Atypical NF-kappaB pathway

No Pathway Network information available for Atypical NF-kappaB pathway

Pathways in the Atypical NF-kappaB pathway SuperPath

#	Name	Source	Genes
1	Atypical NF-kappaB pathway	PubChem	ARRB2 BCL3 BTRC IKBKB LCK MAPK14 NFKB1 NFKBIA PIK3CA PIK3R1 REL RELA SRC SYK (see all 14) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BCL3	BCL3 Transcription Coactivator	Protein Coding	1
2	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
3	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
4	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
5	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
6	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	1
7	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
8	ARRB2	Arrestin Beta 2	Protein Coding	1
9	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
10	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
11	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
12	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
13	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
14	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1

Disorders associated with Atypical NF-kappaB pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.53
2	Colorectal cancer	Enrichment	PIK3CA, PIK3R1, SRC	4.05
3	Severe combined immunodeficiency	Enrichment	IKBKB, LCK	3.29
4	Macrodactyly	Enrichment	PIK3CA	2.99
5	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.99
6	Cowden syndrome 5	Enrichment	PIK3CA	2.99
7	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.99
8	Immunodeficiency 15b	Enrichment	IKBKB	2.99
9	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.99
10	Immunodeficiency 15a	Enrichment	IKBKB	2.99
11	Immunodeficiency 92	Enrichment	REL	2.99
12	Short syndrome	Enrichment	PIK3R1	2.99
13	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.99
14	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.99
15	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.99
16	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.99
17	Immunodeficiency 22	Enrichment	LCK	2.99
18	Thrombocytopenia 6	Enrichment	SRC	2.99
19	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.99
20	Hypospadias	Enrichment	PIK3CA	2.99
21	Colitis	Enrichment	SYK	2.99
22	Rare venous malformation	Enrichment	PIK3CA	2.99
23	Diaphragmatic eventration	Enrichment	PIK3CA	2.99
24	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.99
25	Rare combined vascular malformation	Enrichment	PIK3CA	2.99
26	Cavernous lymphangioma	Enrichment	PIK3CA	2.99
27	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.99
28	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.99
29	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.99
30	Macrodactyly of toe	Enrichment	PIK3CA	2.99
31	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.69
32	Keratosis, seborrheic	Enrichment	PIK3CA	2.69
33	Noonan syndrome 8	Enrichment	PIK3CA	2.69
34	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.69
35	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.69
36	Rela fusion-positive ependymoma	Enrichment	RELA	2.69
37	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.69
38	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.69
39	Arthritis	Enrichment	SYK	2.69
40	Common variable immunodeficiency 12	Enrichment	NFKB1	2.69
41	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.51
42	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.51
43	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.51
44	Immunodeficiency 14	Enrichment	PIK3R1	2.51
45	Keratoacanthoma	Enrichment	PIK3CA	2.51
46	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.38
47	Cerebrovascular disease	Enrichment	PIK3CA	2.38
48	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.38
49	Capillary malformations, congenital	Enrichment	PIK3CA	2.29
50	Hemimegalencephaly	Enrichment	PIK3CA	2.29
51	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.21
52	Cowden syndrome 1	Enrichment	PIK3CA	2.21
53	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.21
54	Breast adenocarcinoma	Enrichment	PIK3CA	2.21
55	Lung squamous cell carcinoma	Enrichment	PIK3CA	2.21
56	Nevus, epidermal	Enrichment	PIK3CA	2.14
57	Myelofibrosis	Enrichment	SRC	2.14
58	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	2.14
59	Gallbladder cancer	Enrichment	PIK3CA	2.14
60	Common variable immunodeficiency	Enrichment	NFKB1	2.14
61	Overgrowth syndrome	Enrichment	PIK3R1	2.14
62	Isolated split hand-split foot malformation	Enrichment	BTRC	2.08
63	Arteriovenous malformation	Enrichment	PIK3CA	2.03
64	Adult hepatocellular carcinoma	Enrichment	PIK3CA	2.03
65	Cowden syndrome	Enrichment	PIK3CA	2.03
66	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.99
67	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.99
68	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.99
69	Immune deficiency disease	Enrichment	SYK	1.95
70	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.95
71	Meningioma	Enrichment	PIK3CA	1.91
72	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.91
73	Osteoporosis	Enrichment	SRC	1.84
74	Lynch syndrome	Enrichment	PIK3CA	1.81
75	Gliosarcoma	Enrichment	NFKBIA	1.79
76	Giant cell glioblastoma	Enrichment	NFKBIA	1.76
77	Endometrial cancer	Enrichment	PIK3CA	1.67
78	Hepatocellular carcinoma	Enrichment	PIK3CA	1.65
79	Bladder cancer	Enrichment	PIK3CA	1.53
80	Prostate cancer	Enrichment	PIK3CA	1.53
81	Lung cancer	Enrichment	PIK3CA	1.49
82	Gastric cancer	Enrichment	PIK3CA	1.36
83	Hereditary breast carcinoma	Enrichment	PIK3CA	1.35
84	Thrombocytopenia	Enrichment	SRC	1.31
85	Hypertelorism	Enrichment	PIK3CA	1.28
86	Breast cancer	Enrichment	PIK3CA	1.13
87	Ovarian cancer	Enrichment	PIK3CA	1.00

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Atypical NF-kappaB pathway

Pathway Network for Atypical NF-kappaB pathway

Member Pathways for Atypical NF-kappaB pathway

Pathways in the Atypical NF-kappaB pathway SuperPath

Associated Genes for Atypical NF-kappaB pathway

Associated Disorders for Atypical NF-kappaB pathway

Disorders associated with Atypical NF-kappaB pathway SuperPath

STRING Interaction Network for Atypical NF-kappaB pathway

Sources for Atypical NF-kappaB pathway