Binding and Uptake of Ligands by Scavenger Receptors

Pathway network for the Binding and Uptake of Ligands by Scavenger Receptors SuperPath

Sources:

Reactome

Pathways in the Binding and Uptake of Ligands by Scavenger Receptors SuperPath

#	Name	Source	Genes
1	Binding and Uptake of Ligands by Scavenger Receptors	Reactome	ALB AMBP APOA1 APOB APOE APOL1 CALR CD163 CD36 COL1A1 COL1A2 COL3A1 COL4A1 COL4A2 COLEC11 COLEC12 FTH1 FTL HBA1 HBA2 HBB HP HPR HPX HSP90AA1 HSP90B1 HSPH1 HYOU1 JCHAIN LRP1 MARCO MASP1 MSR1 SAA1 SCARA5 SCARB1 SCARF1 SCGB3A2 SPARC SSC5D STAB1 STAB2 (see all 42) (see less)
2	Scavenging by Class A Receptors	Reactome	APOA1 APOB APOE CALR COL1A1 COL1A2 COL3A1 COL4A1 COL4A2 COLEC11 COLEC12 FTH1 FTL HSP90B1 MARCO MASP1 MSR1 SCARA5 SCGB3A2 (see all 19) (see less)
3	Scavenging of heme from plasma	Reactome	ALB AMBP APOA1 APOL1 CD163 HBA1 HBA2 HBB HP HPR HPX JCHAIN LRP1 (see all 13) (see less)
4	Scavenging by Class B Receptors	Reactome	APOA1 APOB CD36 SAA1 SCARB1 SSC5D (see all 6) (see less)
5	Scavenging by Class F Receptors	Reactome	APOB CALR HSP90AA1 HSPH1 HYOU1 SCARF1 (see all 6) (see less)
6	Scavenging by Class H Receptors	Reactome	APOB SPARC STAB1 STAB2

Gene overlap in member pathways for Binding and Uptake of Ligands by Scavenger Receptors SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	APOB	Apolipoprotein B	Protein Coding	5
2	APOA1	Apolipoprotein A1	Protein Coding	4
3	CALR	Calreticulin	Protein Coding	3
4	HYOU1	Hypoxia Up-Regulated 1	Protein Coding	2
5	HSPH1	Heat Shock Protein Family H (Hsp110) Member 1	Protein Coding	2
6	SCGB3A2	Secretoglobin Family 3A Member 2	Protein Coding	2
7	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	2
8	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	2
9	COL3A1	Collagen Type III Alpha 1 Chain	Protein Coding	2
10	COL4A1	Collagen Type IV Alpha 1 Chain	Protein Coding	2
11	COL4A2	Collagen Type IV Alpha 2 Chain	Protein Coding	2
12	ALB	Albumin	Protein Coding	2
13	STAB1	Stabilin 1	Protein Coding	2
14	FTH1	Ferritin Heavy Chain 1	Protein Coding	2
15	FTL	Ferritin Light Chain	Protein Coding	2
16	AMBP	Alpha-1-Microglobulin/Bikunin Precursor	Protein Coding	2
17	SSC5D	Scavenger Receptor Cysteine Rich Family Member With 5 Domains	Protein Coding	2
18	SCARA5	Scavenger Receptor Class A Member 5	Protein Coding	2
19	HBA1	Hemoglobin Subunit Alpha 1	Protein Coding	2
20	HBA2	Hemoglobin Subunit Alpha 2	Protein Coding	2
21	HBB	Hemoglobin Subunit Beta	Protein Coding	2
22	HP	Haptoglobin	Protein Coding	2
23	HPR	Haptoglobin-Related Protein	Protein Coding	2
24	HPX	Hemopexin	Protein Coding	2
25	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	2
26	APOE	Apolipoprotein E	Protein Coding	2
27	JCHAIN	Joining Chain Of Multimeric IgA And IgM	Protein Coding	2
28	LRP1	LDL Receptor Related Protein 1	Protein Coding	2
29	MSR1	Macrophage Scavenger Receptor 1	Protein Coding	2
30	STAB2	Stabilin 2	Protein Coding	2
31	MASP1	MBL Associated Serine Protease 1	Protein Coding	2
32	SAA1	Serum Amyloid A1	Protein Coding	2
33	SPARC	Secreted Protein Acidic And Cysteine Rich	Protein Coding	2
34	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	2
35	COLEC11	Collectin Subfamily Member 11	Protein Coding	2
36	COLEC12	Collectin Subfamily Member 12	Protein Coding	2
37	APOL1	Apolipoprotein L1	Protein Coding	2
38	SCARF1	Scavenger Receptor Class F Member 1	Protein Coding	2
39	MARCO	Macrophage Receptor With Collagenous Structure	Protein Coding	2
40	CD163	CD163 Molecule	Protein Coding	2
41	CD36	CD36 Molecule (CD36 Blood Group)	Protein Coding	2
42	SCARB1	Scavenger Receptor Class B Member 1	Protein Coding	2

