Autophagy

Pathway network for the Autophagy SuperPath

Sources:

WikiPathways

Pathways in the Autophagy SuperPath

#	Name	Source	Genes
1	Autophagy	WikiPathways	AKT1S1 AMBRA1 ATG101 ATG12 ATG13 ATG14 ATG16L1 ATG3 ATG5 ATG7 ATG9A BECN1 DEPTOR MAP1LC3B MLST8 MTOR PIK3C3 PIK3R4 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RB1CC1 RPTOR ULK1 UVRAG WIPI2 (see all 30) (see less)
2	Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway	WikiPathways	ACACA AKT1S1 ATG10 ATG101 ATG12 ATG13 ATG14 ATG16L1 ATG2A ATG3 ATG4A ATG5 ATG7 ATP13A2 BECN1 C19orf12 COASY CP DCAF17 DEPTOR FA2H FTL GTPBP2 MAP1LC3A MECP2 MLST8 MTOR PANK2 PIK3C3 PIK3R4 PLA2G6 PRKAA1 RB1CC1 RHEB RPTOR SCP2 SPTLC1 STK11 TSC1 TSC2 ULK1 WDR45 WIPI1 WIPI2 (see all 44) (see less)
3	Nanoparticle triggered autophagic cell death	WikiPathways	AMBRA1 ATG10 ATG12 ATG14 ATG16L1 ATG3 ATG4A ATG5 ATG7 ATG9B BCL2 BECN1 CHAF1A INS INSR MAP1LC3A SH3GLB1 TSC1 TSC2 ULK1 ULK2 UVRAG VMP1 (see all 23) (see less)
4	Host-pathogen interaction of human coronaviruses - autophagy	WikiPathways	ATG10 ATG12 ATG13 ATG16L1 ATG16L2 ATG3 ATG4A ATG5 ATG7 BECN1 MTOR PIK3C3 PIK3R4 RB1CC1 ULK1 ULK2 WIPI1 ZFYVE1 (see all 18) (see less)
5	Autophagy during CoV infection	WikiPathways	ATG10 ATG12 ATG13 ATG7 BECN1 MAP1LC3A MTOR PIK3C3 PIK3R4 RB1CC1 ULK1 ULK2 WIPI1 ZFYVE1 (see all 14) (see less)

Gene overlap in member pathways for Autophagy SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BECN1	Beclin 1	Protein Coding	5
2	ATG7	Autophagy Related 7	Protein Coding	5
3	ATG12	Autophagy Related 12	Protein Coding	5
4	ULK1	Unc-51 Like Autophagy Activating Kinase 1	Protein Coding	5
5	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	4
6	RB1CC1	RB1 Inducible Coiled-Coil 1	Protein Coding	4
7	ATG5	Autophagy Related 5	Protein Coding	4
8	ATG16L1	Autophagy Related 16 Like 1	Protein Coding	4
9	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	4
10	ATG13	Autophagy Related 13	Protein Coding	4
11	ATG3	Autophagy Related 3	Protein Coding	4
12	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	4
13	ATG10	Autophagy Related 10	Protein Coding	4
14	ATG14	Autophagy Related 14	Protein Coding	3
15	MAP1LC3A	Microtubule Associated Protein 1 Light Chain 3 Alpha	Protein Coding	3
16	WIPI1	WD Repeat Domain, Phosphoinositide Interacting 1	Protein Coding	3
17	ATG4A	Autophagy Related 4A Cysteine Peptidase	Protein Coding	3
18	ULK2	Unc-51 Like Autophagy Activating Kinase 2	Protein Coding	3
19	AKT1S1	AKT1 Substrate 1	Protein Coding	2
20	ATG101	Autophagy Related 101	Protein Coding	2
21	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	2
22	AMBRA1	Autophagy And Beclin 1 Regulator 1	Protein Coding	2
23	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	2
24	UVRAG	UV Radiation Resistance Associated	Protein Coding	2
25	DEPTOR	DEP Domain Containing MTOR Interacting Protein	Protein Coding	2
26	MLST8	MTOR Associated Protein MLST8	Protein Coding	2
27	WIPI2	WD Repeat Domain, Phosphoinositide Interacting 2	Protein Coding	2
28	TSC2	TSC Complex Subunit 2	Protein Coding	2
29	TSC1	TSC Complex Subunit 1	Protein Coding	2
30	ZFYVE1	Zinc Finger FYVE-Type Containing 1	Protein Coding	2
31	MAP1LC3B	Microtubule Associated Protein 1 Light Chain 3 Beta	Protein Coding	1
32	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	1
33	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	1
34	PRKAG3	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 3	Protein Coding	1
35	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	1
36	ATG9A	Autophagy Related 9A	Protein Coding	1
37	PRKAG1	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1	Protein Coding	1
38	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	1
39	PLA2G6	Phospholipase A2 Group VI	Protein Coding	1
40	C19orf12	Chromosome 19 Open Reading Frame 12	Protein Coding	1
41	COASY	Coenzyme A Synthase	Protein Coding	1
42	DCAF17	DDB1 And CUL4 Associated Factor 17	Protein Coding	1
43	PANK2	Pantothenate Kinase 2	Protein Coding	1
44	FA2H	Fatty Acid 2-Hydroxylase	Protein Coding	1
45	STK11	Serine/Threonine Kinase 11	Protein Coding	1
46	SCP2	Sterol Carrier Protein 2	Protein Coding	1
47	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	1
48	GTPBP2	GTP Binding Protein 2	Protein Coding	1
49	MECP2	Methyl-CpG Binding Protein 2	Protein Coding	1
50	ACACA	Acetyl-CoA Carboxylase Alpha	Protein Coding	1
51	FTL	Ferritin Light Chain	Protein Coding	1
52	ATP13A2	ATPase Cation Transporting 13A2	Protein Coding	1
53	CP	Ceruloplasmin	Protein Coding	1
54	WDR45	WD Repeat Domain 45	Protein Coding	1
55	SPTLC1	Serine Palmitoyltransferase Long Chain Base Subunit 1	Protein Coding	1
56	ATG2A	Autophagy Related 2A	Protein Coding	1
57	INS	Insulin	Protein Coding	1
58	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
59	INSR	Insulin Receptor	Protein Coding	1
60	CHAF1A	Chromatin Assembly Factor 1 Subunit A	Protein Coding	1
61	VMP1	Vacuole Membrane Protein 1	Protein Coding	1
62	SH3GLB1	SH3 Domain Containing GRB2 Like, Endophilin B1	Protein Coding	1
63	ATG9B	Autophagy Related 9B	Protein Coding	1
64	ATG16L2	Autophagy Related 16 Like 2	Protein Coding	1

