BMP signaling in eyelid development

No Pathway Network information available for BMP signaling in eyelid development

Pathways in the BMP signaling in eyelid development SuperPath

#	Name	Source	Genes
1	BMP signaling in eyelid development	WikiPathways	BMP4 DKK2 EGFR FGF10 FGFR2 FOXC1 FOXC2 INHBB JUN MAP3K1 MAPK3 MAPK9 NOTCH1 PITX2 SFRP1 SHH SMAD1 SMAD4 SMAD5 TGFA (see all 20) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TGFA	Transforming Growth Factor Alpha	Protein Coding	1
2	BMP4	Bone Morphogenetic Protein 4	Protein Coding	1
3	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
4	SFRP1	Secreted Frizzled Related Protein 1	Protein Coding	1
5	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
6	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
7	PITX2	Paired Like Homeodomain 2	Protein Coding	1
8	NOTCH1	Notch Receptor 1	Protein Coding	1
9	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
10	SMAD5	SMAD Family Member 5	Protein Coding	1
11	SMAD4	SMAD Family Member 4	Protein Coding	1
12	SMAD1	SMAD Family Member 1	Protein Coding	1
13	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
14	INHBB	Inhibin Subunit Beta B	Protein Coding	1
15	FOXC2	Forkhead Box C2	Protein Coding	1
16	FOXC1	Forkhead Box C1	Protein Coding	1
17	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
18	FGF10	Fibroblast Growth Factor 10	Protein Coding	1
19	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
20	DKK2	Dickkopf Wnt Signaling Pathway Inhibitor 2	Protein Coding	1