Disorders associated with Binding and Uptake of Ligands by Scavenger Receptors SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Methemoglobinemia, beta type	Enrichment	HBA1, HBA2, HBB	7.86
2	Autosomal dominant secondary polycythemia	Enrichment	HBA1, HBA2, HBB	7.86
3	Heinz body anemias	Enrichment	HBA1, HBA2, HBB	7.42
4	Heinz body anemia	Enrichment	HBA1, HBA2, HBB	7.42
5	Alpha-thalassemia	Enrichment	HBA1, HBA2, HBB	7.24
6	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	ALB, COL1A1, COL1A2	6.96
7	Protein-deficiency anemia	Enrichment	HBA1, HBA2, HBB	6.71
8	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1, COL1A2	5.73
9	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1, COL1A2	5.73
10	Ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2, COL3A1	5.65
11	Alpha thalassemia-intellectual disability syndrome type 1	Enrichment	HBA1, HBA2	5.59
12	Erythrocytosis, familial, 7	Enrichment	HBA1, HBA2	5.29
13	Hemoglobin h disease	Enrichment	HBA1, HBA2	5.29
14	High bone mass osteogenesis imperfecta	Enrichment	COL1A1, COL1A2	5.25
15	Osteogenesis imperfecta, type iv	Enrichment	COL1A1, COL1A2, SPARC	5.11
16	Thalassemia	Enrichment	HBA2, HBB	5.07
17	Brain small vessel disease 1 with or without ocular anomalies	Enrichment	COL4A1, COL4A2	4.95
18	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1, COL1A2	4.95
19	Beta-thalassemia	Enrichment	HBA2, HBB	4.75
20	Beta-thalassemia major	Enrichment	HBA2, HBB	4.75
21	Familial porencephaly	Enrichment	COL4A1, COL4A2	4.73
22	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1, COL1A2	4.56
23	Osteogenesis imperfecta, type i	Enrichment	COL1A1, COL1A2	4.56
24	Hemorrhage, intracerebral	Enrichment	COL4A1, COL4A2	4.56
25	3mc syndrome	Enrichment	COLEC11, MASP1	4.56
26	Keratoconus	Enrichment	COL1A1, COL4A1	4.56
27	Classic ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2	4.56
28	Osteogenesis imperfecta, type ii	Enrichment	COL1A1, COL1A2	4.41
29	Primary bone dysplasia	Enrichment	COL1A1, COL1A2	4.08
30	Osteochondrodysplasia	Enrichment	COL1A1, COL1A2	3.99
31	Osteoporosis	Enrichment	COL1A1, COL1A2	3.78
32	Osteogenesis imperfecta, type iii	Enrichment	COL1A1, COL1A2	3.71
33	Familial hypercholesterolemia	Enrichment	APOB, APOE	3.71
34	Hydrops fetalis, nonimmune	Enrichment	HBA1, HBA2	3.57
35	Hyperferritinemia	Enrichment	STAB1	3.53
36	Coronary heart disease 7	Enrichment	CD36	3.35
37	High density lipoprotein cholesterol level quantitative trait locus 6	Enrichment	SCARB1	3.35
38	Platelet glycoprotein iv deficiency	Enrichment	CD36	3.35
39	Serum amyloid a amyloidosis	Enrichment	SAA1	3.35
40	Brittle bone disorder	Enrichment	COL1A1, COL1A2	3.34
41	Hypobetalipoproteinemia, familial, 1	Enrichment	APOB	3.23
42	Osteogenesis imperfecta, type xvii	Enrichment	SPARC	3.23
43	Hypobetalipoproteinemia	Enrichment	APOB	3.23
