ATM Pathway

No Pathway Network information available for ATM Pathway

Pathways in the ATM Pathway SuperPath

#	Name	Source	Genes
1	ATM Pathway	QIAGEN	ABL1 AP3B2 ATF2 ATF4 ATM BID BRCA1 CCNB1 CCNB2 CCNB3 CDC25A CDC25C CDK1 CDK2 CDKN1A CHEK1 CHEK2 CREB1 CREB3 CREB3L4 FANCD2 GADD45A GADD45B GADD45G H2AX JUN MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MDC1 MDM2 MDM4 MRE11 NBN NFKBIA RAD50 RAD51 RAD9A SMC1A SMC2 SMC3 TLK1 TP53 TP53BP1 TP73 (see all 47) (see less)
2	ATM signaling pathway	WikiPathways	ABL1 AP3B2 ATF2 ATM BID BRCA1 CCNB1 CCNE1 CDC25A CDC25C CDK1 CDK2 CDKN1A CHEK1 CHEK2 CREB1 FANCD2 GADD45A H2AX IKBKG JUN MAPK9 MDC1 MDM2 MRE11 NBN NFKBIA PIDD1 RAD50 RAD51 RAD9A SMC1A TLK1 TP53 TP53BP1 TP73 (see all 36) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TP53BP1	Tumor Protein P53 Binding Protein 1	Protein Coding	2
2	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	2
3	AP3B2	Adaptor Related Protein Complex 3 Subunit Beta 2	Protein Coding	2
4	ATF2	Activating Transcription Factor 2	Protein Coding	2
5	ATM	ATM Serine/Threonine Kinase	Protein Coding	2
6	BID	BH3 Interacting Domain Death Agonist	Protein Coding	2
7	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	2
8	CCNB1	Cyclin B1	Protein Coding	2
9	CDK1	Cyclin Dependent Kinase 1	Protein Coding	2
10	CDC25A	Cell Division Cycle 25A	Protein Coding	2
11	CDC25C	Cell Division Cycle 25C	Protein Coding	2
12	CDK2	Cyclin Dependent Kinase 2	Protein Coding	2
13	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	2
14	CHEK1	Checkpoint Kinase 1	Protein Coding	2
15	CHEK2	Checkpoint Kinase 2	Protein Coding	2
16	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
17	FANCD2	FA Complementation Group D2	Protein Coding	2
18	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	2
19	H2AX	H2A.X Variant Histone	Protein Coding	2
20	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
21	MDC1	Mediator Of DNA Damage Checkpoint 1	Protein Coding	2
22	MDM2	MDM2 Proto-Oncogene	Protein Coding	2
23	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	2
24	NBN	Nibrin	Protein Coding	2
25	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
26	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	2
27	RAD51	RAD51 Recombinase	Protein Coding	2
28	RAD9A	RAD9 Checkpoint Clamp Component A	Protein Coding	2
29	SMC1A	Structural Maintenance Of Chromosomes 1A	Protein Coding	2
30	TLK1	Tousled Like Kinase 1	Protein Coding	2
31	TP53	Tumor Protein P53	Protein Coding	2
32	TP73	Tumor Protein P73	Protein Coding	2
33	ATF4	Activating Transcription Factor 4	Protein Coding	1
34	CCNB2	Cyclin B2	Protein Coding	1
35	CCNB3	Cyclin B3	Protein Coding	1
36	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	1
37	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	1
38	SMC3	Structural Maintenance Of Chromosomes 3	Protein Coding	1
39	GADD45B	Growth Arrest And DNA Damage Inducible Beta	Protein Coding	1
40	GADD45G	Growth Arrest And DNA Damage Inducible Gamma	Protein Coding	1
41	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
42	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
43	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
44	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
45	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
46	MDM4	MDM4 Regulator Of P53	Protein Coding	1
47	SMC2	Structural Maintenance Of Chromosomes 2	Protein Coding	1
48	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
49	CCNE1	Cyclin E1	Protein Coding	1
50	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
51	PIDD1	P53-Induced Death Domain Protein 1	Protein Coding	1

