Aquaporin-mediated transport

Pathway network for the Aquaporin-mediated transport SuperPath

Sources:

Reactome

Pathways in the Aquaporin-mediated transport SuperPath

#	Name	Source	Genes
1	Aquaporin-mediated transport	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AQP1 AQP10 AQP11 AQP12A AQP2 AQP3 AQP4 AQP5 AQP6 AQP7 AQP8 AQP9 AVP AVPR2 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 MIP MYO5B PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAB11A RAB11FIP2 (see all 52) (see less)
2	Vasopressin regulates renal water homeostasis via Aquaporins	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AQP1 AQP2 AQP3 AQP4 AVP AVPR2 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 MYO5B PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAB11A RAB11FIP2 (see all 43) (see less)
3	Passive transport by Aquaporins	Reactome	AQP1 AQP10 AQP11 AQP12A AQP2 AQP3 AQP4 AQP5 AQP6 AQP7 AQP8 AQP9 MIP (see all 13) (see less)
4	Transport of glycerol from adipocytes to the liver by Aquaporins	Reactome	AQP7 AQP9

Gene overlap in member pathways for Aquaporin-mediated transport SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AQP1	Aquaporin 1 (Colton Blood Group)	Protein Coding	3
2	AQP2	Aquaporin 2	Protein Coding	3
3	AQP3	Aquaporin 3 (Gill Blood Group)	Protein Coding	3
4	AQP4	Aquaporin 4	Protein Coding	3
5	AQP7	Aquaporin 7	Protein Coding	3
6	AQP9	Aquaporin 9	Protein Coding	3
7	GNB5	G Protein Subunit Beta 5	Protein Coding	2
8	ADCY1	Adenylate Cyclase 1	Protein Coding	2
9	ADCY2	Adenylate Cyclase 2	Protein Coding	2
10	ADCY3	Adenylate Cyclase 3	Protein Coding	2
11	ADCY5	Adenylate Cyclase 5	Protein Coding	2
12	ADCY6	Adenylate Cyclase 6	Protein Coding	2
13	ADCY7	Adenylate Cyclase 7	Protein Coding	2
14	ADCY8	Adenylate Cyclase 8	Protein Coding	2
15	ADCY9	Adenylate Cyclase 9	Protein Coding	2
16	ADCY4	Adenylate Cyclase 4	Protein Coding	2
17	RAB11FIP2	RAB11 Family Interacting Protein 2	Protein Coding	2
18	GNAS	GNAS Complex Locus	Protein Coding	2
19	GNB1	G Protein Subunit Beta 1	Protein Coding	2
20	GNB2	G Protein Subunit Beta 2	Protein Coding	2
21	GNB3	G Protein Subunit Beta 3	Protein Coding	2
22	GNG3	G Protein Subunit Gamma 3	Protein Coding	2
23	GNG4	G Protein Subunit Gamma 4	Protein Coding	2
24	GNG5	G Protein Subunit Gamma 5	Protein Coding	2
25	GNG7	G Protein Subunit Gamma 7	Protein Coding	2
26	GNG10	G Protein Subunit Gamma 10	Protein Coding	2
27	GNG11	G Protein Subunit Gamma 11	Protein Coding	2
28	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	2
29	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	2
30	AQP11	Aquaporin 11	Protein Coding	2
31	AQP8	Aquaporin 8	Protein Coding	2
32	AQP5	Aquaporin 5	Protein Coding	2
33	AQP6	Aquaporin 6	Protein Coding	2
34	AQP12A	Aquaporin 12A	Protein Coding	2
35	MIP	Major Intrinsic Protein Of Lens Fiber	Protein Coding	2
36	MYO5B	Myosin VB	Protein Coding	2
37	GNG13	G Protein Subunit Gamma 13	Protein Coding	2
38	GNG2	G Protein Subunit Gamma 2	Protein Coding	2
39	AVP	Arginine Vasopressin	Protein Coding	2
40	AVPR2	Arginine Vasopressin Receptor 2	Protein Coding	2
41	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	2
42	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	2
43	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	2
44	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	2
45	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	2
46	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	2
47	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	2
48	GNG12	G Protein Subunit Gamma 12	Protein Coding	2
49	GNB4	G Protein Subunit Beta 4	Protein Coding	2
50	RAB11A	RAB11A, Member RAS Oncogene Family	Protein Coding	2
51	AQP10	Aquaporin 10	Protein Coding	2
52	GNG8	G Protein Subunit Gamma 8	Protein Coding	2

