ATF-2 transcription factor network

No Pathway Network information available for ATF-2 transcription factor network

Pathways in the ATF-2 transcription factor network SuperPath

#	Name	Source	Genes
1	ATF-2 transcription factor network	PubChem	ACHE ARG1 ATF2 ATF3 BCL2 BCL2L1 BRCA1 CBFB CCNA2 CCND1 CDK4 COL24A1 CREB1 CSRP2 CUL3 CXCL8 DDIT3 DUSP1 DUSP10 DUSP5 DUSP8 EP300 ESR1 FOS GADD45A HBG2 HES1 HRK IFNG IL23A IL6 INS JDP2 JUN JUNB JUND KAT5 MACROH2A1 MAPK14 MAPK3 MAPK8 MAPK9 MMP2 NF1 NOS2 PDGFRA PLAU POU2F1 PPARGC1A PRKCA RB1 RUVBL2 SELE SERPINB5 SOCS3 TGFB2 TH (see all 57) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	COL24A1	Collagen Type XXIV Alpha 1 Chain	Protein Coding	1
2	MACROH2A1	MacroH2A.1 Histone	Protein Coding	1
3	HRK	Harakiri, BCL2 Interacting Protein	Protein Coding	1
4	DUSP8	Dual Specificity Phosphatase 8	Protein Coding	1
5	DUSP10	Dual Specificity Phosphatase 10	Protein Coding	1
6	CSRP2	Cysteine And Glycine Rich Protein 2	Protein Coding	1
7	JDP2	Jun Dimerization Protein 2	Protein Coding	1
8	SERPINB5	Serpin Family B Member 5	Protein Coding	1
9	DUSP5	Dual Specificity Phosphatase 5	Protein Coding	1
10	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
11	DUSP1	Dual Specificity Phosphatase 1	Protein Coding	1
12	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
13	IL23A	Interleukin 23 Subunit Alpha	Protein Coding	1
14	IFNG	Interferon Gamma	Protein Coding	1
15	ATF3	Activating Transcription Factor 3	Protein Coding	1
16	RUVBL2	RuvB Like AAA ATPase 2	Protein Coding	1
17	CCNA2	Cyclin A2	Protein Coding	1
18	IL6	Interleukin 6	Protein Coding	1
19	NF1	Neurofibromin 1	Protein Coding	1
20	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
21	CBFB	Core-Binding Factor Subunit Beta	Protein Coding	1
22	POU2F1	POU Class 2 Homeobox 1	Protein Coding	1
23	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
24	CUL3	Cullin 3	Protein Coding	1
25	CCND1	Cyclin D1	Protein Coding	1
26	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
27	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
28	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	1
29	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
30	KAT5	Lysine Acetyltransferase 5	Protein Coding	1
31	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
32	TH	Tyrosine Hydroxylase	Protein Coding	1
33	ARG1	Arginase 1	Protein Coding	1
34	ACHE	Acetylcholinesterase (Yt Blood Group)	Protein Coding	1
35	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
36	HBG2	Hemoglobin Subunit Gamma 2	Protein Coding	1
37	SELE	Selectin E	Protein Coding	1
38	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
39	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
40	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
41	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
42	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
43	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
44	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
45	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	1
46	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
47	PRKCA	Protein Kinase C Alpha	Protein Coding	1
48	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
49	ATF2	Activating Transcription Factor 2	Protein Coding	1
50	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
51	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
52	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
53	BCL2L1	BCL2 Like 1	Protein Coding	1
54	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
55	INS	Insulin	Protein Coding	1
56	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	1
57	ESR1	Estrogen Receptor 1	Protein Coding	1