Disorders associated with Autophagy SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Neurodegeneration with brain iron accumulation	Enrichment	ATP13A2, C19orf12, COASY, CP, DCAF17, FA2H, PLA2G6	16.00
2	Focal cortical dysplasia, type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	9.93
3	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	9.93
4	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	5.56
5	Dystonia	Enrichment	C19orf12, MECP2, PANK2, WDR45	5.33
6	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	5.08
7	Hamartoma	Enrichment	TSC1, TSC2	5.08
8	Tuberous sclerosis	Enrichment	TSC1, TSC2	4.78
9	Adult hepatocellular carcinoma	Enrichment	TSC1, TSC2	4.01
10	Hemimegalencephaly	Enrichment	MTOR, RHEB	3.99
11	Spastic ataxia	Enrichment	C19orf12, FA2H, PLA2G6	3.18
12	Spinocerebellar ataxia, autosomal recessive 25	Enrichment	ATG5	2.88
13	Inflammatory bowel disease 10	Enrichment	ATG16L1	2.88
14	Donohue syndrome	Enrichment	INSR	2.77
15	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.77
16	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.77
17	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.77
18	Fatty liver disease 1	Enrichment	ATG7	2.69
19	Cebalid syndrome	Enrichment	MTOR	2.69
20	Spinocerebellar ataxia, autosomal recessive 31	Enrichment	ATG7	2.69
21	Smith-kingsmore syndrome	Enrichment	MTOR	2.69
22	Intellectual developmental disorder with short stature and variable skeletal anomalies	Enrichment	WIPI2	2.66
23	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	2.66
24	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	2.66
25	Skeletal muscle glycogen content and metabolism quantitative trait locus	Enrichment	PRKAG3	2.66
26	Neuropathy, hereditary sensory and autonomic, type ia	Enrichment	SPTLC1	2.49
27	Osteopetrosis and infantile neuroaxonal dystrophy	Enrichment	PLA2G6	2.49
28	Facial hypertrichosis	Enrichment	MECP2	2.49
29	Aceruloplasminemia	Enrichment	CP	2.49
30	Neurodegeneration with brain iron accumulation 3	Enrichment	FTL	2.49
31	Spastic paraplegia 78, autosomal recessive	Enrichment	ATP13A2	2.49
32	Intellectual developmental disorder, x-linked, syndromic, lubs type	Enrichment	MECP2	2.49
33	Neurodegeneration with brain iron accumulation 2a	Enrichment	PLA2G6	2.49
34	Autism x-linked 3	Enrichment	MECP2	2.49
35	Amyotrophic lateral sclerosis 27, juvenile	Enrichment	SPTLC1	2.49
36	Acetyl-coa carboxylase-alpha deficiency	Enrichment	ACACA	2.49
37	Neurodegeneration with brain iron accumulation 6	Enrichment	COASY	2.49
38	Parkinson disease 14, autosomal recessive	Enrichment	PLA2G6	2.49
39	Kufor-rakeb syndrome	Enrichment	ATP13A2	2.49
40	Neurodegeneration with brain iron accumulation 2b	Enrichment	PLA2G6	2.49
41	Neurodegeneration with brain iron accumulation 4	Enrichment	C19orf12	2.49
42	Spastic paraplegia 43, autosomal recessive	Enrichment	C19orf12	2.49
43	L-ferritin deficiency	Enrichment	FTL	2.49
44	Syndromic x-linked intellectual disability lubs type	Enrichment	MECP2	2.49
45	Leukoencephalopathy with dystonia and motor neuropathy	Enrichment	SCP2	2.49
46	Pontocerebellar hypoplasia, type 12	Enrichment	COASY	2.49
47	Muscular lipidosis	Enrichment	COASY	2.49
