Bacterial infections in CF airways

Pathway network for the Bacterial infections in CF airways SuperPath

Sources:

GeneGo (Thomson Reuters)
PubChem
WikiPathways
QIAGEN

Pathways in the Bacterial infections in CF airways SuperPath

#	Name	Source	Genes
1	Bacterial infections in CF airways	GeneGo (Thomson Reuters)	CCL20 CD14 CFTR CHUK CTSB CTSL CTSS CXCL8 DEFB4A FAS FASLG IFNG IKBKB IKBKG IL1B IL1R1 IL1RAP IL6 IRAK1 IRAK2 IRAK4 IRF1 LBP LY96 MAP3K14 MAP3K7 MUC1 MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NOS2 PIAS1 REL RELA RELB SFTPA1 SFTPD STAT1 TAB1 TAB2 TIRAP TLR1 TLR2 TLR4 TLR5 TNF TRAF6 (see all 50) (see less)
2	Immune response TLR signaling pathways	GeneGo (Thomson Reuters)	BECN1 CCL11 CCL20 CD14 CHUK CXCL10 CXCL11 CXCL8 FN1 IFNB1 IKBKB IL11 IL4 IL6 IRAK1 IRAK2 IRAK3 IRAK4 JUN LBP LY96 MAP2K3 MAP3K14 MAP3K7 MAPK11 MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE REL RELA RELB SFTPA1 TAB1 TAB2 TIRAP TLR1 TLR2 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TOLLIP TRAF6 (see all 48) (see less)
3	Immune response Bacterial infections in normal airways	GeneGo (Thomson Reuters)	CD14 CFTR CHUK CXCL8 DEFB4A FAS FASLG IFNG IFNGR1 IFNGR2 IKBKB IKBKG IL1B IL1R1 IL1RAP IL6 IRAK1 IRAK2 IRAK4 IRF1 JAK1 JAK2 LBP LY96 MAP3K14 MAP3K7 MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NOS2 PIAS1 REL RELA RELB STAT1 TAB1 TAB2 TIRAP TLR1 TLR2 TLR4 TLR5 TRAF6 (see all 46) (see less)
4	IL1-mediated signaling events	PubChem	CASP1 CHUK ERC1 IKBKB IKBKG IL1A IL1B IL1R1 IL1R2 IL1RAP IL1RN IRAK1 IRAK3 IRAK4 JUN MAP2K6 MAP3K3 MAP3K7 MAPK8 MYD88 NFKB1 PIK3CA PIK3R1 RELA SQSTM1 TAB1 TAB2 TICAM2 TMED7-TICAM2 TOLLIP TRAF6 UBE2N UBE2V1 (see all 33) (see less)
5	Signal transduction through IL1R	WikiPathways	CHUK ECSIT IFNB1 IKBKB IL1B IL1RAP IL1RN IRAK1 JUN MAP2K3 MAP2K6 MAP3K1 MAP3K14 MAP3K7 MAPK14 MAPK8 MYD88 NFKB1 RELA TAB1 TRAF6 (see all 21) (see less)
6	NTHi-Induced Signaling	QIAGEN	CHUK DUSP1 IKBKB IKBKG MAP2K3 MAP2K6 MAP3K14 MAP3K7 MAPK11 MAPK14 MUC2 MYD88 NFKB1 NFKBIA NR3C1 RELA SMAD3 SMAD4 TGFBR1 TGFBR2 TLR2 (see all 21) (see less)
7	IL-1 beta-dependent CFTR expression	GeneGo (Thomson Reuters)	CFTR CHUK IKBKB IL1B IL1R1 IL1RAP IRAK1 IRAK2 IRAK4 MAP3K14 MAP3K7 MYD88 NFKB1 NFKBIA NFKBIB NFKBIE RELA TAB1 TAB2 TOLLIP TRAF6 (see all 21) (see less)
8	Altered glycosylation of MUC1 in tumor microenvironment	WikiPathways	CHUK IKBKB IKBKG IL6 MUC1 NFKB1 NFKBIA RELA TNF (see all 9) (see less)

