arachidonate biosynthesis III (metazoa)

Sources:

#	Name	Source	Genes
1	arachidonate biosynthesis III (metazoa)	PubChem	ACSBG1 ACSBG2 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ACSM1 ACSM3 ACSM4 ACSM5 ACSM6 ELOVL5 FADS1 FADS2 SLC27A2 (see all 16) (see less)
2	γ-linolenate biosynthesis	PubChem	ACSBG1 ACSBG2 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ACSM1 ACSM3 ACSM4 ACSM5 ACSM6 FADS2 SLC27A2 (see all 14) (see less)
3	icosapentaenoate biosynthesis II (metazoa)	PubChem	ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ACSM1 ACSM3 ACSM4 ACSM5 ACSM6 ELOVL5 FADS1 FADS2 (see all 13) (see less)
4	fatty acid activation	PubChem	ACSBG1 ACSBG2 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 SLC27A2 (see all 8) (see less)
5	arachidonate biosynthesis III (6-desaturase, mammals)	PubChem	ACSL1 ELOVL5 FADS1 FADS2 SLC27A2
6	γ-linolenate biosynthesis II (animals)	PubChem	ACSL1 FADS2 SLC27A2

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACSL1	Acyl-CoA Synthetase Long Chain Family Member 1	Protein Coding	6
2	FADS2	Fatty Acid Desaturase 2	Protein Coding	5
3	SLC27A2	Solute Carrier Family 27 Member 2	Protein Coding	5
4	ACSL5	Acyl-CoA Synthetase Long Chain Family Member 5	Protein Coding	4
5	ACSL3	Acyl-CoA Synthetase Long Chain Family Member 3	Protein Coding	4
6	ACSL6	Acyl-CoA Synthetase Long Chain Family Member 6	Protein Coding	4
7	ACSL4	Acyl-CoA Synthetase Long Chain Family Member 4	Protein Coding	4
8	ACSM6	Acyl-CoA Synthetase Medium Chain Family Member 6	Protein Coding	3
9	ACSM4	Acyl-CoA Synthetase Medium Chain Family Member 4	Protein Coding	3
10	ACSM5	Acyl-CoA Synthetase Medium Chain Family Member 5	Protein Coding	3
11	ACSM3	Acyl-CoA Synthetase Medium Chain Family Member 3	Protein Coding	3
12	ACSBG2	Acyl-CoA Synthetase Bubblegum Family Member 2	Protein Coding	3
13	ACSBG1	Acyl-CoA Synthetase Bubblegum Family Member 1	Protein Coding	3
14	ACSM1	Acyl-CoA Synthetase Medium Chain Family Member 1	Protein Coding	3
15	ELOVL5	ELOVL Fatty Acid Elongase 5	Protein Coding	3
16	FADS1	Fatty Acid Desaturase 1	Protein Coding	3

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Spinocerebellar ataxia 38	Enrichment	ELOVL5	3.43
2	Intellectual developmental disorder, x-linked 63	Enrichment	ACSL4	3.23
3	Diarrhea 13	Enrichment	ACSL5	3.23
4	Neurodevelopmental disorder with speech delay and variable ocular anomalies	Enrichment	ACSM3	2.72
5	Amme complex	Enrichment	ACSL4	2.63
6	Stroke, ischemic	Enrichment	ACSL4	2.23
7	Non-syndromic x-linked intellectual disability	Enrichment	ACSL4	1.68

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for arachidonate biosynthesis III (metazoa)