BDNF-TrkB signaling

No Pathway Network information available for BDNF-TrkB signaling

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with BDNF-TrkB signaling SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1RasopathyEnrichmentBRAF, HRAS, KRAS, MAP2K1, NRAS, SOS110.69
2Noonan syndrome 1EnrichmentBRAF, HRAS, KRAS, MAP2K1, NRAS, SOS110.56
3Noonan syndrome and noonan-related syndromeEnrichmentBRAF, HRAS, KRAS, MAP2K1, NRAS, SOS110.54
4Focal cortical dysplasia, type iiEnrichmentMTOR, RHEB, TSC1, TSC210.33
5Isolated focal cortical dysplasia type iiEnrichmentMTOR, RHEB, TSC1, TSC210.33
6Lung non-small cell carcinomaEnrichmentBRAF, HRAS, KRAS, MAP2K1, NRAS10.29
7HemimegalencephalyEnrichmentAKT3, MTOR, PTEN, RHEB10.07
8Langerhans cell histiocytosisEnrichmentBRAF, MAP2K1, NRAS7.88
9Schimmelpenning-feuerstein-mims syndromeEnrichmentHRAS, KRAS, NRAS7.28
10Cardiofaciocutaneous syndrome 1EnrichmentBRAF, KRAS, MAP2K17.28
11Cardiofaciocutaneous syndromeEnrichmentBRAF, KRAS, MAP2K17.28
12Bladder cancerEnrichmentKRAS, NF1, PTEN, TSC16.54
13Nevus, epidermalEnrichmentHRAS, KRAS, NRAS6.34
14Thyroid cancer, nonmedullary, 2EnrichmentBRAF, HRAS, NRAS6.34
15Noonan syndrome 3EnrichmentHRAS, KRAS, SOS16.34
16Pilomyxoid astrocytomaEnrichmentBRAF, KRAS, NTRK26.34
17Follicular thyroid carcinomaEnrichmentBRAF, HRAS, NRAS6.34
18Differentiated thyroid carcinomaEnrichmentBRAF, HRAS, KRAS, NRAS6.18
19Melanocytic nevus syndrome, congenitalEnrichmentBRAF, HRAS, NRAS6.14
20Juvenile myelomonocytic leukemiaEnrichmentKRAS, NF1, NRAS5.82
21LymphangioleiomyomatosisEnrichmentTSC1, TSC25.42
22Ras-associated autoimmune leukoproliferative disorderEnrichmentKRAS, NRAS5.42
23Pulmonic stenosisEnrichmentBRAF, SOS15.24
24Tuberous sclerosis 1EnrichmentTSC1, TSC24.94
25HamartomaEnrichmentTSC1, TSC24.94
26Large congenital melanocytic nevusEnrichmentHRAS, NRAS4.76
27Chronic myelogenous leukemia, bcr-abl1 positiveEnrichmentKRAS, NRAS4.64
28Tuberous sclerosisEnrichmentTSC1, TSC24.64
29Pilocytic astrocytomaEnrichmentKRAS, NF14.64
30Ovarian cancerEnrichmentAKT1, KRAS, PTEN, TSC24.35
31Breast adenocarcinomaEnrichmentAKT1, KRAS4.24
32Leukemia, chronic myeloidEnrichmentKRAS, NRAS4.10
33Gastric cancerEnrichmentKRAS, NF1, PTEN4.08
34Hereditary breast carcinomaEnrichmentAKT1, KRAS, PTEN4.05
35Capillary malformation-arteriovenous malformation 1EnrichmentKRAS, MAP2K13.92
36Gallbladder cancerEnrichmentBRAF, KRAS3.92
37Inherited cancer-predisposing syndromeEnrichmentNF1, PTEN, TSC1, TSC23.90
38Adult hepatocellular carcinomaEnrichmentTSC1, TSC23.87
39Cowden syndromeEnrichmentAKT1, PTEN3.87
40West syndromeEnrichmentGRIN1, NTRK2, TSC23.79
41Hereditary breast ovarian cancer syndromeEnrichmentKRAS, NF1, PTEN3.76
42Arteriovenous malformationEnrichmentHRAS, MAP2K13.69
43MeningiomaEnrichmentAKT1, PTEN3.60
44Myopathy, x-linked, with excessive autophagyEnrichmentHRAS, MAP2K13.59
45Lip and oral cavity carcinomaEnrichmentBRAF, HRAS3.43
46Breast cancerEnrichmentAKT1, KRAS, PTEN3.36
47RhabdomyosarcomaEnrichmentNF1, PTEN3.35
48Lung cancer susceptibility 3EnrichmentBRAF, KRAS3.29
49Arteriovenous malformations of the brainEnrichmentBRAF, KRAS3.02
50Congenital nervous system abnormalityEnrichmentCAMK2B, PTEN, TSC22.93
51Nervous system diseaseEnrichmentCAMK2B, PTEN, TSC22.93
52Colorectal cancerEnrichmentAKT1, BRAF, NRAS2.92