Gene overlap in member pathways for Bacterial infections in CF airways SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	8
2	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	8
3	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	8
4	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	8
5	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	7
6	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	7
7	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	6
8	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	6
9	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	6
10	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	6
11	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	6
12	IL1B	Interleukin 1 Beta	Protein Coding	5
13	IL1RAP	Interleukin 1 Receptor Accessory Protein	Protein Coding	5
14	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	5
15	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	5
16	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	5
17	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	4
18	IL6	Interleukin 6	Protein Coding	4
19	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	4
20	NFKBIB	NFKB Inhibitor Beta	Protein Coding	4
21	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	4
22	TLR2	Toll Like Receptor 2	Protein Coding	4
23	CD14	CD14 Molecule	Protein Coding	3
24	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	3
25	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	3
26	LBP	Lipopolysaccharide Binding Protein	Protein Coding	3
27	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	3
28	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	3
29	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	3
30	TLR1	Toll Like Receptor 1	Protein Coding	3
31	TLR4	Toll Like Receptor 4	Protein Coding	3
32	TLR5	Toll Like Receptor 5	Protein Coding	3
33	LY96	Lymphocyte Antigen 96	Protein Coding	3
34	TIRAP	TIR Domain Containing Adaptor Protein	Protein Coding	3
35	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
36	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	3
37	TOLLIP	Toll Interacting Protein	Protein Coding	3
38	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	3
39	FAS	Fas Cell Surface Death Receptor	Protein Coding	2
40	FASLG	Fas Ligand	Protein Coding	2
41	DEFB4A	Defensin Beta 4A	Protein Coding	2
42	IFNG	Interferon Gamma	Protein Coding	2
43	IRF1	Interferon Regulatory Factor 1	Protein Coding	2
44	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	2
45	NOS2	Nitric Oxide Synthase 2	Protein Coding	2
46	CCL20	C-C Motif Chemokine Ligand 20	Protein Coding	2
47	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	2
48	TNF	Tumor Necrosis Factor	Protein Coding	2
49	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	2
50	SFTPA1	Surfactant Protein A1	Protein Coding	2
51	IFNB1	Interferon Beta 1	Protein Coding	2
52	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
53	IRAK3	Interleukin 1 Receptor Associated Kinase 3	Protein Coding	2
54	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	2
55	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
56	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
57	CTSB	Cathepsin B	Protein Coding	1
58	CTSL	Cathepsin L	Protein Coding	1
59	CTSS	Cathepsin S	Protein Coding	1
60	SFTPD	Surfactant Protein D	Protein Coding	1
61	FN1	Fibronectin 1	Protein Coding	1
62	IL4	Interleukin 4	Protein Coding	1
63	IL11	Interleukin 11	Protein Coding	1
64	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	1
65	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	1
66	CXCL11	C-X-C Motif Chemokine Ligand 11	Protein Coding	1
67	BECN1	Beclin 1	Protein Coding	1
68	TLR6	Toll Like Receptor 6	Protein Coding	1
69	TLR7	Toll Like Receptor 7	Protein Coding	1
70	TLR8	Toll Like Receptor 8	Protein Coding	1
71	TLR9	Toll Like Receptor 9	Protein Coding	1
72	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	1
73	IFNGR2	Interferon Gamma Receptor 2	Protein Coding	1
74	JAK1	Janus Kinase 1	Protein Coding	1
75	JAK2	Janus Kinase 2	Protein Coding	1
76	ERC1	ELKS/RAB6-Interacting/CAST Family Member 1	Protein Coding	1
77	IL1R2	Interleukin 1 Receptor Type 2	Protein Coding	1
78	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
79	TICAM2	TIR Domain Containing Adaptor Molecule 2	Protein Coding	1
80	TMED7-TICAM2	TMED7-TICAM2 Readthrough	Protein Coding	1
81	CASP1	Caspase 1	Protein Coding	1
82	IL1A	Interleukin 1 Alpha	Protein Coding	1
83	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	1
84	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	1
85	SQSTM1	Sequestosome 1	Protein Coding	1
86	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
87	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
88	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
89	ECSIT	ECSIT Signaling Integrator	Protein Coding	1
90	DUSP1	Dual Specificity Phosphatase 1	Protein Coding	1
91	SMAD3	SMAD Family Member 3	Protein Coding	1
92	SMAD4	SMAD Family Member 4	Protein Coding	1
93	MUC2	Mucin 2, Oligomeric Mucus/Gel-Forming	Protein Coding	1
94	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	1
95	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
96	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1

