Bile acids synthesis and enterohepatic circulation

No Pathway Network information available for Bile acids synthesis and enterohepatic circulation

Pathways in the Bile acids synthesis and enterohepatic circulation SuperPath

#	Name	Source	Genes
1	Bile acids synthesis and enterohepatic circulation	WikiPathways	ABCB11 ABCG5 ABCG8 CYP7A1 FGF19 FGFR4 FXR1 LDLR MAPK1 MAPK3 SLC10A1 SLC10A2 (see all 12) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	1
2	SLC10A1	Solute Carrier Family 10 Member 1	Protein Coding	1
3	SLC10A2	Solute Carrier Family 10 Member 2	Protein Coding	1
4	FGF19	Fibroblast Growth Factor 19	Protein Coding	1
5	ABCB11	ATP Binding Cassette Subfamily B Member 11	Protein Coding	1
6	ABCG8	ATP Binding Cassette Subfamily G Member 8	Protein Coding	1
7	ABCG5	ATP Binding Cassette Subfamily G Member 5	Protein Coding	1
8	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
9	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
10	LDLR	Low Density Lipoprotein Receptor	Protein Coding	1
11	CYP7A1	Cytochrome P450 Family 7 Subfamily A Member 1	Protein Coding	1
12	FXR1	FMR1 Autosomal Homolog 1	Protein Coding	1

Disorders associated with Bile acids synthesis and enterohepatic circulation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lipid metabolism disorder	Enrichment	ABCG5, ABCG8, LDLR	7.97
2	Homozygous familial hypercholesterolemia	Enrichment	ABCG5, ABCG8, LDLR	7.53
3	Coronary heart disease 5	Enrichment	ABCG5, ABCG8, LDLR	7.35
4	Gallbladder disease 4	Enrichment	ABCG5, ABCG8	6.14
5	Sitosterolemia 1	Enrichment	ABCG5, ABCG8	5.67
6	Sitosterolemia	Enrichment	ABCG5, ABCG8	5.67
7	Noonan syndrome 13	Enrichment	MAPK1	3.05
8	Bile acid malabsorption, primary, 1	Enrichment	SLC10A2	3.05
9	Hypercholanemia, familial, 2	Enrichment	SLC10A1	3.05
10	Congenital myopathy 9b, proximal, with minicore lesions	Enrichment	FXR1	3.05
11	Congenital myopathy 9a	Enrichment	FXR1	3.05
12	Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency	Enrichment	CYP7A1	3.05
13	Cholestasis, progressive familial intrahepatic, 3	Enrichment	ABCB11	2.75
14	Cholestasis, benign recurrent intrahepatic, 2	Enrichment	ABCB11	2.75
15	Cholestasis, progressive familial intrahepatic, 4	Enrichment	ABCB11	2.75
16	Cholestasis, intrahepatic, of pregnancy 3	Enrichment	ABCB11	2.75
17	Cholestasis, progressive familial intrahepatic, 2	Enrichment	ABCB11	2.75
18	Sitosterolemia 2	Enrichment	ABCG5	2.75
19	Hyperlipoproteinemia, type iii	Enrichment	LDLR	2.75
20	Short-rib thoracic dysplasia 15 with polydactyly	Enrichment	ABCG5	2.75
21	Intrahepatic cholestasis	Enrichment	ABCB11	2.75
22	Hypercholesterolemia, familial, 2	Enrichment	LDLR	2.58
23	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	LDLR	2.58
24	Hypercholesterolemia, familial, 4	Enrichment	LDLR	2.58
25	Syndromic x-linked intellectual disability najm type	Enrichment	LDLR	2.58
26	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.45
27	Intrahepatic cholestasis of pregnancy	Enrichment	ABCB11	2.45
28	Hyperlipidemia, familial combined, 3	Enrichment	LDLR	2.35
29	Cowden syndrome 1	Enrichment	LDLR	2.28
30	Familial hypercholanemia	Enrichment	SLC10A1	2.28
31	Progressive familial intrahepatic cholestasis	Enrichment	ABCB11	2.21
32	Specific learning disability	Enrichment	MAPK1	2.01
33	Hypercholesterolemia, familial, 1	Enrichment	LDLR	1.94
34	Familial hypercholesterolemia	Enrichment	LDLR	1.88
35	Heart, malformation of	Enrichment	MAPK1	1.80
36	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	ABCG5	1.54
37	Microcephaly	Enrichment	MAPK1	0.98

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Bile acids synthesis and enterohepatic circulation

Pathway Network for Bile acids synthesis and enterohepatic circulation

Member Pathways for Bile acids synthesis and enterohepatic circulation

Pathways in the Bile acids synthesis and enterohepatic circulation SuperPath

Associated Genes for Bile acids synthesis and enterohepatic circulation

Associated Disorders for Bile acids synthesis and enterohepatic circulation

Disorders associated with Bile acids synthesis and enterohepatic circulation SuperPath

STRING Interaction Network for Bile acids synthesis and enterohepatic circulation

Sources for Bile acids synthesis and enterohepatic circulation