Biogenic amine synthesis

Pathway network for the Biogenic amine synthesis SuperPath

Sources:

WikiPathways
Reactome
PubChem

Pathways in the Biogenic amine synthesis SuperPath

#	Name	Source	Genes
1	Biogenic amine synthesis	WikiPathways	AANAT ACHE ASMT CHAT COMT DBH DDC GAD1 GAD2 HDC MAOA PAH PNMT TH TPH1 (see all 15) (see less)
2	Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine	WikiPathways	AANAT ASMT COMT DBH DHFR DNAJC12 GCH1 MAOA MAOB PAH PNMT PTS QDPR SPR TH (see all 15) (see less)
3	Neurotransmitter disorders	WikiPathways	COMT DBH DDC PNMT SLC18A2 SLC6A3 TH TPH1 TPH2 (see all 9) (see less)
4	Catecholamine biosynthesis	Reactome	DBH DDC PNMT TH
5	catecholamine biosynthesis	PubChem	DBH DDC PNMT

Gene overlap in member pathways for Biogenic amine synthesis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DBH	Dopamine Beta-Hydroxylase	Protein Coding	5
2	PNMT	Phenylethanolamine N-Methyltransferase	Protein Coding	5
3	TH	Tyrosine Hydroxylase	Protein Coding	4
4	DDC	Dopa Decarboxylase	Protein Coding	4
5	COMT	Catechol-O-Methyltransferase	Protein Coding	3
6	TPH1	Tryptophan Hydroxylase 1	Protein Coding	2
7	PAH	Phenylalanine Hydroxylase	Protein Coding	2
8	ASMT	Acetylserotonin O-Methyltransferase	Protein Coding	2
9	MAOA	Monoamine Oxidase A	Protein Coding	2
10	AANAT	Aralkylamine N-Acetyltransferase	Protein Coding	2
11	ACHE	Acetylcholinesterase (Yt Blood Group)	Protein Coding	1
12	HDC	Histidine Decarboxylase	Protein Coding	1
13	GAD2	Glutamate Decarboxylase 2	Protein Coding	1
14	GAD1	Glutamate Decarboxylase 1	Protein Coding	1
15	CHAT	Choline O-Acetyltransferase	Protein Coding	1
16	DNAJC12	DnaJ Heat Shock Protein Family (Hsp40) Member C12	Protein Coding	1
17	QDPR	Quinoid Dihydropteridine Reductase	Protein Coding	1
18	MAOB	Monoamine Oxidase B	Protein Coding	1
19	GCH1	GTP Cyclohydrolase 1	Protein Coding	1
20	PTS	6-Pyruvoyltetrahydropterin Synthase	Protein Coding	1
21	DHFR	Dihydrofolate Reductase	Protein Coding	1
22	SPR	Sepiapterin Reductase	Protein Coding	1
23	TPH2	Tryptophan Hydroxylase 2	Protein Coding	1
24	SLC6A3	Solute Carrier Family 6 Member 3	Protein Coding	1
25	SLC18A2	Solute Carrier Family 18 Member A2	Protein Coding	1