Disorders associated with Bacterial infections in CF airways SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome	Enrichment	SMAD3, TGFBR1, TGFBR2	6.57
2	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	6.41
3	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD3, SMAD4, TGFBR1, TGFBR2	6.26
4	Malaria	Enrichment	IKBKG, NOS2, TIRAP, TNF	5.86
5	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	5.64
6	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	IRAK4, MYD88	5.64
7	Immunodeficiency 33	Enrichment	IKBKG, IRAK4	5.24
8	Loeys-dietz syndrome 1	Enrichment	TGFBR1, TGFBR2	5.16
9	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	4.86
10	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.76
11	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2	4.47
12	Behcet syndrome	Enrichment	FAS, IFNGR1, TLR4	4.47
13	Multisystem inflammatory syndrome in children	Enrichment	IFNB1, IRAK3, TLR6	4.21
14	Autoimmune lymphoproliferative syndrome	Enrichment	FAS, FASLG	4.17
15	Marfan syndrome	Enrichment	TGFBR1, TGFBR2	3.99
16	Gastric cancer	Enrichment	IL1B, IL1RN, PIK3CA	3.82
17	Lung cancer	Enrichment	FAS, FASLG, IRF1	3.77
18	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.63
19	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFBR2	3.42
20	Incontinentia pigmenti	Enrichment	IKBKG	3.18
21	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	3.18
22	Tubulointerstitial kidney disease, autosomal dominant 2	Enrichment	MUC1	3.18
23	Fetal encasement syndrome	Enrichment	CHUK	3.18
24	Immunodeficiency 15b	Enrichment	IKBKB	3.18
25	Immunodeficiency 15a	Enrichment	IKBKB	3.18
26	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	3.18
27	Bartsocas-papas syndrome 2	Enrichment	CHUK	3.18
28	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	3.18
29	Connective tissue disease	Enrichment	SMAD3, TGFBR2	2.96
30	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.88
31	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.88
32	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.88
33	Immunodeficiency 127	Enrichment	TNF	2.88
34	Rela fusion-positive ependymoma	Enrichment	RELA	2.88
35	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.88
36	Common variable immunodeficiency 12	Enrichment	NFKB1	2.88
37	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.81
38	Immunodeficiency 68	Enrichment	MYD88	2.81
39	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.81
40	46,xy sex reversal 6	Enrichment	MAP3K1	2.81
41	Chronic recurrent multifocal osteomyelitis 2, with periostitis and pustulosis	Enrichment	IL1RN	2.81
42	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.81
43	Microvascular complications of diabetes 4	Enrichment	IL1RN	2.81
44	Immunodeficiency 112	Enrichment	MAP3K14	2.81
45	Waldenstram macroglobulinemia	Enrichment	MYD88	2.81
46	Nik deficiency	Enrichment	MAP3K14	2.81
47	Leprosy 3	Enrichment	TLR2	2.81
48	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.81
49	Glucocorticoid resistance, generalized	Enrichment	NR3C1	2.81
50	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.81
51	Heritable thoracic aortic disease	Enrichment	SMAD4	2.81
52	Chronic recurrent multifocal osteomyelitis 3	Enrichment	IL1R1	2.81
53	Immunodeficiency 67	Enrichment	IRAK4	2.81
54	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	2.81
55	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.81
56	Psoriatic arthritis	Enrichment	TNF	2.70
57	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.70
58	Migraine without aura	Enrichment	TNF	2.70
59	Macrodactyly	Enrichment	PIK3CA	2.61
60	Paget disease of bone 3	Enrichment	SQSTM1	2.61
61	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.61
62	Cowden syndrome 5	Enrichment	PIK3CA	2.61
