Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling

Pathway network for the Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling SuperPath

Sources:

R&D Systems
Reactome

Pathways in the Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling SuperPath

#	Name	Source	Genes
1	Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling	R&D Systems	ACTB AFDN CDH5 CGN CLDN1 CLDN10 CLDN11 CLDN12 CLDN15 CLDN17 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CTNNA1 CTNNA2 CTNNA3 CTNNB1 CTNND1 CYBA EZR F11R ICAM1 ITGA4 ITGAL ITGB1 ITGB2 JAM2 JAM3 MMP2 MMP9 MSN MYL3 MYLK NCF1 NCF2 NCF4 NOX4 OCLN PAK1 PAK2 PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PPP1CA PPP1R12A PPP1R12B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCZ PTK2B PTPN11 RAC1 RDX RHOA ROCK1 ROCK2 SRC TJP1 TJP2 VCAM1 (see all 78) (see less)
2	Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling	R&D Systems	ACTB AFDN AKT1 AKT2 AKT3 CALM1 CAMKK1 CDH5 CGN CLDN1 CLDN10 CLDN11 CLDN12 CLDN15 CLDN17 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CTNNA1 CTNNA2 CTNNA3 CTNNB1 CTNND1 CTTN CYBA EZR F11R HSPB1 ICAM1 ITGA4 ITGAL ITGB1 ITGB2 JAM2 JAM3 MSN MYL3 MYLK NCF1 NCF2 NCF4 NOS3 NOX4 OCLN PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PPP1CA PPP1R12A PPP1R12B PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCZ PTK2B RDX RHOA ROCK1 ROCK2 SRC TJP1 TJP2 VCAM1 (see all 84) (see less)
3	Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling	R&D Systems	ACTB AFDN AKR1B10 AKT1 AKT2 AKT3 CALM1 CDH5 CGN CLDN1 CLDN10 CLDN11 CLDN12 CLDN15 CLDN17 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CTNNA1 CTNNA2 CTNNA3 CTNNB1 CTNND1 EPN1 F11R FOXO1 ITCH JAM2 JAM3 KDR LEF1 MYL3 NOS3 OCLN PAK1 PAK2 PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PRKCB RAC1 SH2D2A SRC TJP1 TJP2 VAV1 VEGFA (see all 61) (see less)
4	Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling	R&D Systems	ACTB AFDN CCL2 CCR2 CDH5 CGN CLDN1 CLDN10 CLDN11 CLDN12 CLDN15 CLDN17 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CTNNA1 CTNNA2 CTNNA3 CTNNB1 CTNND1 F11R JAM2 JAM3 MYL3 MYLK OCLN PLCB1 PLCB3 PLCB4 PPP1CA PPP1R12A PPP1R12B PRKCA PRKCZ RHOA ROCK1 ROCK2 TJP1 TJP2 (see all 48) (see less)
5	Tight junction interactions	Reactome	CLDN1 CLDN10 CLDN11 CLDN12 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CRB3 F11R PALS1 PARD3 PARD6A PARD6B PARD6G PATJ PRKCI (see all 30) (see less)

