	Enrichment	ASAH1	0.89
437	Microcephaly	Enrichment	ACTB, ACTG1	0.89
438	Distal arthrogryposis	Enrichment	ASAH1	0.88
439	Autosomal recessive non-syndromic intellectual disability	Enrichment	CRADD	0.88
440	Tooth agenesis	Enrichment	IRF6	0.88
441	Asphyxiating thoracic dystrophy	Enrichment	SPTAN1	0.88
442	Centralopathic epilepsy	Enrichment	ASAH1	0.88
443	Leukemia, acute myeloid	Enrichment	TP53	0.87
444	Type 2 diabetes mellitus	Enrichment	PTPN1	0.85
445	Non-immune hydrops fetalis	Enrichment	ACTA1	0.83
446	Connective tissue disease	Enrichment	ACTA2	0.82
447	Peripheral nervous system disease	Enrichment	NGF	0.82
448	Neuropathy	Enrichment	NGF	0.82
449	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	SPTAN1	0.81
450	Cakut	Enrichment	ACTG1	0.80
451	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.79
452	Developmental and epileptic encephalopathy	Enrichment	SPTAN1	0.77
453	Non-syndromic genetic deafness	Enrichment	ACTG1	0.77
454	Myeloma, multiple	Enrichment	TP53	0.74
455	Myopathy	Enrichment	ACTA1	0.73
456	Hereditary spastic paraplegia	Enrichment	SPTAN1	0.71
457	Nonsyndromic hearing loss	Enrichment	ACTG1	0.71
458	West syndrome	Enrichment	SPTAN1	0.70
459	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2	0.70
460	Inherited cancer-predisposing syndrome	Enrichment	CDKN2A, TP53	0.68
461	Dilated cardiomyopathy	Enrichment	RAF1	0.63
462	Spastic ataxia	Enrichment	SPTAN1	0.62
463	Cone-rod dystrophy 2	Enrichment	ATF6	0.59
464	Congenital nervous system abnormality	Enrichment	ASAH1	0.53
465	Nervous system disease	Enrichment	ASAH1	0.53
466	Autism spectrum disorder	Enrichment	MAP2K1	0.52
467	Complex neurodevelopmental disorder	Enrichment	MADD	0.51
468	Primary ovarian insufficiency	Enrichment	TP63	0.50
469	Rare genetic deafness	Enrichment	ACTG1	0.48
470	Hereditary retinal dystrophy	Enrichment	ATF6	0.14
471	Fundus dystrophy	Enrichment	ATF6	0.14

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Apoptosis and survival TNFR1 signaling pathway

Pathway Network for Apoptosis and survival TNFR1 signaling pathway

Pathway network for the Apoptosis and survival TNFR1 signaling pathway SuperPath

Member Pathways for Apoptosis and survival TNFR1 signaling pathway

Pathways in the Apoptosis and survival TNFR1 signaling pathway SuperPath

Gene overlap in member pathways for Apoptosis and survival TNFR1 signaling pathway SuperPath

Associated Genes for Apoptosis and survival TNFR1 signaling pathway

Associated Disorders for Apoptosis and survival TNFR1 signaling pathway

Disorders associated with Apoptosis and survival TNFR1 signaling pathway SuperPath

STRING Interaction Network for Apoptosis and survival TNFR1 signaling pathway

Sources for Apoptosis and survival TNFR1 signaling pathway