63	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.61
64	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	2.61
65	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	2.61
66	Short syndrome	Enrichment	PIK3R1	2.61
67	Asthma-related traits 5	Enrichment	IRAK3	2.61
68	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.61
69	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.61
70	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.61
71	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.61
72	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.61
73	Hypospadias	Enrichment	PIK3CA	2.61
74	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.61
75	Rare venous malformation	Enrichment	PIK3CA	2.61
76	Diaphragmatic eventration	Enrichment	PIK3CA	2.61
77	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.61
78	Rare combined vascular malformation	Enrichment	PIK3CA	2.61
79	Cavernous lymphangioma	Enrichment	PIK3CA	2.61
80	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.61
81	Distal monosomy 12p	Enrichment	ERC1	2.61
82	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.61
83	Verrucous hemangioma	Enrichment	MAP3K3	2.61
84	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.61
85	Macrodactyly of toe	Enrichment	PIK3CA	2.61
86	Kaposi sarcoma	Enrichment	IL6	2.58
87	Cerebral malaria	Enrichment	TNF	2.58
88	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	2.58
89	Myhre syndrome	Enrichment	SMAD4	2.51
90	Galactosemia ii	Enrichment	NR3C1	2.51
91	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.51
92	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.51
93	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.51
94	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	2.51
95	Congenital dyserythropoietic anemia	Enrichment	IRAK4	2.51
96	Congenital heart defects, multiple types, 2	Enrichment	TAB2	2.51
97	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	2.51
98	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.48
99	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	2.48
100	Vascular dementia	Enrichment	TNF	2.48
101	Helicobacter pylori infection	Enrichment	IFNGR1	2.47
102	Legionnaire disease	Enrichment	TLR5	2.47
103	Bacteremia 1	Enrichment	TIRAP	2.47
104	Leprosy 5	Enrichment	TLR1	2.47
105	Immunodeficiency 27a	Enrichment	IFNGR1	2.47
106	Immunodeficiency 69	Enrichment	IFNG	2.47
107	Immunodeficiency 92	Enrichment	REL	2.47
108	Systemic lupus erythematosus 1	Enrichment	TLR5	2.47
109	Immunodeficiency 27b	Enrichment	IFNGR1	2.47
110	Immunodeficiency 31a	Enrichment	STAT1	2.47
111	Melioidosis	Enrichment	TLR5	2.47
112	Macular degeneration, age-related, 10	Enrichment	TLR4	2.47
113	Immunodeficiency 31b	Enrichment	STAT1	2.47
114	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.47
115	Immunodeficiency 53	Enrichment	RELB	2.47
116	Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial ifngammar2 deficiency	Enrichment	IFNGR2	2.47
117	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.47
118	Interstitial lung disease 1	Enrichment	SFTPA1	2.45
119	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	2.45
120	X-linked immunodeficiency 74	Enrichment	TLR7	2.45
121	Systemic lupus erythematosus 17	Enrichment	TLR7	2.45
122	Keratolytic winter erythema	Enrichment	CTSB	2.43
123	Type 1 diabetes mellitus	Enrichment	IL6	2.40
124	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.33
125	Juvenile polyposis syndrome	Enrichment	SMAD4	2.33
126	Pelvic organ prolapse	Enrichment	TAB2	2.33
127	Nuchal bleb, familial	Enrichment	CFTR	2.33
128	Welander distal myopathy	Enrichment	SQSTM1	2.31
129	Keratosis, seborrheic	Enrichment	PIK3CA	2.31
130	Noonan syndrome 8	Enrichment	PIK3CA	2.31
