B Cell Receptor Signaling Pathway

No Pathway Network information available for B Cell Receptor Signaling Pathway

Pathways in the B Cell Receptor Signaling Pathway SuperPath

#	Name	Source	Genes
1	B Cell Receptor Signaling Pathway	Sino Biological	AKT1 AKT1S1 AKT2 AKT3 AKTIP APBB1IP ATF2 ATF4 BCAP29 BCAP31 BCL2A1 BCL2L1 BCL6 BTK CALM1 CALM2 CALM3 CALML3 CALML5 CAMK1 CAMK1D CAMK1G CAMK2A CAMK2B CAMK2G CAMK4 CAMKK1 CAMKV CD19 CD22 CD40 CDC42 CLTA CREB1 CREB3 CREB3L1 CREB3L2 CREB3L4 CREBZF DCLK1 DOK3 EGR1 ELK1 ETS1 EZR FCGR2B GAB1 GAB2 GNAI3 GSK3B HRAS IKBKB IKBKE JUN KRAS LAT2 LYN MALT1 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP3K2 MAP3K3 MAP3K7 MAPK1 MAPK14 MAPK3 MAPK8 MAPK9 MEF2C MTOR NFATC1 NFATC3 NFKB1 NFKBIA NFKBIB NRAS PIK3CA PIK3CB PIK3R1 PIK3R2 PIR PNCK PPP3CA PPP3R1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCZ PTEN PTPN11 PTPN6 PTPRC RAC1 RAC2 RAC3 RAF1 RAP1A RAP1B RASSF5 RELA RPS6KB1 RPS6KB2 SYK VAV1 YWHAB (see all 113) (see less)
2	T Cell Receptor Signaling Pathway	Sino Biological	ACTN1 ACTN2 ACTN3 ACTN4 ADAP1 ADAP2 AKT1 AKT1S1 AKT2 AKT3 AKTIP CALM1 CALM2 CALM3 CALML3 CALML5 CAMK4 CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPNS1 CAPNS2 CBL CD28 CD3D CD3E CD3G CD4 CDC42 CREB1 CREB3 CREB3L1 CREB3L2 CREB3L4 CREBZF FOS GADD45A GNAI3 IKBKB IKBKE JUN LAT LAT2 LCK LCP2 MALT1 MAP2K1 MAP2K2 MAP2K4 MAP3K2 MAP3K3 MAP3K7 MAPK1 MAPK12 MAPK14 MAPK15 MAPK3 MAPK6 MAPK7 MAPK9 NFATC1 NFATC3 NFKB1 NFKBIA NFKBIB ORAI1 PDK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PPP3CA PPP3R1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCZ PTPRC RAC1 RAC2 RAC3 RAF1 REL RELA TLN1 TLN2 VAV1 WAS ZAP70 (see all 95) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
2	AKT1S1	AKT1 Substrate 1	Protein Coding	2
3	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
4	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
5	AKTIP	AKT Interacting Protein	Protein Coding	2
6	CALM1	Calmodulin 1	Protein Coding	2
7	CALM2	Calmodulin 2	Protein Coding	2
8	CALM3	Calmodulin 3	Protein Coding	2
9	CALML3	Calmodulin Like 3	Protein Coding	2
10	CALML5	Calmodulin Like 5	Protein Coding	2
11	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	2
12	CDC42	Cell Division Cycle 42	Protein Coding	2
13	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
14	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	2
15	CREB3L1	CAMP Responsive Element Binding Protein 3 Like 1	Protein Coding	2
16	CREB3L2	CAMP Responsive Element Binding Protein 3 Like 2	Protein Coding	2
17	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	2
18	CREBZF	CREB/ATF BZIP Transcription Factor	Protein Coding	2
19	GNAI3	G Protein Subunit Alpha I3	Protein Coding	2
20	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
21	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	2
22	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
23	LAT2	Linker For Activation Of T Cells Family Member 2	Protein Coding	2
24	MALT1	MALT1 Paracaspase	Protein Coding	2
25	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
26	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
27	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	2
28	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	2
29	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	2
30	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	2
31	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
32	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
33	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
34	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	2
35	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	2
36	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	2
37	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
38	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
39	NFKBIB	NFKB Inhibitor Beta	Protein Coding	2
40	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
41	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
42	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
43	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
44	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	2
45	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	2
46	PRKCA	Protein Kinase C Alpha	Protein Coding	2
47	PRKCB	Protein Kinase C Beta	Protein Coding	2
48	PRKCD	Protein Kinase C Delta	Protein Coding	2
49	PRKCE	Protein Kinase C Epsilon	Protein Coding	2
50	PRKCG	Protein Kinase C Gamma	Protein Coding	2
51	PRKCH	Protein Kinase C Eta	Protein Coding	2
52	PRKCI	Protein Kinase C Iota	Protein Coding	2
53	PRKCZ	Protein Kinase C Zeta	Protein Coding	2
54	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	2
55	RAC1	Rac Family Small GTPase 1	Protein Coding	2
56	RAC2	Rac Family Small GTPase 2	Protein Coding	2
57	RAC3	Rac Family Small GTPase 3	Protein Coding	2
58	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
59	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