Disorders associated with ATM Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast cancer	Enrichment	ATM, BRCA1, CHEK2, JUN, MRE11, NBN, RAD50, RAD51, TP53	16.00
2	Hereditary breast carcinoma	Enrichment	ATM, BRCA1, CHEK2, NBN, RAD50, RAD51, TP53	11.41
3	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BRCA1, CHEK2, MRE11, NBN, RAD50, RAD51, TP53	11.18
4	Ovarian cancer	Enrichment	ATM, BRCA1, CHEK2, FANCD2, MRE11, NBN, RAD50, TP53	9.73
5	Pancreatic cancer	Enrichment	ATM, BRCA1, CHEK2, NBN, TP53	8.30
6	Prostate cancer	Enrichment	ATM, BRCA1, CHEK2, NBN, TP53	7.95
7	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, CHEK2, NBN	7.53
8	Inherited cancer-predisposing syndrome	Enrichment	ATM, BRCA1, CHEK2, MRE11, NBN, RAD50, TP53	7.33
9	Gastric cancer	Enrichment	ATM, BRCA1, CHEK2, NBN, TP53	7.05
10	Li-fraumeni syndrome	Enrichment	CHEK2, MDM2, TP53	6.47
11	Bladder cancer	Enrichment	ATM, BRCA1, CDKN1A, TP53	6.02
12	Colonic benign neoplasm	Enrichment	ATM, CHEK2, MRE11	5.85
13	Uterine corpus cancer	Enrichment	ATM, BRCA1, CHEK2	5.55
14	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	5.16
15	Sarcoma	Enrichment	CHEK2, TP53	5.16
16	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	5.16
17	Gliosarcoma	Enrichment	ATM, NFKBIA, TP53	5.03
18	Giant cell glioblastoma	Enrichment	ATM, NFKBIA, TP53	4.94
19	Diffuse large b-cell lymphoma	Enrichment	CHEK2, NBN, TP53	4.79
20	Osteogenic sarcoma	Enrichment	CHEK2, TP53	4.69
21	Nasopharyngeal carcinoma	Enrichment	NFKBIA, TP53	4.69
22	Adenocarcinoma	Enrichment	ATM, TP53	4.69
23	Bone osteosarcoma	Enrichment	CHEK2, TP53	4.69
24	Endometrial cancer	Enrichment	ATM, BRCA1, CHEK2	4.66
25	Hepatocellular carcinoma	Enrichment	NBN, RAD50, TP53	4.59
26	Small cell cancer of the lung	Enrichment	TP53, TP73	4.39
27	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	4.39
28	Colorectal cancer	Enrichment	ATM, BRCA1, CHEK2, TP53	4.10
29	Fanconi anemia, complementation group a	Enrichment	BRCA1, FANCD2, RAD51	3.97
30	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, TP53	3.85
31	Wiedemann-steiner syndrome	Enrichment	SMC1A, SMC3	3.76
32	Lynch syndrome 1	Enrichment	ATM, CHEK2	3.52
33	Leukemia, chronic lymphocytic	Enrichment	ATM, TP53	3.52
34	Familial colorectal cancer type x	Enrichment	ATM, CHEK2	3.43
35	Cornelia de lange syndrome 1	Enrichment	SMC1A, SMC3	3.38
36	Cornelia de lange syndrome	Enrichment	SMC1A, SMC3	3.38
37	Lip and oral cavity carcinoma	Enrichment	ABL1, TP53	3.35
38	Rhabdomyosarcoma	Enrichment	BRCA1, TP53	3.10
39	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.58
40	Developmental and epileptic encephalopathy 85 with or without midline brain defects	Enrichment	SMC1A	2.58
41	Incontinentia pigmenti	Enrichment	IKBKG	2.58
42	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.58
43	Mirror movements 2	Enrichment	RAD51	2.58
44	Accelerated tumor formation	Enrichment	MDM2	2.58
45	Ciliary dyskinesia, primary, 47, and lissencephaly	Enrichment	TP73	2.58
46	Fanconi anemia, complementation group r	Enrichment	RAD51	2.58
47	Lessel-kubisch syndrome	Enrichment	MDM2	2.58
48	Bone marrow failure syndrome 5	Enrichment	TP53	2.58
49	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.58
50	Papilloma of choroid plexus	Enrichment	TP53	2.58
51	Basal cell carcinoma 7	Enrichment	TP53	2.58
52	Anaplastic thyroid carcinoma	Enrichment	TP53	2.58
53	Infant-type hemispheric glioma	Enrichment	BRCA1	2.58
54	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.58
55	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	2.58