131	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	2.31
132	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.31
133	Macrocephaly, dysmorphic facies, and psychomotor retardation	Enrichment	ERC1	2.31
134	Paget's disease of bone	Enrichment	SQSTM1	2.31
135	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	2.31
136	Inflammatory bowel disease 1	Enrichment	IL6	2.22
137	Coronary heart disease 5	Enrichment	IKBKG	2.22
138	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	2.21
139	Idiopathic bronchiectasis	Enrichment	CFTR	2.21
140	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	2.18
141	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.17
142	Thrombocythemia 3	Enrichment	JAK2	2.17
143	Immunodeficiency 31c	Enrichment	STAT1	2.17
144	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.17
145	Polycythemia	Enrichment	JAK2	2.17
146	Hypereosinophilic syndrome	Enrichment	JAK2	2.17
147	Immunodeficiency 117	Enrichment	IRF1	2.17
148	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.15
149	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.15
150	Leprosy 1	Enrichment	TLR6	2.15
151	Asthma	Enrichment	TNF	2.14
152	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.14
153	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.14
154	Immunodeficiency 14	Enrichment	PIK3R1	2.14
155	Keratoacanthoma	Enrichment	PIK3CA	2.14
156	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.11
157	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	2.11
158	Colorectal cancer	Enrichment	SMAD4, TLR2	2.10
159	Systemic lupus erythematosus	Enrichment	IRAK1, TLR7	2.08
160	Alzheimer's disease	Enrichment	TNF	2.07
161	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	2.03
162	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	2.01
163	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.01
164	Cerebrovascular disease	Enrichment	PIK3CA	2.01
165	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.01
166	Paget's disease of bone 2	Enrichment	SQSTM1	2.01
167	Polycythemia vera	Enrichment	JAK2	1.99
168	Tuberous sclerosis 1	Enrichment	IFNG	1.99
169	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	1.99
170	Hepatitis c virus	Enrichment	IFNG	1.99
171	Tuberous sclerosis 2	Enrichment	IFNG	1.99
172	Immunodeficiency 28	Enrichment	IFNGR2	1.99
173	Vogt-koyanagi-harada disease	Enrichment	FAS	1.99
174	Gliosarcoma	Enrichment	NFKBIA	1.98
175	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	1.98
176	Esophageal cancer	Enrichment	TGFBR2	1.97
177	Gallbladder cancer	Enrichment	SMAD4	1.97
178	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.97
179	Giant cell glioblastoma	Enrichment	NFKBIA	1.95
180	Capillary malformations, congenital	Enrichment	PIK3CA	1.92
181	Hemimegalencephaly	Enrichment	PIK3CA	1.92
182	Arteriovenous malformations of the brain	Enrichment	IL6	1.90
183	Erythrocytosis, familial, 1	Enrichment	JAK2	1.87
184	Budd-chiari syndrome	Enrichment	JAK2	1.87
185	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.87
186	Hepatitis b	Enrichment	IFNGR1	1.87
187	Primary hyperaldosteronism	Enrichment	NR3C1	1.86
188	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.86
189	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	1.86
190	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	1.86
191	Anemia, autoimmune hemolytic	Enrichment	TLR8	1.85
192	Breast cancer	Enrichment	JUN, PIK3CA	1.85
193	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.84
194	Cowden syndrome 1	Enrichment	PIK3CA	1.84
195	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.84
196	Breast adenocarcinoma	Enrichment	PIK3CA	1.84
197	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.84
198	Myeloproliferative neoplasm	Enrichment	JAK2	1.77