Disorders associated with ATF-2 transcription factor network SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Inherited cancer-predisposing syndrome	Enrichment	BRCA1, CDK4, NF1, PDGFRA, RB1	3.65
2	Bladder cancer	Enrichment	BRCA1, NF1, RB1	3.62
3	Type 1 diabetes mellitus	Enrichment	IL6, INS	3.59
4	Gastric cancer	Enrichment	BRCA1, CDK4, NF1	3.11
5	Rhabdomyosarcoma	Enrichment	BRCA1, NF1	2.70
6	Breast cancer	Enrichment	BRCA1, ESR1, JUN	2.42
7	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.38
8	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	2.38
9	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.38
10	Dermatitis, atopic, 4	Enrichment	SOCS3	2.38
11	Yt blood group antigen	Enrichment	ACHE	2.38
12	Pseudohypoaldosteronism, type iie	Enrichment	CUL3	2.38
13	Gist-plus syndrome	Enrichment	PDGFRA	2.38
14	Immunodeficiency 69	Enrichment	IFNG	2.38
15	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	2.38
16	Infant-type hemispheric glioma	Enrichment	BRCA1	2.38
17	Camurati-engelmann disease 2	Enrichment	TGFB2	2.38
18	Neurodevelopmental disorder with or without autism or seizures	Enrichment	CUL3	2.38
19	Trilateral retinoblastoma	Enrichment	RB1	2.38
20	Plexiform neurofibroma	Enrichment	NF1	2.38
21	Neurofibroma	Enrichment	NF1	2.38
22	Neurofibromatosis	Enrichment	NF1	2.38
23	Chromosome 17q11.2 deletion syndrome	Enrichment	NF1	2.38
24	Optic nerve glioma	Enrichment	NF1	2.38
25	Hemoglobinopathy toms river	Enrichment	HBG2	2.38
26	Primary peritoneal carcinoma	Enrichment	BRCA1	2.38
27	Lung oat cell carcinoma	Enrichment	RB1	2.38
28	Colorectal cancer	Enrichment	BRCA1, CCND1, EP300	2.24
29	Cafe-au-lait spots, multiple	Enrichment	NF1	2.08
30	Argininemia	Enrichment	ARG1	2.08
31	Quebec platelet disorder	Enrichment	PLAU	2.08
32	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.08
33	Pseudohypoaldosteronism, type i, autosomal dominant	Enrichment	CUL3	2.08
34	Segawa syndrome, autosomal recessive	Enrichment	TH	2.08
35	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.08
36	Maturity-onset diabetes of the young, type 10	Enrichment	INS	2.08
37	Cyanosis, transient neonatal	Enrichment	HBG2	2.08
38	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	2.08
39	Hyperproinsulinemia	Enrichment	INS	2.08
40	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.08
41	Menke-hennekam syndrome 2	Enrichment	EP300	2.08
42	Chromosome 17q11.2 duplication syndrome, 1.4-mb	Enrichment	NF1	2.08
43	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.08
44	Pancreatic cancer 4	Enrichment	BRCA1	2.08
45	Cleidocranial dysplasia 2	Enrichment	CBFB	2.08
46	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	2.08
47	Loeys-dietz syndrome 4	Enrichment	TGFB2	2.08
48	Bardet-biedl syndrome 9	Enrichment	NF1	2.08
49	Inflammatory breast carcinoma	Enrichment	BRCA1	2.08
50	Peritoneum cancer	Enrichment	BRCA1	2.08
51	Bilateral breast cancer	Enrichment	BRCA1	2.08
52	Chronic eosinophilic leukemia	Enrichment	PDGFRA	2.08
53	Brachydactyly-elbow wrist dysplasia syndrome	Enrichment	MACROH2A1	2.08
54	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	2.08
55	Familial retinoblastoma	Enrichment	RB1	2.08
56	Pleomorphic rhabdomyosarcoma	Enrichment	NF1	2.08
57	Ovarian cancer	Enrichment	BRCA1, PDGFRA, RB1	2.06
58	Type 1 diabetes mellitus 2	Enrichment	INS	1.90
59	Dystonia, dopa-responsive	Enrichment	TH	1.90
60	Retinoblastoma	Enrichment	RB1	1.90
61	Pseudohypoaldosteronism, type iia	Enrichment	CUL3	1.90
62	Tuberous sclerosis 1	Enrichment	IFNG	1.90
63	Watson syndrome	Enrichment	NF1	1.90
64	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	1.90
65	Osteogenic sarcoma	Enrichment	RB1	1.90
66	Hepatitis c virus	Enrichment	IFNG	1.90
67	Neurofibromatosis, familial spinal	Enrichment	NF1	1.90
68	Estrogen resistance	Enrichment	ESR1	1.90
69	Tuberous sclerosis 2	Enrichment	IFNG	1.90
70	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.90
71	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	NF1	1.90
72	Hypotrichosis 8	Enrichment	RB1	1.90
73	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	1.90
74	Dedifferentiated liposarcoma	Enrichment	CDK4	1.90
75	Myxoid liposarcoma	Enrichment	DDIT3	1.90
76	Squamous cell carcinoma	Enrichment	RB1	1.90
77	Migraine without aura	Enrichment	ESR1	1.90
78	Brain cancer	Enrichment	NF1	1.90
79	Bone osteosarcoma	Enrichment	RB1	1.90
80	Melanoma of soft tissue	Enrichment	CREB1	1.90
81	Well-differentiated liposarcoma	Enrichment	CDK4	1.90
82	Hereditary breast carcinoma	Enrichment	BRCA1, ESR1	1.83
83	Kaposi sarcoma	Enrichment	IL6	1.78
84	Small cell cancer of the lung	Enrichment	RB1	1.78
85	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	1.78
86	Neurofibromatosis-noonan syndrome	Enrichment	NF1	1.78
