Blood group systems biosynthesis
Pathway network for the Blood group systems biosynthesis SuperPath
Sources:
- Reactome
- PubChem
- WikiPathways
Pathways in the Blood group systems biosynthesis SuperPath
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | FUT3 | Fucosyltransferase 3 (Lewis Blood Group) | Protein Coding | 6 |
| 2 | ABO | ABO, Alpha 1-3-N-Acetylgalactosaminyltransferase And Alpha 1-3-Galactosyltransferase | Protein Coding | 6 |
| 3 | B3GALT5 | Beta-1,3-Galactosyltransferase 5 | Protein Coding | 5 |
| 4 | FUT2 | Fucosyltransferase 2 (H Blood Group) | Protein Coding | 5 |
| 5 | ST3GAL3 | ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3 | Protein Coding | 5 |
| 6 | FUT9 | Fucosyltransferase 9 | Protein Coding | 4 |
| 7 | FUT1 | Fucosyltransferase 1 (H Blood Group) | Protein Coding | 4 |
| 8 | FUT5 | Fucosyltransferase 5 | Protein Coding | 4 |
| 9 | FUT6 | Fucosyltransferase 6 | Protein Coding | 4 |
| 10 | ST3GAL4 | ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4 | Protein Coding | 4 |
| 11 | B3GALT1 | Beta-1,3-Galactosyltransferase 1 | Protein Coding | 4 |
| 12 | FUT4 | Fucosyltransferase 4 | Protein Coding | 3 |
| 13 | FUT7 | Fucosyltransferase 7 | Protein Coding | 3 |
| 14 | ST3GAL6 | ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6 | Protein Coding | 2 |
| 15 | B4GALNT2 | Beta-1,4-N-Acetyl-Galactosaminyltransferase 2 (SID Blood Group) | Protein Coding | 2 |
| 16 | ST6GALNAC6 | ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6 | Protein Coding | 2 |
| 17 | RHCE | Rh Blood Group CcEe Antigens | Protein Coding | 2 |
| 18 | RHD | Rh Blood Group D Antigen | Protein Coding | 2 |
| 19 | B3GALT4 | Beta-1,3-Galactosyltransferase 4 | Protein Coding | 2 |
| 20 | B3GALT2 | Beta-1,3-Galactosyltransferase 2 | Protein Coding | 2 |
| 21 | B4GALT2 | Beta-1,4-Galactosyltransferase 2 | Protein Coding | 2 |
| 22 | B4GALT3 | Beta-1,4-Galactosyltransferase 3 | Protein Coding | 2 |
| 23 | CHST1 | Carbohydrate Sulfotransferase 1 | Protein Coding | 2 |
| 24 | B4GALT1 | Beta-1,4-Galactosyltransferase 1 | Protein Coding | 2 |
| 25 | CHST2 | Carbohydrate Sulfotransferase 2 | Protein Coding | 1 |
| 26 | ST8SIA2 | ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 2 | Protein Coding | 1 |
Disorders associated with Blood group systems biosynthesis SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Bombay phenotype | Enrichment | FUT1, FUT2 | 7.49 |
| 2 | Hemolytic disease of fetus and newborn, rh-induced | Enrichment | RHCE, RHD | 7.49 |
| 3 | Blood group, rh system | Enrichment | RHD | 3.83 |
| 4 | Rh-null, amorph type | Enrichment | RHCE | 3.83 |
| 5 | Vitamin b12 plasma level quantitative trait locus 1 | Enrichment | FUT2 | 3.35 |
| 6 | Intellectual developmental disorder, autosomal recessive 12 | Enrichment | ST3GAL3 | 3.35 |
| 7 | Blood group, lewis system | Enrichment | FUT3 | 3.35 |
| 8 | St3gal3-cdg | Enrichment | ST3GAL3 | 3.35 |
| 9 | Developmental and epileptic encephalopathy 15 | Enrichment | ST3GAL3 | 3.05 |
| 10 | Congenital disorder of glycosylation, type iid | Enrichment | B4GALT1 | 3.02 |
| 11 | Fucosyltransferase 6 deficiency | Enrichment | FUT6 | 3.02 |
| 12 | Combined low ldl and fibrinogen | Enrichment | B4GALT1 | 3.02 |
| 13 | Blood group, sid system | Enrichment | B4GALNT2 | 2.93 |
| 14 | Variegate porphyria | Enrichment | B4GALT3 | 2.32 |
| 15 | Developmental and epileptic encephalopathy | Enrichment | ST3GAL3 | 1.80 |
