Apoptotic cleavage of cellular proteins

Pathway network for the Apoptotic cleavage of cellular proteins SuperPath

Sources:

Reactome

Pathways in the Apoptotic cleavage of cellular proteins SuperPath

#	Name	Source	Genes
1	Apoptotic cleavage of cellular proteins	Reactome	ACIN1 APC BCAP31 BIRC2 BMX CASP8 CLSPN CTNNB1 DSG3 FNTA LMNA LMNB1 PRKCD PTK2 ROCK1 SATB1 SPTAN1 STK24 STK26 TJP1 TJP2 VIM (see all 22) (see less)
2	Apoptotic execution phase	Reactome	ACIN1 APC BCAP31 BIRC2 BMX CASP8 CLSPN CTNNB1 DNM1L DSG3 FNTA HMGB1 KPNA1 KPNB1 LMNA LMNB1 PAK2 PRKCD PTK2 ROCK1 SATB1 SPTAN1 STK24 STK26 TJP1 TJP2 VIM (see all 27) (see less)
3	Apoptotic cleavage of cell adhesion proteins	Reactome	CTNNB1 DSG3 TJP1 TJP2
4	Caspase-mediated cleavage of cytoskeletal proteins	Reactome	CASP8 SPTAN1 VIM
5	Apoptosis induced DNA fragmentation	Reactome	HMGB1 KPNA1 KPNB1
6	Activation, myristolyation of BID and translocation to mitochondria	Reactome	CASP8

Gene overlap in member pathways for Apoptotic cleavage of cellular proteins SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CASP8	Caspase 8	Protein Coding	4
2	CTNNB1	Catenin Beta 1	Protein Coding	3
3	DSG3	Desmoglein 3	Protein Coding	3
4	SPTAN1	Spectrin Alpha, Non-Erythrocytic 1	Protein Coding	3
5	TJP1	Tight Junction Protein 1	Protein Coding	3
6	VIM	Vimentin	Protein Coding	3
7	TJP2	Tight Junction Protein 2	Protein Coding	3
8	BCAP31	B Cell Receptor Associated Protein 31	Protein Coding	2
9	ACIN1	Apoptotic Chromatin Condensation Inducer 1	Protein Coding	2
10	FNTA	Farnesyltransferase, CAAX Box, Subunit Alpha	Protein Coding	2
11	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	2
12	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	2
13	LMNA	Lamin A/C	Protein Coding	2
14	LMNB1	Lamin B1	Protein Coding	2
15	STK26	Serine/Threonine Kinase 26	Protein Coding	2
16	PRKCD	Protein Kinase C Delta	Protein Coding	2
17	PTK2	Protein Tyrosine Kinase 2	Protein Coding	2
18	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	2
19	SATB1	SATB Homeobox 1	Protein Coding	2
20	CLSPN	Claspin	Protein Coding	2
21	BMX	BMX Non-Receptor Tyrosine Kinase	Protein Coding	2
22	STK24	Serine/Threonine Kinase 24	Protein Coding	2
23	HMGB1	High Mobility Group Box 1	Protein Coding	2
24	KPNA1	Karyopherin Subunit Alpha 1	Protein Coding	2
25	KPNB1	Karyopherin Subunit Beta 1	Protein Coding	2
26	DNM1L	Dynamin 1 Like	Protein Coding	1
27	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1

