Aurora B signaling

Pathway network for the Aurora B signaling SuperPath

Sources:

PubChem

Pathways in the Aurora B signaling SuperPath

#	Name	Source	Genes
1	Aurora B signaling	PubChem	AURKA AURKB AURKC BIRC5 BUB1 CBX5 CDCA8 CENPA CUL3 DES EVI5 INCENP KIF20A KIF23 KIF2C KLHL13 KLHL9 MYLK NCAPD2 NCAPG NCAPH NCL NDC80 NPM1 NSUN2 PEBP1 PPP1CC PPP2R5D PSMA3 RACGAP1 RASA1 RHOA SEPTIN1 SGO1 SMC2 SMC4 STMN1 TACC1 VIM (see all 39) (see less)
2	Aurora C signaling	PubChem	AURKB AURKC INCENP
3	Signaling by Aurora kinases	PubChem	AURKA AURKB AURKC

Gene overlap in member pathways for Aurora B signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AURKC	Aurora Kinase C	Protein Coding	3
2	AURKB	Aurora Kinase B	Protein Coding	3
3	AURKA	Aurora Kinase A	Protein Coding	2
4	INCENP	Inner Centromere Protein	Protein Coding	2
5	EVI5	Ecotropic Viral Integration Site 5	Protein Coding	1
6	KLHL9	Kelch Like Family Member 9	Protein Coding	1
7	KLHL13	Kelch Like Family Member 13	Protein Coding	1
8	SEPTIN1	Septin 1	Protein Coding	1
9	NDC80	NDC80 Kinetochore Complex Component	Protein Coding	1
10	TACC1	Transforming Acidic Coiled-Coil Containing Protein 1	Protein Coding	1
11	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	1
12	NSUN2	NOP2/Sun RNA Methyltransferase 2	Protein Coding	1
13	NCL	Nucleolin	Protein Coding	1
14	NPM1	Nucleophosmin 1	Protein Coding	1
15	KIF20A	Kinesin Family Member 20A	Protein Coding	1
16	KIF23	Kinesin Family Member 23	Protein Coding	1
17	NCAPD2	Non-SMC Condensin I Complex Subunit D2	Protein Coding	1
18	NCAPH	Non-SMC Condensin I Complex Subunit H	Protein Coding	1
19	NCAPG	Non-SMC Condensin I Complex Subunit G	Protein Coding	1
20	SMC4	Structural Maintenance Of Chromosomes 4	Protein Coding	1
21	SMC2	Structural Maintenance Of Chromosomes 2	Protein Coding	1
22	DES	Desmin	Protein Coding	1
23	CENPA	Centromere Protein A	Protein Coding	1
24	CDCA8	Cell Division Cycle Associated 8	Protein Coding	1
25	SGO1	Shugoshin 1	Protein Coding	1
26	BUB1	BUB1 Mitotic Checkpoint Serine/Threonine Kinase	Protein Coding	1
27	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
28	PPP1CC	Protein Phosphatase 1 Catalytic Subunit Gamma	Protein Coding	1
29	MYLK	Myosin Light Chain Kinase	Protein Coding	1
30	PEBP1	Phosphatidylethanolamine Binding Protein 1	Protein Coding	1
31	CUL3	Cullin 3	Protein Coding	1
32	STMN1	Stathmin 1	Protein Coding	1
33	VIM	Vimentin	Protein Coding	1
34	RACGAP1	Rac GTPase Activating Protein 1	Protein Coding	1
35	CBX5	Chromobox 5	Protein Coding	1
36	KIF2C	Kinesin Family Member 2C	Protein Coding	1
37	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
38	RHOA	Ras Homolog Family Member A	Protein Coding	1
39	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	1

