ATP/ITP metabolism

No Pathway Network information available for ATP/ITP metabolism

Pathways in the ATP/ITP metabolism SuperPath

#	Name	Source	Genes
1	ATP/ITP metabolism	GeneGo (Thomson Reuters)	ACP2 ACP3 ACP5 ACYP1 ACYP2 ADA ADAR ADARB1 ADARB2 ADK ADSL ADSS1 ADSS2 AK1 AK2 AK4 AK5 AK7 ALPP AMPD1 AMPD2 AMPD3 APRT DIS3 ENTPD1 ENTPD2 ENTPD3 ENTPD6 EPHX2 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 HPRT1 ITPA NME1 NME1-NME2 NME2 NME2P1 NME3 NME4 NME6 NME7 NT5C1A NT5C1B NT5C2 NT5E PNP POLR1A POLR1B POLR1C POLR1D POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J2 POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLRMT RRM1 RRM2 RRM2B TAF9 (see all 85) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACP2	Acid Phosphatase 2, Lysosomal	Protein Coding	1
2	ACP5	Acid Phosphatase 5, Tartrate Resistant	Protein Coding	1
3	ACP3	Acid Phosphatase 3	Protein Coding	1
4	ACYP1	Acylphosphatase 1	Protein Coding	1
5	ACYP2	Acylphosphatase 2	Protein Coding	1
6	ADA	Adenosine Deaminase	Protein Coding	1
7	ADAR	Adenosine Deaminase RNA Specific	Protein Coding	1
8	ADARB1	Adenosine Deaminase RNA Specific B1	Protein Coding	1
9	ADARB2	Adenosine Deaminase RNA Specific B2 (Inactive)	Protein Coding	1
10	ADK	Adenosine Kinase	Protein Coding	1
11	ADSL	Adenylosuccinate Lyase	Protein Coding	1
12	ADSS2	Adenylosuccinate Synthase 2	Protein Coding	1
13	AK1	Adenylate Kinase 1	Protein Coding	1
14	AK2	Adenylate Kinase 2	Protein Coding	1
15	AK4	Adenylate Kinase 4	Protein Coding	1
16	ALPP	Alkaline Phosphatase, Placental	Protein Coding	1
17	AMPD1	Adenosine Monophosphate Deaminase 1	Protein Coding	1
18	AMPD2	Adenosine Monophosphate Deaminase 2	Protein Coding	1
19	AMPD3	Adenosine Monophosphate Deaminase 3	Protein Coding	1
20	APRT	Adenine Phosphoribosyltransferase	Protein Coding	1
21	POLR3D	RNA Polymerase III Subunit D	Protein Coding	1
22	ENTPD1	Ectonucleoside Triphosphate Diphosphohydrolase 1	Protein Coding	1
23	ENTPD2	Ectonucleoside Triphosphate Diphosphohydrolase 2	Protein Coding	1
24	ENTPD6	Ectonucleoside Triphosphate Diphosphohydrolase 6	Protein Coding	1
25	ENTPD3	Ectonucleoside Triphosphate Diphosphohydrolase 3	Protein Coding	1
26	EPHX2	Epoxide Hydrolase 2	Protein Coding	1
27	HPRT1	Hypoxanthine Phosphoribosyltransferase 1	Protein Coding	1
28	ITPA	Inosine Triphosphatase	Protein Coding	1
29	NME1	NME/NM23 Nucleoside Diphosphate Kinase 1	Protein Coding	1
30	NME2	NME/NM23 Nucleoside Diphosphate Kinase 2	Protein Coding	1
31	NME3	NME/NM23 Nucleoside Diphosphate Kinase 3	Protein Coding	1
32	NME4	NME/NM23 Nucleoside Diphosphate Kinase 4	Protein Coding	1
33	PNP	Purine Nucleoside Phosphorylase	Protein Coding	1
34	NT5E	5''-Nucleotidase Ecto	Protein Coding	1
35	EXOSC9	Exosome Component 9	Protein Coding	1
36	EXOSC10	Exosome Component 10	Protein Coding	1