44	Hypercholesterolemia, familial, 2	Enrichment	APOB	3.05
45	Hypoalphalipoproteinemia, primary, 2, intermediate	Enrichment	APOA1	3.05
46	Amyloidosis, hereditary systemic 3	Enrichment	APOA1	3.05
47	Immunodeficiency 59 and hypoglycemia	Enrichment	HYOU1	3.05
48	Atrophoderma vermiculata	Enrichment	LRP1	3.02
49	Focal segmental glomerulosclerosis 4	Enrichment	APOL1	3.02
50	Keratosis pilaris atrophicans	Enrichment	LRP1	3.02
51	Hyperthyroxinemia, familial dysalbuminemic	Enrichment	ALB	3.02
52	Anhaptoglobinemia	Enrichment	HP	3.02
53	Congenital analbuminemia	Enrichment	ALB	3.02
54	Sickle cell-beta-thalassemia disease syndrome	Enrichment	HBB	3.02
55	Analbuminemia	Enrichment	ALB	3.02
56	Hemoglobin c-beta-thalassemia syndrome	Enrichment	HBB	3.02
57	Sickle cell s-o arab disease	Enrichment	HBB	3.02
58	Sickle cell-beta zero-thalassemia	Enrichment	HBB	3.02
59	Sickle cell s-d punjab disease	Enrichment	HBB	3.02
60	Sickle cell s-c disease	Enrichment	HBB	3.02
61	Sickle cell s-e disease	Enrichment	HBB	3.02
62	Homozygous hemoglobin o arab disease	Enrichment	HBB	3.02
63	Sickle cell s-other specified hemoglobin variant	Enrichment	HBB	3.02
64	Hyperalphalipoproteinemia 1	Enrichment	SCARB1	2.88
65	Hypoalphalipoproteinemia, primary, 2	Enrichment	APOA1	2.88
66	Spastic paraplegia 50, autosomal recessive	Enrichment	APOA1	2.88
67	Thrombocythemia 1	Enrichment	CALR	2.88
68	Cerebral palsy	Enrichment	COL4A1, COL4A2	2.87
69	3mc syndrome 1	Enrichment	MASP1	2.85
70	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.85
71	Sea-blue histiocyte disease	Enrichment	APOE	2.85
72	Neurodegeneration with brain iron accumulation 3	Enrichment	FTL	2.85
73	Lipoprotein glomerulopathy	Enrichment	APOE	2.85
74	Acrogeria, gottron type	Enrichment	COL3A1	2.85
75	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.85
76	Porencephaly	Enrichment	COL4A1	2.85
77	L-ferritin deficiency	Enrichment	FTL	2.85
78	Asphyxia neonatorum	Enrichment	COL1A1	2.85
79	Col4a1-related disorders	Enrichment	COL4A1	2.85
80	Genetic hyperferritinemia without iron overload	Enrichment	FTL	2.85
81	Col4a1 or col4a2-related cerebral small vessel disease	Enrichment	COL4A1	2.85
82	Abdominal aortic aneurysm	Enrichment	COL3A1	2.85
83	Hyperlipidemia, familial combined, 3	Enrichment	APOB	2.83
84	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1, COL3A1	2.77
85	Hypoalphalipoproteinemia, primary, 1	Enrichment	APOA1	2.75
86	Blood platelet disease	Enrichment	CD36	2.75
87	Cerebral malaria	Enrichment	CD36	2.75
88	Budd-chiari syndrome	Enrichment	CALR	2.75
89	Methemoglobinemia, alpha type	Enrichment	HBA1	2.72
90	Developmental dysplasia of the hip 3	Enrichment	LRP1	2.72
91	Glomerulonephritis	Enrichment	APOL1	2.72
92	Hemoglobin lepore-beta-thalassemia syndrome	Enrichment	HBB	2.72
93	Sickle cell s-lepore disease	Enrichment	HBB	2.72
94	Amyloidosis, hereditary systemic 2	Enrichment	APOA1	2.66