60	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	2
61	APBB1IP	Amyloid Beta Precursor Protein Binding Family B Member 1 Interacting Protein	Protein Coding	1
62	ATF2	Activating Transcription Factor 2	Protein Coding	1
63	ATF4	Activating Transcription Factor 4	Protein Coding	1
64	BCAP29	B Cell Receptor Associated Protein 29	Protein Coding	1
65	BCAP31	B Cell Receptor Associated Protein 31	Protein Coding	1
66	BCL2A1	BCL2 Related Protein A1	Protein Coding	1
67	BCL2L1	BCL2 Like 1	Protein Coding	1
68	BCL6	BCL6 Transcription Repressor	Protein Coding	1
69	BTK	Bruton Tyrosine Kinase	Protein Coding	1
70	CAMK1	Calcium/Calmodulin Dependent Protein Kinase I	Protein Coding	1
71	CAMK1D	Calcium/Calmodulin Dependent Protein Kinase ID	Protein Coding	1
72	CAMK1G	Calcium/Calmodulin Dependent Protein Kinase IG	Protein Coding	1
73	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
74	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
75	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	1
76	CAMKK1	Calcium/Calmodulin Dependent Protein Kinase Kinase 1	Protein Coding	1
77	CAMKV	CaM Kinase Like Vesicle Associated	Protein Coding	1
78	CD19	CD19 Molecule	Protein Coding	1
79	CD22	CD22 Molecule	Protein Coding	1
80	CD40	CD40 Molecule	Protein Coding	1
81	CLTA	Clathrin Light Chain A	Protein Coding	1
82	DCLK1	Doublecortin Like Kinase 1	Protein Coding	1
83	DOK3	Docking Protein 3	Protein Coding	1
84	EGR1	Early Growth Response 1	Protein Coding	1
85	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
86	ETS1	ETS Proto-Oncogene 1, Transcription Factor	Protein Coding	1
87	EZR	Ezrin	Protein Coding	1
88	FCGR2B	Fc Gamma Receptor IIb	Protein Coding	1
89	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
90	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1
91	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
92	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
93	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
94	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
95	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
96	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
97	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
98	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
99	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
100	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
101	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
102	PIR	Pirin	Protein Coding	1
103	PNCK	Pregnancy Up-Regulated Nonubiquitous CaM Kinase	Protein Coding	1
104	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
105	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
106	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
107	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
108	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	1
109	RASSF5	Ras Association Domain Family Member 5	Protein Coding	1
110	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
111	RPS6KB2	Ribosomal Protein S6 Kinase B2	Protein Coding	1
112	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
113	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
114	ACTN1	Actinin Alpha 1	Protein Coding	1
115	ACTN2	Actinin Alpha 2	Protein Coding	1
116	ACTN3	Actinin Alpha 3	Protein Coding	1
117	ACTN4	Actinin Alpha 4	Protein Coding	1
118	ADAP1	ArfGAP With Dual PH Domains 1	Protein Coding	1
119	ADAP2	ArfGAP With Dual PH Domains 2	Protein Coding	1
120	CAPN1	Calpain 1	Protein Coding	1
121	CAPN2	Calpain 2	Protein Coding	1
122	CAPN3	Calpain 3	Protein Coding	1
123	CAPN5	Calpain 5	Protein Coding	1
124	CAPN6	Calpain 6	Protein Coding	1
125	CAPNS1	Calpain Small Subunit 1	Protein Coding	1
126	CAPNS2	Calpain Small Subunit 2	Protein Coding	1
127	CBL	Cbl Proto-Oncogene	Protein Coding	1
128	CD28	CD28 Molecule	Protein Coding	1
129	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	1
130	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
131	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	1
132	CD4	CD4 Molecule	Protein Coding	1
133	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
134	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
135	LAT	Linker For Activation Of T Cells	Protein Coding	1
136	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
137	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	1
138	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
139	MAPK15	Mitogen-Activated Protein Kinase 15	Protein Coding	1
140	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
141	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
142	ORAI1	ORAI Calcium Release-Activated Calcium Modulator 1	Protein Coding	1
143	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	1
144	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
145	TLN1	Talin 1	Protein Coding	1
146	TLN2	Talin 2	Protein Coding	1
147	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	1
148	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1

