Aurora A signaling

No Pathway Network information available for Aurora A signaling

Pathways in the Aurora A signaling SuperPath

#	Name	Source	Genes
1	Aurora A signaling	PubChem	AJUBA AKT1 ARHGEF7 AURKA AURKAIP1 AURKB BIRC5 BRCA1 CDC25B CENPA CKAP5 CPEB1 DLGAP5 FZR1 GADD45A GIT1 GSK3B KPNA1 KPNB1 MDM2 NDEL1 NFKBIA OAZ1 PAK1 PPP2R5D PRKACA RAN RASA1 TACC1 TACC3 TDRD7 TP53 TPX2 (see all 33) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CPEB1	Cytoplasmic Polyadenylation Element Binding Protein 1	Protein Coding	1
2	TACC1	Transforming Acidic Coiled-Coil Containing Protein 1	Protein Coding	1
3	TDRD7	Tudor Domain Containing 7	Protein Coding	1
4	OAZ1	Ornithine Decarboxylase Antizyme 1	Protein Coding	1
5	AURKAIP1	Aurora Kinase A Interacting Protein 1	Protein Coding	1
6	TPX2	TPX2 Microtubule Nucleation Factor	Protein Coding	1
7	AURKA	Aurora Kinase A	Protein Coding	1
8	CDC25B	Cell Division Cycle 25B	Protein Coding	1
9	FZR1	Fizzy And Cell Division Cycle 20 Related 1	Protein Coding	1
10	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
11	CENPA	Centromere Protein A	Protein Coding	1
12	NDEL1	NudE Neurodevelopment Protein 1 Like 1	Protein Coding	1
13	AURKB	Aurora Kinase B	Protein Coding	1
14	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
15	DLGAP5	DLG Associated Protein 5	Protein Coding	1
16	TACC3	Transforming Acidic Coiled-Coil Containing Protein 3	Protein Coding	1
17	KPNA1	Karyopherin Subunit Alpha 1	Protein Coding	1
18	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
19	KPNB1	Karyopherin Subunit Beta 1	Protein Coding	1
20	RAN	RAN, Member RAS Oncogene Family	Protein Coding	1
21	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
22	AJUBA	Ajuba LIM Protein	Protein Coding	1
23	GIT1	GIT ArfGAP 1	Protein Coding	1
24	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
25	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
26	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
27	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
28	CKAP5	Cytoskeleton Associated Protein 5	Protein Coding	1
29	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
30	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	1
31	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
32	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
33	TP53	Tumor Protein P53	Protein Coding	1