Disorders associated with Aurora B signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Anemia, congenital dyserythropoietic, type iiia	Enrichment	KIF23, RACGAP1	5.09
2	Nk-cell enteropathy	Enrichment	AURKB, CUL3	3.21
3	Spermatogenic failure 5	Enrichment	AURKC	2.75
4	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.54
5	Pseudohypoaldosteronism, type iie	Enrichment	CUL3	2.54
6	Scapuloperoneal syndrome, neurogenic, kaeser type	Enrichment	DES	2.54
7	Cardiomyopathy, familial restrictive, 6	Enrichment	KIF20A	2.54
8	Neurodevelopmental disorder with or without autism or seizures	Enrichment	CUL3	2.54
9	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.54
10	Microcephaly 23, primary, autosomal recessive	Enrichment	NCAPH	2.54
11	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.54
12	Microcephaly 30, primary, autosomal recessive	Enrichment	BUB1	2.54
13	Klhl9-related early-onset distal myopathy	Enrichment	KLHL9	2.54
14	Congenital dyserythropoietic anemia type iiib	Enrichment	RACGAP1	2.54
15	Acute myeloid leukemia with multilineage dysplasia	Enrichment	NPM1	2.54
16	Acute myeloid leukemia with npm1 somatic mutations	Enrichment	NPM1	2.54
17	Gorham's disease	Enrichment	RASA1	2.54
18	Anemia, congenital dyserythropoietic, type iiib, autosomal recessive	Enrichment	RACGAP1	2.54
19	Premature aging	Enrichment	VIM	2.54
20	Male infertility with spermatogenesis disorder	Enrichment	AURKC	2.48
21	Pseudohypoaldosteronism, type i, autosomal dominant	Enrichment	CUL3	2.24
22	Intellectual developmental disorder, autosomal recessive 5	Enrichment	NSUN2	2.24
23	Dubowitz syndrome	Enrichment	NSUN2	2.24
24	Cardiomyopathy, dilated, 1i	Enrichment	DES	2.24
25	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.24
26	Microcephaly 21, primary, autosomal recessive	Enrichment	NCAPD2	2.24
27	Progressive familial heart block	Enrichment	DES	2.24
28	Cataract 30	Enrichment	VIM	2.24
29	Chronic atrial and intestinal dysrhythmia	Enrichment	SGO1	2.24
30	Acute myeloid leukemia without maturation	Enrichment	NPM1	2.24
31	Lymphomatoid papulosis	Enrichment	NPM1	2.24
32	Primary cutaneous anaplastic large cell lymphoma	Enrichment	NPM1	2.24
33	Nephronophthisis	Enrichment	INCENP	2.14
34	Pseudohypoaldosteronism, type iia	Enrichment	CUL3	2.07
35	Myopathy, myofibrillar, 1	Enrichment	DES	2.07
36	Aortic aneurysm, familial thoracic 7	Enrichment	MYLK	2.07
37	Wieacker-wolff syndrome	Enrichment	RASA1	2.07
38	Phenylketonuria	Enrichment	NSUN2	1.94
39	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	MYLK	1.94
40	Myeloma, multiple	Enrichment	AURKA	1.91
41	Capillary malformations, congenital	Enrichment	RASA1	1.84
42	Visceral myopathy 1	Enrichment	MYLK	1.84
43	Acute myeloid leukemia with maturation	Enrichment	NPM1	1.84
44	Histiocytoid hemangioma	Enrichment	VIM	1.84
45	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	1.77
46	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.77
47	Hemihyperplasia, isolated	Enrichment	RHOA	1.77
48	Hemangioma, capillary infantile	Enrichment	RASA1	1.77
49	Basal cell carcinoma 1	Enrichment	RASA1	1.77
50	Autosomal recessive intellectual developmental disorder	Enrichment	NSUN2	1.77
51	Colorectal cancer	Enrichment	AURKA	1.72
52	Capillary malformation-arteriovenous malformation 1	Enrichment	RASA1	1.70
53	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.70
54	Myofibrillar myopathy	Enrichment	DES	1.70
55	Familial isolated restrictive cardiomyopathy	Enrichment	KIF20A	1.70
56	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1	1.64
57	Arteriovenous malformation	Enrichment	RASA1	1.59
58	Familial thoracic aortic aneurysm and dissection	Enrichment	MYLK	1.59
59	Cataract 30, multiple types	Enrichment	VIM	1.55
60	Myopathy, x-linked, with excessive autophagy	Enrichment	RASA1	1.55
61	Acute promyelocytic leukemia	Enrichment	NPM1	1.43
62	Aortic aneurysm, familial thoracic 1	Enrichment	MYLK	1.40
63	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	DES	1.35
64	Gliosarcoma	Enrichment	TACC1	1.35
65	Cardiomyopathy, dilated, 1e	Enrichment	DES	1.32
66	Giant cell glioblastoma	Enrichment	TACC1	1.32
67	Neuromuscular disease	Enrichment	DES	1.30
68	Dyskeratosis congenita	Enrichment	NPM1	1.27
69	Familial hypertrophic cardiomyopathy	Enrichment	DES	1.04
70	Leukemia, acute myeloid	Enrichment	NPM1	0.96
71	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MYLK	0.92
72	Familial isolated dilated cardiomyopathy	Enrichment	DES	0.85
73	Autosomal recessive non-syndromic intellectual disability	Enrichment	NSUN2	0.81
74	Dilated cardiomyopathy	Enrichment	DES	0.69
75	Autism spectrum disorder	Enrichment	CUL3	0.57
76	Microcephaly	Enrichment	KIF23	0.52
77	Complex neurodevelopmental disorder	Enrichment	CUL3	0.52

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Aurora B signaling

Pathway Network for Aurora B signaling

Pathway network for the Aurora B signaling SuperPath

Member Pathways for Aurora B signaling

Pathways in the Aurora B signaling SuperPath

Gene overlap in member pathways for Aurora B signaling SuperPath

Associated Genes for Aurora B signaling

Associated Disorders for Aurora B signaling

Disorders associated with Aurora B signaling SuperPath

STRING Interaction Network for Aurora B signaling

Sources for Aurora B signaling