56	Endometrial serous adenocarcinoma	Enrichment	ATM	2.58
57	Ductal carcinoma in situ	Enrichment	TP53	2.58
58	Leiomyosarcoma	Enrichment	CHEK2	2.58
59	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.58
60	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.58
61	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.58
62	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	2.58
63	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.58
64	Choroid plexus cancer	Enrichment	TP53	2.58
65	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.58
66	Intellectual developmental disorder, autosomal recessive 75, with neuropsychiatric features and variant lissencephaly	Enrichment	PIDD1	2.58
67	Primary peritoneal carcinoma	Enrichment	BRCA1	2.58
68	Lung cancer	Enrichment	BRCA1, CHEK2	2.49
69	Cornelia de lange syndrome 3 with or without midline brain defects	Enrichment	SMC3	2.46
70	Bone marrow failure syndrome 6	Enrichment	MDM4	2.46
71	Microcephaly	Enrichment	ABL1, NBN, SMC1A	2.38
72	Leukemia, acute myeloid	Enrichment	FANCD2, TP53	2.30
73	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.28
74	Cervical cancer	Enrichment	TP53	2.28
75	Cornelia de lange syndrome 2	Enrichment	SMC1A	2.28
76	Immunodeficiency 33	Enrichment	IKBKG	2.28
77	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.28
78	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.28
79	Lymphoma, hodgkin, classic	Enrichment	TP53	2.28
80	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	2.28
81	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.28
82	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.28
83	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.28
84	Pancreatic cancer 4	Enrichment	BRCA1	2.28
85	Microcephaly and chorioretinopathy, autosomal recessive, 3	Enrichment	TP53BP1	2.28
86	Congenital fibrosarcoma	Enrichment	TP53	2.28
87	High grade glioma	Enrichment	ATM	2.28
88	Cervix carcinoma	Enrichment	TP53	2.28
89	Hodgkin's lymphoma	Enrichment	TP53	2.28
90	T-cell prolymphocytic leukemia	Enrichment	ATM	2.28
91	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.28
92	Inflammatory breast carcinoma	Enrichment	BRCA1	2.28
93	Peritoneum cancer	Enrichment	BRCA1	2.28
94	Bilateral breast cancer	Enrichment	BRCA1	2.28
95	Microcephaly and chorioretinopathy 3	Enrichment	TP53BP1	2.28
96	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.28
97	Ataxia-telangiectasia	Enrichment	ATM	2.10
98	Nijmegen breakage syndrome	Enrichment	NBN	2.10
99	Polycythemia vera	Enrichment	ATM	2.10
100	Koolen-de vries syndrome	Enrichment	ATM	2.10
101	Dedifferentiated liposarcoma	Enrichment	MDM2	2.10
102	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.10
103	Anaplastic astrocytoma	Enrichment	TP53	2.10
104	Squamous cell carcinoma	Enrichment	TP53	2.10
105	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	2.10
106	Respiratory failure	Enrichment	TP73	2.10
107	Melanoma of soft tissue	Enrichment	CREB1	2.10
108	Well-differentiated liposarcoma	Enrichment	MDM2	2.10
109	Myeloma, multiple	Enrichment	ATM, TP53	2.02
110	Mirror movements 1	Enrichment	RAD51	1.98
111	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	1.98
112	Erythrocytosis, familial, 2	Enrichment	FANCD2	1.98
113	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.98
114	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	1.98
115	Cholangiocarcinoma	Enrichment	BRCA1	1.98
116	Developmental and epileptic encephalopathy 48	Enrichment	AP3B2	1.98
117	Mantle cell lymphoma	Enrichment	ATM	1.98
118	Lung sarcomatoid carcinoma	Enrichment	TP53	1.98
119	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.98