95	Malaria	Enrichment	CD36, HBB	2.64
96	Homozygous familial hypercholesterolemia	Enrichment	APOB	2.63
97	Coronary heart disease 5	Enrichment	APOB	2.58
98	Ehlers-danlos syndrome, vascular type	Enrichment	COL3A1	2.55
99	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.55
100	Ehlers-danlos syndrome, hypermobility type	Enrichment	COL3A1	2.55
101	Vitreoretinochoroidopathy	Enrichment	FTH1	2.55
102	Bruck syndrome 1	Enrichment	COL1A2	2.55
103	Alzheimer disease 3	Enrichment	APOE	2.55
104	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	2.55
105	3mc syndrome 2	Enrichment	COLEC11	2.55
106	Retinitis pigmentosa 50	Enrichment	FTH1	2.55
107	Hyperferritinemia with or without cataract	Enrichment	FTL	2.55
108	Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 1	Enrichment	COL4A2	2.55
109	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.55
110	Polymicrogyria with or without vascular-type ehlers-danlos syndrome	Enrichment	COL3A1	2.55
111	Hyperlipoproteinemia, type iii	Enrichment	APOE	2.55
112	Hemochromatosis, type 5	Enrichment	FTH1	2.55
113	Aortic dissection	Enrichment	COL3A1	2.55
114	Stickler syndrome, type ii	Enrichment	COL1A1	2.55
115	Neurodegeneration with brain iron accumulation 9	Enrichment	FTH1	2.55
116	Dentinogenesis imperfecta	Enrichment	COL1A2	2.55
117	Keratosis follicularis spinulosa decalvans	Enrichment	LRP1	2.54
118	Hemoglobin e disease	Enrichment	HBB	2.54
119	Sickle cell-hemoglobin c disease	Enrichment	HBB	2.54
120	Hemoglobin d disease	Enrichment	HBB	2.54
121	Delta beta-thalassemia	Enrichment	HBB	2.54
122	Unstable hemoglobin disease	Enrichment	HBB	2.54
123	Hemoglobin e/beta thalassemia disease	Enrichment	HBB	2.54
124	Myelofibrosis	Enrichment	CALR	2.51
125	Essential thrombocythemia	Enrichment	CALR	2.51
126	Sickle cell disease	Enrichment	HBB	2.42
127	Beta-thalassemia, dominant inclusion body type	Enrichment	HBB	2.42
128	Erythrocytosis, familial, 6	Enrichment	HBB	2.42
129	Beta-thalassemia intermedia	Enrichment	HBB	2.42
130	Hemoglobinopathy	Enrichment	HBB	2.42
131	Hemoglobin c disease	Enrichment	HBB	2.42
132	Hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome	Enrichment	HBB	2.42
133	Methemoglobinemia, beta-globin type	Enrichment	HBB	2.42
134	Hypercholesterolemia, familial, 1	Enrichment	APOB	2.42
135	Retinal arteries, tortuosity of	Enrichment	COL4A1	2.38
136	Alzheimer disease 4	Enrichment	APOE	2.38
137	Caffey disease	Enrichment	COL1A1	2.38
138	Brain small vessel disease 2	Enrichment	COL4A2	2.38
139	Microangiopathy and leukoencephalopathy, pontine, autosomal dominant	Enrichment	COL4A1	2.38
140	Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps	Enrichment	COL4A1	2.38
141	Hereditary persistence of fetal hemoglobin-sickle cell disease syndrome	Enrichment	HBB	2.32
142	Phenylketonuria	Enrichment	COL1A1	2.25