48	Genetic hyperferritinemia without iron overload	Enrichment	FTL	2.49
49	Mitochondrial membrane protein-associated neurodegeneration	Enrichment	C19orf12	2.49
50	Intestinal polyposis syndrome	Enrichment	STK11	2.49
51	Parkinsonism due to atp13a2 deficiency	Enrichment	ATP13A2	2.49
52	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.47
53	Maturity-onset diabetes of the young, type 10	Enrichment	INS	2.47
54	Hyperproinsulinemia	Enrichment	INS	2.47
55	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.47
56	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	2.47
57	Congenital nervous system abnormality	Enrichment	MECP2, PLA2G6, TSC2	2.31
58	Nervous system disease	Enrichment	MECP2, PLA2G6, TSC2	2.31
59	Type 1 diabetes mellitus 2	Enrichment	INS	2.29
60	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	2.29
61	Tuberous sclerosis 2	Enrichment	TSC2	2.29
62	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.29
63	Xanthinuria, type ii	Enrichment	TSC2	2.29
64	Breast adenocarcinoma	Enrichment	RB1CC1	2.21
65	Peutz-jeghers syndrome	Enrichment	STK11	2.19
66	Woodhouse-sakati syndrome	Enrichment	DCAF17	2.19
67	Encephalopathy, neonatal severe, due to mecp2 mutations	Enrichment	MECP2	2.19
68	Spastic paraplegia 35, autosomal recessive, with or without neurodegeneration	Enrichment	FA2H	2.19
69	Hermansky-pudlak syndrome 3	Enrichment	CP	2.19
70	Hyperferritinemia with or without cataract	Enrichment	FTL	2.19
71	Intellectual developmental disorder, x-linked, syndromic 13	Enrichment	MECP2	2.19
72	X-linked intellectual disability-psychosis-macroorchidism syndrome	Enrichment	MECP2	2.19
73	Hereditary spastic paraplegia 35	Enrichment	FA2H	2.19
74	Jaberi-elahi syndrome	Enrichment	GTPBP2	2.19
75	Progressive bulbar palsy	Enrichment	MECP2	2.19
76	Infantile osteopetrosis with neuroaxonal dysplasia	Enrichment	PLA2G6	2.19
77	Bruxism	Enrichment	MECP2	2.19
78	Neonatal diabetes mellitus	Enrichment	INS	2.17
79	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	2.14
80	Overgrowth syndrome	Enrichment	MTOR	2.14
81	Hereditary spastic paraplegia	Enrichment	C19orf12, FA2H	2.09
82	Follicular lymphoma	Enrichment	BCL2	2.07
83	Inherited cancer-predisposing syndrome	Enrichment	STK11, TSC1, TSC2	2.05
84	West syndrome	Enrichment	TSC2, WDR45	2.05
85	Laryngomalacia	Enrichment	MECP2	2.01
86	Neurodegeneration with brain iron accumulation 5	Enrichment	WDR45	2.01
87	Optic atrophy 2	Enrichment	WDR45	2.01
88	Cerebral-cerebellar-coloboma syndrome, x-linked	Enrichment	WDR45	2.01
89	Testicular germ cell cancer	Enrichment	STK11	2.01
90	Testicular cancer	Enrichment	STK11	2.01
91	Apc-associated polyposis conditions	Enrichment	STK11	2.01
92	Craniofacial microsomia 1	Enrichment	CHAF1A	1.99
93	Type 1 diabetes mellitus	Enrichment	INS	1.99
94	Keratoconus	Enrichment	TSC1	1.99
95	46,xy disorder of sex development	Enrichment	INSR	1.99
96	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.93
97	Polycystic kidney disease 1	Enrichment	TSC2	1.93
98	Neurodegeneration with brain iron accumulation 1	Enrichment	PANK2	1.89
99	Albinism, oculocutaneous, type vii	Enrichment	WDR45	1.89
100	Basal ganglia calcification	Enrichment	WDR45	1.89
101	Sick sinus syndrome	Enrichment	MECP2	1.89
