Articular Cartilage Extracellular Matrix

No Pathway Network information available for Articular Cartilage Extracellular Matrix

Pathways in the Articular Cartilage Extracellular Matrix SuperPath

#	Name	Source	Genes
1	Articular Cartilage Extracellular Matrix	R&D Systems	ACAN BGN CD44 CHST1 CHST10 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 COL13A1 COL2A1 COMP DCN DDR2 FMOD FN1 HAPLN1 HPSE HS2ST1 HS3ST1 HS3ST4 HS6ST1 HS6ST2 HS6ST3 HYAL4 ITGA10 ITGA2 ITGA2B ITGA5 ITGB1 MATN4 PRELP SDC1 SDC3 (see all 36) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FMOD	Fibromodulin	Protein Coding	1
2	DCN	Decorin	Protein Coding	1
3	ACAN	Aggrecan	Protein Coding	1
4	COL2A1	Collagen Type II Alpha 1 Chain	Protein Coding	1
5	COMP	Cartilage Oligomeric Matrix Protein	Protein Coding	1
6	MATN4	Matrilin 4	Protein Coding	1
7	BGN	Biglycan	Protein Coding	1
8	PRELP	Proline And Arginine Rich End Leucine Rich Repeat Protein	Protein Coding	1
9	ITGA5	Integrin Subunit Alpha 5	Protein Coding	1
10	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
11	ITGA10	Integrin Subunit Alpha 10	Protein Coding	1
12	ITGA2	Integrin Subunit Alpha 2	Protein Coding	1
13	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	1
14	CD44	CD44 Molecule (IN Blood Group)	Protein Coding	1
15	SDC1	Syndecan 1	Protein Coding	1
16	SDC3	Syndecan 3	Protein Coding	1
17	COL13A1	Collagen Type XIII Alpha 1 Chain	Protein Coding	1
18	DDR2	Discoidin Domain Receptor Tyrosine Kinase 2	Protein Coding	1
19	CHST1	Carbohydrate Sulfotransferase 1	Protein Coding	1
20	CHST2	Carbohydrate Sulfotransferase 2	Protein Coding	1
21	CHST5	Carbohydrate Sulfotransferase 5	Protein Coding	1
22	CHST6	Carbohydrate Sulfotransferase 6	Protein Coding	1
23	HPSE	Heparanase	Protein Coding	1
24	HS2ST1	Heparan Sulfate 2-O-Sulfotransferase 1	Protein Coding	1
25	HS3ST1	Heparan Sulfate-Glucosamine 3-Sulfotransferase 1	Protein Coding	1
26	HS3ST4	Heparan Sulfate-Glucosamine 3-Sulfotransferase 4	Protein Coding	1
27	HS6ST1	Heparan Sulfate 6-O-Sulfotransferase 1	Protein Coding	1
28	HS6ST2	Heparan Sulfate 6-O-Sulfotransferase 2	Protein Coding	1
29	HS6ST3	Heparan Sulfate 6-O-Sulfotransferase 3	Protein Coding	1
30	HYAL4	Hyaluronidase 4	Protein Coding	1
31	CHST3	Carbohydrate Sulfotransferase 3	Protein Coding	1
32	CHST7	Carbohydrate Sulfotransferase 7	Protein Coding	1
33	CHST10	Carbohydrate Sulfotransferase 10	Protein Coding	1
34	CHST15	Carbohydrate Sulfotransferase 15	Protein Coding	1
35	FN1	Fibronectin 1	Protein Coding	1
36	HAPLN1	Hyaluronan And Proteoglycan Link Protein 1	Protein Coding	1

