Aryl hydrocarbon receptor pathway

No Pathway Network information available for Aryl hydrocarbon receptor pathway

Pathways in the Aryl hydrocarbon receptor pathway SuperPath

#	Name	Source	Genes
1	Aryl hydrocarbon receptor pathway	WikiPathways	AHR AHRR AIP ARNT CCL1 CD36 CDC37 CDK2 CDKN1A CDKN1B CYP1A1 CYP1A2 CYP1B1 E2F1 EGFR HRAS HSP90AA1 KLF6 KRAS MAP2K1 NFE2L2 NFKB1 NRAS PSRC1 PTGS2 RAF1 RB1 RELA TNF VEGFA (see all 30) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CD36	CD36 Molecule (CD36 Blood Group)	Protein Coding	1
2	AIP	AHR Interacting HSP90 Co-Chaperone	Protein Coding	1
3	PSRC1	Proline And Serine Rich Coiled-Coil 1	Protein Coding	1
4	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
5	TNF	Tumor Necrosis Factor	Protein Coding	1
6	CCL1	C-C Motif Chemokine Ligand 1	Protein Coding	1
7	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
8	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
9	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
10	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
11	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
12	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
13	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
14	NFE2L2	NFE2 Like BZIP Transcription Factor 2	Protein Coding	1
15	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	Protein Coding	1
16	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
17	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
18	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
19	AHR	Aryl Hydrocarbon Receptor	Protein Coding	1
20	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
21	E2F1	E2F Transcription Factor 1	Protein Coding	1
22	CYP1B1	Cytochrome P450 Family 1 Subfamily B Member 1	Protein Coding	1
23	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	1
24	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	1
25	KLF6	KLF Transcription Factor 6	Protein Coding	1
26	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
27	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
28	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
29	CDC37	Cell Division Cycle 37, HSP90 Cochaperone	Protein Coding	1
30	AHRR	Aryl Hydrocarbon Receptor Repressor	Protein Coding	1

