Bisphosphonate Pathway, Pharmacodynamics

No Pathway Network information available for Bisphosphonate Pathway, Pharmacodynamics

Pathways in the Bisphosphonate Pathway, Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Bisphosphonate Pathway, Pharmacodynamics	PharmGKB	CDC42 FDFT1 FDPS HMGCR HMGCS1 HRAS KRAS MRAS NRAS RAB1A RAC1 RAC2 RAC3 RAP1A RHOA RRAS SQLE (see all 17) (see less)
2	RalA downstream regulated genes	WikiPathways	CDC42 EXOC2 EXOC8 HRAS KRAS NRAS RAC1 RAC2 RAC3 RALA RALBP1 YBX3 (see all 12) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RAC1	Rac Family Small GTPase 1	Protein Coding	2
2	RAC2	Rac Family Small GTPase 2	Protein Coding	2
3	RAC3	Rac Family Small GTPase 3	Protein Coding	2
4	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
5	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
6	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
7	CDC42	Cell Division Cycle 42	Protein Coding	2
8	RRAS	RAS Related	Protein Coding	1
9	RAB1A	RAB1A, Member RAS Oncogene Family	Protein Coding	1
10	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
11	FDFT1	Farnesyl-Diphosphate Farnesyltransferase 1	Protein Coding	1
12	FDPS	Farnesyl Diphosphate Synthase	Protein Coding	1
13	SQLE	Squalene Epoxidase	Protein Coding	1
14	HMGCR	3-Hydroxy-3-Methylglutaryl-CoA Reductase	Protein Coding	1
15	HMGCS1	3-Hydroxy-3-Methylglutaryl-CoA Synthase 1	Protein Coding	1
16	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
17	RHOA	Ras Homolog Family Member A	Protein Coding	1
18	RALA	RAS Like Proto-Oncogene A	Protein Coding	1
19	RALBP1	RalA Binding Protein 1	Protein Coding	1
20	EXOC8	Exocyst Complex Component 8	Protein Coding	1
21	YBX3	Y-Box Binding Protein 3	Protein Coding	1
22	EXOC2	Exocyst Complex Component 2	Protein Coding	1

Disorders associated with Bisphosphonate Pathway, Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Enrichment	HRAS, KRAS, MRAS, NRAS, RRAS	10.17
2	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	8.67
3	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	7.73
4	Rasopathy	Enrichment	HRAS, KRAS, MRAS, NRAS	7.61
5	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS	7.06
6	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS	6.62
7	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	6.45
8	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	6.14
9	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	5.72
10	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	5.67
11	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	5.37
12	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	4.82
13	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.82
14	Noonan syndrome 3	Enrichment	HRAS, KRAS	4.82
15	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	4.82
16	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	4.70
17	Bladder cancer	Enrichment	HRAS, KRAS	3.54
18	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	3.48
19	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	3.26
20	Oculoectodermal syndrome	Enrichment	KRAS	3.05
21	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	3.05
22	Melanosis, neurocutaneous	Enrichment	NRAS	3.05
23	Noonan syndrome 6	Enrichment	NRAS	3.05
24	Hiatt-neu-cooper neurodevelopmental syndrome	Enrichment	RALA	3.05
25	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	3.05
26	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	3.05
27	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	3.05
28	Takenouchi-kosaki syndrome	Enrichment	CDC42	3.05
29	Neurodevelopmental disorder with microcephaly, seizures, and brain atrophy	Enrichment	EXOC8	3.05
30	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	3.05
31	Congenital pulmonary airway malformation	Enrichment	KRAS	3.05
32	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	3.05
33	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	3.05
34	Nocarh syndrome	Enrichment	CDC42	3.05
35	Phakomatosis pigmentokeratotica	Enrichment	HRAS	3.05
36	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	3.05
37	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	3.05
38	Neurocutaneous melanocytosis	Enrichment	NRAS	3.05
39	Noonan syndrome 11	Enrichment	MRAS	2.90
40	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.90
41	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.90
42	Low density lipoprotein cholesterol level quantitative trait locus 3	Enrichment	HMGCR	2.90
43	Muscular dystrophy, limb-girdle, autosomal recessive 28	Enrichment	HMGCR	2.90
44	Costello syndrome	Enrichment	HRAS	2.75
45	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.75
46	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.75
47	Immune system disease	Enrichment	CDC42	2.75
48	Neurodevelopmental disorder with dysmorphic facies and cerebellar hypoplasia	Enrichment	EXOC2	2.75
49	Wooly hair nevus	Enrichment	HRAS	2.75
50	Squalene synthase deficiency	Enrichment	FDFT1	2.60
51	Porokeratosis 9, multiple types	Enrichment	FDPS	2.60
52	Langerhans cell histiocytosis	Enrichment	NRAS	2.58
53	Spermatocytoma	Enrichment	HRAS	2.58
54	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.45
55	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.45
56	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.45
57	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.45
58	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.45
59	Pilocytic astrocytoma	Enrichment	KRAS	2.45
60	Epidermolytic nevus	Enrichment	HRAS	2.45
61	Porokeratosis	Enrichment	FDPS	2.30
62	Complex neurodevelopmental disorder	Enrichment	RAC3, RALA	2.29
63	Breast adenocarcinoma	Enrichment	KRAS	2.28
64	Lung squamous cell carcinoma	Enrichment	KRAS	2.28
65	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS	2.21
66	Gallbladder cancer	Enrichment	KRAS	2.21
67	Pilomyxoid astrocytoma	Enrichment	KRAS	2.21
68	Congenital myopathy 3 with rigid spine	Enrichment	HMGCS1	2.20
69	Hemihyperplasia, isolated	Enrichment	RHOA	2.13
70	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	2.10
71	Arteriovenous malformation	Enrichment	HRAS	2.10
72	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	2.05
73	Lip and oral cavity carcinoma	Enrichment	HRAS	1.98
74	Limb-girdle muscular dystrophy	Enrichment	HMGCR	1.95
75	Protein-deficiency anemia	Enrichment	NRAS	1.94
76	Lung cancer susceptibility 3	Enrichment	KRAS	1.91
77	Lynch syndrome	Enrichment	KRAS	1.88
78	Rhabdomyosarcoma	Enrichment	HRAS	1.85
79	Arteriovenous malformations of the brain	Enrichment	KRAS	1.78
80	Pancreatic cancer	Enrichment	KRAS	1.66
81	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.64
82	Lung cancer	Enrichment	KRAS	1.55
83	Gastric cancer	Enrichment	KRAS	1.43
84	Hereditary breast carcinoma	Enrichment	KRAS	1.42
85	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.32
86	Myeloma, multiple	Enrichment	KRAS	1.31
87	Breast cancer	Enrichment	KRAS	1.19
88	Colorectal cancer	Enrichment	NRAS	1.13
89	Ovarian cancer	Enrichment	KRAS	1.07

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Bisphosphonate Pathway, Pharmacodynamics

Pathway Network for Bisphosphonate Pathway, Pharmacodynamics

Member Pathways for Bisphosphonate Pathway, Pharmacodynamics

Pathways in the Bisphosphonate Pathway, Pharmacodynamics SuperPath

Associated Genes for Bisphosphonate Pathway, Pharmacodynamics

Associated Disorders for Bisphosphonate Pathway, Pharmacodynamics

Disorders associated with Bisphosphonate Pathway, Pharmacodynamics SuperPath

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