Disorders associated with Articular Cartilage Extracellular Matrix SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	COL2A1, FN1	5.16
2	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	COL2A1, FN1	5.16
3	Multiple epiphyseal dysplasia	Enrichment	COL2A1, COMP	4.69
4	Spondyloepiphyseal dysplasia with congenital joint dislocations	Enrichment	ACAN, CHST3	3.99
5	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2, ITGA2B	3.99
6	Stickler syndrome, type i	Enrichment	COL2A1	2.58
7	Short stature and advanced bone age with or without early-onset osteoarthritis and/or osteochondritis dissecans	Enrichment	ACAN	2.58
8	Epiphyseal dysplasia, multiple, with myopia and conductive deafness	Enrichment	COL2A1	2.58
9	Macular dystrophy, corneal	Enrichment	CHST6	2.58
10	Pseudoachondroplasia	Enrichment	COMP	2.58
11	Spondylometaphyseal dysplasia, algerian type	Enrichment	COL2A1	2.58
12	Osteoarthritis with mild chondrodysplasia	Enrichment	COL2A1	2.58
13	Avascular necrosis of femoral head, primary, 1	Enrichment	COL2A1	2.58
14	Czech dysplasia	Enrichment	COL2A1	2.58
15	Kniest dysplasia	Enrichment	COL2A1	2.58
16	Platyspondylic lethal skeletal dysplasia, torrance type	Enrichment	COL2A1	2.58
17	Spondyloepiphyseal dysplasia, stanescu type	Enrichment	COL2A1	2.58
18	Achondrogenesis, type ii	Enrichment	COL2A1	2.58
19	Carpal tunnel syndrome 2	Enrichment	COMP	2.58
20	Neurofacioskeletal syndrome with or without renal agenesis	Enrichment	HS2ST1	2.58
21	Myasthenic syndrome, congenital, 19	Enrichment	COL13A1	2.58
22	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.58
23	Meester-loeys syndrome	Enrichment	BGN	2.58
24	Spondyloperipheral dysplasia	Enrichment	COL2A1	2.58
25	Spondylometaepiphyseal dysplasia, short limb-hand type	Enrichment	DDR2	2.58
26	Paganini-miozzo syndrome	Enrichment	HS6ST2	2.58
27	Spondyloepimetaphyseal dysplasia, aggrecan type	Enrichment	ACAN	2.58
28	Spondyloepiphyseal dysplasia, kimberley type	Enrichment	ACAN	2.58
29	Stickler syndrome, type i, nonsyndromic ocular	Enrichment	COL2A1	2.58
30	Hypogonadotropic hypogonadism 15 with or without anosmia	Enrichment	HS6ST1	2.58
31	Arteriosclerosis	Enrichment	HS3ST1	2.58
32	Warburg-cinotti syndrome	Enrichment	DDR2	2.58
33	Vitreoretinopathy with phalangeal epiphyseal dysplasia	Enrichment	COL2A1	2.58
34	Autosomal dominant rhegmatogenous retinal detachment	Enrichment	COL2A1	2.58
35	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	2.58
36	Multiple epiphyseal dysplasia with myopia and deafness	Enrichment	COL2A1	2.58
37	Hypochondrogenesis	Enrichment	COL2A1	2.58
38	Osteochondritis dissecans	Enrichment	ACAN	2.58
39	Dysspondyloenchondromatosis	Enrichment	COL2A1	2.58
40	Type 2 collagen-related bone disorder	Enrichment	COL2A1	2.58
41	Short stature-advanced bone age-early-onset osteoarthritis syndrome	Enrichment	ACAN	2.58
42	Epiphyseal dysplasia, multiple, 1	Enrichment	COMP	2.28
43	Otospondylomegaepiphyseal dysplasia, autosomal recessive	Enrichment	COL2A1	2.28
44	Spondyloepimetaphyseal dysplasia, x-linked	Enrichment	BGN	2.28
45	Corneal dystrophy, congenital stromal	Enrichment	DCN	2.28
46	Legg-calve-perthes disease	Enrichment	COL2A1	2.28
47	Otospondylomegaepiphyseal dysplasia, autosomal dominant	Enrichment	COL2A1	2.28
48	Familial avascular necrosis of the femoral head	Enrichment	COL2A1	2.28
49	Mccune-albright syndrome	Enrichment	COL2A1	2.10
50	Larsen syndrome	Enrichment	CHST3	2.10
51	Spondyloepiphyseal dysplasia congenita	Enrichment	COL2A1	2.10
52	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B	2.10
53	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.10
54	Multiple joint dislocations, short stature, and craniofacial dysmorphism with or without congenital heart defects	Enrichment	CHST3	2.10
55	Larsen-like syndrome b3gat3 type	Enrichment	CHST3	2.10
56	Diabetes insipidus	Enrichment	MATN4	1.98
57	Coronary artery anomaly	Enrichment	HS3ST1	1.98
58	Retinal detachment	Enrichment	COL2A1	1.88
59	Holoprosencephaly	Enrichment	MATN4	1.88
60	Developmental dysplasia of the hip 1	Enrichment	COL2A1	1.80
61	Holoprosencephaly 1	Enrichment	MATN4	1.80
62	Glanzmann thrombasthenia 1	Enrichment	ITGA2B	1.73
63	Multiple enchondromatosis, maffucci type	Enrichment	COL2A1	1.73
64	Marfan syndrome	Enrichment	COL2A1	1.58
65	Stickler syndrome	Enrichment	COL2A1	1.58
66	Autosomal dominant macrothrombocytopenia	Enrichment	ITGA2B	1.58
67	Presynaptic congenital myasthenic syndromes	Enrichment	COL13A1	1.54
68	Postsynaptic congenital myasthenic syndromes	Enrichment	COL13A1	1.50
69	Neural tube defects	Enrichment	ITGB1	1.47
70	Myopia	Enrichment	COL2A1	1.41
71	Heart, malformation of	Enrichment	COL2A1	1.33
72	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	HS6ST1	1.33
73	Kallmann syndrome	Enrichment	HS6ST1	1.23
74	Scoliosis	Enrichment	COL2A1	1.21
75	Stargardt disease 1	Enrichment	COL2A1	1.12
76	Connective tissue disease	Enrichment	COL2A1	1.09
77	Nephrotic syndrome	Enrichment	FN1	0.97
78	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	BGN	0.96
79	Thrombocytopenia	Enrichment	ITGA2B	0.92
80	Body mass index quantitative trait locus 11	Enrichment	SDC3	0.90
81	Microcephaly	Enrichment	MATN4	0.55
82	Complex neurodevelopmental disorder	Enrichment	HS2ST1	0.55
83	Hereditary retinal dystrophy	Enrichment	COL2A1	0.27
84	Fundus dystrophy	Enrichment	COL2A1	0.27

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Articular Cartilage Extracellular Matrix

Pathway Network for Articular Cartilage Extracellular Matrix

Member Pathways for Articular Cartilage Extracellular Matrix

Pathways in the Articular Cartilage Extracellular Matrix SuperPath

Associated Genes for Articular Cartilage Extracellular Matrix

Associated Disorders for Articular Cartilage Extracellular Matrix

Disorders associated with Articular Cartilage Extracellular Matrix SuperPath

STRING Interaction Network for Articular Cartilage Extracellular Matrix

Sources for Articular Cartilage Extracellular Matrix