Beta3 integrin cell surface interactions

No Pathway Network information available for Beta3 integrin cell surface interactions

Pathways in the Beta3 integrin cell surface interactions SuperPath

#	Name	Source	Genes
1	Beta3 integrin cell surface interactions	PubChem	CCN1 CD47 COL1A1 COL1A2 COL4A3 EDIL3 F11R FBN1 FGA FGB FGG FN1 HMGB1 IBSP ITGA2B ITGAV ITGB3 KDR L1CAM LAMA4 LAMB1 LAMC1 PDGFB PDGFRB PECAM1 PLAU PLAUR PVR SDC1 SDC4 SPHK1 SPP1 TGFBI TGFBR2 THBS1 THY1 TNC VEGFA VTN (see all 39) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	COL4A3	Collagen Type IV Alpha 3 Chain	Protein Coding	1
2	THY1	Thy-1 Cell Surface Antigen	Protein Coding	1
3	CCN1	Cellular Communication Network Factor 1	Protein Coding	1
4	TGFBI	Transforming Growth Factor Beta Induced	Protein Coding	1
5	SDC4	Syndecan 4	Protein Coding	1
6	EDIL3	EGF Like And Discoidin Domains 3	Protein Coding	1
7	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	1
8	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	1
9	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
10	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
11	SPHK1	Sphingosine Kinase 1	Protein Coding	1
12	SDC1	Syndecan 1	Protein Coding	1
13	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	1
14	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
15	FGA	Fibrinogen Alpha Chain	Protein Coding	1
16	LAMA4	Laminin Subunit Alpha 4	Protein Coding	1
17	FGB	Fibrinogen Beta Chain	Protein Coding	1
18	FGG	Fibrinogen Gamma Chain	Protein Coding	1
19	FBN1	Fibrillin 1	Protein Coding	1
20	IBSP	Integrin Binding Sialoprotein	Protein Coding	1
21	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	1
22	TNC	Tenascin C	Protein Coding	1
23	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
24	VTN	Vitronectin	Protein Coding	1
25	THBS1	Thrombospondin 1	Protein Coding	1
26	FN1	Fibronectin 1	Protein Coding	1
27	CD47	CD47 Molecule	Protein Coding	1
28	F11R	F11 Receptor	Protein Coding	1
29	PVR	PVR Cell Adhesion Molecule	Protein Coding	1
30	LAMC1	Laminin Subunit Gamma 1	Protein Coding	1
31	L1CAM	L1 Cell Adhesion Molecule	Protein Coding	1
32	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
33	LAMB1	Laminin Subunit Beta 1	Protein Coding	1
34	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	1
35	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
36	KDR	Kinase Insert Domain Receptor	Protein Coding	1
37	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
38	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
39	HMGB1	High Mobility Group Box 1	Protein Coding	1