Disorders associated with Apoptotic cleavage of cellular proteins SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hepatocellular carcinoma	Enrichment	APC, CASP8, CTNNB1	5.25
2	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	5.12
3	Desmoid tumor	Enrichment	APC, CTNNB1	5.12
4	Craniopharyngioma	Enrichment	APC, CTNNB1	4.82
5	Histiocytoid hemangioma	Enrichment	LMNA, VIM	4.60
6	Caspase 8 deficiency	Enrichment	CASP8	4.13
7	Adult hepatocellular carcinoma	Enrichment	CASP8, CTNNB1	4.05
8	Developmental and epileptic encephalopathy 5	Enrichment	SPTAN1	3.66
9	Spastic paraplegia 91, autosomal dominant, with or without cerebellar ataxia	Enrichment	SPTAN1	3.66
10	Developmental delay with or without epilepsy	Enrichment	SPTAN1	3.66
11	Neuronopathy, distal hereditary motor, autosomal dominant 11	Enrichment	SPTAN1	3.66
12	Premature aging	Enrichment	VIM	3.66
13	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	3.66
14	Medulloblastoma	Enrichment	APC, CTNNB1	3.65
15	Deafness, autosomal dominant 51	Enrichment	TJP2	3.53
16	Blistering, acantholytic, of oral and laryngeal mucosa	Enrichment	DSG3	3.53
17	Adenoid ameloblastoma	Enrichment	CTNNB1	3.53
18	Microcystic stromal tumor	Enrichment	CTNNB1	3.53
19	Neuromuscular disease	Enrichment	LMNA, SPTAN1	3.42
20	Intellectual developmental disorder, x-linked, syndromic, raymond type	Enrichment	SPTAN1	3.35
21	Cataract 30	Enrichment	VIM	3.35
22	Hepatoblastoma	Enrichment	APC, CTNNB1	3.29
23	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	3.23
24	Cholestasis, progressive familial intrahepatic, 4	Enrichment	TJP2	3.23
25	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	3.23
26	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	3.23
27	Teratoma	Enrichment	CTNNB1	3.23
28	Short-rib thoracic dysplasia 11 with or without polydactyly	Enrichment	SPTAN1	3.18
29	Hypercholanemia, familial 1	Enrichment	TJP2	3.05
30	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	3.05
31	Anus, imperforate	Enrichment	CTNNB1	3.05
32	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	3.05
33	Charcot-marie-tooth hereditary neuropathy	Enrichment	SPTAN1	3.05
34	Pilomatrixoma	Enrichment	CTNNB1	2.93
35	Alazami syndrome	Enrichment	CTNNB1	2.93
36	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	2.83
37	Focal epilepsy	Enrichment	SPTAN1	2.81
38	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, typical	Enrichment	LMNB1	2.79
39	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.79
40	Developmental delay with dysmorphic facies and dental anomalies	Enrichment	SATB1	2.79
41	Deafness, dystonia, and cerebral hypomyelination	Enrichment	BCAP31	2.79
42	Adult onset demyelinating leukodystrophy	Enrichment	LMNB1	2.79
43	Microcephaly 26, primary, autosomal dominant	Enrichment	LMNB1	2.79
44	Atypical werner syndrome	Enrichment	LMNA	2.79
45	Den hoed-de boer-voisin syndrome	Enrichment	SATB1	2.79
46	Mandibuloacral dysplasia	Enrichment	LMNA	2.79
47	Atrioventricular block	Enrichment	LMNA	2.79
48	Familial adenomatous polyposis	Enrichment	APC	2.79
49	Lmna-related cardiocutaneous progeria syndrome	Enrichment	LMNA	2.79
50	Gardner syndrome	Enrichment	APC	2.79
51	5q22 microdeletion syndrome	Enrichment	APC	2.79
52	Attenuated familial adenomatous polyposis	Enrichment	APC	2.79
53	Autosomal semi-dominant severe lipodystrophic laminopathy	Enrichment	LMNA	2.79
54	Intellectual disability-acpilepsy-dental anomalies-facial dysmorphism syndrome	Enrichment	SATB1	2.79
55	Autosomal recessive axonal hereditary motor and sensory neuropathy	Enrichment	LMNA	2.79
56	Laminopathy	Enrichment	LMNA	2.79
57	Branchiootorenal syndrome 1	Enrichment	TJP2	2.75
58	Weyers acrofacial dysostosis	Enrichment	CTNNB1	2.75
59	Adrenocortical carcinoma	Enrichment	CTNNB1	2.75
60	Familial hypercholanemia	Enrichment	TJP2	2.75
61	Optic atrophy 5	Enrichment	DNM1L	2.70
62	Encephalopathy due to defective mitochondrial and peroxisomal fission 1	Enrichment	DNM1L	2.70
63	Knobloch syndrome 2	Enrichment	PAK2	2.70
64	Encephalopathy due to mitochondrial and peroxisomal fission defect	Enrichment	DNM1L	2.70
65	Branchiootorenal syndrome	Enrichment	TJP2	2.69
66	Gallbladder cancer	Enrichment	CTNNB1	2.69
67	Cataract 30, multiple types	Enrichment	VIM	2.66
68	Exudative vitreoretinopathy	Enrichment	CTNNB1	2.63
69	Lung cancer	Enrichment	CASP8	2.63
70	Primary biliary cholangitis	Enrichment	TJP2	2.58
71	Mandibuloacral dysplasia with type a lipodystrophy	Enrichment	LMNA	2.49
72	Hyperaldosteronism, familial, type ii	Enrichment	SATB1	2.49
73	Heart-hand syndrome, slovenian type	Enrichment	LMNA	2.49
74	Charcot-marie-tooth disease, axonal, type 2b1	Enrichment	LMNA	2.49
75	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	Enrichment	LMNA	2.49
76	Cardiomyopathy, dilated, 1d	Enrichment	LMNA	2.49
77	Restrictive dermopathy 2	Enrichment	LMNA	2.49
78	Emery-dreifuss muscular dystrophy 3, autosomal recessive	Enrichment	LMNA	2.49
