Bone morphogenic protein signaling and regulation

No Pathway Network information available for Bone morphogenic protein signaling and regulation

Pathways in the Bone morphogenic protein signaling and regulation SuperPath

#	Name	Source	Genes
1	Bone morphogenic protein signaling and regulation	WikiPathways	BMP2 BMPR1A BMPR1B BMPR2 NOG RUNX2 SMAD1 SMAD4 SMAD6 SMURF1 TOB1 TOB2 (see all 12) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NOG	Noggin	Protein Coding	1
2	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	1
3	BMPR2	Bone Morphogenetic Protein Receptor Type 2	Protein Coding	1
4	BMPR1B	Bone Morphogenetic Protein Receptor Type 1B	Protein Coding	1
5	BMPR1A	Bone Morphogenetic Protein Receptor Type 1A	Protein Coding	1
6	BMP2	Bone Morphogenetic Protein 2	Protein Coding	1
7	SMURF1	SMAD Specific E3 Ubiquitin Protein Ligase 1	Protein Coding	1
8	SMAD6	SMAD Family Member 6	Protein Coding	1
9	SMAD4	SMAD Family Member 4	Protein Coding	1
10	SMAD1	SMAD Family Member 1	Protein Coding	1
11	TOB2	Transducer Of ERBB2, 2	Protein Coding	1
12	TOB1	Transducer Of ERBB2, 1	Protein Coding	1

Disorders associated with Bone morphogenic protein signaling and regulation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Craniosynostosis 7	Enrichment	BMP2, SMAD6	6.14
2	Juvenile polyposis syndrome	Enrichment	BMPR1A, SMAD4	5.67
3	Brachydactyly, type a2	Enrichment	BMP2, BMPR1B	5.37
4	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	BMPR1A, SMAD4	5.14
5	Stapes ankylosis with broad thumbs and toes	Enrichment	NOG	3.05
6	Tarsal-carpal coalition syndrome	Enrichment	NOG	3.05
7	Polyposis syndrome, hereditary mixed, 2	Enrichment	BMPR1A	3.05
8	Acromesomelic dysplasia 3	Enrichment	BMPR1B	3.05
9	Brachydactyly, type b2	Enrichment	NOG	3.05
10	Symphalangism, proximal, 1a	Enrichment	NOG	3.05
11	Multiple synostoses syndrome 1	Enrichment	NOG	3.05
12	Brachydactyly, type a1, d	Enrichment	BMPR1B	3.05
13	Radioulnar synostosis, nonsyndromic	Enrichment	SMAD6	3.05
14	20p12.3 microdeletion syndrome	Enrichment	BMP2	3.05
15	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1	Enrichment	BMP2	3.05
16	Heritable thoracic aortic disease	Enrichment	SMAD4	3.05
17	Primary pulmonary hypertension	Enrichment	BMPR2	3.05
18	Pulmonary hypertension	Enrichment	BMPR2	3.05
19	Drug- or toxin-induced pulmonary arterial hypertension	Enrichment	BMPR2	3.05
20	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	2.75
21	Myhre syndrome	Enrichment	SMAD4	2.75
22	Pulmonary venoocclusive disease 1, autosomal dominant	Enrichment	BMPR2	2.75
23	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.75
24	Fibrodysplasia ossificans progressiva	Enrichment	BMPR2	2.75
25	Pulmonary venoocclusive disease 1	Enrichment	BMPR2	2.75
26	Aortic valve disease 2	Enrichment	SMAD6	2.75
27	Proximal symphalangism	Enrichment	NOG	2.75
28	Hereditary mixed polyposis syndrome	Enrichment	BMPR1A	2.75
29	Radioulnar synostosis	Enrichment	SMAD6	2.75
30	Pulmonary venoocclusive disease	Enrichment	BMPR2	2.75
31	Juvenile polyposis of infancy	Enrichment	BMPR1A	2.75
32	Idiopathic/heritable pulmonary arterial hypertension	Enrichment	BMPR2	2.75
33	Brachydactyly, type a1	Enrichment	BMPR1B	2.58
34	Cleidocranial dysplasia 1	Enrichment	RUNX2	2.58
35	Brachydactyly, type c	Enrichment	BMPR1B	2.58
36	Acromesomelic dysplasia 2a	Enrichment	BMPR1B	2.58
37	Acromesomelic dysplasia 2c	Enrichment	BMPR1B	2.58
38	Acromesomelic dysplasia 2b	Enrichment	BMPR1B	2.58
39	Transposition of the great arteries, dextro-looped	Enrichment	BMP2	2.58
40	Cleidocranial dysplasia	Enrichment	RUNX2	2.58
41	Pulmonary arterial hypertension associated with congenital heart disease	Enrichment	BMPR2	2.58
42	Multiple synostoses syndrome	Enrichment	NOG	2.45
43	Ventricular septal defect 1	Enrichment	BMP2	2.35
44	Atrial septal defect 1	Enrichment	BMP2	2.28
45	Inherited cancer-predisposing syndrome	Enrichment	BMPR1A, SMAD4	2.24
46	Gallbladder cancer	Enrichment	SMAD4	2.21
47	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	2.21
48	Hemochromatosis, type 1	Enrichment	BMP2	2.15
49	Tooth agenesis, selective, 1	Enrichment	BMPR2	2.10
50	Polydactyly	Enrichment	SMAD6	2.10
51	Heritable pulmonary arterial hypertension	Enrichment	BMPR2	2.01
52	Familial colorectal cancer type x	Enrichment	BMPR1A	2.01
53	Aortic valve disease 1	Enrichment	SMAD6	1.94
54	Pulmonary hypertension, primary, 1	Enrichment	BMPR2	1.94
55	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD6	1.91
56	Heart, malformation of	Enrichment	SMAD6	1.80
57	Craniosynostosis	Enrichment	SMAD6	1.76
58	Pancreatic cancer	Enrichment	SMAD4	1.66
59	Gastric cancer	Enrichment	SMAD4	1.43
60	Nephrotic syndrome	Enrichment	RUNX2	1.43
61	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD4	1.42
62	Thrombocytopenia	Enrichment	SMAD4	1.38
63	Colorectal cancer	Enrichment	SMAD4	1.13
64	Ovarian cancer	Enrichment	BMPR1A	1.07

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Bone morphogenic protein signaling and regulation

Pathway Network for Bone morphogenic protein signaling and regulation

Member Pathways for Bone morphogenic protein signaling and regulation

Pathways in the Bone morphogenic protein signaling and regulation SuperPath

Associated Genes for Bone morphogenic protein signaling and regulation

Associated Disorders for Bone morphogenic protein signaling and regulation

Disorders associated with Bone morphogenic protein signaling and regulation SuperPath

STRING Interaction Network for Bone morphogenic protein signaling and regulation

Sources for Bone morphogenic protein signaling and regulation