102	Permanent neonatal diabetes mellitus	Enrichment	INS	1.87
103	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.81
104	Rare genetic intellectual disability	Enrichment	MTOR	1.81
105	Familial adenomatous polyposis 1	Enrichment	STK11	1.79
106	Rubinstein-taybi syndrome 2	Enrichment	PANK2	1.79
107	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	STK11	1.79
108	Diabetes mellitus	Enrichment	INS	1.73
109	Angelman syndrome	Enrichment	MECP2	1.71
110	Testicular germ cell tumor	Enrichment	STK11	1.71
111	Rett syndrome	Enrichment	MECP2	1.65
112	Hereditary sensory and autonomic neuropathy type 1	Enrichment	SPTLC1	1.65
113	Focal epilepsy	Enrichment	MECP2	1.65
114	Autism	Enrichment	MECP2, WDR45	1.64
115	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.60
116	Kidney disease	Enrichment	TSC1	1.60
117	Rett syndrome, congenital variant	Enrichment	MECP2	1.59
118	Neurofibromatosis, type i	Enrichment	C19orf12	1.54
119	Juvenile amyotrophic lateral sclerosis	Enrichment	SPTLC1	1.54
120	Melanoma	Enrichment	STK11	1.50
121	Maturity-onset diabetes of the young	Enrichment	INS	1.48
122	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	1.46
123	Lip and oral cavity carcinoma	Enrichment	STK11	1.42
124	Stereotypic movement disorder	Enrichment	MECP2	1.38
125	Hereditary breast carcinoma	Enrichment	RB1CC1	1.35
126	Hermansky-pudlak syndrome	Enrichment	CP	1.32
127	Bladder cancer	Enrichment	TSC1	1.32
128	Autism spectrum disorder	Enrichment	MECP2, TSC2	1.31
129	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	PLA2G6	1.30
130	Hermansky-pudlak syndrome 1	Enrichment	CP	1.30
131	Melanoma, cutaneous malignant 1	Enrichment	STK11	1.27
132	Beckwith-wiedemann syndrome	Enrichment	SPTLC1	1.25
133	Microcephaly	Enrichment	MECP2, PLA2G6	1.22
134	Type 2 diabetes mellitus	Enrichment	INSR	1.16
135	Attention deficit-hyperactivity disorder	Enrichment	MECP2	1.16
136	Familial hypertrophic cardiomyopathy	Enrichment	PRKAG2	1.15
137	Breast cancer	Enrichment	RB1CC1	1.13
138	Pancreatic cancer	Enrichment	STK11	1.11
139	Hypertrophic cardiomyopathy	Enrichment	PRKAG2	1.04
140	Primary ovarian insufficiency	Enrichment	ATG9B	1.02
141	Non-syndromic x-linked intellectual disability	Enrichment	MECP2	0.96
142	Systemic lupus erythematosus	Enrichment	MECP2	0.92
143	Epilepsy	Enrichment	MECP2	0.91
144	Charcot-marie-tooth disease	Enrichment	SPTLC1	0.90
145	Gastric cancer	Enrichment	STK11	0.88
146	Ovarian cancer	Enrichment	TSC2	0.80
147	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SPTLC1	0.76
148	Cone-rod dystrophy 2	Enrichment	PANK2	0.70
149	Retinitis pigmentosa	Enrichment	PANK2	0.30
150	Hereditary retinal dystrophy	Enrichment	PANK2	0.21
151	Fundus dystrophy	Enrichment	PANK2	0.21

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Autophagy

Pathway Network for Autophagy

Pathway network for the Autophagy SuperPath

Member Pathways for Autophagy

Pathways in the Autophagy SuperPath

Gene overlap in member pathways for Autophagy SuperPath

Associated Genes for Autophagy

Associated Disorders for Autophagy

Disorders associated with Autophagy SuperPath

STRING Interaction Network for Autophagy

Sources for Autophagy