199	Idiopathic aplastic anemia	Enrichment	IFNG	1.77
200	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.77
201	Pectus excavatum	Enrichment	TGFBR1	1.77
202	Migraine with or without aura 1	Enrichment	TAB2	1.77
203	Nevus, epidermal	Enrichment	PIK3CA	1.77
204	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.77
205	Overgrowth syndrome	Enrichment	PIK3R1	1.77
206	Aortic valve disease 1	Enrichment	TAB2	1.70
207	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.70
208	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.67
209	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.67
210	Hereditary chronic pancreatitis	Enrichment	CFTR	1.67
211	Arteriovenous malformation	Enrichment	PIK3CA	1.66
212	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.66
213	Cowden syndrome	Enrichment	PIK3CA	1.66
214	Behavioral variant of frontotemporal dementia	Enrichment	SQSTM1	1.66
215	Severe combined immunodeficiency	Enrichment	IKBKB	1.66
216	Lynch syndrome	Enrichment	TGFBR2	1.64
217	Myelofibrosis	Enrichment	JAK2	1.63
218	Essential thrombocythemia	Enrichment	JAK2	1.63
219	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1	1.62
220	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.62
221	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.62
222	Pancreatitis, hereditary	Enrichment	CFTR	1.58
223	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.58
224	Patent foramen ovale	Enrichment	TAB2	1.56
225	Type 2 diabetes mellitus	Enrichment	IL6	1.56
226	Meningioma	Enrichment	PIK3CA	1.54
227	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.54
228	Diffuse large b-cell lymphoma	Enrichment	MYD88	1.54
229	Rheumatoid arthritis	Enrichment	TLR1	1.52
230	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.52
231	Aplastic anemia	Enrichment	IFNG	1.48
232	Autoinflammatory disease	Enrichment	IL1RN	1.44
233	Pancreatic cancer	Enrichment	SMAD4	1.42
234	Cystic fibrosis	Enrichment	CFTR	1.31
235	Endometrial cancer	Enrichment	PIK3CA	1.30
236	Male infertility	Enrichment	CFTR	1.29
237	Hepatocellular carcinoma	Enrichment	PIK3CA	1.28
238	Interstitial lung disease 2	Enrichment	SFTPA1	1.23
239	Human immunodeficiency virus type 1	Enrichment	IFNG	1.23
240	Bladder cancer	Enrichment	PIK3CA	1.17
241	Prostate cancer	Enrichment	PIK3CA	1.17
242	Differentiated thyroid carcinoma	Enrichment	ERC1	1.17
243	Thrombocytopenia	Enrichment	SMAD4	1.14
244	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	CFTR	1.08
245	Hereditary breast carcinoma	Enrichment	PIK3CA	0.99
246	Nephronophthisis	Enrichment	PIAS1	0.97
247	Dilated cardiomyopathy	Enrichment	TAB2	0.93
248	Hypertelorism	Enrichment	PIK3CA	0.92
249	Leukemia, acute myeloid	Enrichment	JAK2	0.90
250	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SQSTM1	0.88
251	Nephrotic syndrome	Enrichment	FN1	0.85
252	Ovarian cancer	Enrichment	MAP3K1	0.84
253	Primary ovarian insufficiency	Enrichment	JAK2	0.74
254	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.73

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Bacterial infections in CF airways

Pathway Network for Bacterial infections in CF airways

Pathway network for the Bacterial infections in CF airways SuperPath

Member Pathways for Bacterial infections in CF airways

Pathways in the Bacterial infections in CF airways SuperPath

Gene overlap in member pathways for Bacterial infections in CF airways SuperPath

Associated Genes for Bacterial infections in CF airways

Associated Disorders for Bacterial infections in CF airways

Disorders associated with Bacterial infections in CF airways SuperPath

STRING Interaction Network for Bacterial infections in CF airways

Sources for Bacterial infections in CF airways