120	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.98
121	Hemoglobin c disease	Enrichment	CHEK2	1.98
122	Autosomal recessive chorioretinopathy-microcephaly syndrome	Enrichment	TP53BP1	1.98
123	Oculomotor apraxia	Enrichment	ATM	1.98
124	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	1.98
125	Primary ovarian insufficiency	Enrichment	CHEK2, NBN	1.97
126	Fanconi anemia, complementation group d2	Enrichment	FANCD2	1.88
127	Von hippel-lindau syndrome	Enrichment	FANCD2	1.88
128	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.88
129	Rhabdomyosarcoma 2	Enrichment	TP53	1.88
130	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.88
131	Lymphoma	Enrichment	TP53	1.88
132	Glioblastoma	Enrichment	ATM	1.88
133	Acute megakaryocytic leukemia	Enrichment	TP53	1.88
134	Pregnancy loss, recurrent 1	Enrichment	CCNB3	1.86
135	Wilms tumor 5	Enrichment	CHEK2	1.80
136	Adrenocortical carcinoma	Enrichment	TP53	1.80
137	Clear cell renal cell carcinoma	Enrichment	ATM	1.80
138	Breast adenocarcinoma	Enrichment	TP53	1.80
139	Esophageal cancer	Enrichment	TP53	1.73
140	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.73
141	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.73
142	Leukemia, chronic myeloid	Enrichment	ABL1	1.73
143	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.73
144	Essential thrombocythemia	Enrichment	TP53	1.73
145	Gallbladder cancer	Enrichment	TP53	1.73
146	Moyamoya angiopathy	Enrichment	ABL1	1.73
147	Glioma susceptibility 1	Enrichment	TP53	1.68
148	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.68
149	Rett syndrome, congenital variant	Enrichment	SMC1A	1.68
150	Coronary heart disease 5	Enrichment	IKBKG	1.63
151	Adult hepatocellular carcinoma	Enrichment	TP53	1.63
152	Primary hyperaldosteronism	Enrichment	TP53	1.63
153	Aplastic anemia	Enrichment	NBN	1.58
154	Melanoma	Enrichment	CHEK2	1.58
155	Familial colorectal cancer	Enrichment	TP53	1.58
156	Immune deficiency disease	Enrichment	ATM	1.54
157	Leukemia, acute lymphoblastic	Enrichment	NBN	1.54
158	Myelodysplastic syndrome	Enrichment	TP53	1.54
159	Premature menopause	Enrichment	NBN	1.47
160	Nk-cell enteropathy	Enrichment	CHEK2	1.47
161	Lung cancer susceptibility 3	Enrichment	TP53	1.44
162	Periventricular nodular heterotopia	Enrichment	BRCA1	1.44
163	Heart disease	Enrichment	ABL1	1.44
164	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.41
165	Wilms tumor 1	Enrichment	CHEK2	1.41
166	Lynch syndrome	Enrichment	CHEK2	1.41
167	Polycystic liver disease	Enrichment	CDC25A	1.35
168	Autosomal dominant polycystic liver disease	Enrichment	CDC25A	1.35
169	Semilobar holoprosencephaly	Enrichment	SMC1A	1.33
170	Lissencephaly	Enrichment	NBN	1.27
171	Hepatoblastoma	Enrichment	TP53	1.27
172	Diamond-blackfan anemia 1	Enrichment	TP53	1.23
173	Malaria	Enrichment	IKBKG	1.23
174	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.23
175	Diamond-blackfan anemia	Enrichment	TP53	1.04
176	Undetermined early-onset epileptic encephalopathy	Enrichment	AP3B2	0.86
177	Congenital nervous system abnormality	Enrichment	SMC1A	0.61
178	Nervous system disease	Enrichment	SMC1A	0.61
179	Autism spectrum disorder	Enrichment	SMC3	0.50

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

ATM Pathway

Pathway Network for ATM Pathway

Member Pathways for ATM Pathway

Pathways in the ATM Pathway SuperPath

Associated Genes for ATM Pathway

Associated Disorders for ATM Pathway

Disorders associated with ATM Pathway SuperPath

STRING Interaction Network for ATM Pathway

Sources for ATM Pathway