Apoptosis modulation and signaling

No Pathway Network information available for Apoptosis modulation and signaling

Pathways in the Apoptosis modulation and signaling SuperPath

#	Name	Source	Genes
1	Apoptosis modulation and signaling	WikiPathways	AIFM1 AIFM2 BBC3 BCL2L11 BIRC5 BIRC7 CASP1 CASP2 CASP4 CYCS DIABLO HSPA1A HTRA2 MADD MIR29B1 MIR29B2 NAIP PEA15 PIDD1 PMAIP1 PRKD1 PTPN13 PTRH2 RIPK1 SEPTIN4 TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFSF10 TP53 XIAP (see all 32) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AIFM1	Apoptosis Inducing Factor Mitochondria Associated 1	Protein Coding	1
2	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	1
3	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	1
4	TNFRSF10C	TNF Receptor Superfamily Member 10c	Protein Coding	1
5	TNFSF10	TNF Superfamily Member 10	Protein Coding	1
6	CASP4	Caspase 4	Protein Coding	1
7	CASP2	Caspase 2	Protein Coding	1
8	CASP1	Caspase 1	Protein Coding	1
9	BIRC7	Baculoviral IAP Repeat Containing 7	Protein Coding	1
10	TP53	Tumor Protein P53	Protein Coding	1
11	DIABLO	Diablo IAP-Binding Mitochondrial Protein	Protein Coding	1
12	PRKD1	Protein Kinase D1	Protein Coding	1
13	PIDD1	P53-Induced Death Domain Protein 1	Protein Coding	1
14	CYCS	Cytochrome C, Somatic	Protein Coding	1
15	PMAIP1	Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Protein Coding	1
16	PTRH2	Peptidyl-TRNA Hydrolase 2	Protein Coding	1
17	MIR29B2	MicroRNA 29b-2	RNA Gene	1
18	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
19	XIAP	X-Linked Inhibitor Of Apoptosis	Protein Coding	1
20	HSPA1A	Heat Shock Protein Family A (Hsp70) Member 1A	Protein Coding	1
21	HTRA2	HtrA Serine Peptidase 2	Protein Coding	1
22	BBC3	BCL2 Binding Component 3	Protein Coding	1
23	BCL2L11	BCL2 Like 11	Protein Coding	1
24	TNFRSF10D	TNF Receptor Superfamily Member 10d	Protein Coding	1
25	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
26	PEA15	Proliferation And Apoptosis Adaptor Protein 15	Protein Coding	1
27	MADD	MAP Kinase Activating Death Domain	Protein Coding	1
28	AIFM2	AIF Family Member 2	Protein Coding	1
29	PTPN13	Protein Tyrosine Phosphatase Non-Receptor Type 13	Protein Coding	1
30	SEPTIN4	Septin 4	Protein Coding	1
31	NAIP	NLR Family Apoptosis Inhibitory Protein	Protein Coding	1
32	MIR29B1	MicroRNA 29b-1	RNA Gene	1

