Biosynthesis of specialized proresolving mediators (SPMs)

Sources:

#	Name	Source	Genes
1	Biosynthesis of specialized proresolving mediators (SPMs)	Reactome	ALOX12 ALOX15 ALOX5 ALOX5AP CYP1A1 CYP1A2 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4 EPHX2 GPX4 GSTM4 HPGD LTA4H LTC4S PTGR1 PTGS2 (see all 19) (see less)
2	Biosynthesis of DHA-derived SPMs	Reactome	ALOX12 ALOX15 ALOX5 CYP1A1 CYP1A2 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4 EPHX2 GPX4 GSTM4 HPGD LTA4H LTC4S PTGS2 (see all 17) (see less)
3	Biosynthesis of maresins	Reactome	ALOX5 CYP1A2 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4 EPHX2 (see all 8) (see less)
4	Biosynthesis of EPA-derived SPMs	Reactome	ALOX15 ALOX5 GPX4 HPGD LTA4H PTGS2 (see all 6) (see less)
5	Biosynthesis of maresin-like SPMs	Reactome	CYP1A2 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4 (see all 6) (see less)
6	Biosynthesis of Lipoxins (LX)	Reactome	ALOX12 ALOX5 ALOX5AP HPGD LTC4S PTGR1 (see all 6) (see less)
7	Biosynthesis of E-series 18(S)-resolvins	Reactome	ALOX15 ALOX5 GPX4 HPGD LTA4H
8	Methoxyflurane Pathway, Pharmacokinetics	PharmGKB	CYP1A2 CYP2C9 CYP2D6 CYP2E1
9	Biosynthesis of E-series 18(R)-resolvins	Reactome	ALOX15 ALOX5 GPX4 LTA4H
10	Biosynthesis of protectins	Reactome	ALOX15 CYP1A1 CYP1A2 LTA4H
11	Biosynthesis of D-series resolvins	Reactome	ALOX5 GPX4 HPGD LTA4H
12	Biosynthesis of aspirin-triggered D-series resolvins	Reactome	ALOX5 GPX4 LTA4H
13	ALA oxylipin metabolism	WikiPathways	ALOX15 ALOX5 EPHX2

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ALOX5	Arachidonate 5-Lipoxygenase	Protein Coding	10
2	LTA4H	Leukotriene A4 Hydrolase	Protein Coding	8
3	ALOX15	Arachidonate 15-Lipoxygenase	Protein Coding	7
4	GPX4	Glutathione Peroxidase 4	Protein Coding	7
5	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	6
6	HPGD	15-Hydroxyprostaglandin Dehydrogenase	Protein Coding	6
7	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	5
8	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	5
9	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	5
10	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	4
11	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	4
12	EPHX2	Epoxide Hydrolase 2	Protein Coding	4
13	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	3
14	ALOX12	Arachidonate 12-Lipoxygenase, 12S Type	Protein Coding	3
15	LTC4S	Leukotriene C4 Synthase	Protein Coding	3
16	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	3
17	PTGR1	Prostaglandin Reductase 1	Protein Coding	2
18	ALOX5AP	Arachidonate 5-Lipoxygenase Activating Protein	Protein Coding	2
19	GSTM4	Glutathione S-Transferase Mu 4	Protein Coding	2

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Spondylometaphyseal dysplasia, sedaghatian type	Enrichment	GPX4	3.66
2	Atherosclerosis	Enrichment	ALOX5	3.66
3	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	3.53
4	Digital clubbing, isolated congenital	Enrichment	HPGD	3.53
5	Drug metabolism, altered, cyp2c8-related	Enrichment	CYP2C8	3.35
6	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	3.35
7	Leukotriene c4 synthase deficiency	Enrichment	LTC4S	3.35
8	Primary hypertrophic osteoarthropathy	Enrichment	HPGD	3.23
9	Coumarin resistance	Enrichment	CYP2C9	3.05
10	Hypertrophic osteoarthropathy, primary, autosomal recessive, 1	Enrichment	HPGD	3.05
11	Currarino syndrome	Enrichment	HPGD	2.93
12	Asthma	Enrichment	ALOX5	2.61
13	Hypercholesterolemia, familial, 1	Enrichment	EPHX2	2.54
14	Familial hypercholesterolemia	Enrichment	EPHX2	2.48
15	Stroke, ischemic	Enrichment	ALOX5AP	2.35

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Biosynthesis of specialized proresolving mediators (SPMs)