Disorders associated with Beta3 integrin cell surface interactions SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Dysfibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	7.66
2	Familial dysfibrinogenemia	Enrichment	FGA, FGB, FGG	7.66
3	Familial hypofibrinogenemia	Enrichment	FGA, FGB, FGG	7.66
4	Afibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	7.06
5	Dermatofibrosarcoma protuberans	Enrichment	COL1A1, PDGFB	5.09
6	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1, COL1A2	5.09
7	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1, COL1A2	5.09
8	Ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2, TGFBR2	4.69
9	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	4.62
10	High bone mass osteogenesis imperfecta	Enrichment	COL1A1, COL1A2	4.62
11	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1, COL1A2	4.32
12	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1, COL1A2	4.32
13	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1, COL1A2	3.92
14	Osteogenesis imperfecta, type i	Enrichment	COL1A1, COL1A2	3.92
15	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2B, ITGB3	3.92
16	Classic ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2	3.92
17	Osteogenesis imperfecta, type ii	Enrichment	COL1A1, COL1A2	3.78
18	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	3.78
19	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	3.65
20	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1, FBN1, TGFBR2	3.57
21	Loeys-dietz syndrome	Enrichment	FBN1, TGFBR2	3.54
22	Thrombocytopenia	Enrichment	FGG, ITGA2B, ITGB3	3.46
23	Marfan syndrome	Enrichment	FBN1, TGFBR2	3.45
24	Autosomal dominant macrothrombocytopenia	Enrichment	ITGA2B, ITGB3	3.45
25	Primary bone dysplasia	Enrichment	COL1A1, COL1A2	3.45
26	Osteochondrodysplasia	Enrichment	COL1A1, COL1A2	3.36
27	Osteogenesis imperfecta, type iv	Enrichment	COL1A1, COL1A2	3.21
28	Osteoporosis	Enrichment	COL1A1, COL1A2	3.14
29	Osteogenesis imperfecta, type iii	Enrichment	COL1A1, COL1A2	3.08
30	Brittle bone disorder	Enrichment	COL1A1, COL1A2	2.71
31	Corneal dystrophy, epithelial basement membrane	Enrichment	TGFBI	2.54
32	Corneal dystrophy, groenouw type i	Enrichment	TGFBI	2.54
33	Ectopia lentis 1, isolated, autosomal dominant	Enrichment	FBN1	2.54
34	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.54
35	Hydrocephalus due to congenital stenosis of aqueduct of sylvius	Enrichment	L1CAM	2.54
36	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.54
37	Corneal dystrophy, avellino type	Enrichment	TGFBI	2.54
38	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	2.54
39	Cardiomyopathy, dilated, 1jj	Enrichment	LAMA4	2.54
40	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.54
41	Corneal dystrophy, lattice type i	Enrichment	TGFBI	2.54
42	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.54
43	Lissencephaly 5	Enrichment	LAMB1	2.54
44	Weill-marchesani syndrome 2	Enrichment	FBN1	2.54
45	Deafness, autosomal dominant 56	Enrichment	TNC	2.54
46	Geleophysic dysplasia 2	Enrichment	FBN1	2.54
47	Protrusio acetabuli	Enrichment	FBN1	2.54
48	Corneal dystrophy, thiel-behnke type	Enrichment	TGFBI	2.54
49	Corpus callosum, partial agenesis of, x-linked	Enrichment	L1CAM	2.54
50	Hydrocephalus, congenital, x-linked	Enrichment	L1CAM	2.54
51	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.54
52	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.54
53	Lymphoplasmacytic lymphoma	Enrichment	FBN1	2.54
54	Masa syndrome	Enrichment	L1CAM	2.54
55	Epithelial-stromal tgfbi dystrophy	Enrichment	TGFBI	2.54
56	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.54
57	Corneal dystrophy, lattice type iiia	Enrichment	TGFBI	2.54
58	Corneal dystrophy, reis-bucklers type	Enrichment	TGFBI	2.54
59	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.54
60	Granular corneal dystrophy	Enrichment	TGFBI	2.54
61	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.54
62	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.54
63	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.54
64	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.54
65	Tufted angioma of skin	Enrichment	KDR	2.54
66	Asphyxia neonatorum	Enrichment	COL1A1	2.54
67	Epithelial basement membrane dystrophy	Enrichment	TGFBI	2.54
68	Congenital fibrinogen deficiency	Enrichment	FGG	2.54
69	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.54
70	X-linked complicated spastic paraplegia type 1	Enrichment	L1CAM	2.54
71	Neonatal marfan syndrome	Enrichment	FBN1	2.54
72	Connective tissue disease	Enrichment	FBN1, TGFBR2	2.42
73	Acromicric dysplasia	Enrichment	FBN1	2.24
74	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.24
75	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.24
76	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.24
77	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.24
78	Bruck syndrome 1	Enrichment	COL1A2	2.24
79	Stiff skin syndrome	Enrichment	FBN1	2.24
80	Quebec platelet disorder	Enrichment	PLAU	2.24
81	Loeys-dietz syndrome 2	Enrichment	TGFBR2	2.24
82	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.24