Disorders associated with B Cell Receptor Signaling Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RAF1	10.45
2	Severe combined immunodeficiency	Enrichment	CD3D, CD3E, CD3G, IKBKB, LCK, MALT1, PTPRC, ZAP70	10.34
3	Noonan syndrome 1	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RAF1	9.27
4	Rasopathy	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RAF1	8.87
5	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, MAP2K1, NRAS, PIK3CA	7.79
6	Hemimegalencephaly	Enrichment	AKT3, MTOR, PIK3CA, PTEN	7.64
7	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	6.80
8	Noonan syndrome 3	Enrichment	HRAS, KRAS, PTPN11, RAF1	6.80
9	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	5.88
10	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.65
11	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1, MAP2K2	5.65
12	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1, MAP2K2	5.65
13	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	4.96
14	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	4.74
15	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS, PTEN	4.72
16	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, PIK3CA	4.72
17	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS, PTEN	4.72
18	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS, RAF1	4.51
19	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	4.34
20	Cowden syndrome	Enrichment	AKT1, PIK3CA, PTEN	4.34
21	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	4.19
22	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.16
23	Bladder cancer	Enrichment	HRAS, KRAS, PIK3CA, PTEN	4.03
24	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, PTPN11	3.98
25	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, PTPN11	3.93
26	Meningioma	Enrichment	AKT1, PIK3CA, PTEN	3.93
27	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.84
28	Myxofibrosarcoma	Enrichment	CREB3L1, CREB3L2	3.84
29	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD3D, CD3E	3.84
30	Langerhans cell histiocytosis	Enrichment	MAP2K1, NRAS	3.69
31	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.69
32	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.54
33	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, CDC42	3.54
34	Breast cancer	Enrichment	AKT1, JUN, KRAS, PIK3CA, PTEN	3.40
35	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.39
36	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	3.39
37	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PIK3CA, PTEN	3.32
38	Cowden syndrome 1	Enrichment	PIK3CA, PTEN	3.00
39	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	3.00
40	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.85
41	Gallbladder cancer	Enrichment	KRAS, PIK3CA	2.85
42	Pilomyxoid astrocytoma	Enrichment	KRAS, RAF1	2.85
43	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	2.85
44	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	2.76
45	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS, PTPN11	2.67
46	Combined immunodeficiency	Enrichment	MALT1, ZAP70	2.59
47	Combined t cell and b cell immunodeficiency	Enrichment	MALT1, ZAP70	2.59
48	Combined t and b cell immunodeficiency	Enrichment	MALT1, ZAP70	2.59
49	Specific learning disability	Enrichment	MAPK1, PTPN11	2.44
50	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	2.37
51	Gastric cancer	Enrichment	KRAS, PIK3CA, PTEN	2.26
52	Colorectal cancer	Enrichment	AKT1, NRAS, PIK3CA, PIK3R1	2.22
53	Lynch syndrome	Enrichment	KRAS, PIK3CA	2.17
54	Macrodactyly	Enrichment	PIK3CA	2.15
55	Proteus syndrome	Enrichment	AKT1	2.15
56	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.15
57	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.15
58	Thrombocytopenia 1	Enrichment	WAS	2.15
59	Focal segmental glomerulosclerosis 1	Enrichment	ACTN4	2.15
60	Noonan syndrome 5	Enrichment	RAF1	2.15
61	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.15
62	Cardiomyopathy, dilated, 1aa, with or without left ventricular noncompaction	Enrichment	ACTN2	2.15
63	Melorheostosis, isolated	Enrichment	MAP2K1	2.15
64	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.15
65	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.15