Disorders associated with Aurora A signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Gliosarcoma	Enrichment	NFKBIA, TACC1, TACC3, TP53	7.29
2	Giant cell glioblastoma	Enrichment	NFKBIA, TACC1, TACC3, TP53	7.17
3	Nasopharyngeal carcinoma	Enrichment	NFKBIA, TP53	4.76
4	Colorectal cancer	Enrichment	AKT1, AURKA, BRCA1, TP53	4.25
5	Li-fraumeni syndrome	Enrichment	MDM2, TP53	4.07
6	Breast adenocarcinoma	Enrichment	AKT1, TP53	4.07
7	Hereditary breast carcinoma	Enrichment	AKT1, BRCA1, TP53	3.79
8	Rhabdomyosarcoma	Enrichment	BRCA1, TP53	3.17
9	Breast cancer	Enrichment	AKT1, BRCA1, TP53	3.10
10	Pancreatic cancer	Enrichment	BRCA1, TP53	2.78
11	Ovarian cancer	Enrichment	AKT1, BRCA1, TP53	2.73
12	Bladder cancer	Enrichment	BRCA1, TP53	2.65
13	Prostate cancer	Enrichment	BRCA1, TP53	2.65
14	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.61
15	Proteus syndrome	Enrichment	AKT1	2.61
16	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.61
17	Accelerated tumor formation	Enrichment	MDM2	2.61
18	Cataract 36	Enrichment	TDRD7	2.61
19	Lessel-kubisch syndrome	Enrichment	MDM2	2.61
20	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.61
21	Bone marrow failure syndrome 5	Enrichment	TP53	2.61
22	Papilloma of choroid plexus	Enrichment	TP53	2.61
23	Basal cell carcinoma 7	Enrichment	TP53	2.61
24	Anaplastic thyroid carcinoma	Enrichment	TP53	2.61
25	Infant-type hemispheric glioma	Enrichment	BRCA1	2.61
26	Developmental and epileptic encephalopathy 109	Enrichment	FZR1	2.61
27	Cowden syndrome 6	Enrichment	AKT1	2.61
28	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.61
29	Ductal carcinoma in situ	Enrichment	TP53	2.61
30	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.61
31	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.61
32	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.61
33	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.61
34	Choroid plexus cancer	Enrichment	TP53	2.61
35	Gorham's disease	Enrichment	RASA1	2.61
36	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.61
37	Primary peritoneal carcinoma	Enrichment	BRCA1	2.61
38	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.31
39	Cervical cancer	Enrichment	TP53	2.31
40	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.31
41	Lymphoma, hodgkin, classic	Enrichment	TP53	2.31
42	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.31
43	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.31
44	Pancreatic cancer 4	Enrichment	BRCA1	2.31
45	Congenital fibrosarcoma	Enrichment	TP53	2.31
46	Li-fraumeni syndrome 1	Enrichment	TP53	2.31
47	Sarcoma	Enrichment	TP53	2.31
48	Fibrolamellar carcinoma	Enrichment	PRKACA	2.31
49	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.31
50	Cervix carcinoma	Enrichment	TP53	2.31
51	Hodgkin's lymphoma	Enrichment	TP53	2.31
52	Inflammatory breast carcinoma	Enrichment	BRCA1	2.31
53	Peritoneum cancer	Enrichment	BRCA1	2.31
54	Bilateral breast cancer	Enrichment	BRCA1	2.31
55	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.31
56	Gastric cancer	Enrichment	BRCA1, TP53	2.31
57	Osteogenic sarcoma	Enrichment	TP53	2.14
58	Wieacker-wolff syndrome	Enrichment	RASA1	2.14
59	Dedifferentiated liposarcoma	Enrichment	MDM2	2.14
60	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.14
61	Anaplastic astrocytoma	Enrichment	TP53	2.14
62	Squamous cell carcinoma	Enrichment	TP53	2.14
63	Adenocarcinoma	Enrichment	TP53	2.14
64	Bone osteosarcoma	Enrichment	TP53	2.14
65	Well-differentiated liposarcoma	Enrichment	MDM2	2.14
66	Hereditary breast ovarian cancer syndrome	Enrichment	BRCA1, TP53	2.10
67	Myeloma, multiple	Enrichment	AURKA, TP53	2.09
68	Small cell cancer of the lung	Enrichment	TP53	2.01
69	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.01
70	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	2.01
71	Cholangiocarcinoma	Enrichment	BRCA1	2.01
72	Lung sarcomatoid carcinoma	Enrichment	TP53	2.01
73	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.01
74	Capillary malformations, congenital	Enrichment	RASA1	1.92
75	Rhabdomyosarcoma 2	Enrichment	TP53	1.92
76	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.92
77	Lymphoma	Enrichment	TP53	1.92
78	Acute megakaryocytic leukemia	Enrichment	TP53	1.92
79	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	1.84
80	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.84
81	Hemangioma, capillary infantile	Enrichment	RASA1	1.84
82	Basal cell carcinoma 1	Enrichment	RASA1	1.84
83	Adrenocortical carcinoma	Enrichment	TP53	1.84
84	Esophageal cancer	Enrichment	TP53	1.77
85	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.77
86	Capillary malformation-arteriovenous malformation 1	Enrichment	RASA1	1.77
87	Essential thrombocythemia	Enrichment	TP53	1.77
88	Gallbladder cancer	Enrichment	TP53	1.77
89	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.77
90	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.77
91	Glioma susceptibility 1	Enrichment	TP53	1.71
92	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.71
93	Ellis-van creveld syndrome	Enrichment	PRKACA	1.66
94	Arteriovenous malformation	Enrichment	RASA1	1.66
95	Adult hepatocellular carcinoma	Enrichment	TP53	1.66
96	Primary hyperaldosteronism	Enrichment	TP53	1.66
97	Cowden syndrome	Enrichment	AKT1	1.66
98	Leukemia, chronic lymphocytic	Enrichment	TP53	1.62
99	Myopathy, x-linked, with excessive autophagy	Enrichment	RASA1	1.62
100	Familial colorectal cancer	Enrichment	TP53	1.62
101	Myelodysplastic syndrome	Enrichment	TP53	1.58
102	Uterine corpus cancer	Enrichment	BRCA1	1.58
103	Meningioma	Enrichment	AKT1	1.54
104	Lip and oral cavity carcinoma	Enrichment	TP53	1.54
105	Breast-ovarian cancer, familial 1	Enrichment	BRCA1	1.51
106	Nk-cell enteropathy	Enrichment	AURKB	1.51
107	Lung cancer susceptibility 3	Enrichment	TP53	1.47
108	Periventricular nodular heterotopia	Enrichment	BRCA1	1.47
109	Inherited cancer-predisposing syndrome	Enrichment	BRCA1, TP53	1.39
110	Diffuse large b-cell lymphoma	Enrichment	TP53	1.34
111	Endometrial cancer	Enrichment	BRCA1	1.30
112	Hepatoblastoma	Enrichment	TP53	1.30
113	Hepatocellular carcinoma	Enrichment	TP53	1.28
114	Diamond-blackfan anemia 1	Enrichment	TP53	1.26
115	Lung cancer	Enrichment	BRCA1	1.12
116	Fanconi anemia, complementation group a	Enrichment	BRCA1	1.09
117	Diamond-blackfan anemia	Enrichment	TP53	1.08
118	Leukemia, acute myeloid	Enrichment	TP53	1.03
119	Undetermined early-onset epileptic encephalopathy	Enrichment	FZR1	0.89

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Aurora A signaling

Pathway Network for Aurora A signaling

Member Pathways for Aurora A signaling

Pathways in the Aurora A signaling SuperPath

Associated Genes for Aurora A signaling

Associated Disorders for Aurora A signaling

Disorders associated with Aurora A signaling SuperPath

STRING Interaction Network for Aurora A signaling

Sources for Aurora A signaling