Disorders associated with Aquaporin-mediated transport SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS, PRKAR1A	5.01
2	Nephrogenic diabetes insipidus	Enrichment	AQP2, AVPR2	4.53
3	Diabetes insipidus	Enrichment	AQP2, AVP	4.23
4	Glycerol quantitative trait locus	Enrichment	AQP7	3.83
5	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.46
6	Body mass index quantitative trait locus 11	Enrichment	ADCY3, AQP7, GNAS	3.04
7	Blood group, colton system	Enrichment	AQP1	3.02
8	Cataract 15, multiple types	Enrichment	MIP	3.02
9	Megalencephalic leukoencephalopathy with subcortical cysts 4, remitting	Enrichment	AQP4	3.02
10	Palmoplantar keratoderma, bothnian type	Enrichment	AQP5	2.72
11	Diabetes insipidus, nephrogenic, 2, autosomal	Enrichment	AQP2	2.72
12	Diabetes insipidus, neurohypophyseal	Enrichment	AVP	2.50
13	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.50
14	Nephrogenic syndrome of inappropriate antidiuresis	Enrichment	AVPR2	2.50
15	Diabetes insipidus, nephrogenic, 1, x-linked	Enrichment	AVPR2	2.50
16	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.50
17	Carney complex, type 1	Enrichment	PRKAR1A	2.50
18	Osseous heteroplasia, progressive	Enrichment	GNAS	2.50
19	Dyskinesia with orofacial involvement, autosomal dominant	Enrichment	ADCY5	2.50
20	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.50
21	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.50
22	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.50
23	Neurodevelopmental disorder with hyperkinetic movements and dyskinesia	Enrichment	ADCY5	2.50
24	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.50
25	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.50
26	Central diabetes insipidus	Enrichment	AVP	2.50
27	Myxoma, intracardiac	Enrichment	PRKAR1A	2.50
28	X-linked nephrogenic diabetes insipidus	Enrichment	AVPR2	2.50
29	Dyskinesia with orofacial involvement, autosomal recessive	Enrichment	ADCY5	2.50
30	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.50
31	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.50
32	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.50
33	Disorders of gnas inactivation	Enrichment	GNAS	2.50
34	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.50
35	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.50
36	Sick sinus syndrome 4	Enrichment	GNB2	2.50
37	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.50
38	Monostotic fibrous dysplasia	Enrichment	GNAS	2.50
39	Mazabraud syndrome	Enrichment	GNAS	2.50
40	Hereditary arginine vasopressin deficiency	Enrichment	AVP	2.50
41	Congenital blue dot cataract	Enrichment	MIP	2.42
42	Persistent hyperplastic primary vitreous	Enrichment	MIP	2.32
43	Early-onset sutural cataract	Enrichment	MIP	2.24
44	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.20
45	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	2.20
46	Diarrhea 2, with microvillus atrophy, with or without cholestasis	Enrichment	MYO5B	2.20
47	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.20
48	Lethal congenital contracture syndrome 8	Enrichment	ADCY6	2.20
49	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.20
50	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.20
51	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	2.20
52	Cholestasis, progressive familial intrahepatic, 10	Enrichment	MYO5B	2.20
53	Usher syndrome, type iv	Enrichment	PRKAR1A	2.20
54	Acrodysostosis	Enrichment	PRKAR1A	2.20
55	Pseudohypoparathyroidism	Enrichment	GNAS	2.20
56	Body mass index quantitative trait locus 19	Enrichment	ADCY3	2.20
57	Fibrolamellar carcinoma	Enrichment	PRKACA	2.20
58	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	2.20
59	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.20
60	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	2.20
61	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.20
62	Cerebral visual impairment	Enrichment	GNB1	2.20
63	Early-onset posterior polar cataract	Enrichment	MIP	2.12
64	Mccune-albright syndrome	Enrichment	GNAS	2.02
65	Microvillus inclusion disease	Enrichment	MYO5B	2.02
66	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	2.02
67	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	ADCY6	2.02
68	Early-onset lamellar cataract	Enrichment	MIP	1.98
69	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1, RAB11A	1.96
70	Chorea, benign hereditary	Enrichment	ADCY5	1.90
71	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.90
72	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.90
73	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.90
74	Carney complex variant	Enrichment	PRKAR1A	1.90
75	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.90
76	Familial sick sinus syndrome	Enrichment	GNB2	1.90
77	Cataract 44	Enrichment	MIP	1.79
78	Early-onset nuclear cataract	Enrichment	MIP	1.77
79	Cholestasis, progressive familial intrahepatic, 1	Enrichment	MYO5B	1.72
80	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.72
81	Brachydactyly	Enrichment	GNAS	1.66
82	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.60
83	Hypothyroidism	Enrichment	GNB1	1.60
84	Inflammatory bowel disease 1	Enrichment	MYO5B	1.55
85	Primary hyperaldosteronism	Enrichment	GNAS	1.55
86	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.46
87	Myelodysplastic syndrome	Enrichment	GNB1	1.46
88	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.39
89	Isolated congenital microcephaly	Enrichment	RAB11A	1.30
90	Hypertension, essential	Enrichment	GNB3	1.28
91	Cleft palate, isolated	Enrichment	GNB1	1.28
92	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.17
93	Congenital stationary night blindness	Enrichment	GNB3	1.15
94	Strabismus	Enrichment	GNB1	1.08
95	Dystonia	Enrichment	GNB1	0.98
96	Cerebral palsy	Enrichment	GNB1	0.93
97	Breast cancer	Enrichment	GNG3	0.67
98	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.67
99	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.61
100	Congenital nervous system abnormality	Enrichment	GNB5	0.54
101	Nervous system disease	Enrichment	GNB5	0.54
102	Autism spectrum disorder	Enrichment	GNB1	0.53
103	Microcephaly	Enrichment	GNB1	0.49
104	Complex neurodevelopmental disorder	Enrichment	GNB2	0.49
105	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A	0.46

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Aquaporin-mediated transport

Pathway Network for Aquaporin-mediated transport

Pathway network for the Aquaporin-mediated transport SuperPath

Member Pathways for Aquaporin-mediated transport

Pathways in the Aquaporin-mediated transport SuperPath

Gene overlap in member pathways for Aquaporin-mediated transport SuperPath

Associated Genes for Aquaporin-mediated transport

Associated Disorders for Aquaporin-mediated transport

Disorders associated with Aquaporin-mediated transport SuperPath

STRING Interaction Network for Aquaporin-mediated transport

Sources for Aquaporin-mediated transport