66	Cowden syndrome 5	Enrichment	PIK3CA	2.15
67	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.15
68	Osteogenesis imperfecta, type xvi	Enrichment	CREB3L1	2.15
69	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.15
70	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.15
71	Vitreoretinopathy, neovascular inflammatory	Enrichment	CAPN5	2.15
72	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.15
73	Immunodeficiency 15b	Enrichment	IKBKB	2.15
74	Noonan syndrome 13	Enrichment	MAPK1	2.15
75	Immunodeficiency 81	Enrichment	LCP2	2.15
76	Immunodeficiency 15a	Enrichment	IKBKB	2.15
77	Immunodeficiency 92	Enrichment	REL	2.15
78	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.15
79	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	2.15
80	Congenital myopathy 8	Enrichment	ACTN2	2.15
81	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.15
82	Pulmonary hypertension, primary, 6	Enrichment	CAPNS1	2.15
83	Immunodeficiency 48	Enrichment	ZAP70	2.15
84	Short syndrome	Enrichment	PIK3R1	2.15
85	Okt4 epitope deficiency	Enrichment	CD4	2.15
86	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.15
87	Immunodeficiency 18	Enrichment	CD3E	2.15
88	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.15
89	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.15
90	Actn3 deficiency	Enrichment	ACTN3	2.15
91	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.15
92	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.15
93	Melorheostosis	Enrichment	MAP2K1	2.15
94	Leopard syndrome 2	Enrichment	RAF1	2.15
95	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.15
96	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.15
97	Long qt syndrome 16	Enrichment	CALM3	2.15
98	Cowden syndrome 6	Enrichment	AKT1	2.15
99	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	2.15
100	Immunodeficiency 12	Enrichment	MALT1	2.15
101	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.15
102	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.15
103	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.15
104	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.15
105	Immunodeficiency 22	Enrichment	LCK	2.15
106	Was-related disorders	Enrichment	WAS	2.15
107	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.15
108	Myopathy, distal, 6, adult-onset, autosomal dominant	Enrichment	ACTN2	2.15
109	Immunodeficiency 79	Enrichment	CD4	2.15
110	Cd45 deficiency	Enrichment	PTPRC	2.15
111	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.15
112	Trigonitis	Enrichment	RAF1	2.15
113	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.15
114	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.15
115	Long qt syndrome 15	Enrichment	CALM2	2.15
116	Hypospadias	Enrichment	PIK3CA	2.15
117	Capillary hemangioma	Enrichment	AKT3	2.15
118	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.15
119	Rare venous malformation	Enrichment	PIK3CA	2.15
120	Progressive muscular atrophy	Enrichment	CAPN3	2.15
121	Diaphragmatic eventration	Enrichment	PIK3CA	2.15
122	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.15
123	Capillary leak syndrome	Enrichment	TLN1	2.15
124	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.15
125	Nocarh syndrome	Enrichment	CDC42	2.15
126	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.15
127	Immunodeficiency 19	Enrichment	CD3D	2.15
128	Rare combined vascular malformation	Enrichment	PIK3CA	2.15
129	Cavernous lymphangioma	Enrichment	PIK3CA	2.15
130	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.15
131	Qualitative or quantitative defects of calpain	Enrichment	CAPN3	2.15
132	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.15
133	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.15
134	Verrucous hemangioma	Enrichment	MAP3K3	2.15
135	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.15
136	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.15
137	Macrodactyly of toe	Enrichment	PIK3CA	2.15
138	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.15
139	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.15
140	Rhabdomyosarcoma	Enrichment	HRAS, PTEN	2.12
141	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, PPP3CA	2.08