83	Lissencephaly 1	Enrichment	LAMB1	2.24
84	Beaulieu-boycott-innes syndrome	Enrichment	FBN1	2.24
85	Angioma, tufted	Enrichment	KDR	2.24
86	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.24
87	Infantile myofibromatosis	Enrichment	PDGFRB	2.24
88	Aortic dissection	Enrichment	FBN1	2.24
89	Marfanoid-progeroid-lipodystrophy syndrome	Enrichment	FBN1	2.24
90	Stickler syndrome, type ii	Enrichment	COL1A1	2.24
91	Dentinogenesis imperfecta	Enrichment	COL1A2	2.24
92	Lens subluxation	Enrichment	FBN1	2.24
93	Nephrotic syndrome	Enrichment	COL4A3, FN1	2.17
94	Contractural arachnodactyly, congenital	Enrichment	FBN1	2.07
95	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.07
96	Achondroplasia	Enrichment	FBN1	2.07
97	Mccune-albright syndrome	Enrichment	FBN1	2.07
98	Hematuria, benign familial, 1	Enrichment	COL4A3	2.07
99	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.07
100	Caffey disease	Enrichment	COL1A1	2.07
101	Pilarowski-bjornsson syndrome	Enrichment	COL4A3	2.07
102	Alport syndrome 3b, autosomal recessive	Enrichment	COL4A3	2.07
103	Weill-marchesani syndrome 1	Enrichment	FBN1	2.07
104	Isolated ectopia lentis	Enrichment	FBN1	2.07
105	Loeys-dietz syndrome 1	Enrichment	TGFBR2	2.07
106	Hematuria, benign familial, 2	Enrichment	COL4A3	2.07
107	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.07
108	Geleophysic dysplasia	Enrichment	FBN1	2.07
109	Digenic alport syndrome	Enrichment	COL4A3	2.07
110	Alport syndrome 2, autosomal recessive	Enrichment	COL4A3	1.94
111	Phenylketonuria	Enrichment	COL1A1	1.94
112	Weill-marchesani syndrome	Enrichment	FBN1	1.94
113	Aortic aneurysm	Enrichment	FBN1	1.94
114	Corneal dystrophy	Enrichment	TGFBI	1.94
115	Autosomal recessive alport syndrome	Enrichment	COL4A3	1.94
116	Mitral valve insufficiency	Enrichment	FBN1	1.94
117	Pediatric systemic lupus erythematosus	Enrichment	SPP1	1.94
118	Primary ovarian insufficiency	Enrichment	KDR, THBS1	1.91
119	Alport syndrome 3a, autosomal dominant	Enrichment	COL4A3	1.84
120	Polycystic liver disease 1 with or without kidney cysts	Enrichment	FBN1	1.84
121	Alzheimer disease 2	Enrichment	PLAU	1.84
122	Amyloidosis, hereditary systemic 2	Enrichment	FGA	1.84
123	Arthrogryposis, renal dysfunction, and cholestasis 1	Enrichment	FBN1	1.84
124	Goldberg-shprintzen syndrome	Enrichment	FBN1	1.84
125	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.84
126	Muscular dystrophy, limb-girdle, autosomal recessive 23	Enrichment	L1CAM	1.84
127	Autosomal dominant alport syndrome	Enrichment	COL4A3	1.84
128	Polycystic liver disease 1	Enrichment	FBN1	1.84
129	Alport syndrome	Enrichment	COL4A3	1.84
130	Primary hypereosinophilic syndrome	Enrichment	PDGFRB	1.84
131	Hemangioma, capillary infantile	Enrichment	KDR	1.77
132	Inguinal hernia	Enrichment	FBN1	1.77
133	Keratoconus	Enrichment	COL1A1	1.77
134	Esophageal cancer	Enrichment	TGFBR2	1.70
135	Thrombophilia due to thrombin defect	Enrichment	FGA	1.70
136	Brugada syndrome 1	Enrichment	FBN1	1.70
137	Spastic paraplegia 4, autosomal dominant	Enrichment	FGG	1.64
138	Orthostatic intolerance	Enrichment	FBN1	1.64
139	Familial thoracic aortic aneurysm and dissection	Enrichment	FBN1	1.59
140	Hydrops fetalis	Enrichment	L1CAM	1.59
141	Stroke, ischemic	Enrichment	FBN1	1.55
142	Melanoma	Enrichment	FBN1	1.55
143	Pectus excavatum	Enrichment	FBN1	1.51
144	Meningioma, familial	Enrichment	PDGFB	1.51
145	Meningioma	Enrichment	PDGFB	1.47
146	Diaphragmatic hernia, congenital	Enrichment	FBN1	1.43
147	Multiple sclerosis	Enrichment	LAMB1	1.40
148	Aortic aneurysm, familial thoracic 1	Enrichment	FBN1	1.40
149	Hydrocephalus	Enrichment	PDGFRB	1.37
150	Myopia	Enrichment	FBN1	1.37
151	Lynch syndrome	Enrichment	TGFBR2	1.37
152	Kidney disease	Enrichment	COL4A3	1.37
153	Perrault syndrome 1	Enrichment	FBN1	1.35
154	Alzheimer disease, familial, 1	Enrichment	PLAU	1.32
155	Dandy-walker syndrome	Enrichment	PDGFRB	1.32
156	Myocardial infarction	Enrichment	ITGB3	1.21
157	Scoliosis	Enrichment	FBN1	1.18
158	Tetralogy of fallot	Enrichment	KDR	1.14
159	Severe covid-19	Enrichment	ITGAV	1.10
160	Genetic steroid-resistant nephrotic syndrome	Enrichment	COL4A3	1.03
161	Systemic lupus erythematosus	Enrichment	SPP1	0.97
162	Cerebral palsy	Enrichment	PDGFRB	0.97
163	Myopathy	Enrichment	FBN1	0.96
164	Hypertelorism	Enrichment	COL1A1	0.86
165	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TNC	0.86
166	Familial isolated dilated cardiomyopathy	Enrichment	LAMA4	0.85
167	Dilated cardiomyopathy	Enrichment	FBN1	0.69

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Beta3 integrin cell surface interactions

Pathway Network for Beta3 integrin cell surface interactions

Member Pathways for Beta3 integrin cell surface interactions

Pathways in the Beta3 integrin cell surface interactions SuperPath

Associated Genes for Beta3 integrin cell surface interactions

Associated Disorders for Beta3 integrin cell surface interactions

Disorders associated with Beta3 integrin cell surface interactions SuperPath

STRING Interaction Network for Beta3 integrin cell surface interactions

Sources for Beta3 integrin cell surface interactions