Autophagy in pancreatic ductal adenocarcinoma

No Pathway Network information available for Autophagy in pancreatic ductal adenocarcinoma

Pathways in the Autophagy in pancreatic ductal adenocarcinoma SuperPath

#	Name	Source	Genes
1	Autophagy in pancreatic ductal adenocarcinoma	WikiPathways	AGER ATG7 BECN1 HMGB1 IPO8 KRAS MAP1LC3B MDM2 MITF NFE2L2 NFKB1 PINK1 PRKN SHOC2 SQSTM1 STAT3 TFE3 TFEB TP53 VMP1 (see all 20) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SQSTM1	Sequestosome 1	Protein Coding	1
2	BECN1	Beclin 1	Protein Coding	1
3	MAP1LC3B	Microtubule Associated Protein 1 Light Chain 3 Beta	Protein Coding	1
4	SHOC2	SHOC2 Leucine Rich Repeat Scaffold Protein	Protein Coding	1
5	TFEB	Transcription Factor EB	Protein Coding	1
6	TP53	Tumor Protein P53	Protein Coding	1
7	TFE3	Transcription Factor Binding To IGHM Enhancer 3	Protein Coding	1
8	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
9	PINK1	PTEN Induced Kinase 1	Protein Coding	1
10	PRKN	Parkin RBR E3 Ubiquitin Protein Ligase	Protein Coding	1
11	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
12	NFE2L2	NFE2 Like BZIP Transcription Factor 2	Protein Coding	1
13	MITF	Melanocyte Inducing Transcription Factor	Protein Coding	1
14	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
15	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
16	HMGB1	High Mobility Group Box 1	Protein Coding	1
17	AGER	Advanced Glycosylation End-Product Specific Receptor	Protein Coding	1
18	ATG7	Autophagy Related 7	Protein Coding	1
19	IPO8	Importin 8	Protein Coding	1
20	VMP1	Vacuole Membrane Protein 1	Protein Coding	1