53Autism spectrum disorderEnrichmentNF1, PTEN, TSC22.89
54Proteus syndromeEnrichmentAKT12.70
55Oculoectodermal syndromeEnrichmentKRAS2.70
56Vacterl association with hydrocephalusEnrichmentPTEN2.70
57Melanosis, neurocutaneousEnrichmentNRAS2.70
58Noonan syndrome 6EnrichmentNRAS2.70
59Noonan syndrome 13EnrichmentMAPK12.70
60Developmental and epileptic encephalopathy 58EnrichmentNTRK22.70
61Intellectual developmental disorder, autosomal dominant 54EnrichmentCAMK2B2.70
62Papillary tumor of the pineal regionEnrichmentPTEN2.70
63Cardiofaciocutaneous syndrome 2EnrichmentKRAS2.70
64Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2EnrichmentAKT32.70
65Brugada syndrome 3EnrichmentCACNA1C2.70
66Cowden syndrome 6EnrichmentAKT12.70
67Obesity, hyperphagia, and developmental delayEnrichmentNTRK22.70
68Glioma susceptibility 2EnrichmentPTEN2.70
69Plexiform neurofibromaEnrichmentNF12.70
70NeurofibromaEnrichmentNF12.70
71Capillary hemangiomaEnrichmentAKT32.70
72NeurofibromatosisEnrichmentNF12.70
73Chromosome 17q11.2 deletion syndromeEnrichmentNF12.70
74Congenital pulmonary airway malformationEnrichmentKRAS2.70
75Optic nerve gliomaEnrichmentNF12.70
76Atypical timothy syndromeEnrichmentCACNA1C2.70
7715q11q13 microduplication syndromeEnrichmentUBE3A2.70
78Timothy syndrome type 2EnrichmentCACNA1C2.70
79Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndromeEnrichmentPTEN2.70
80Timothy syndrome type 1EnrichmentCACNA1C2.70
81Neurocutaneous melanocytosisEnrichmentNRAS2.70
82Cacna1c-related disordersEnrichmentCACNA1C2.70
83Deafness, autosomal recessive 26EnrichmentGAB12.61
84Noonan syndrome 4EnrichmentSOS12.61
85Melorheostosis, isolatedEnrichmentMAP2K12.61
86Noonan syndrome 7EnrichmentBRAF2.61
87Leopard syndrome 3EnrichmentBRAF2.61
88Focal segmental glomerulosclerosis 2EnrichmentTRPC62.61
89Cardiofaciocutaneous syndrome 3EnrichmentMAP2K12.61
90Deafness, autosomal recessive 44EnrichmentADCY12.61
91Spinocerebellar ataxia 41EnrichmentTRPC32.61
92Immune dysregulation, autoimmunity, and autoinflammationEnrichmentPLCG12.61
93LymphangiomaEnrichmentBRAF2.61
94Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessiveEnrichmentGRIN12.61
95Phace associationEnrichmentBRAF2.61
96MelorheostosisEnrichmentMAP2K12.61
97Immunodeficiency 97 with autoinflammationEnrichmentPIK3CG2.61
98Developmental and epileptic encephalopathy 101EnrichmentGRIN12.61
99Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominantEnrichmentGRIN12.61
100Syringocystadenoma papilliferumEnrichmentBRAF2.61
101GangliogliomaEnrichmentBRAF2.61
102Intellectual disability, autosomal dominant 8EnrichmentGRIN12.61
103Nongerminomatous germ cell tumorEnrichmentBRAF2.61
104Phace syndromeEnrichmentBRAF2.61
105Phakomatosis pigmentokeratoticaEnrichmentHRAS2.61
106Classic hairy cell leukemiaEnrichmentBRAF2.61
107Non-immune hydrops fetalisEnrichmentHRAS, KRAS2.59
108Lung cancerEnrichmentBRAF, KRAS2.57
109Leukemia, acute myeloidEnrichmentKRAS, NRAS2.55
110Cafe-au-lait spots, multipleEnrichmentNF12.40
111Timothy syndromeEnrichmentCACNA1C2.40
112Encephalocraniocutaneous lipomatosisEnrichmentKRAS2.40
113Long qt syndrome 8EnrichmentCACNA1C2.40
114Cebalid syndromeEnrichmentMTOR2.40
115Chromosome 17q11.2 duplication syndrome, 1.4-mbEnrichmentNF12.40
116Senior-loken syndrome 7EnrichmentAKT32.40
117Bardet-biedl syndrome 9EnrichmentNF12.40
