Benzodiazepine Pathway, Pharmacodynamics

No Pathway Network information available for Benzodiazepine Pathway, Pharmacodynamics

Pathways in the Benzodiazepine Pathway, Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Benzodiazepine Pathway, Pharmacodynamics	PharmGKB	ACBD3 DBI GABRA1 GABRB2 GABRG2 SLC25A4 SLC32A1 SLC6A1 SLC6A11 SLC6A12 SLC6A13 TSPO TSPOAP1 VDAC1 (see all 14) (see less)
2	Reuptake of GABA	Reactome	SLC6A1 SLC6A11 SLC6A12 SLC6A13

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLC6A1	Solute Carrier Family 6 Member 1	Protein Coding	2
2	SLC6A11	Solute Carrier Family 6 Member 11	Protein Coding	2
3	SLC6A12	Solute Carrier Family 6 Member 12	Protein Coding	2
4	SLC6A13	Solute Carrier Family 6 Member 13	Protein Coding	2
5	ACBD3	Acyl-CoA Binding Domain Containing 3	Protein Coding	1
6	VDAC1	Voltage Dependent Anion Channel 1	Protein Coding	1
7	TSPO	Translocator Protein	Protein Coding	1
8	GABRA1	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha1	Protein Coding	1
9	GABRB2	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta2	Protein Coding	1
10	GABRG2	Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma2	Protein Coding	1
11	DBI	Diazepam Binding Inhibitor, Acyl-CoA Binding Protein	Protein Coding	1
12	SLC25A4	Solute Carrier Family 25 Member 4	Protein Coding	1
13	TSPOAP1	TSPO Associated Protein 1	Protein Coding	1
14	SLC32A1	Solute Carrier Family 32 Member 1	Protein Coding	1

Disorders associated with Benzodiazepine Pathway, Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Childhood absence epilepsy	Enrichment	GABRA1, GABRG2	4.83
2	Dravet syndrome	Enrichment	GABRA1, GABRG2	4.35
3	Generalized epilepsy with febrile seizures plus	Enrichment	GABRG2, SLC32A1	4.05
4	Slc6a1-related neurodevelopmental disorder	Enrichment	SLC6A1	3.23
5	Benign epilepsy with centrotemporal spikes	Enrichment	GABRG2, SLC6A1	3.10
6	Centralopathic epilepsy	Enrichment	GABRG2, SLC6A1	3.06
7	Developmental and epileptic encephalopathy 94	Enrichment	SLC6A1	3.05
8	Febrile seizures, familial, 8	Enrichment	GABRG2	2.99
9	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 2	Enrichment	SLC25A4	2.99
10	Epilepsy, idiopathic generalized 13	Enrichment	GABRA1	2.99
11	Mitochondrial dna depletion syndrome 12b , autosomal recessive	Enrichment	SLC25A4	2.99
12	Dystonia 22, adult-onset	Enrichment	TSPOAP1	2.99
13	Developmental and epileptic encephalopathy 74	Enrichment	GABRG2	2.99
14	Mitochondrial dna depletion syndrome 12a , autosomal dominant	Enrichment	SLC25A4	2.99
15	Developmental and epileptic encephalopathy 19	Enrichment	GABRA1	2.99
16	Generalized epilepsy with febrile seizures plus, type 12	Enrichment	SLC32A1	2.99
17	Mitochondrial metabolism disease	Enrichment	SLC25A4	2.99
18	Developmental and epileptic encephalopathy 92	Enrichment	GABRB2	2.99
19	Developmental and epileptic encephalopathy 114	Enrichment	SLC32A1	2.99
20	Undetermined early-onset epileptic encephalopathy	Enrichment	GABRB2, GABRG2	2.83
21	Segawa syndrome, autosomal recessive	Enrichment	TSPOAP1	2.69
22	Dystonia 22, juvenile-onset	Enrichment	TSPOAP1	2.69
23	Myoclonic-atonic epilepsy	Enrichment	SLC6A1	2.58
24	Sengers syndrome	Enrichment	SLC25A4	2.51
25	Autosomal dominant nocturnal frontal lobe epilepsy	Enrichment	GABRG2	2.38
26	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1	Enrichment	SLC25A4	2.21
27	Lennox-gastaut syndrome	Enrichment	GABRG2	2.08
28	Epilepsy, myoclonic juvenile	Enrichment	GABRA1	1.95
29	Epilepsy, idiopathic generalized	Enrichment	GABRA1	1.95
30	Mitochondrial myopathy	Enrichment	SLC25A4	1.95
31	Autosomal dominant non-syndromic intellectual disability	Enrichment	SLC6A1	1.83
32	Myopia	Enrichment	SLC25A4	1.81
33	Early infantile developmental and epileptic encephalopathy	Enrichment	SLC32A1	1.73
34	Epilepsy	Enrichment	GABRA1	1.39
35	Bardet-biedl syndrome	Enrichment	TSPOAP1	1.37
36	Hypertrophic cardiomyopathy	Enrichment	SLC25A4	1.36
37	Schizophrenia	Enrichment	GABRB2	1.23
38	Mitochondrial disease	Enrichment	SLC25A4	1.06

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Benzodiazepine Pathway, Pharmacodynamics

Pathway Network for Benzodiazepine Pathway, Pharmacodynamics

Member Pathways for Benzodiazepine Pathway, Pharmacodynamics

Pathways in the Benzodiazepine Pathway, Pharmacodynamics SuperPath

Associated Genes for Benzodiazepine Pathway, Pharmacodynamics

Associated Disorders for Benzodiazepine Pathway, Pharmacodynamics

Disorders associated with Benzodiazepine Pathway, Pharmacodynamics SuperPath

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