143	Schizencephaly	Enrichment	COL4A1	2.25
144	Macular degeneration, age-related, 1	Enrichment	APOE	2.25
145	Bestrophinopathy, autosomal recessive	Enrichment	FTH1	2.25
146	Barrett esophagus	Enrichment	MSR1	2.25
147	Hemolytic anemia	Enrichment	HBB	2.17
148	Alzheimer disease 2	Enrichment	APOE	2.16
149	Macular dystrophy, vitelliform, 2	Enrichment	FTH1	2.16
150	Familial cerebral saccular aneurysm	Enrichment	COL3A1	2.16
151	Fetal hemoglobin quantitative trait locus 1	Enrichment	HBB	2.12
152	Anterior segment dysgenesis 5	Enrichment	COL4A1	2.08
153	Lipid metabolism disorder	Enrichment	APOE	2.08
154	Spastic paraplegia 4, autosomal dominant	Enrichment	COL3A1	1.95
155	Familial thoracic aortic aneurysm and dissection	Enrichment	COL3A1	1.90
156	Peters-plus syndrome	Enrichment	COL4A1	1.86
157	Atypical hemolytic-uremic syndrome	Enrichment	HBB	1.85
158	Asthma	Enrichment	SCGB3A2	1.82
159	Alzheimer's disease	Enrichment	APOE	1.74
160	Focal segmental glomerulosclerosis	Enrichment	APOL1	1.72
161	Aortic aneurysm, familial thoracic 1	Enrichment	COL3A1	1.71
162	Walker-warburg syndrome	Enrichment	COL4A1	1.71
163	Corpus callosum, agenesis of	Enrichment	COL4A1	1.68
164	Anterior segment dysgenesis	Enrichment	COL4A1	1.68
165	Isolated corpus callosum agenesis	Enrichment	COL4A1	1.68
166	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	COL4A1	1.68
167	Multisystem inflammatory syndrome in children	Enrichment	CD163	1.68
168	Alzheimer disease, familial, 1	Enrichment	APOE	1.63
169	Non-immune hydrops fetalis	Enrichment	HBA2	1.53
170	Genetic steroid-resistant nephrotic syndrome	Enrichment	APOL1	1.49
171	Prostate cancer	Enrichment	MSR1	1.40
172	Cakut	Enrichment	COL4A1	1.33
173	Hypertelorism	Enrichment	COL1A1	1.15
174	Ovarian cancer	Enrichment	MSR1	0.88
175	Microcephaly	Enrichment	COL4A1	0.80
176	Hereditary retinal dystrophy	Enrichment	FTH1	0.47
177	Fundus dystrophy	Enrichment	FTH1	0.47

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Binding and Uptake of Ligands by Scavenger Receptors

Pathway Network for Binding and Uptake of Ligands by Scavenger Receptors

Pathway network for the Binding and Uptake of Ligands by Scavenger Receptors SuperPath

Member Pathways for Binding and Uptake of Ligands by Scavenger Receptors

Pathways in the Binding and Uptake of Ligands by Scavenger Receptors SuperPath

Gene overlap in member pathways for Binding and Uptake of Ligands by Scavenger Receptors SuperPath

Associated Genes for Binding and Uptake of Ligands by Scavenger Receptors

Associated Disorders for Binding and Uptake of Ligands by Scavenger Receptors

Disorders associated with Binding and Uptake of Ligands by Scavenger Receptors SuperPath

STRING Interaction Network for Binding and Uptake of Ligands by Scavenger Receptors

Sources for Binding and Uptake of Ligands by Scavenger Receptors