Disorders associated with BMP signaling in eyelid development SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Peters-plus syndrome	Enrichment	BMP4, FOXC1, PITX2	6.49
2	Axenfeld-rieger anomaly with partially absent eye muscles, distinctive face, hydrocephaly, and skeletal abnormalities	Enrichment	FOXC1, PITX2	5.69
3	Axenfeld-rieger syndrome	Enrichment	FOXC1, PITX2	5.69
4	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGF10, FGFR2	5.21
5	Lung cancer susceptibility 3	Enrichment	EGFR, FGF10	3.73
6	Anterior segment dysgenesis	Enrichment	FOXC1, PITX2	3.67
7	Holoprosencephaly 3	Enrichment	SHH	2.83
8	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.83
9	Axenfeld-rieger syndrome, type 1	Enrichment	PITX2	2.83
10	Hypertelorism and tetralogy of fallot	Enrichment	FOXC1	2.83
11	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.83
12	Apert syndrome	Enrichment	FGFR2	2.83
13	Microphthalmia/coloboma 5	Enrichment	SHH	2.83
14	Anterior segment dysgenesis 4	Enrichment	PITX2	2.83
15	Ring dermoid of cornea	Enrichment	PITX2	2.83
16	46,xy sex reversal 6	Enrichment	MAP3K1	2.83
17	Aplasia of lacrimal and salivary glands	Enrichment	FGF10	2.83
18	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.83
19	Microphthalmia, syndromic 6	Enrichment	BMP4	2.83
20	Orofacial cleft 11	Enrichment	BMP4	2.83
21	Lacrimoauriculodentodigital syndrome 3	Enrichment	FGF10	2.83
22	Heritable thoracic aortic disease	Enrichment	SMAD4	2.83
23	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.83
24	Interstitial lung disease specific to childhood	Enrichment	FGF10	2.83
25	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	2.83
26	Gastric cancer	Enrichment	FGFR2, SMAD4	2.75
27	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1, SMAD4	2.73
28	Myhre syndrome	Enrichment	SMAD4	2.53
29	Pulmonary hypoplasia, primary	Enrichment	FGF10	2.53
30	Axenfeld-rieger syndrome, type 3	Enrichment	FOXC1	2.53
31	Atrial fibrillation, familial, 1	Enrichment	PITX2	2.53
32	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.53
33	Lymphedema-distichiasis syndrome	Enrichment	FOXC2	2.53
34	Aural atresia, congenital	Enrichment	FGFR2	2.53
35	Pfeiffer syndrome	Enrichment	FGFR2	2.53
36	Jackson-weiss syndrome	Enrichment	FGFR2	2.53
37	Solitary median maxillary central incisor	Enrichment	SHH	2.53
38	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.53
39	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.53
40	Anterior segment dysgenesis 3	Enrichment	FOXC1	2.53
41	Split hand-foot malformation	Enrichment	FGFR2	2.53
42	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.53
43	Isolated radial hemimelia	Enrichment	SHH	2.53
44	Crouzon syndrome	Enrichment	FGFR2	2.35
45	Juvenile polyposis syndrome	Enrichment	SMAD4	2.35
46	Syndactyly, type iv	Enrichment	SHH	2.35
47	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.35
48	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	2.35
49	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.35
50	Keratoacanthoma	Enrichment	NOTCH1	2.35
51	Polydactyly, preaxial ii	Enrichment	SHH	2.23
52	Schizencephaly	Enrichment	SHH	2.23
53	Saethre-chotzen syndrome	Enrichment	FGFR2	2.23
54	Glioma	Enrichment	FGFR2	2.23
55	Colorectal cancer	Enrichment	FGFR2, SMAD4	2.14
56	Hemifacial hyperplasia	Enrichment	FGFR2	2.13
57	Juvenile glaucoma	Enrichment	FOXC1	2.13
58	Aniridia	Enrichment	FOXC1	2.13
59	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	2.13
60	Cowden syndrome 1	Enrichment	EGFR	2.05
61	Split-hand/foot malformation 1	Enrichment	FGFR2	2.05
62	Anterior segment dysgenesis 5	Enrichment	BMP4	2.05
63	Lung squamous cell carcinoma	Enrichment	EGFR	2.05
64	Ovarian cancer	Enrichment	EGFR, MAP3K1	2.02
65	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.99
66	Adams-oliver syndrome	Enrichment	NOTCH1	1.99
67	Gallbladder cancer	Enrichment	SMAD4	1.99
68	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.99
69	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.93
70	Orofacial cleft 1	Enrichment	FGF10	1.88
71	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.83
72	Stickler syndrome	Enrichment	BMP4	1.83
73	Inherited cancer-predisposing syndrome	Enrichment	EGFR, SMAD4	1.80
74	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.79
75	Lung non-small cell carcinoma	Enrichment	EGFR	1.79
76	Septooptic dysplasia	Enrichment	SHH	1.76
77	Renal hypodysplasia/aplasia 3	Enrichment	BMP4	1.76
78	Lip and oral cavity carcinoma	Enrichment	EGFR	1.76
79	Aortic valve disease 1	Enrichment	NOTCH1	1.72
80	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.69
81	Cleft lip/palate	Enrichment	BMP4	1.69
82	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.69
83	Hydrocephalus	Enrichment	FGFR2	1.66
84	Septopreoptic holoprosencephaly	Enrichment	SHH	1.66
85	Midline interhemispheric variant of holoprosencephaly	Enrichment	SHH	1.66
86	Gliosarcoma	Enrichment	EGFR	1.63
87	Microform holoprosencephaly	Enrichment	SHH	1.63
88	Lobar holoprosencephaly	Enrichment	SHH	1.63
89	Giant cell glioblastoma	Enrichment	EGFR	1.61
90	Alobar holoprosencephaly	Enrichment	SHH	1.61
91	Semilobar holoprosencephaly	Enrichment	SHH	1.58
92	Arteriovenous malformations of the brain	Enrichment	EGFR	1.56
93	Macs syndrome	Enrichment	SHH	1.54
94	Craniosynostosis	Enrichment	FGFR2	1.54
95	Endometrial cancer	Enrichment	FGFR2	1.52
96	Tooth agenesis	Enrichment	TGFA	1.50
97	Familial atrial fibrillation	Enrichment	PITX2	1.46
98	Pancreatic cancer	Enrichment	SMAD4	1.44
99	Tetralogy of fallot	Enrichment	NOTCH1	1.42
100	Hydrops fetalis, nonimmune	Enrichment	FOXC2	1.42
101	Bladder cancer	Enrichment	EGFR	1.38
102	Non-immune hydrops fetalis	Enrichment	FOXC2	1.35
103	Lung cancer	Enrichment	EGFR	1.34
104	Connective tissue disease	Enrichment	NOTCH1	1.34
105	Cakut	Enrichment	FOXC1	1.31
106	Thrombocytopenia	Enrichment	SMAD4	1.16
107	Hypertelorism	Enrichment	FGFR2	1.13
108	Autism	Enrichment	SHH	1.00
109	Breast cancer	Enrichment	JUN	0.98

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

BMP signaling in eyelid development

Pathway Network for BMP signaling in eyelid development

Member Pathways for BMP signaling in eyelid development

Pathways in the BMP signaling in eyelid development SuperPath

Associated Genes for BMP signaling in eyelid development

Associated Disorders for BMP signaling in eyelid development

Disorders associated with BMP signaling in eyelid development SuperPath

STRING Interaction Network for BMP signaling in eyelid development

Sources for BMP signaling in eyelid development