142	Metachondromatosis	Enrichment	PTPN11	2.08
143	Oculoectodermal syndrome	Enrichment	KRAS	2.08
144	Vacterl association with hydrocephalus	Enrichment	PTEN	2.08
145	Deafness, autosomal recessive 26	Enrichment	GAB1	2.08
146	Leopard syndrome 1	Enrichment	PTPN11	2.08
147	Melanosis, neurocutaneous	Enrichment	NRAS	2.08
148	Noonan syndrome 6	Enrichment	NRAS	2.08
149	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.08
150	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.08
151	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.08
152	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.08
153	Deafness, dystonia, and cerebral hypomyelination	Enrichment	BCAP31	2.08
154	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.08
155	Papillary tumor of the pineal region	Enrichment	PTEN	2.08
156	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.08
157	Immunodeficiency with hyper-igm, type 3	Enrichment	CD40	2.08
158	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	2.08
159	Immunodeficiency, common variable, 3	Enrichment	CD19	2.08
160	Glioma susceptibility 2	Enrichment	PTEN	2.08
161	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.08
162	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.08
163	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.08
164	Colitis	Enrichment	SYK	2.08
165	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.08
166	Congenital pulmonary airway malformation	Enrichment	KRAS	2.08
167	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.08
168	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.08
169	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.08
170	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.08
171	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.08
172	Mef2c-related disorder	Enrichment	MEF2C	2.08
173	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.08
174	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.08
175	Neurocutaneous melanocytosis	Enrichment	NRAS	2.08
176	Malignant astrocytoma	Enrichment	PTPN11	2.08
177	Ovarian cancer	Enrichment	AKT1, KRAS, PIK3CA, PTEN	2.00
178	Diffuse large b-cell lymphoma	Enrichment	BTK, PTEN	1.97
179	Autism spectrum disorder	Enrichment	MAP2K1, MEF2C, PTEN, PTPN11	1.89
180	Endometrial cancer	Enrichment	PIK3CA, PTEN	1.89
181	Scoliosis, isolated 1	Enrichment	MAPK7	1.86
182	Neutropenia, severe congenital, x-linked	Enrichment	WAS	1.86
183	Stormorken syndrome	Enrichment	ORAI1	1.86
184	Ovarian germ cell cancer	Enrichment	CBL	1.86
185	Wiskott-aldrich syndrome	Enrichment	WAS	1.86
186	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.86
187	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.86
188	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.86
189	Keratosis, seborrheic	Enrichment	PIK3CA	1.86
190	Immunodeficiency 9	Enrichment	ORAI1	1.86
191	Noonan syndrome 8	Enrichment	PIK3CA	1.86
192	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.86
193	Spastic paraplegia 76, autosomal recessive	Enrichment	CAPN1	1.86
194	Long qt syndrome 14	Enrichment	CALM1	1.86
195	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.86
196	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.86
197	Rela fusion-positive ependymoma	Enrichment	RELA	1.86
198	Myopathy, tubular aggregate, 2	Enrichment	ORAI1	1.86
199	Senior-loken syndrome 7	Enrichment	AKT3	1.86
200	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.86
201	Immunodeficiency 104, severe combined	Enrichment	PTPRC	1.86
202	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	1.86
203	Immunodeficiency 17	Enrichment	CD3G	1.86
204	Immune system disease	Enrichment	CDC42	1.86
205	Bardet-biedl syndrome 16	Enrichment	AKT3	1.86
206	Immunodeficiency 52	Enrichment	LAT	1.86
207	Malignant germ cell tumor of ovary	Enrichment	CBL	1.86
208	Common variable immunodeficiency 12	Enrichment	NFKB1	1.86
209	Tafro syndrome	Enrichment	MAP2K2	1.86
210	Costello syndrome	Enrichment	HRAS	1.78
211	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.78
212	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.78
213	Agammaglobulinemia, x-linked	Enrichment	BTK	1.78
214	Werner syndrome	Enrichment	PTPN11	1.78
