Astrocytic Glutamate-Glutamine Uptake And Metabolism

Sources:

#	Name	Source	Genes
1	Astrocytic Glutamate-Glutamine Uptake And Metabolism	Reactome	GLUL SLC1A2 SLC1A3 SLC38A1
2	Neurotransmitter uptake and metabolism In glial cells	Reactome	GLUL SLC1A2 SLC1A3 SLC38A1
3	Defective SLC1A3 causes episodic ataxia 6 (EA6)	Reactome	SLC1A3

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLC1A3	Solute Carrier Family 1 Member 3	Protein Coding	3
2	GLUL	Glutamate-Ammonia Ligase	Protein Coding	2
3	SLC1A2	Solute Carrier Family 1 Member 2	Protein Coding	2
4	SLC38A1	Solute Carrier Family 38 Member 1	Protein Coding	2

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Episodic ataxia	Direct
2	Episodic ataxia, type 6	Enrichment	SLC1A3	3.53
3	Developmental and epileptic encephalopathy 41	Enrichment	SLC1A2	3.53
4	Developmental and epileptic encephalopathy 116	Enrichment	GLUL	3.53
5	Glutamine deficiency, congenital	Enrichment	GLUL	3.23
6	Developmental and epileptic encephalopathy 16	Enrichment	GLUL	3.23
7	Congenital brain dysgenesis due to glutamine synthetase deficiency	Enrichment	GLUL	3.23
8	Alternating hemiplegia of childhood	Enrichment	SLC1A3	2.63
9	Undetermined early-onset epileptic encephalopathy	Enrichment	SLC1A2	1.78

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Astrocytic Glutamate-Glutamine Uptake And Metabolism