118Bardet-biedl syndrome 16EnrichmentAKT32.40
119Smith-kingsmore syndromeEnrichmentMTOR2.40
120Vacterl with hydrocephalusEnrichmentPTEN2.40
121Angelman syndrome due to maternal 15q11q13 deletionEnrichmentUBE3A2.40
122Juvenile polyposis of infancyEnrichmentPTEN2.40
123Pleomorphic rhabdomyosarcomaEnrichmentNF12.40
124Fibromatosis, gingival, 1EnrichmentSOS12.31
125Costello syndromeEnrichmentHRAS2.31
126Histiocytoma, angiomatoid fibrousEnrichmentCREB12.31
127Bilateral generalized polymicrogyriaEnrichmentGRIN12.31
128Vulto-van silfhout-de vries syndromeEnrichmentDLG42.31
129Wooly hair nevusEnrichmentHRAS2.31
130Myeloma, multipleEnrichmentKRAS, NF12.26
131Watson syndromeEnrichmentNF12.22
132Polycystic kidney disease, infantile severe, with tuberous sclerosisEnrichmentTSC22.22
133Neurofibromatosis, familial spinalEnrichmentNF12.22
134Tuberous sclerosis 2EnrichmentTSC22.22
135Chromosome 17q11.2 deletion syndrome, 1.4-mbEnrichmentNF12.22
136Auditory neuropathy and optic atrophyEnrichmentGRIN2C2.22
137Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizuresEnrichmentCACNA1C2.22
138Xanthinuria, type iiEnrichmentTSC22.22
139Brain cancerEnrichmentNF12.22
140Laryngeal squamous cell carcinomaEnrichmentPTEN2.22
141Angelman syndrome due to imprinting defect in 15q11-q13EnrichmentUBE3A2.22
142Ataxia-telangiectasiaEnrichmentBRAF2.14
143Heart defects, congenital, and other congenital anomaliesEnrichmentDLG42.14
144Nuchal bleb, familialEnrichmentSOS12.14
145Tethered spinal cord syndromeEnrichmentBRAF2.14
146Intellectual developmental disorder, autosomal dominant 62EnrichmentDLG42.14
147Neurodevelopmental disorder with hypotonia and impaired expressive language and with or without seizuresEnrichmentDLG42.14
148Dlg4-related synaptopathyEnrichmentDLG42.14
149SpermatocytomaEnrichmentHRAS2.14
150Melanoma of soft tissueEnrichmentCREB12.14
151Diffuse gastric and lobular breast cancer syndromeEnrichmentKRAS2.10
152Neurofibromatosis-noonan syndromeEnrichmentNF12.10
153Megalencephaly-capillary malformation-polymicrogyria syndromeEnrichmentAKT32.10
154Ventricular fibrillation, paroxysmal familial, 1EnrichmentCACNA1C2.10
155Chromosome 22q11.2 deletion syndrome, distalEnrichmentMAPK12.10
156Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1EnrichmentAKT32.10
157Lung sarcomatoid carcinomaEnrichmentKRAS2.10
158Embryonal rhabdomyosarcomaEnrichmentNF12.10
159GliomaEnrichmentPTEN2.10
160Middle aortic syndromeEnrichmentNF12.10
161Acyl-coa dehydrogenase, very long-chain, deficiency ofEnrichmentDLG42.01
162Thyroid cancer, nonmedullary, 1EnrichmentBRAF2.01
163CraniopharyngiomaEnrichmentBRAF2.01
164Noonan syndrome with multiple lentiginesEnrichmentBRAF2.01
165Newborn respiratory distress syndromeEnrichmentBRAF2.01
166Epidermolytic nevusEnrichmentHRAS2.01
167Gingival fibromatosisEnrichmentSOS12.01
168Rhabdomyosarcoma 2EnrichmentNF12.00
169Macrocephaly/autism syndromeEnrichmentPTEN2.00
170Heart conduction diseaseEnrichmentCACNA1C2.00
171HemangiomaEnrichmentPTEN2.00
172Acute megakaryocytic leukemiaEnrichmentPTEN2.00
173Angelman syndromeEnrichmentUBE3A1.92
174Cowden syndrome 1EnrichmentPTEN1.92
175Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndromeEnrichmentBDNF1.92
176KeratoconusEnrichmentTSC11.92
177Lung squamous cell carcinomaEnrichmentKRAS1.92