Gene overlap in member pathways for Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CLDN1	Claudin 1	Protein Coding	5
2	CLDN2	Claudin 2	Protein Coding	5
3	CLDN3	Claudin 3	Protein Coding	5
4	CLDN4	Claudin 4	Protein Coding	5
5	CLDN5	Claudin 5	Protein Coding	5
6	CLDN6	Claudin 6	Protein Coding	5
7	CLDN7	Claudin 7	Protein Coding	5
8	CLDN8	Claudin 8	Protein Coding	5
9	CLDN9	Claudin 9	Protein Coding	5
10	CLDN10	Claudin 10	Protein Coding	5
11	CLDN11	Claudin 11	Protein Coding	5
12	CLDN12	Claudin 12	Protein Coding	5
13	CLDN15	Claudin 15	Protein Coding	5
14	CLDN17	Claudin 17	Protein Coding	5
15	CLDN19	Claudin 19	Protein Coding	5
16	CLDN20	Claudin 20	Protein Coding	5
17	CLDN22	Claudin 22	Protein Coding	5
18	CLDN23	Claudin 23	Protein Coding	5
19	F11R	F11 Receptor	Protein Coding	5
20	MYL3	Myosin Light Chain 3	Protein Coding	4
21	ACTB	Actin Beta	Protein Coding	4
22	TJP1	Tight Junction Protein 1	Protein Coding	4
23	TJP2	Tight Junction Protein 2	Protein Coding	4
24	OCLN	Occludin	Protein Coding	4
25	AFDN	Afadin, Adherens Junction Formation Factor	Protein Coding	4
26	CGN	Cingulin	Protein Coding	4
27	JAM2	Junctional Adhesion Molecule 2	Protein Coding	4
28	JAM3	Junctional Adhesion Molecule 3	Protein Coding	4
29	CDH5	Cadherin 5	Protein Coding	4
30	CTNND1	Catenin Delta 1	Protein Coding	4
31	CTNNB1	Catenin Beta 1	Protein Coding	4
32	CTNNA1	Catenin Alpha 1	Protein Coding	4
33	CTNNA2	Catenin Alpha 2	Protein Coding	4
34	CTNNA3	Catenin Alpha 3	Protein Coding	4
35	PRKCA	Protein Kinase C Alpha	Protein Coding	3
36	PRKCB	Protein Kinase C Beta	Protein Coding	3
37	PRKCZ	Protein Kinase C Zeta	Protein Coding	3
38	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	3
39	PLCG1	Phospholipase C Gamma 1	Protein Coding	3
40	PLCG2	Phospholipase C Gamma 2	Protein Coding	3
41	RHOA	Ras Homolog Family Member A	Protein Coding	3
42	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	3
43	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	3
44	PPP1CA	Protein Phosphatase 1 Catalytic Subunit Alpha	Protein Coding	3
45	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	3
46	PPP1R12B	Protein Phosphatase 1 Regulatory Subunit 12B	Protein Coding	3
47	MYLK	Myosin Light Chain Kinase	Protein Coding	3
48	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	3
49	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
50	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	3
51	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	3
52	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	3
53	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	3
54	ITGA4	Integrin Subunit Alpha 4	Protein Coding	2
55	ITGB1	Integrin Subunit Beta 1	Protein Coding	2
56	ITGAL	Integrin Subunit Alpha L	Protein Coding	2
57	ITGB2	Integrin Subunit Beta 2	Protein Coding	2
58	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	2
59	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	2
60	EZR	Ezrin	Protein Coding	2
61	RDX	Radixin	Protein Coding	2
62	MSN	Moesin	Protein Coding	2
63	PRKCD	Protein Kinase C Delta	Protein Coding	2
64	PRKCE	Protein Kinase C Epsilon	Protein Coding	2
65	PRKCG	Protein Kinase C Gamma	Protein Coding	2
66	PRKCQ	Protein Kinase C Theta	Protein Coding	2
67	RAC1	Rac Family Small GTPase 1	Protein Coding	2
68	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
69	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	2
70	NOX4	NADPH Oxidase 4	Protein Coding	2
71	NCF2	Neutrophil Cytosolic Factor 2	Protein Coding	2
72	NCF4	Neutrophil Cytosolic Factor 4	Protein Coding	2
73	NCF1	Neutrophil Cytosolic Factor 1	Protein Coding	2
74	CYBA	Cytochrome B-245 Alpha Chain	Protein Coding	2
75	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	2
76	CALM1	Calmodulin 1	Protein Coding	2
77	NOS3	Nitric Oxide Synthase 3	Protein Coding	2
78	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
79	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
80	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
81	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
82	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
83	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
84	CTTN	Cortactin	Protein Coding	1
85	CAMKK1	Calcium/Calmodulin Dependent Protein Kinase Kinase 1	Protein Coding	1
86	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	1
87	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	1
88	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	1
89	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	1
90	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
91	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
92	KDR	Kinase Insert Domain Receptor	Protein Coding	1
93	AKR1B10	Aldo-Keto Reductase Family 1 Member B10	Protein Coding	1
94	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
95	EPN1	Epsin 1	Protein Coding	1
96	SH2D2A	SH2 Domain Containing 2A	Protein Coding	1
97	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
98	FOXO1	Forkhead Box O1	Protein Coding	1
99	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
100	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
101	CCR2	C-C Motif Chemokine Receptor 2	Protein Coding	1
102	PLCB1	Phospholipase C Beta 1	Protein Coding	1
103	PLCB3	Phospholipase C Beta 3	Protein Coding	1
104	PLCB4	Phospholipase C Beta 4	Protein Coding	1
105	PATJ	PATJ Crumbs Cell Polarity Complex Component	Protein Coding	1
106	CLDN16	Claudin 16	Protein Coding	1
107	CLDN14	Claudin 14	Protein Coding	1
108	PARD6A	Par-6 Family Cell Polarity Regulator Alpha	Protein Coding	1
109	CLDN18	Claudin 18	Protein Coding	1
110	PRKCI	Protein Kinase C Iota	Protein Coding	1
111	PARD3	Par-3 Family Cell Polarity Regulator	Protein Coding	1
112	PALS1	Protein Associated With LIN7 1, MAGUK P55 Family Member	Protein Coding	1
113	PARD6G	Par-6 Family Cell Polarity Regulator Gamma	Protein Coding	1
114	PARD6B	Par-6 Family Cell Polarity Regulator Beta	Protein Coding	1
115	CRB3	Crumbs Cell Polarity Complex Component 3	Protein Coding	1