Disorders associated with Autophagy in pancreatic ductal adenocarcinoma SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lung cancer susceptibility 3	Enrichment	KRAS, PRKN, TP53	6.01
2	Lung sarcomatoid carcinoma	Enrichment	KRAS, TP53	4.91
3	Lung cancer	Enrichment	KRAS, NFE2L2, PRKN	4.88
4	Li-fraumeni syndrome	Enrichment	MDM2, TP53	4.51
5	Breast adenocarcinoma	Enrichment	KRAS, TP53	4.51
6	Renal cell carcinoma with mit translocations	Enrichment	TFE3, TFEB	4.36
7	Gallbladder cancer	Enrichment	KRAS, TP53	4.36
8	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, MITF, TP53	4.16
9	Early-onset parkinson's disease	Enrichment	PINK1, PRKN	3.87
10	Noonan syndrome and noonan-related syndrome	Enrichment	KRAS, SHOC2	3.67
11	Diffuse large b-cell lymphoma	Enrichment	STAT3, TP53	3.46
12	Ovarian cancer	Enrichment	KRAS, PRKN, TP53	3.38
13	Noonan syndrome 1	Enrichment	KRAS, SHOC2	3.29
14	Pancreatic cancer	Enrichment	KRAS, TP53	3.22
15	Rasopathy	Enrichment	KRAS, SHOC2	3.18
16	Bladder cancer	Enrichment	KRAS, TP53	3.09
17	Paget disease of bone 3	Enrichment	SQSTM1	2.83
18	Oculoectodermal syndrome	Enrichment	KRAS	2.83
19	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	2.83
20	Heterochromia iridis	Enrichment	MITF	2.83
21	Tietz albinism-deafness syndrome	Enrichment	MITF	2.83
22	Leprosy 2	Enrichment	PRKN	2.83
23	Accelerated tumor formation	Enrichment	MDM2	2.83
24	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	2.83
25	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	2.83
26	Lessel-kubisch syndrome	Enrichment	MDM2	2.83
27	Bone marrow failure syndrome 5	Enrichment	TP53	2.83
28	Renal cell carcinoma, xp11-associated	Enrichment	TFE3	2.83
29	Intellectual developmental disorder, x-linked, syndromic, with pigmentary mosaicism and coarse facies	Enrichment	TFE3	2.83
30	Immunodeficiency, developmental delay, and hypohomocysteinemia	Enrichment	NFE2L2	2.83
31	Papilloma of choroid plexus	Enrichment	TP53	2.83
32	Basal cell carcinoma 7	Enrichment	TP53	2.83
33	Anaplastic thyroid carcinoma	Enrichment	TP53	2.83
34	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.83
35	Coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness	Enrichment	MITF	2.83
36	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.83
37	Noonan syndrome-like disorder with loose anagen hair 1	Enrichment	SHOC2	2.83
38	Ductal carcinoma in situ	Enrichment	TP53	2.83
39	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.83
40	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.83
41	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.83
42	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.83
43	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.83
44	Congenital pulmonary airway malformation	Enrichment	KRAS	2.83
45	Choroid plexus cancer	Enrichment	TP53	2.83
46	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.83
47	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.83
48	Leukemia, acute myeloid	Enrichment	KRAS, TP53	2.81
49	Gastric cancer	Enrichment	KRAS, TP53	2.75
50	Hereditary breast carcinoma	Enrichment	KRAS, TP53	2.73
51	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.53
52	Cervical cancer	Enrichment	TP53	2.53
53	Parkinson disease 12	Enrichment	PRKN	2.53
54	Alveolar soft part sarcoma	Enrichment	TFE3	2.53
55	Welander distal myopathy	Enrichment	SQSTM1	2.53
56	Duane-radial ray syndrome	Enrichment	IPO8	2.53
57	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.53
58	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS	2.53
59	Fatty liver disease 1	Enrichment	ATG7	2.53
60	Lymphoma, hodgkin, classic	Enrichment	TP53	2.53
61	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.53
62	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	2.53
63	Melanoma, cutaneous malignant 8	Enrichment	MITF	2.53
64	Noonan syndrome-like disorder with loose anagen hair	Enrichment	SHOC2	2.53
65	Spinocerebellar ataxia, autosomal recessive 31	Enrichment	ATG7	2.53
66	Papillary renal cell carcinoma	Enrichment	MITF	2.53
67	Congenital fibrosarcoma	Enrichment	TP53	2.53
68	Li-fraumeni syndrome 1	Enrichment	TP53	2.53
69	Sarcoma	Enrichment	TP53	2.53
70	Cervix carcinoma	Enrichment	TP53	2.53
71	Hodgkin's lymphoma	Enrichment	TP53	2.53
72	Paget's disease of bone	Enrichment	SQSTM1	2.53
73	Common variable immunodeficiency 12	Enrichment	NFKB1	2.53
74	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.53
75	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	2.53
76	Myeloma, multiple	Enrichment	KRAS, TP53	2.52
77	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.35
78	Waardenburg syndrome, type 2a	Enrichment	MITF	2.35
79	Osteogenic sarcoma	Enrichment	TP53	2.35
80	Nasopharyngeal carcinoma	Enrichment	TP53	2.35
81	Viss syndrome	Enrichment	IPO8	2.35
82	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.35
83	Hyper ige syndrome	Enrichment	STAT3	2.35
84	Polycystic kidney disease 4	Enrichment	SHOC2	2.35
85	Dedifferentiated liposarcoma	Enrichment	MDM2	2.35
86	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.35
87	Anaplastic astrocytoma	Enrichment	TP53	2.35
88	Squamous cell carcinoma	Enrichment	TP53	2.35
89	Adenocarcinoma	Enrichment	TP53	2.35
90	Bone osteosarcoma	Enrichment	TP53	2.35
91	Well-differentiated liposarcoma	Enrichment	MDM2	2.35
92	Renal cell carcinoma	Enrichment	TFE3	2.35