87	Cholangiocarcinoma	Enrichment	BRCA1	1.78
88	Lynch syndrome 4	Enrichment	RB1	1.78
89	Congenital generalized lipodystrophy	Enrichment	FOS	1.78
90	Mantle cell lymphoma	Enrichment	CCND1	1.78
91	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.78
92	Neonatal diabetes mellitus	Enrichment	INS	1.78
93	Embryonal rhabdomyosarcoma	Enrichment	NF1	1.78
94	Pilocytic astrocytoma	Enrichment	NF1	1.78
95	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	CBFB	1.78
96	Hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome	Enrichment	HBG2	1.78
97	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.78
98	Middle aortic syndrome	Enrichment	NF1	1.78
99	Alzheimer disease 2	Enrichment	PLAU	1.68
100	Von hippel-lindau syndrome	Enrichment	CCND1	1.68
101	Rhabdomyosarcoma 2	Enrichment	NF1	1.68
102	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.68
103	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.68
104	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.68
105	Follicular lymphoma	Enrichment	BCL2	1.68
106	Histiocytoid hemangioma	Enrichment	FOS	1.68
107	Hereditary persistence of fetal hemoglobin-sickle cell disease syndrome	Enrichment	HBG2	1.68
108	Primary hypereosinophilic syndrome	Enrichment	PDGFRA	1.68
109	Idiopathic aplastic anemia	Enrichment	IFNG	1.68
110	Hereditary breast ovarian cancer syndrome	Enrichment	BRCA1, NF1	1.65
111	Myeloma, multiple	Enrichment	CCND1, NF1	1.64
112	Atrial septal defect 1	Enrichment	TGFB2	1.60
113	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.60
114	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.60
115	Gastrointestinal stromal tumor	Enrichment	PDGFRA	1.54
116	Fetal hemoglobin quantitative trait locus 1	Enrichment	HBG2	1.48
117	Ewing sarcoma	Enrichment	NF1	1.48
118	Permanent neonatal diabetes mellitus	Enrichment	INS	1.48
119	Neurofibromatosis, type i	Enrichment	NF1	1.43
120	Charge syndrome	Enrichment	EP300	1.43
121	Inflammatory bowel disease 1	Enrichment	IL6	1.43
122	Leukemia, acute lymphoblastic 3	Enrichment	NF1	1.43
123	Loeys-dietz syndrome	Enrichment	TGFB2	1.43
124	Marfan syndrome	Enrichment	TGFB2	1.38
125	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.38
126	Aplastic anemia	Enrichment	IFNG	1.38
127	Migraine with or without aura 1	Enrichment	ESR1	1.34
128	Diabetes mellitus	Enrichment	INS	1.34
129	Uterine corpus cancer	Enrichment	BRCA1	1.34
130	Juvenile myelomonocytic leukemia	Enrichment	NF1	1.31
131	Lip and oral cavity carcinoma	Enrichment	RB1	1.31
132	Breast-ovarian cancer, familial 1	Enrichment	BRCA1	1.27
133	Nk-cell enteropathy	Enrichment	CUL3	1.27
134	Pheochromocytoma	Enrichment	NF1	1.24
135	Lung cancer susceptibility 3	Enrichment	RB1	1.24
136	Periventricular nodular heterotopia	Enrichment	BRCA1	1.24
137	Cleft lip/palate	Enrichment	PDGFRA	1.24
138	Polydactyly, postaxial, type a1	Enrichment	EP300	1.21
139	Rare genetic intellectual disability	Enrichment	EP300	1.21
140	Alzheimer disease, familial, 1	Enrichment	PLAU	1.16
141	Melanoma, cutaneous malignant 1	Enrichment	CDK4	1.16
142	Human immunodeficiency virus type 1	Enrichment	IFNG	1.14
143	Autism spectrum disorder	Enrichment	CUL3, NF1	1.11
144	Arteriovenous malformations of the brain	Enrichment	IL6	1.11
145	Ehlers-danlos syndrome	Enrichment	TGFB2	1.11
146	Maturity-onset diabetes of the young	Enrichment	INS	1.09
147	Endometrial cancer	Enrichment	BRCA1	1.07
148	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	NF1	1.07
149	Myocardial infarction	Enrichment	ESR1	1.05
150	Skin disease	Enrichment	NF1	1.05
151	Malaria	Enrichment	NOS2	1.03
152	Pancreatic cancer	Enrichment	BRCA1	1.00
153	Rasopathy	Enrichment	NF1	0.98
154	Prostate cancer	Enrichment	BRCA1	0.94
155	Lung cancer	Enrichment	BRCA1	0.90
156	Fanconi anemia, complementation group a	Enrichment	BRCA1	0.86
157	Dystonia	Enrichment	TH	0.86
158	Type 2 diabetes mellitus	Enrichment	IL6	0.79
159	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	TGFB2	0.77
160	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	0.66
161	Microcephaly	Enrichment	EP300	0.39
162	Complex neurodevelopmental disorder	Enrichment	CUL3	0.39

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

ATF-2 transcription factor network

Pathway Network for ATF-2 transcription factor network

Member Pathways for ATF-2 transcription factor network

Pathways in the ATF-2 transcription factor network SuperPath

Associated Genes for ATF-2 transcription factor network

Associated Disorders for ATF-2 transcription factor network

Disorders associated with ATF-2 transcription factor network SuperPath

STRING Interaction Network for ATF-2 transcription factor network

Sources for ATF-2 transcription factor network