Disorders associated with Biogenic amine synthesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hyperphenylalaninemia, bh4-deficient, a	Enrichment	GCH1, PAH, PTS, QDPR	10.36
2	Dystonia, dopa-responsive	Enrichment	GCH1, TH	5.47
3	Hyperphenylalaninemia, bh4-deficient, b	Enrichment	GCH1, PTS	5.47
4	Hyperphenylalaninemia due to tetrahydrobiopterin deficiency	Enrichment	PTS, QDPR	5.47
5	Dystonia	Enrichment	GCH1, SPR, TH	5.15
6	Rasopathy	Enrichment	DDC, PAH	3.44
7	Orthostatic hypotension 1	Enrichment	DBH	3.35
8	Aromatic l-amino acid decarboxylase deficiency	Enrichment	DDC	3.35
9	Dopamine beta-hydroxylase deficiency	Enrichment	DBH	3.35
10	Segawa syndrome, autosomal recessive	Enrichment	TH	3.23
11	Parkinsonism-dystonia 1, infantile-onset	Enrichment	SLC6A3	3.18
12	Classic dopamine transporter deficiency syndrome	Enrichment	SLC6A3	3.18
13	Catechol-o-methyltransferase activity, variation in	Enrichment	COMT	3.18
14	Parkinsonism-dystonia, infantile	Enrichment	SLC6A3	3.18
15	Apnea, central sleep	Enrichment	CHAT	2.96
16	Yt blood group antigen	Enrichment	ACHE	2.96
17	Developmental and epileptic encephalopathy 89	Enrichment	GAD1	2.96
18	Brunner syndrome	Enrichment	MAOA	2.96
19	Aspiration pneumonia	Enrichment	CHAT	2.96
20	Tetrahydrobiopterin-responsive hyperphenylalaninemia/phenylketonuria	Enrichment	PAH	2.96
21	Hyperphenylalaninemia, mild, non-bh4-deficient	Enrichment	DNAJC12	2.96
22	Megaloblastic anemia due to dihydrofolate reductase deficiency	Enrichment	DHFR	2.96
23	Hyperphenylalaninemia due to dnajc12 deficiency	Enrichment	DNAJC12	2.96
24	Major affective disorder 1	Enrichment	TPH2	2.88
25	Parkinsonism-dystonia 2, infantile-onset	Enrichment	SLC18A2	2.88
26	Gilles de la tourette syndrome	Enrichment	HDC	2.66
27	Neurodevelopmental disorder with spasticity, hypomyelinating leukodystrophy, and brain abnormalities	Enrichment	PAH	2.66
28	Myasthenic syndrome, congenital, 21, presynaptic	Enrichment	CHAT	2.66
29	Hyperphenylalaninemia, bh4-deficient, c	Enrichment	QDPR	2.66
30	Dystonia, dopa-responsive, due to sepiapterin reductase deficiency	Enrichment	SPR	2.66
31	Tobacco addiction	Enrichment	SLC6A3	2.58
32	Major depressive disorder	Enrichment	TPH2	2.48
33	Myasthenic syndrome, congenital, 6, presynaptic	Enrichment	CHAT	2.48
34	Pituitary hormone deficiency, combined, 2	Enrichment	PAH	2.48
35	Bronchopulmonary dysplasia	Enrichment	CHAT	2.48
36	Familial adenomatous polyposis 4	Enrichment	DHFR	2.48
37	Gtp cyclohydrolase 1-deficient dopa-responsive dystonia	Enrichment	GCH1	2.48
38	Phenylketonuria	Enrichment	PAH	2.35
39	Propionic acidemia	Enrichment	PAH	2.35
40	Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities	Enrichment	GAD1	2.35
41	Spastic quadriplegic cerebral palsy	Enrichment	GAD1	2.35
42	Sleep disorder	Enrichment	GCH1	2.26
43	Digeorge syndrome	Enrichment	COMT	2.10
44	Gastroesophageal reflux	Enrichment	CHAT	2.05
45	Myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency	Enrichment	CHAT	1.96
46	Presynaptic congenital myasthenic syndromes	Enrichment	CHAT	1.92
47	Lactic acidosis	Enrichment	CHAT	1.88
48	Pulmonary hypertension, primary, 1	Enrichment	PAH	1.85
49	Congenital myasthenic syndrome	Enrichment	CHAT	1.81
50	Endometrial cancer	Enrichment	DHFR	1.64
51	Bardet-biedl syndrome	Enrichment	COMT	1.56
52	Schizophrenia	Enrichment	COMT	1.41
53	Breast cancer	Enrichment	PAH	1.10
54	Inherited cancer-predisposing syndrome	Enrichment	DHFR	0.86

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Biogenic amine synthesis

Pathway Network for Biogenic amine synthesis

Pathway network for the Biogenic amine synthesis SuperPath

Member Pathways for Biogenic amine synthesis

Pathways in the Biogenic amine synthesis SuperPath

Gene overlap in member pathways for Biogenic amine synthesis SuperPath

Associated Genes for Biogenic amine synthesis

Associated Disorders for Biogenic amine synthesis

Disorders associated with Biogenic amine synthesis SuperPath

STRING Interaction Network for Biogenic amine synthesis

Sources for Biogenic amine synthesis