215	Cebalid syndrome	Enrichment	MTOR	1.78
216	Intravascular large b-cell lymphoma	Enrichment	BCL6	1.78
217	Smith-kingsmore syndrome	Enrichment	MTOR	1.78
218	Common variable immunodeficiency phenotype due to cd19/cd81 deficiency	Enrichment	CD19	1.78
219	Cadds	Enrichment	BCAP31	1.78
220	Vacterl with hydrocephalus	Enrichment	PTEN	1.78
221	Arthritis	Enrichment	SYK	1.78
222	Primary mediastinal large b-cell lymphoma	Enrichment	BCL6	1.78
223	Juvenile polyposis of infancy	Enrichment	PTEN	1.78
224	Wooly hair nevus	Enrichment	HRAS	1.78
225	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	1.71
226	Long qt syndrome	Enrichment	CALM1, CALM2	1.70
227	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.68
228	Mycosis fungoides	Enrichment	CD28	1.68
229	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.68
230	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.68
231	Muscular dystrophy, limb-girdle, autosomal dominant 4	Enrichment	CAPN3	1.68
232	Autosomal recessive limb-girdle muscular dystrophy type 2a	Enrichment	CAPN3	1.68
233	Intrinsic cardiomyopathy	Enrichment	ACTN2	1.68
234	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.68
235	Immunodeficiency 14	Enrichment	PIK3R1	1.68
236	Melanoma of soft tissue	Enrichment	CREB1	1.68
237	Keratoacanthoma	Enrichment	PIK3CA	1.68
238	Saczary syndrome	Enrichment	CD28	1.68
239	Familial hypertrophic cardiomyopathy	Enrichment	ACTN2, RAF1	1.65
240	Prostate cancer	Enrichment	PIK3CA, PTEN	1.62
241	Jacobsen syndrome	Enrichment	ETS1	1.61
242	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.61
243	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	1.61
244	Agammaglobulinemia 1	Enrichment	BTK	1.61
245	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL6	1.61
246	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.61
247	Spermatocytoma	Enrichment	HRAS	1.61
248	Tricuspid valve insufficiency	Enrichment	PTPN11	1.61
249	Left ventricular noncompaction	Enrichment	ACTN2, RAF1	1.60
250	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.56
251	Auriculocondylar syndrome 1	Enrichment	GNAI3	1.56
252	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.56
253	Achromatopsia 4	Enrichment	GNAI3	1.56
254	Congenital generalized lipodystrophy	Enrichment	FOS	1.56
255	Hereditary ataxia	Enrichment	PRKCG	1.56
256	Cerebrovascular disease	Enrichment	PIK3CA	1.56
257	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.56
258	Lung cancer	Enrichment	KRAS, PIK3CA	1.54
259	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.48
260	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.48
261	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.48
262	Pilocytic astrocytoma	Enrichment	KRAS	1.48
263	Epidermolytic nevus	Enrichment	HRAS	1.48
264	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.48
265	Glioma	Enrichment	PTEN	1.48
266	Lymphoma, mucosa-associated lymphoid type	Enrichment	MALT1	1.46
267	Capillary malformations, congenital	Enrichment	PIK3CA	1.46
268	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	CAPN3	1.46
269	Myeloproliferative neoplasm	Enrichment	CBL	1.46
270	Histiocytoid hemangioma	Enrichment	FOS	1.46
271	Aggressive systemic mastocytosis	Enrichment	CBL	1.46
272	Macrocephaly/autism syndrome	Enrichment	PTEN	1.39
273	Follicular lymphoma	Enrichment	BCL6	1.39
274	Lymphoma	Enrichment	PTPN11	1.39
275	Hemangioma	Enrichment	PTEN	1.39
276	Acute megakaryocytic leukemia	Enrichment	PTEN	1.39
277	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.38
278	Muscular dystrophy, limb-girdle, autosomal recessive 1	Enrichment	CAPN3	1.38
279	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.38
280	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.38
281	Systemic lupus erythematosus	Enrichment	ETS1, FCGR2B	1.38
282	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.36
283	Thrombocytopenia	Enrichment	ACTN1, WAS	1.35
284	Megacolon	Enrichment	AKT3	1.32
285	Common variable immunodeficiency	Enrichment	NFKB1	1.32
286	Patent ductus arteriosus	Enrichment	PTPN11	1.31
287	Familial isolated dilated cardiomyopathy	Enrichment	ACTN2, RAF1	1.27
288	Myopathy, tubular aggregate, 1	Enrichment	ORAI1	1.26