Disorders associated with Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Chronic granulomatous disease	Enrichment	CYBA, NCF1, NCF2, NCF4	6.90
2	Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis	Enrichment	CLDN1, CLDN16	5.33
3	Hypomagnesemia 5, renal, with or without ocular involvement	Enrichment	CLDN16, CLDN19	5.33
4	Renal hypomagnesemia 5 with ocular involvement	Enrichment	CLDN16, CLDN19	5.33
5	Colorectal cancer	Enrichment	AKT1, CTNNA1, CTNNB1, PIK3R1, SRC	4.36
6	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.23
7	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.23
8	Granulomatous disease, chronic, autosomal recessive, 2	Enrichment	NCF1, NCF2	4.01
9	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3R2	3.93
10	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.93
11	Nephrocalcinosis	Enrichment	CLDN16, CLDN19	3.68
12	Nephrolithiasis	Enrichment	CLDN16, CLDN19	3.68
13	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.06
14	Human immunodeficiency virus type 1	Enrichment	CCL2, CCR2	2.74
15	Hypomagnesemia 3, renal	Enrichment	CLDN16	2.66
16	Helix syndrome	Enrichment	CLDN10	2.66
17	Deafness, autosomal recessive 116	Enrichment	CLDN9	2.66
18	Azoospermia, obstructive, with nephrolithiasis	Enrichment	CLDN2	2.66
19	Leukodystrophy, hypomyelinating, 22	Enrichment	CLDN11	2.66
20	Primary hypomagnesemia	Enrichment	CLDN16	2.66
21	Pseudo-torch syndrome 1	Enrichment	OCLN	2.45
22	Baraitser-winter syndrome 1	Enrichment	ACTB	2.45
23	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	2.45
24	Deafness, autosomal dominant 51	Enrichment	TJP2	2.45
25	Cardiomyopathy, familial hypertrophic, 8	Enrichment	MYL3	2.45
26	Polycystic lung disease	Enrichment	CCR2	2.45
27	Arrhythmogenic right ventricular dysplasia, familial, 13	Enrichment	CTNNA3	2.45
28	Basal ganglia calcification, idiopathic, 8, autosomal recessive	Enrichment	JAM2	2.45
29	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.45
30	Cortical dysplasia, complex, with other brain malformations 9	Enrichment	CTNNA2	2.45
31	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.45
32	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.45
33	Becker nevus syndrome	Enrichment	ACTB	2.45
34	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.45
35	Hemorrhagic destruction of the brain, subependymal calcification, and cataracts	Enrichment	JAM3	2.45
36	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.45
37	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.45
38	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.45
39	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.45
40	Adenoid ameloblastoma	Enrichment	CTNNB1	2.45
41	Baraitser-winter syndrome	Enrichment	ACTB	2.45
42	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.45
43	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.45
44	Porencephaly-microcephaly-bilateral congenital cataract syndrome	Enrichment	JAM3	2.45
45	Microcystic stromal tumor	Enrichment	CTNNB1	2.45
46	Deafness, autosomal recessive 29	Enrichment	CLDN14	2.35
47	Proteus syndrome	Enrichment	AKT1	2.35
48	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.35
49	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.35
50	Knobloch syndrome 2	Enrichment	PAK2	2.35
51	Short syndrome	Enrichment	PIK3R1	2.35
52	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.35
53	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.35
54	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.35
55	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.35
56	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.35
57	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.35
58	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.35
59	Cowden syndrome 6	Enrichment	AKT1	2.35
60	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.35
61	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.35
