Arf6 downstream pathway

No Pathway Network information available for Arf6 downstream pathway

#	Name	Source	Genes
1	Arf6 downstream pathway	PubChem	ARF1 ARF6 KALRN MAPK3 NME1 PIP5K1A PLAUR PLD1 RAB11A RAB11FIP3 RAC1 RHOA TIAM1 (see all 13) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PLD1	Phospholipase D1	Protein Coding	1
2	PIP5K1A	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha	Protein Coding	1
3	NME1	NME/NM23 Nucleoside Diphosphate Kinase 1	Protein Coding	1
4	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	1
5	KALRN	Kalirin RhoGEF Kinase	Protein Coding	1
6	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
7	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
8	RHOA	Ras Homolog Family Member A	Protein Coding	1
9	RAB11FIP3	RAB11 Family Interacting Protein 3	Protein Coding	1
10	RAC1	Rac Family Small GTPase 1	Protein Coding	1
11	ARF6	ARF GTPase 6	Protein Coding	1
12	ARF1	ARF GTPase 1	Protein Coding	1
13	RAB11A	RAB11A, Member RAS Oncogene Family	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cardiac valvular dysplasia 1	Enrichment	PLD1	3.02
2	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	3.02
3	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	3.02
4	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	3.02
5	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	3.02
6	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.72
7	Periventricular nodular heterotopia 8	Enrichment	ARF1	2.72
8	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	PIP5K1A	2.72
9	Hemihyperplasia, isolated	Enrichment	RHOA	2.24
10	Coronary heart disease 5	Enrichment	KALRN	2.07
11	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	2.07
12	Periventricular nodular heterotopia	Enrichment	ARF1	1.87
13	Isolated congenital microcephaly	Enrichment	RAB11A	1.82
14	Autosomal dominant non-syndromic intellectual disability	Enrichment	RAB11A	1.33
15	Complex neurodevelopmental disorder	Enrichment	TIAM1	0.95

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Arf6 downstream pathway