Binimetinib Pathway, Pharmacokinetics/Pharmacodynamics

No Pathway Network information available for Binimetinib Pathway, Pharmacokinetics/Pharmacodynamics

#	Name	Source	Genes
1	Binimetinib Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	CYP1A2 CYP2C19 MAP2K1 MAP2K2 UGT1A1

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	1
2	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
3	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
4	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	1
5	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	6.19
2	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	6.19
3	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, MAP2K2	4.94
4	Noonan syndrome 1	Enrichment	MAP2K1, MAP2K2	4.56
5	Rasopathy	Enrichment	MAP2K1, MAP2K2	4.45
6	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	3.43
7	Melorheostosis, isolated	Enrichment	MAP2K1	3.43
8	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	3.43
9	Melorheostosis	Enrichment	MAP2K1	3.43
10	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	3.43
11	Tafro syndrome	Enrichment	MAP2K2	3.13
12	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.96
13	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	2.83
14	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	2.59
15	Arteriovenous malformation	Enrichment	MAP2K1	2.48
16	Crigler-najjar syndrome, type i	Enrichment	UGT1A1	2.43
17	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A1	2.43
18	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	2.43
19	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A1	2.43
20	Crigler-najjar syndrome, type ii	Enrichment	UGT1A1	2.43
21	Gilbert syndrome	Enrichment	UGT1A1	2.39
22	Bilirubin metabolic disorder	Enrichment	UGT1A1	2.39
23	Lung non-small cell carcinoma	Enrichment	MAP2K1	2.39
24	Autism spectrum disorder	Enrichment	MAP2K1	1.40

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Binimetinib Pathway, Pharmacokinetics/Pharmacodynamics