62	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.35
63	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.35
64	Thrombocytopenia 6	Enrichment	SRC	2.35
65	Tufted angioma of skin	Enrichment	KDR	2.35
66	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.35
67	Capillary hemangioma	Enrichment	AKT3	2.35
68	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.35
69	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.35
70	Bladder cancer	Enrichment	CTNNA3, CTNNB1	2.33
71	Metachondromatosis	Enrichment	PTPN11	2.24
72	Granulomatous disease, chronic, autosomal recessive, 4	Enrichment	CYBA	2.24
73	Immunodeficiency 50	Enrichment	MSN	2.24
74	Deafness, autosomal recessive 24	Enrichment	RDX	2.24
75	Leopard syndrome 1	Enrichment	PTPN11	2.24
76	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.24
77	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.24
78	Malignant astrocytoma	Enrichment	PTPN11	2.24
79	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.21
80	Thrombocytopenia 5	Enrichment	CLDN16	2.18
81	Arachnoid cyst	Enrichment	PALS1	2.18
82	Blepharocheilodontic syndrome 1	Enrichment	CTNND1	2.15
83	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.15
84	Cholestasis, progressive familial intrahepatic, 4	Enrichment	TJP2	2.15
85	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	2.15
86	Blepharocheilodontic syndrome 2	Enrichment	CTNND1	2.15
87	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.15
88	Ocular melanoma	Enrichment	PLCB4	2.15
89	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB	2.15
90	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.15
91	Teratoma	Enrichment	CTNNB1	2.15
92	Long qt syndrome	Enrichment	CALM1, CTNNA3	2.07
93	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.05
94	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.05
95	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.05
96	Angioma, tufted	Enrichment	KDR	2.05
97	Long qt syndrome 14	Enrichment	CALM1	2.05
98	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.05
99	Senior-loken syndrome 7	Enrichment	AKT3	2.05
100	Split hand-foot malformation	Enrichment	LEF1	2.05
101	Immune system disease	Enrichment	PIK3CD	2.05
102	Bardet-biedl syndrome 16	Enrichment	AKT3	2.05
103	Desmoid disease, hereditary	Enrichment	CTNNB1	1.98
104	Hypercholanemia, familial 1	Enrichment	TJP2	1.98
105	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.98
106	Aortic aneurysm, familial thoracic 7	Enrichment	MYLK	1.98
107	Anus, imperforate	Enrichment	CTNNB1	1.98
108	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.98
109	Desmoid tumor	Enrichment	CTNNB1	1.98
110	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	1.98
111	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	1.94
112	Granulomatous disease, chronic, autosomal recessive, 1	Enrichment	NCF1	1.94
113	Granulomatous disease, chronic, autosomal recessive, 3	Enrichment	NCF4	1.94
114	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	1.94
115	Albinism, oculocutaneous, type ia	Enrichment	NOX4	1.94
116	Werner syndrome	Enrichment	PTPN11	1.94
117	Metaphyseal anadysplasia 2	Enrichment	MMP9	1.94
118	Metaphyseal anadysplasia	Enrichment	MMP9	1.94
119	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	1.91
120	Anxiety	Enrichment	PALS1	1.88
121	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.87
122	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CTNNA1	1.85
123	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	MYLK	1.85
124	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	1.85
125	Auriculocondylar syndrome 1	Enrichment	PLCB4	1.85
126	Pilomatrixoma	Enrichment	CTNNB1	1.85
127	Aminoacylase 1 deficiency	Enrichment	ACTB	1.85
128	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.85
129	Alazami syndrome	Enrichment	CTNNB1	1.85
130	Craniopharyngioma	Enrichment	CTNNB1	1.85
131	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.85