37	POLR2A	RNA Polymerase II Subunit A	Protein Coding	1
38	POLR2B	RNA Polymerase II Subunit B	Protein Coding	1
39	POLR2C	RNA Polymerase II Subunit C	Protein Coding	1
40	POLR2D	RNA Polymerase II Subunit D	Protein Coding	1
41	POLR2E	RNA Polymerase II, I And III Subunit E	Protein Coding	1
42	POLR2F	RNA Polymerase II, I And III Subunit F	Protein Coding	1
43	POLR2G	RNA Polymerase II Subunit G	Protein Coding	1
44	POLR2H	RNA Polymerase II, I And III Subunit H	Protein Coding	1
45	POLR2I	RNA Polymerase II Subunit I	Protein Coding	1
46	POLR2J	RNA Polymerase II Subunit J	Protein Coding	1
47	POLR2K	RNA Polymerase II, I And III Subunit K	Protein Coding	1
48	POLR2L	RNA Polymerase II, I And III Subunit L	Protein Coding	1
49	POLRMT	RNA Polymerase Mitochondrial	Protein Coding	1
50	RRM1	Ribonucleotide Reductase Catalytic Subunit M1	Protein Coding	1
51	RRM2	Ribonucleotide Reductase Regulatory Subunit M2	Protein Coding	1
52	TAF9	TATA-Box Binding Protein Associated Factor 9	Protein Coding	1
53	POLR1C	RNA Polymerase I And III Subunit C	Protein Coding	1
54	NME6	NME/NM23 Nucleoside Diphosphate Kinase 6	Protein Coding	1
55	POLR3F	RNA Polymerase III Subunit F	Protein Coding	1
56	POLR3G	RNA Polymerase III Subunit G	Protein Coding	1
57	POLR3C	RNA Polymerase III Subunit C	Protein Coding	1
58	POLR3A	RNA Polymerase III Subunit A	Protein Coding	1
59	EXOSC8	Exosome Component 8	Protein Coding	1
60	DIS3	DIS3 Exosome Endoribonuclease And 3''''-5'''' Exoribonuclease	Protein Coding	1
61	NT5C2	5''-Nucleotidase, Cytosolic II	Protein Coding	1
62	EXOSC7	Exosome Component 7	Protein Coding	1
63	EXOSC2	Exosome Component 2	Protein Coding	1
64	POLR1A	RNA Polymerase I Subunit A	Protein Coding	1
65	AK5	Adenylate Kinase 5	Protein Coding	1
66	NME7	NME/NM23 Family Member 7	Protein Coding	1
67	RRM2B	Ribonucleotide Reductase Regulatory TP53 Inducible Subunit M2B	Protein Coding	1
68	EXOSC3	Exosome Component 3	Protein Coding	1
69	EXOSC1	Exosome Component 1	Protein Coding	1
70	POLR1D	RNA Polymerase I And III Subunit D	Protein Coding	1
71	POLR3K	RNA Polymerase III Subunit K	Protein Coding	1
72	EXOSC4	Exosome Component 4	Protein Coding	1
73	POLR3B	RNA Polymerase III Subunit B	Protein Coding	1
74	POLR3E	RNA Polymerase III Subunit E	Protein Coding	1
75	EXOSC5	Exosome Component 5	Protein Coding	1
76	POLR1B	RNA Polymerase I Subunit B	Protein Coding	1
77	NT5C1A	5''-Nucleotidase, Cytosolic IA	Protein Coding	1
78	NT5C1B	5''-Nucleotidase, Cytosolic IB	Protein Coding	1
79	EXOSC6	Exosome Component 6	Protein Coding	1
80	AK7	Adenylate Kinase 7	Protein Coding	1
81	ADSS1	Adenylosuccinate Synthase 1	Protein Coding	1
82	POLR3H	RNA Polymerase III Subunit H	Protein Coding	1
83	POLR2J2	RNA Polymerase II Subunit J2	Protein Coding	1
84	NME2P1	NME2 Pseudogene 1	Pseudogene	1
85	NME1-NME2	NME1-NME2 Readthrough	Protein Coding	1