Disorders associated with Apoptosis modulation and signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Squamous cell carcinoma, head and neck	Enrichment	TNFRSF10B, TP53	3.95
2	Lymphoproliferative syndrome, x-linked, 2	Enrichment	XIAP	2.63
3	Parkinson disease 13, autosomal dominant	Enrichment	HTRA2	2.63
4	Bone marrow failure syndrome 5	Enrichment	TP53	2.63
5	Papilloma of choroid plexus	Enrichment	TP53	2.63
6	Basal cell carcinoma 7	Enrichment	TP53	2.63
7	Spermatogenic failure 99	Enrichment	SEPTIN4	2.63
8	Anaplastic thyroid carcinoma	Enrichment	TP53	2.63
9	Deeah syndrome	Enrichment	MADD	2.63
10	Thrombocytopenia 4	Enrichment	CYCS	2.63
11	Ductal carcinoma in situ	Enrichment	TP53	2.63
12	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.63
13	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.63
14	Neurodevelopmental disorder with dysmorphic facies, impaired speech, and hypotonia	Enrichment	MADD	2.63
15	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.63
16	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.63
17	Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly	Enrichment	CASP2	2.63
18	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.63
19	Choroid plexus cancer	Enrichment	TP53	2.63
20	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.63
21	Intellectual developmental disorder, autosomal recessive 75, with neuropsychiatric features and variant lissencephaly	Enrichment	PIDD1	2.63
22	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.63
23	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.33
24	Spondyloepimetaphyseal dysplasia, x-linked, with hypomyelinating leukodystrophy	Enrichment	AIFM1	2.33
25	Charcot-marie-tooth disease, x-linked recessive, 4, with or without cerebellar ataxia	Enrichment	AIFM1	2.33
26	Combined oxidative phosphorylation deficiency 6	Enrichment	AIFM1	2.33
27	Cervical cancer	Enrichment	TP53	2.33
28	Lymphoma, hodgkin, classic	Enrichment	TP53	2.33
29	Deafness, autosomal dominant 64	Enrichment	DIABLO	2.33
30	Congenital fibrosarcoma	Enrichment	TP53	2.33
31	Li-fraumeni syndrome 1	Enrichment	TP53	2.33
32	Sarcoma	Enrichment	TP53	2.33
33	Cervix carcinoma	Enrichment	TP53	2.33
34	Hodgkin's lymphoma	Enrichment	TP53	2.33
35	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.33
36	Charcot-marie-tooth disease x-linked recessive 4	Enrichment	AIFM1	2.33
37	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.33
38	Spinal muscular atrophy, type iii	Enrichment	NAIP	2.15
39	Spinal muscular atrophy, type i	Enrichment	NAIP	2.15
40	Spinal muscular atrophy, type ii	Enrichment	NAIP	2.15
41	Osteogenic sarcoma	Enrichment	TP53	2.15
42	Nasopharyngeal carcinoma	Enrichment	TP53	2.15
43	Deafness, x-linked 5, with peripheral neuropathy	Enrichment	AIFM1	2.15
44	X-linked deafness 5	Enrichment	AIFM1	2.15
45	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.15
46	Anaplastic astrocytoma	Enrichment	TP53	2.15
47	Squamous cell carcinoma	Enrichment	TP53	2.15
48	Adenocarcinoma	Enrichment	TP53	2.15
49	Combined oxidative phosphorylation deficiency	Enrichment	AIFM1	2.15
50	Laryngeal squamous cell carcinoma	Enrichment	TNFRSF10B	2.15
51	Bone osteosarcoma	Enrichment	TP53	2.15
52	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1, TP53	2.13
53	Small cell cancer of the lung	Enrichment	TP53	2.03
54	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.03
55	Lymphoproliferative syndrome 2	Enrichment	XIAP	2.03
56	Lung sarcomatoid carcinoma	Enrichment	TP53	2.03
57	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	PTRH2	2.03
58	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.03
59	3-methylglutaconic aciduria, type viii	Enrichment	HTRA2	2.03
60	Rhabdomyosarcoma 2	Enrichment	TP53	1.93
61	Lymphoma	Enrichment	TP53	1.93
62	Acute megakaryocytic leukemia	Enrichment	TP53	1.93
63	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.93
64	Multiple acyl-coa dehydrogenase deficiency, severe neonatal type	Enrichment	MADD	1.93
65	Li-fraumeni syndrome	Enrichment	TP53	1.85
66	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.85
67	Adrenocortical carcinoma	Enrichment	TP53	1.85
68	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.85
69	Breast adenocarcinoma	Enrichment	TP53	1.85
70	Esophageal cancer	Enrichment	TP53	1.79
71	Essential thrombocythemia	Enrichment	TP53	1.79
72	Gallbladder cancer	Enrichment	TP53	1.79
73	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.79
74	Glioma susceptibility 1	Enrichment	TP53	1.73
75	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.73
76	Male infertility due to globozoospermia	Enrichment	SEPTIN4	1.73
77	Adult hepatocellular carcinoma	Enrichment	TP53	1.68
78	Primary hyperaldosteronism	Enrichment	TP53	1.68
79	Leukemia, chronic lymphocytic	Enrichment	TP53	1.63
80	Familial colorectal cancer	Enrichment	TP53	1.63
81	Immune deficiency disease	Enrichment	RIPK1	1.59
82	Myelodysplastic syndrome	Enrichment	TP53	1.59
83	Early-onset parkinson's disease	Enrichment	HTRA2	1.55
84	Lip and oral cavity carcinoma	Enrichment	TP53	1.55
85	Lung cancer susceptibility 3	Enrichment	TP53	1.49
86	Rhabdomyosarcoma	Enrichment	TP53	1.43
87	Gliosarcoma	Enrichment	TP53	1.43
88	Giant cell glioblastoma	Enrichment	TP53	1.40
89	Diffuse large b-cell lymphoma	Enrichment	TP53	1.36
90	Leukodystrophy	Enrichment	AIFM1	1.34
91	Hepatoblastoma	Enrichment	TP53	1.31
92	Hepatocellular carcinoma	Enrichment	TP53	1.30
93	Diamond-blackfan anemia 1	Enrichment	TP53	1.28
94	Ear malformation	Enrichment	AIFM1	1.26
95	Autoinflammatory disease	Enrichment	XIAP	1.26
96	Pancreatic cancer	Enrichment	TP53	1.24
97	Auditory neuropathy	Enrichment	AIFM1	1.22
98	Bladder cancer	Enrichment	TP53	1.18
99	Prostate cancer	Enrichment	TP53	1.18
100	Diamond-blackfan anemia	Enrichment	TP53	1.09
101	Leukemia, acute myeloid	Enrichment	TP53	1.04
102	Gastric cancer	Enrichment	TP53	1.01
103	Hereditary breast carcinoma	Enrichment	TP53	1.01
104	Sensorineural hearing loss	Enrichment	AIFM1	0.97
105	Thrombocytopenia	Enrichment	CYCS	0.97
106	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	DIABLO	0.94
107	Myeloma, multiple	Enrichment	TP53	0.91
108	Breast cancer	Enrichment	TP53	0.79
109	Colorectal cancer	Enrichment	TP53	0.73
110	Ovarian cancer	Enrichment	TP53	0.67
111	Complex neurodevelopmental disorder	Enrichment	MADD	0.59
112	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.57

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Apoptosis modulation and signaling

Pathway Network for Apoptosis modulation and signaling

Member Pathways for Apoptosis modulation and signaling

Pathways in the Apoptosis modulation and signaling SuperPath

Associated Genes for Apoptosis modulation and signaling

Associated Disorders for Apoptosis modulation and signaling

Disorders associated with Apoptosis modulation and signaling SuperPath

STRING Interaction Network for Apoptosis modulation and signaling

Sources for Apoptosis modulation and signaling