132	Hereditary breast ovarian cancer syndrome	Enrichment	CTNNA1, CTNNA2	1.79
133	Autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	Enrichment	CYBA	1.77
134	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	1.77
135	Autoimmune polyendocrine syndrome type 1	Enrichment	CYBA	1.77
136	Tricuspid valve insufficiency	Enrichment	PTPN11	1.77
137	Perrault syndrome	Enrichment	CLDN14	1.76
138	Visceral myopathy 1	Enrichment	MYLK	1.76
139	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.76
140	Knobloch syndrome	Enrichment	PAK2	1.75
141	Melanoma, uveal	Enrichment	PLCB4	1.68
142	Branchiootorenal syndrome 1	Enrichment	TJP2	1.68
143	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.68
144	Hemihyperplasia, isolated	Enrichment	RHOA	1.68
145	Adrenocortical carcinoma	Enrichment	CTNNB1	1.68
146	Familial hypercholanemia	Enrichment	TJP2	1.68
147	Cleft lip with or without cleft palate	Enrichment	CTNND1	1.68
148	Alzheimer disease 2	Enrichment	NOS3	1.65
149	Rhabdomyosarcoma 2	Enrichment	FOXO1	1.65
150	Knobloch syndrome 1	Enrichment	PAK2	1.65
151	Pre-eclampsia	Enrichment	NOS3	1.65
152	Hemimegalencephaly	Enrichment	AKT3	1.65
153	Granulomatous disease, chronic, x-linked	Enrichment	NCF1	1.64
154	Retinitis pigmentosa 26	Enrichment	ITGA4	1.64
155	Hereditary ataxia	Enrichment	PRKCG	1.64
156	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.64
157	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	1.64
158	Cerebral malaria	Enrichment	ICAM1	1.64
159	Branchiootorenal syndrome	Enrichment	TJP2	1.61
160	Gallbladder cancer	Enrichment	CTNNB1	1.61
161	Hypertrophic cardiomyopathy	Enrichment	MYL3, PTPN11	1.60
162	Split-hand/foot malformation 1	Enrichment	LEF1	1.57
163	Hemangioma, capillary infantile	Enrichment	KDR	1.57
164	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.57
165	Breast adenocarcinoma	Enrichment	AKT1	1.57
166	Basal ganglia calcification, idiopathic, 1	Enrichment	JAM2	1.55
167	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.55
168	Neural tube defects	Enrichment	PARD3	1.55
169	Lymphoma	Enrichment	PTPN11	1.55
170	Primary ovarian insufficiency	Enrichment	KDR, NOS3	1.54
171	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.51
172	Thrombocytopenia	Enrichment	PTPN11, SRC	1.51
173	Myelofibrosis	Enrichment	SRC	1.51
174	Megacolon	Enrichment	AKT3	1.51
175	Overgrowth syndrome	Enrichment	PIK3R1	1.51
176	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.50
177	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.50
178	Primary biliary cholangitis	Enrichment	TJP2	1.50
179	Familial thoracic aortic aneurysm and dissection	Enrichment	MYLK	1.50
180	Microcephaly	Enrichment	ACTB, CTNNB1, PTPN11	1.47
181	Patent ductus arteriosus	Enrichment	PTPN11	1.47
182	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.45
183	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1	1.45
184	Noonan syndrome 3	Enrichment	PTPN11	1.40
185	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.40
186	Cowden syndrome	Enrichment	AKT1	1.40
187	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	CTNNA3	1.38
188	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	CTNNA3	1.38
189	Stroke, ischemic	Enrichment	NOS3	1.36
190	Polymicrogyria	Enrichment	AKT3	1.36
191	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.35
192	Medulloblastoma	Enrichment	CTNNB1	1.31
193	Aortic aneurysm, familial thoracic 1	Enrichment	MYLK	1.31
194	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CTNNA3	1.31
195	Cardiomyopathy, familial hypertrophic, 4	Enrichment	NCF1	1.30
196	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.30
197	Meningioma	Enrichment	AKT1	1.28
198	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	CTNNA3	1.26
199	Isolated congenital microcephaly	Enrichment	OCLN	1.26
200	Nk-cell enteropathy	Enrichment	PIK3CB	1.24
201	Polycystic liver disease	Enrichment	CTNNB1	1.23
202	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.23