79	Lipodystrophy, familial partial, type 1	Enrichment	LMNA	2.49
80	Periampullary adenoma	Enrichment	APC	2.49
81	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	2.49
82	Autosomal dominant primary microcephaly	Enrichment	LMNB1	2.49
83	Familial partial lipodystrophy	Enrichment	LMNA	2.49
84	Cadds	Enrichment	BCAP31	2.49
85	Charcot-marie-tooth disease type 2b1	Enrichment	LMNA	2.49
86	Restrictive dermopathy 1	Enrichment	LMNA	2.31
87	Lipodystrophy, familial partial, type 2	Enrichment	LMNA	2.31
88	Cenani-lenz syndactyly syndrome	Enrichment	APC	2.31
89	Muscular dystrophy, congenital, lmna-related	Enrichment	LMNA	2.31
90	Restrictive dermopathy	Enrichment	LMNA	2.31
91	Colon adenocarcinoma	Enrichment	APC	2.31
92	Apc-associated polyposis conditions	Enrichment	APC	2.31
93	Polycystic liver disease	Enrichment	CTNNB1	2.30
94	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	2.30
95	Jeune thoracic dystrophy	Enrichment	SPTAN1	2.26
96	Breast cancer	Enrichment	CASP8	2.26
97	Autosomal dominant optic atrophy, classic form	Enrichment	DNM1L	2.22
98	Asphyxiating thoracic dystrophy	Enrichment	SPTAN1	2.21
99	Hutchinson-gilford progeria syndrome	Enrichment	LMNA	2.19
100	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	LMNA	2.19
101	Microtia-anotia	Enrichment	LMNA	2.19
102	Emery-dreifuss muscular dystrophy	Enrichment	LMNA	2.19
103	Sick sinus syndrome	Enrichment	LMNA	2.19
104	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	SPTAN1	2.14
105	Knobloch syndrome	Enrichment	PAK2	2.10
106	Developmental and epileptic encephalopathy	Enrichment	SPTAN1	2.10
107	Familial adenomatous polyposis 1	Enrichment	APC	2.09
108	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	LMNA	2.09
109	Bladder cancer	Enrichment	CTNNB1	2.07
110	Colorectal cancer	Enrichment	APC, CTNNB1	2.06
111	Benign epilepsy with centrotemporal spikes	Enrichment	SPTAN1	2.04
112	Hereditary spastic paraplegia	Enrichment	SPTAN1	2.03
113	Centralopathic epilepsy	Enrichment	SPTAN1	2.02
114	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	LMNA	2.01
115	West syndrome	Enrichment	SPTAN1	2.01
116	Knobloch syndrome 1	Enrichment	PAK2	2.00
117	Bethlem myopathy 1a	Enrichment	LMNA	1.95
118	Ovarian cancer	Enrichment	APC, CTNNB1	1.94
119	Spastic ataxia	Enrichment	SPTAN1	1.93
120	Congenital muscular dystrophy	Enrichment	LMNA	1.89
121	Myocarditis	Enrichment	LMNA	1.89
122	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	LMNA	1.84
123	Colonic benign neoplasm	Enrichment	APC	1.84
124	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TJP2	1.82
125	Cardiac conduction defect	Enrichment	LMNA	1.71
126	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	LMNA	1.71
127	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	LMNA	1.71
128	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	LMNA	1.71
129	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	LMNA	1.65
130	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	LMNA	1.59
131	Cardiomyopathy, dilated, 1e	Enrichment	LMNA	1.56
132	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	LMNA	1.52
133	Congenital nervous system abnormality	Enrichment	CTNNB1	1.51
134	Nervous system disease	Enrichment	CTNNB1	1.51
135	Cardiomyopathy, dilated, 1a	Enrichment	LMNA	1.47
136	Microcephaly	Enrichment	CTNNB1	1.45
137	Cardiomyopathy, familial hypertrophic, 1	Enrichment	LMNA	1.42
138	Muscular dystrophy	Enrichment	LMNA	1.42
139	Brugada syndrome	Enrichment	LMNA	1.38
140	Long qt syndrome	Enrichment	LMNA	1.31
141	Peripheral nervous system disease	Enrichment	LMNA	1.30
142	Neuropathy	Enrichment	LMNA	1.30
143	Left ventricular noncompaction	Enrichment	LMNA	1.26
144	Charcot-marie-tooth disease	Enrichment	LMNA	1.19
145	Gastric cancer	Enrichment	APC	1.17
146	Hereditary breast carcinoma	Enrichment	APC	1.16
147	Familial isolated dilated cardiomyopathy	Enrichment	LMNA	1.08
148	Body mass index quantitative trait locus 11	Enrichment	DNM1L	1.02
149	Dilated cardiomyopathy	Enrichment	LMNA	0.91
150	Mitochondrial disease	Enrichment	DNM1L	0.80
151	Inherited cancer-predisposing syndrome	Enrichment	APC	0.71

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Apoptotic cleavage of cellular proteins

Pathway Network for Apoptotic cleavage of cellular proteins

Pathway network for the Apoptotic cleavage of cellular proteins SuperPath

Member Pathways for Apoptotic cleavage of cellular proteins

Pathways in the Apoptotic cleavage of cellular proteins SuperPath

Gene overlap in member pathways for Apoptotic cleavage of cellular proteins SuperPath

Associated Genes for Apoptotic cleavage of cellular proteins

Associated Disorders for Apoptotic cleavage of cellular proteins

Disorders associated with Apoptotic cleavage of cellular proteins SuperPath

STRING Interaction Network for Apoptotic cleavage of cellular proteins

Sources for Apoptotic cleavage of cellular proteins