Disorders associated with ATP/ITP metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism	Enrichment	POLR1C, POLR3A, POLR3B	5.63
2	Pontocerebellar hypoplasia, type 1e	Enrichment	EXOSC3, EXOSC8, EXOSC9	5.33
3	Treacher collins syndrome 1	Enrichment	POLR1B, POLR1C, POLR1D	5.09
4	Adenosine monophosphate deaminase deficiency	Enrichment	AMPD1, AMPD3	4.41
5	Polr3-related leukodystrophy	Enrichment	POLR3A, POLR3B	3.94
6	Pontocerebellar hypoplasia	Enrichment	AMPD2, EXOSC3, EXOSC9	3.74
7	Hypomyelinating leukodystrophy 7	Enrichment	POLR3A, POLR3B	3.64
8	Severe combined immunodeficiency	Enrichment	ADA, AK2, PNP	2.95
9	Spastic ataxia	Enrichment	AMPD2, EXOSC8, POLR3A	2.35
10	Calcification of joints and arteries	Enrichment	NT5E	2.20
11	Erythrocyte amp deaminase deficiency	Enrichment	AMPD3	2.20
12	Adenylosuccinase deficiency	Enrichment	ADSL	2.20
13	Spondyloenchondrodysplasia with immune dysregulation	Enrichment	ACP5	2.20
14	Hypermethioninemia due to adenosine kinase deficiency	Enrichment	ADK	2.20
15	Acid phosphatase deficiency	Enrichment	ACP2	2.20
16	Pontocerebellar hypoplasia, type 1f	Enrichment	EXOSC1	2.20
17	Cerebellar ataxia, brain abnormalities, and cardiac conduction defects	Enrichment	EXOSC5	2.20
18	Leukodystrophy, hypomyelinating, 27	Enrichment	POLR1A	2.20
19	Treacher collins syndrome 4	Enrichment	POLR1B	2.20
20	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6	Enrichment	RRM1	2.20
21	Spermatogenic failure 27	Enrichment	AK7	2.20
22	Mitochondrial dna depletion syndrome 8b	Enrichment	RRM2B	2.20
23	Immunodeficiency 101	Enrichment	POLR3F	2.20
24	Leukodystrophy, hypomyelinating, 21	Enrichment	POLR3K	2.20
25	Treacher collins syndrome 2	Enrichment	POLR1D	2.20
26	Myopathy, distal, 5	Enrichment	ADSS1	2.20
27	Purine nucleoside phosphorylase deficiency	Enrichment	PNP	2.20
28	Pontocerebellar hypoplasia, type 1c	Enrichment	EXOSC8	2.20
29	Pontocerebellar hypoplasia, type 1d	Enrichment	EXOSC9	2.20
30	Myopathy due to myoadenylate deaminase deficiency	Enrichment	AMPD1	2.20
31	Short stature, hearing loss, retinitis pigmentosa, and distinctive facies	Enrichment	EXOSC2	2.20
32	Combined oxidative phosphorylation deficiency 55	Enrichment	POLRMT	2.20
33	Adar-related hereditary spastic paraplegia	Enrichment	ADAR	2.20
34	Odontoleukodystrophy	Enrichment	POLR3A	2.20
35	Rrm2b mitochondrial dna maintenance defects	Enrichment	RRM2B	2.20
36	Leukodystrophy	Enrichment	POLR3A, POLR3B	2.16
37	Fanconi renotubular syndrome 1	Enrichment	RRM2B	1.90
38	Immunoerythromyeloid hypoplasia	Enrichment	AK2	1.90
39	Reticular dysgenesis	Enrichment	AK2	1.90
40	Treacher collins syndrome 3	Enrichment	POLR1C	1.90
41	Rod-cone dystrophy, sensorineural deafness, and fanconi-type renal dysfunction	Enrichment	RRM2B	1.90
42	Leukodystrophy, hypomyelinating, 4	Enrichment	POLR3A	1.90
43	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 5	Enrichment	RRM2B	1.90
44	Waardenburg syndrome, type 4c	Enrichment	POLR2F	1.90
45	Mitochondrial dna depletion syndrome 8a	Enrichment	RRM2B	1.90
46	Dyschromatosis symmetrica hereditaria	Enrichment	ADAR	1.90
47	Adenine phosphoribosyltransferase deficiency	Enrichment	APRT	1.90
48	Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism	Enrichment	POLR3B	1.90
49	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 2	Enrichment	RRM2B	1.90
50	Inosine triphosphatase deficiency	Enrichment	ITPA	1.90
51	Aicardi-goutieres syndrome 6	Enrichment	ADAR	1.90
52	Leukoencephalopathy, progressive, with ovarian failure	Enrichment	POLR1C	1.90
53	Neurodevelopmental disorder with hypotonia, microcephaly, and seizures	Enrichment	ADARB1	1.90
54	Charcot-marie-tooth disease, demyelinating, type 1i	Enrichment	POLR3B	1.90
55	Spastic paraplegia 64, autosomal recessive	Enrichment	ENTPD1	1.90
56	Leukodystrophy, hypomyelinating, 11	Enrichment	POLR1C	1.90
57	Developmental and epileptic encephalopathy 35	Enrichment	ITPA	1.90
58	Peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	Enrichment	POLR2F	1.90
59	Anemia, congenital, nonspherocytic hemolytic, 3	Enrichment	AK1	1.90
60	Spastic paraplegia 45, autosomal recessive	Enrichment	NT5C2	1.90