289	Congenital muscular dystrophy	Enrichment	CAPN3	1.26
290	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.26
291	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.24
292	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.24
293	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.21
294	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.21
295	Limb-girdle muscular dystrophy	Enrichment	CAPN3	1.21
296	Stroke, ischemic	Enrichment	PRKCH	1.17
297	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.17
298	Polymicrogyria	Enrichment	AKT3	1.17
299	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1	1.17
300	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.17
301	Migraine with or without aura 1	Enrichment	CAPN3	1.13
302	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, PTEN	1.11
303	Myeloma, multiple	Enrichment	KRAS, PIK3R2	1.10
304	Melanoma	Enrichment	PTEN	1.10
305	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	CAPN3	1.09
306	Microcephaly	Enrichment	CAMK2B, MAPK1, PTPN11	1.08
307	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.06
308	Nk-cell enteropathy	Enrichment	PIK3CB	1.06
309	Pectus excavatum	Enrichment	PTPN11	1.06
310	Immune deficiency disease	Enrichment	SYK	1.06
311	Meningioma, familial	Enrichment	PTEN	1.06
312	Uterine corpus cancer	Enrichment	PTEN	1.06
313	Epicanthus	Enrichment	PTPN11	1.02
314	Congenital long qt syndrome	Enrichment	PTPN11	1.02
315	Osteogenesis imperfecta, type iii	Enrichment	CREB3L1	1.00
316	Protein-deficiency anemia	Enrichment	NRAS	0.99
317	Creatine phosphokinase, elevated serum	Enrichment	CAPN3	0.97
318	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	ACTN2	0.97
319	Isolated elevated serum creatine phosphokinase levels	Enrichment	CAPN3	0.97
320	Gliosarcoma	Enrichment	NFKBIA	0.97
321	Dilated cardiomyopathy	Enrichment	ACTN2, RAF1	0.97
322	Lung cancer susceptibility 3	Enrichment	KRAS	0.96
323	Sudden infant death syndrome	Enrichment	CALM2	0.95
324	Giant cell glioblastoma	Enrichment	NFKBIA	0.95
325	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	0.93
326	Rare genetic intellectual disability	Enrichment	MTOR	0.93
327	Heart, malformation of	Enrichment	MAPK1	0.92
328	Autosomal recessive limb-girdle muscular dystrophy	Enrichment	CAPN3	0.90
329	Patent foramen ovale	Enrichment	PTPN11	0.85
330	Hepatocellular carcinoma	Enrichment	PIK3CA	0.84
331	Arteriovenous malformations of the brain	Enrichment	KRAS	0.83
332	Brittle bone disorder	Enrichment	CREB3L1	0.83
333	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.81
334	Muscular dystrophy	Enrichment	CAPN3	0.81
335	Malaria	Enrichment	FCGR2B	0.76
336	Scoliosis	Enrichment	PTPN11	0.74
337	Pancreatic cancer	Enrichment	KRAS	0.72
338	Strabismus	Enrichment	PTPN11	0.69
339	Genetic steroid-resistant nephrotic syndrome	Enrichment	ACTN4	0.67
340	Congenital nervous system abnormality	Enrichment	CAMK2B, PTEN	0.66
341	Nervous system disease	Enrichment	CAMK2B, PTEN	0.66
342	Myopathy	Enrichment	CAPN3	0.61
343	Dystonia	Enrichment	CAMK2B	0.60
344	Type 2 diabetes mellitus	Enrichment	AKT2	0.59
345	Hypertrophic cardiomyopathy	Enrichment	ACTN2	0.58
346	Inherited cancer-predisposing syndrome	Enrichment	PTEN, PTPN11	0.52
347	Hypertelorism	Enrichment	PIK3CA	0.51
348	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.49
349	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.43
350	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.41
351	Autosomal recessive non-syndromic intellectual disability	Enrichment	EZR	0.41
352	Autism	Enrichment	CAMK2G	0.34
353	Complex neurodevelopmental disorder	Enrichment	RAC3	0.23

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

B Cell Receptor Signaling Pathway

Pathway Network for B Cell Receptor Signaling Pathway

Member Pathways for B Cell Receptor Signaling Pathway

Pathways in the B Cell Receptor Signaling Pathway SuperPath

Associated Genes for B Cell Receptor Signaling Pathway

Associated Disorders for B Cell Receptor Signaling Pathway

Disorders associated with B Cell Receptor Signaling Pathway SuperPath

STRING Interaction Network for B Cell Receptor Signaling Pathway

Sources for B Cell Receptor Signaling Pathway