Disorders associated with Aryl hydrocarbon receptor pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, KRAS, MAP2K1, NRAS	10.46
2	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, MAP2K1, NRAS, RAF1	9.87
3	Noonan syndrome 1	Enrichment	HRAS, KRAS, MAP2K1, NRAS, RAF1	8.91
4	Rasopathy	Enrichment	HRAS, KRAS, MAP2K1, NRAS, RAF1	8.63
5	Bladder cancer	Enrichment	CDKN1A, EGFR, HRAS, KRAS, RB1	8.37
6	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	7.41
7	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	6.47
8	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1	6.47
9	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS, RAF1	6.27
10	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS, RB1	5.67
11	Lung cancer susceptibility 3	Enrichment	EGFR, KRAS, RB1	5.46
12	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.33
13	Langerhans cell histiocytosis	Enrichment	MAP2K1, NRAS	4.85
14	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.85
15	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1	4.55
16	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1	4.55
17	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.55
18	Cerebral malaria	Enrichment	CD36, TNF	4.55
19	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	4.46
20	Lung cancer	Enrichment	EGFR, KRAS, NFE2L2	4.33
21	Ovarian cancer	Enrichment	CDKN1B, EGFR, KRAS, RB1	4.17
22	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS	4.15
23	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	4.01
24	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	4.01
25	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	4.01
26	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.01
27	Pilomyxoid astrocytoma	Enrichment	KRAS, RAF1	4.01
28	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	4.01
29	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	3.77
30	Inherited cancer-predisposing syndrome	Enrichment	AIP, CDKN1B, EGFR, RB1	3.71
31	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	3.68
32	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	3.51
33	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	3.10
34	Malaria	Enrichment	CD36, TNF	2.93
35	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.68
36	Oculoectodermal syndrome	Enrichment	KRAS	2.66
37	Suppression of tumorigenicity 12	Enrichment	KLF6	2.66
38	Noonan syndrome 5	Enrichment	RAF1	2.66
39	Coronary heart disease 7	Enrichment	CD36	2.66
40	Melorheostosis, isolated	Enrichment	MAP2K1	2.66
41	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.66
42	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.66
43	Melanosis, neurocutaneous	Enrichment	NRAS	2.66
44	Noonan syndrome 6	Enrichment	NRAS	2.66
45	Retinitis pigmentosa 85	Enrichment	AHR	2.66
46	Immunodeficiency, developmental delay, and hypohomocysteinemia	Enrichment	NFE2L2	2.66
47	Foveal hypoplasia 3	Enrichment	AHR	2.66
48	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.66
49	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.66
50	Melorheostosis	Enrichment	MAP2K1	2.66
51	Platelet glycoprotein iv deficiency	Enrichment	CD36	2.66
52	Neuroendocrine tumor	Enrichment	CDKN1B	2.66
53	Leopard syndrome 2	Enrichment	RAF1	2.66
54	Trigonitis	Enrichment	RAF1	2.66
55	Trilateral retinoblastoma	Enrichment	RB1	2.66
56	Congenital pulmonary airway malformation	Enrichment	KRAS	2.66
57	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.66
58	Neurocutaneous melanocytosis	Enrichment	NRAS	2.66
59	Lung oat cell carcinoma	Enrichment	RB1	2.66
60	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.46
61	Gastric cancer	Enrichment	KLF6, KRAS	2.39
62	Glaucoma 1, open angle, a	Enrichment	CYP1B1	2.35
63	Costello syndrome	Enrichment	HRAS	2.35
64	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.35
65	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.35
66	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.35
67	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.35
68	Anterior segment dysgenesis 6	Enrichment	CYP1B1	2.35
69	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.35
70	Immunodeficiency 127	Enrichment	TNF	2.35
71	Rela fusion-positive ependymoma	Enrichment	RELA	2.35
72	Acromegaly	Enrichment	AIP	2.35
73	Primary congenital glaucoma	Enrichment	CYP1B1	2.35
74	Familial retinoblastoma	Enrichment	RB1	2.35
75	Common variable immunodeficiency 12	Enrichment	NFKB1	2.35
76	Null pituitary adenoma	Enrichment	AIP	2.35
77	Familial isolated pituitary adenoma	Enrichment	AIP	2.35
78	Silent pituitary adenoma	Enrichment	AIP	2.35
79	Wooly hair nevus	Enrichment	HRAS	2.35
80	Gigantism	Enrichment	AIP	2.35
81	Retinoblastoma	Enrichment	RB1	2.18
82	Osteogenic sarcoma	Enrichment	RB1	2.18
83	Psoriatic arthritis	Enrichment	TNF	2.18
84	Pituitary adenoma 1, multiple types	Enrichment	AIP	2.18
85	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.18
86	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.18
87	Hypotrichosis 8	Enrichment	RB1	2.18
88	Squamous cell carcinoma	Enrichment	RB1	2.18
89	Migraine without aura	Enrichment	TNF	2.18
90	Bone osteosarcoma	Enrichment	RB1	2.18
91	Growth hormone secreting pituitary adenoma	Enrichment	AIP	2.18
92	Spermatocytoma	Enrichment	HRAS	2.18
93	Aip familial isolated pituitary adenomas	Enrichment	AIP	2.18
94	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.18
95	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.05
96	Small cell cancer of the lung	Enrichment	RB1	2.05
97	Glaucoma 3, primary infantile, b	Enrichment	CYP1B1	2.05
98	Lynch syndrome 4	Enrichment	RB1	2.05
99	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.05
100	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.05
101	Pilocytic astrocytoma	Enrichment	KRAS	2.05
102	Prolactinoma	Enrichment	AIP	2.05
103	Blood platelet disease	Enrichment	CD36	2.05
104	Epidermolytic nevus	Enrichment	HRAS	2.05
105	Primary hyperparathyroidism	Enrichment	CDKN1B	2.05
106	Juvenile glaucoma	Enrichment	CYP1B1	1.96
107	Vascular dementia	Enrichment	TNF	1.96
108	Glaucoma, primary open angle	Enrichment	CYP1B1	1.88
109	Cowden syndrome 1	Enrichment	EGFR	1.88
110	Anterior segment dysgenesis 5	Enrichment	CYP1B1	1.88
111	Breast adenocarcinoma	Enrichment	KRAS	1.88
112	Glaucoma 3, primary congenital, a	Enrichment	CYP1B1	1.81
113	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.81
114	Gallbladder cancer	Enrichment	KRAS	1.81
115	Common variable immunodeficiency	Enrichment	NFKB1	1.81
116	Colorectal cancer	Enrichment	NFE2L2, NRAS	1.80
117	Peters-plus syndrome	Enrichment	CYP1B1	1.66
118	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.66
119	Asthma	Enrichment	TNF	1.62
120	Alzheimer's disease	Enrichment	TNF	1.55
121	Protein-deficiency anemia	Enrichment	NRAS	1.55
122	Anterior segment dysgenesis	Enrichment	CYP1B1	1.49
123	Lynch syndrome	Enrichment	KRAS	1.49
124	Rhabdomyosarcoma	Enrichment	HRAS	1.46
125	Gliosarcoma	Enrichment	EGFR	1.46
126	Giant cell glioblastoma	Enrichment	EGFR	1.43
127	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.29
128	Pancreatic cancer	Enrichment	KRAS	1.27
129	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.25
130	Prostate cancer	Enrichment	KLF6	1.21
131	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.15
132	Left ventricular noncompaction	Enrichment	RAF1	1.13
133	Systemic lupus erythematosus	Enrichment	TNF	1.08
134	Hereditary breast carcinoma	Enrichment	KRAS	1.03
135	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.95
136	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.94
137	Myeloma, multiple	Enrichment	KRAS	0.93
138	Breast cancer	Enrichment	KRAS	0.81
139	Dilated cardiomyopathy	Enrichment	RAF1	0.79
140	Autism spectrum disorder	Enrichment	MAP2K1	0.67
141	Retinitis pigmentosa	Enrichment	AHR	0.42

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Aryl hydrocarbon receptor pathway

Pathway Network for Aryl hydrocarbon receptor pathway

Member Pathways for Aryl hydrocarbon receptor pathway

Pathways in the Aryl hydrocarbon receptor pathway SuperPath

Associated Genes for Aryl hydrocarbon receptor pathway

Associated Disorders for Aryl hydrocarbon receptor pathway

Disorders associated with Aryl hydrocarbon receptor pathway SuperPath

STRING Interaction Network for Aryl hydrocarbon receptor pathway

Sources for Aryl hydrocarbon receptor pathway