61	Acrofacial dysostosis, cincinnati type	Enrichment	POLR1A	1.90
62	Congenital pontocerebellar hypoplasia type 1	Enrichment	EXOSC3	1.90
63	Symmetrical dyschromatosis of extremities	Enrichment	ADAR	1.90
64	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	ADA	1.73
65	Waardenburg syndrome, type 2a	Enrichment	POLR2F	1.73
66	Wiedemann-rautenstrauch syndrome	Enrichment	POLR3A	1.73
67	Lesch-nyhan syndrome	Enrichment	HPRT1	1.73
68	Hyperuricemia, hprt-related	Enrichment	HPRT1	1.73
69	Burn-mckeown syndrome	Enrichment	POLR1A	1.73
70	Pontocerebellar hypoplasia, type 9	Enrichment	AMPD2	1.73
71	Infantile cerebellar-retinal degeneration	Enrichment	POLR3H	1.73
72	Optic atrophy 9	Enrichment	POLR3H	1.73
73	Pontocerebellar hypoplasia, type 1b	Enrichment	EXOSC3	1.73
74	Viss syndrome	Enrichment	POLR3B	1.73
75	Cerebellar disease	Enrichment	EXOSC3	1.73
76	Spastic paraplegia 63, autosomal recessive	Enrichment	AMPD2	1.73
77	Idiopathic camptocormia	Enrichment	RRM2B	1.73
78	Neonatal pseudo-hydrocephalic progeroid syndrome	Enrichment	POLR3A	1.73
79	Fetal akinesia deformation sequence 1	Enrichment	ADSS1, EXOSC3	1.65
80	Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	Enrichment	POLR2A	1.60
81	Adenosine deaminase deficiency	Enrichment	ADA	1.60
82	Familial infantile bilateral striatal necrosis	Enrichment	ADAR	1.60
83	Kearns-sayre syndrome	Enrichment	RRM2B	1.51
84	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	ADA	1.51
85	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	POLR2F	1.51
86	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1	Enrichment	RRM2B	1.43
87	Waardenburg syndrome, type 4a	Enrichment	POLR2F	1.43
88	Early myoclonic encephalopathy	Enrichment	ADSL	1.43
89	Waardenburg syndrome	Enrichment	POLR2F	1.43
90	Waardenburg syndrome, type 1	Enrichment	POLR2F	1.37
91	Waardenburg syndrome, type 2e	Enrichment	POLR2F	1.37
92	Tooth agenesis, selective, 1	Enrichment	ITPA	1.26
93	Aicardi-goutiares syndrome	Enrichment	ADAR	1.26
94	Mitochondrial neurogastrointestinal encephalomyopathy	Enrichment	RRM2B	1.26
95	Omenn syndrome	Enrichment	ADA	1.22
96	Aicardi-goutieres syndrome	Enrichment	ADAR	1.22
97	Movement disease	Enrichment	POLR3A	1.18
98	46 xx gonadal dysgenesis	Enrichment	POLR3H	1.14
99	Hypercholesterolemia, familial, 1	Enrichment	EPHX2	1.11
100	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	POLR3B	1.07
101	Familial hypercholesterolemia	Enrichment	EPHX2	1.05
102	Esophageal atresia/tracheoesophageal fistula	Enrichment	POLR2B	0.95
103	Congenital myopathy	Enrichment	EXOSC3	0.95
104	Lissencephaly	Enrichment	EXOSC3	0.91
105	Tooth agenesis	Enrichment	ITPA	0.89
106	Kallmann syndrome	Enrichment	POLR2F	0.87
107	Non-syndromic male infertility due to sperm motility disorder	Enrichment	AK7	0.87
108	Congenital nervous system abnormality	Enrichment	AMPD2, EXOSC3	0.85
109	Nervous system disease	Enrichment	AMPD2, EXOSC3	0.85
110	Developmental and epileptic encephalopathy 1	Enrichment	ITPA	0.84
111	Hirschsprung disease 1	Enrichment	POLR2F	0.78
112	Severe covid-19	Enrichment	ENTPD2	0.78
113	Visceral heterotaxy 5	Enrichment	NME7	0.75
114	Microcephaly	Enrichment	ACYP1, EXOSC3	0.74
115	Developmental and epileptic encephalopathy	Enrichment	ITPA	0.69
116	Distal arthrogryposis	Enrichment	ADSS1	0.63
117	Optic atrophy plus syndrome	Enrichment	POLR3H	0.62
118	Sensorineural hearing loss	Enrichment	RRM2B	0.58
119	Myeloma, multiple	Enrichment	DIS3	0.53
120	Rare genetic deafness	Enrichment	POLR2F	0.41
121	Colorectal cancer	Enrichment	ADAR	0.37
122	Mitochondrial disease	Enrichment	RRM2B	0.37
123	Retinitis pigmentosa	Enrichment	RRM2B	0.13

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

ATP/ITP metabolism

Pathway Network for ATP/ITP metabolism

Member Pathways for ATP/ITP metabolism

Pathways in the ATP/ITP metabolism SuperPath

Associated Genes for ATP/ITP metabolism

Associated Disorders for ATP/ITP metabolism

Disorders associated with ATP/ITP metabolism SuperPath

STRING Interaction Network for ATP/ITP metabolism

Sources for ATP/ITP metabolism