ATR signaling

No Pathway Network information available for ATR signaling

#	Name	Source	Genes
1	ATR signaling	WikiPathways	ATR ATRIP-TREX1 CHEK1 HUS1 RAD1 RAD9A RAD9B RPA1 TOPBP1 (see all 9) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RPA1	Replication Protein A1	Protein Coding	1
2	RAD9A	RAD9 Checkpoint Clamp Component A	Protein Coding	1
3	ATR	ATR Checkpoint Kinase	Protein Coding	1
4	CHEK1	Checkpoint Kinase 1	Protein Coding	1
5	TOPBP1	DNA Topoisomerase II Binding Protein 1	Protein Coding	1
6	RAD9B	RAD9 Checkpoint Clamp Component B	Protein Coding	1
7	ATRIP-TREX1	ATRIP-TREX1 Readthrough	RNA Gene	1
8	RAD1	RAD1 Checkpoint DNA Exonuclease	Protein Coding	1
9	HUS1	HUS1 Checkpoint Clamp Component	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Seckel syndrome	Enrichment	ATR, ATRIP-TREX1	4.45
2	Seckel syndrome 1	Enrichment	ATR	3.18
3	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6	Enrichment	RPA1	3.18
4	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	3.18
5	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	3.18
6	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	3.18
7	Vasculopathy, retinal, with cerebral leukoencephalopathy and systemic manifestations	Enrichment	ATRIP-TREX1	2.70
8	Chilblain lupus 1	Enrichment	ATRIP-TREX1	2.70
9	Chilblain lupus	Enrichment	ATRIP-TREX1	2.70
10	Aicardi-goutieres syndrome 1	Enrichment	ATRIP-TREX1	2.58
11	Thrombotic microangiopathy	Enrichment	ATRIP-TREX1	2.58
12	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	2.58
13	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	ATRIP-TREX1	2.48
14	Vascular dementia	Enrichment	ATRIP-TREX1	2.48
15	Aicardi-goutieres syndrome	Enrichment	ATRIP-TREX1	2.18
16	Neural tube defects	Enrichment	RAD9B	2.07
17	Systemic lupus erythematosus	Enrichment	ATRIP-TREX1	1.59
18	Hereditary retinal dystrophy	Enrichment	ATRIP-TREX1	0.75
19	Fundus dystrophy	Enrichment	ATRIP-TREX1	0.75

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for ATR signaling