178Polycystic kidney disease 1 with or without polycystic liver diseaseEnrichmentTSC21.86
179Squamous cell carcinoma, head and neckEnrichmentPTEN1.86
180Renal cell carcinoma, papillary, 1EnrichmentMTOR1.86
181Polycystic kidney disease 1EnrichmentTSC21.86
182MegacolonEnrichmentAKT31.86
183Overgrowth syndromeEnrichmentMTOR1.86
184Wilms tumor 5EnrichmentBRAF1.84
185Ewing sarcomaEnrichmentNF11.80
186Neurofibromatosis, type iEnrichmentNF11.75
187Leukemia, acute lymphoblastic 3EnrichmentNF11.75
188Neurodevelopmental disorder with dysmorphic facies and distal limb anomaliesEnrichmentCACNA1C1.75
189Congenital central hypoventilation syndromeEnrichmentBDNF1.75
190Lymphoma, non-hodgkin, familialEnrichmentBRAF1.71
191PolymicrogyriaEnrichmentAKT31.70
192MelanomaEnrichmentPTEN1.70
193Meningioma, familialEnrichmentPTEN1.66
194Uterine corpus cancerEnrichmentPTEN1.66
195Specific learning disabilityEnrichmentMAPK11.66
196Cardiomyopathy, familial hypertrophic, 4EnrichmentBRAF1.66
197Primary hyperaldosteronismEnrichmentBRAF1.66
198Ventricular septal defectEnrichmentBRAF1.66
199Cardiac conduction defectEnrichmentCACNA1C1.63
200MicrocephalyEnrichmentCAMK2B, MAPK11.61
201Protein-deficiency anemiaEnrichmentNRAS1.59
202PheochromocytomaEnrichmentNF11.56
203Renal cell carcinoma, nonpapillaryEnrichmentMTOR1.53
204Lynch syndromeEnrichmentKRAS1.53
205Autosomal dominant polycystic kidney diseaseEnrichmentTSC21.53
206Kidney diseaseEnrichmentTSC11.53
207Rare genetic intellectual disabilityEnrichmentMTOR1.53
208Aortic valve disease 1EnrichmentSOS11.51
20946,xy partial gonadal dysgenesisEnrichmentSOS11.47
210Heart, malformation ofEnrichmentMAPK11.45
211Wilms tumor 1EnrichmentBRAF1.44
212Diffuse large b-cell lymphomaEnrichmentPTEN1.43
213Melanoma, cutaneous malignant 1EnrichmentBRAF1.39
214Dandy-walker syndromeEnrichmentBRAF1.39
215Endometrial cancerEnrichmentPTEN1.39
216Hereditary paraganglioma-pheochromocytoma syndromesEnrichmentNF11.39
217Skin diseaseEnrichmentNF11.37
218Early infantile developmental and epileptic encephalopathyEnrichmentGRIN11.37
219Cardiomyopathy, familial hypertrophic, 1EnrichmentCACNA1C1.33
220Focal segmental glomerulosclerosisEnrichmentTRPC61.32
221Pancreatic cancerEnrichmentKRAS1.31
222Brugada syndromeEnrichmentCACNA1C1.30
223Prostate cancerEnrichmentPTEN1.25
224Long qt syndrome 1EnrichmentCACNA1C1.24
225Developmental and epileptic encephalopathy 1EnrichmentGRIN11.23
226Long qt syndromeEnrichmentCACNA1C1.22
227Hydrops fetalis, nonimmuneEnrichmentHRAS1.21
228DystoniaEnrichmentCAMK2B1.17
229Cerebral palsyEnrichmentCACNA1C1.13
230Genetic steroid-resistant nephrotic syndromeEnrichmentTRPC61.10
231Body mass index quantitative trait locus 11EnrichmentBDNF1.02
232Autosomal dominant non-syndromic intellectual disabilityEnrichmentCAMK2B1.02
233Benign epilepsy with centrotemporal spikesEnrichmentGRIN11.02
234Centralopathic epilepsyEnrichmentGRIN11.00
235Nephrotic syndromeEnrichmentTRPC61.00
236Undetermined early-onset epileptic encephalopathyEnrichmentNTRK20.98
237Autosomal recessive non-syndromic intellectual disabilityEnrichmentGRIN10.88
238Dilated cardiomyopathyEnrichmentBRAF0.75
239Rare autosomal recessive non-syndromic sensorineural deafness type dfnbEnrichmentADCY10.71
240Complex neurodevelopmental disorderEnrichmentCACNA1C0.66

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