93	Breast cancer	Enrichment	KRAS, TP53	2.27
94	Schimmelpenning-feuerstein-mims syndrome	Enrichment	KRAS	2.23
95	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.23
96	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.23
97	Small cell cancer of the lung	Enrichment	TP53	2.23
98	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.23
99	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	2.23
100	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.23
101	Malignant epithelioid hemangioendothelioma	Enrichment	TFE3	2.23
102	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS	2.23
103	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.23
104	Pilocytic astrocytoma	Enrichment	KRAS	2.23
105	Paget's disease of bone 2	Enrichment	SQSTM1	2.23
106	Complex hereditary spastic paraplegia	Enrichment	PRKN	2.23
107	Clear cell papillary renal cell carcinoma	Enrichment	MITF	2.23
108	Colorectal cancer	Enrichment	NFE2L2, TP53	2.14
109	Polycystic kidney disease 3 with or without polycystic liver disease	Enrichment	SHOC2	2.13
110	Parkinson disease 2, autosomal recessive juvenile	Enrichment	PRKN	2.13
111	Rhabdomyosarcoma 2	Enrichment	TP53	2.13
112	Lymphoma	Enrichment	TP53	2.13
113	Parkin type of early-onset parkinson disease	Enrichment	PRKN	2.13
114	Acute megakaryocytic leukemia	Enrichment	TP53	2.13
115	Waardenburg syndrome, type 4a	Enrichment	MITF	2.05
116	Parkinson disease 6, autosomal recessive early-onset	Enrichment	PINK1	2.05
117	Adrenocortical carcinoma	Enrichment	TP53	2.05
118	Lung squamous cell carcinoma	Enrichment	KRAS	2.05
119	Waardenburg syndrome	Enrichment	MITF	2.05
120	Esophageal cancer	Enrichment	TP53	1.99
121	Nevus, epidermal	Enrichment	KRAS	1.99
122	Waardenburg syndrome, type 1	Enrichment	MITF	1.99
123	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.99
124	Waardenburg syndrome, type 2e	Enrichment	MITF	1.99
125	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS	1.99
126	Leukemia, chronic myeloid	Enrichment	KRAS	1.99
127	Noonan syndrome 3	Enrichment	KRAS	1.99
128	Essential thrombocythemia	Enrichment	TP53	1.99
129	Pilomyxoid astrocytoma	Enrichment	KRAS	1.99
130	Common variable immunodeficiency	Enrichment	NFKB1	1.99
131	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.99
132	Glioma susceptibility 1	Enrichment	TP53	1.93
133	Polycystic kidney disease 4 with or without polycystic liver disease	Enrichment	SHOC2	1.93
134	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.93
135	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.93
136	Loeys-dietz syndrome	Enrichment	IPO8	1.88
137	Adult hepatocellular carcinoma	Enrichment	TP53	1.88
138	Primary hyperaldosteronism	Enrichment	TP53	1.88
139	Behavioral variant of frontotemporal dementia	Enrichment	SQSTM1	1.88
140	Leukemia, chronic lymphocytic	Enrichment	TP53	1.83
141	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1	1.83
142	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.83
143	Melanoma	Enrichment	MITF	1.83
144	Familial colorectal cancer	Enrichment	TP53	1.83
145	Inherited cancer-predisposing syndrome	Enrichment	MITF, TP53	1.80
146	Pectus excavatum	Enrichment	SHOC2	1.79
147	Myelodysplastic syndrome	Enrichment	TP53	1.79
148	Lung non-small cell carcinoma	Enrichment	KRAS	1.79
149	Juvenile myelomonocytic leukemia	Enrichment	KRAS	1.76
150	Lip and oral cavity carcinoma	Enrichment	TP53	1.76
151	Acute promyelocytic leukemia	Enrichment	STAT3	1.72
152	Lynch syndrome	Enrichment	KRAS	1.66
153	Rhabdomyosarcoma	Enrichment	TP53	1.63
154	Gliosarcoma	Enrichment	TP53	1.63
155	Melanoma, cutaneous malignant 1	Enrichment	MITF	1.61
156	Giant cell glioblastoma	Enrichment	TP53	1.61
157	Arteriovenous malformations of the brain	Enrichment	KRAS	1.56
158	Parkinson's disease	Enrichment	PRKN	1.56
159	Hepatoblastoma	Enrichment	TP53	1.52
160	Hepatocellular carcinoma	Enrichment	TP53	1.50
161	Diamond-blackfan anemia 1	Enrichment	TP53	1.48
162	Ear malformation	Enrichment	MITF	1.46
163	Parkinson disease, late-onset	Enrichment	PRKN	1.46
164	Prostate cancer	Enrichment	TP53	1.38
165	Differentiated thyroid carcinoma	Enrichment	KRAS	1.38
166	Non-immune hydrops fetalis	Enrichment	KRAS	1.35
167	Diamond-blackfan anemia	Enrichment	TP53	1.29
168	Non-syndromic genetic deafness	Enrichment	MITF	1.29
169	Nonsyndromic hearing loss	Enrichment	MITF	1.22
170	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MITF	1.13
171	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SQSTM1	1.09
172	Schizophrenia	Enrichment	PRKN	1.08
173	Autism	Enrichment	PRKN	1.00
174	Rare genetic deafness	Enrichment	MITF	0.96
175	Autism spectrum disorder	Enrichment	PRKN	0.83

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Autophagy in pancreatic ductal adenocarcinoma

Pathway Network for Autophagy in pancreatic ductal adenocarcinoma

Member Pathways for Autophagy in pancreatic ductal adenocarcinoma

Pathways in the Autophagy in pancreatic ductal adenocarcinoma SuperPath

Associated Genes for Autophagy in pancreatic ductal adenocarcinoma

Associated Disorders for Autophagy in pancreatic ductal adenocarcinoma

Disorders associated with Autophagy in pancreatic ductal adenocarcinoma SuperPath

STRING Interaction Network for Autophagy in pancreatic ductal adenocarcinoma

Sources for Autophagy in pancreatic ductal adenocarcinoma