203	Osteoporosis	Enrichment	SRC	1.21
204	Pectus excavatum	Enrichment	PTPN11	1.21
205	Specific learning disability	Enrichment	PTPN11	1.21
206	Epicanthus	Enrichment	PTPN11	1.17
207	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.17
208	Congenital long qt syndrome	Enrichment	PTPN11	1.17
209	Craniosynostosis	Enrichment	CTNNA1	1.16
210	Hepatoblastoma	Enrichment	CTNNB1	1.14
211	Male infertility	Enrichment	CLDN2	1.14
212	Alzheimer disease, familial, 1	Enrichment	NOS3	1.13
213	Hypertension, essential	Enrichment	NOS3	1.13
214	Hepatocellular carcinoma	Enrichment	CTNNB1	1.12
215	Ovarian cancer	Enrichment	AKT1, CTNNB1	1.12
216	Isolated macular dystrophy	Enrichment	ITGA4	1.11
217	Diffuse large b-cell lymphoma	Enrichment	FOXO1	1.09
218	Cerebral palsy	Enrichment	PALS1	1.08
219	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.08
220	Patent foramen ovale	Enrichment	PTPN11	1.01
221	Sensorineural hearing loss	Enrichment	CLDN14	1.00
222	Williams-beuren syndrome	Enrichment	NCF1	0.96
223	Familial hypertrophic cardiomyopathy	Enrichment	MYL3	0.96
224	Tetralogy of fallot	Enrichment	KDR	0.96
225	Noonan syndrome 1	Enrichment	PTPN11	0.91
226	Malaria	Enrichment	ICAM1	0.91
227	Long qt syndrome 1	Enrichment	CALM1	0.90
228	Scoliosis	Enrichment	PTPN11	0.89
229	Deafness, autosomal recessive	Enrichment	CLDN14	0.88
230	Autosomal recessive nonsyndromic deafness	Enrichment	CLDN14	0.88
231	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.87
232	Hydrops fetalis, nonimmune	Enrichment	PTPN11	0.86
233	Rasopathy	Enrichment	PTPN11	0.86
234	Centralopathic epilepsy	Enrichment	PLCB1	0.85
235	Strabismus	Enrichment	PTPN11	0.84
236	West syndrome	Enrichment	PLCB1	0.84
237	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MYLK	0.84
238	Non-immune hydrops fetalis	Enrichment	PTPN11	0.79
239	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TJP2	0.77
240	Type 2 diabetes mellitus	Enrichment	AKT2	0.76
241	Inherited cancer-predisposing syndrome	Enrichment	CTNNA1, PTPN11	0.75
242	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	CLDN14	0.75
243	Hereditary breast carcinoma	Enrichment	AKT1	0.74
244	Non-syndromic genetic deafness	Enrichment	RDX	0.73
245	Nonsyndromic hearing loss	Enrichment	RDX	0.67
246	Myeloma, multiple	Enrichment	PIK3R2	0.65
247	Charcot-marie-tooth disease	Enrichment	HSPB1	0.65
248	Complex neurodevelopmental disorder	Enrichment	PALS1	0.62
249	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.56
250	Autosomal recessive non-syndromic intellectual disability	Enrichment	EZR	0.55
251	Breast cancer	Enrichment	AKT1	0.54
252	Congenital nervous system abnormality	Enrichment	CTNNB1	0.50
253	Nervous system disease	Enrichment	CTNNB1	0.50
254	Cone-rod dystrophy 2	Enrichment	ITGA4	0.49
255	Rare genetic deafness	Enrichment	RDX	0.44
256	Autism spectrum disorder	Enrichment	PTPN11	0.33
257	Hereditary retinal dystrophy	Enrichment	CTNNA1, ITGA4	0.30
258	Fundus dystrophy	Enrichment	CTNNA1, ITGA4	0.30

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling

Pathway Network for Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling

Pathway network for the Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling SuperPath

Member Pathways for Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling

Pathways in the Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling SuperPath

Gene overlap in member pathways for Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling SuperPath

Associated Genes for Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling

Associated Disorders for Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling

Disorders associated with Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling SuperPath

STRING Interaction Network for Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling

Sources for Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling